LETM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LETM1
Entrez Gene ID	3954
Full Name	leucine zipper and EF-hand containing transmembrane protein 1
Synonyms	SLC55A1
General protein information	Preferred Names leucine zipper and EF-hand containing transmembrane protein 1 Names mitochondrial proton/calcium exchanger protein LETM1 and EF-hand domain-containing protein 1, mitochondrial Mdm38 homolog leucine zipper-EF-hand containing transmembrane protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.3
Summary	This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009].
Disorder MIM:	604407

mRNA and Protein(s)

mRNA	Protein	Name
NM_012318.2	NP_036450.1	mitochondrial proton/calcium exchanger protein precursor
XM_006713884.1	XP_006713947.1	mitochondrial proton/calcium exchanger protein isoform X1
XM_017008187.1	XP_016863676.1	LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X2
NM_012318.3	NP_036450.1	mitochondrial proton/calcium exchanger protein precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LETM1	NP_001069082.1
Mus musculus (house mouse)	Letm1	NP_062668.1
Danio rerio (zebrafish)	letm1	NP_001038673.1
Kluyveromyces lactis	KLLA0B11341g	XP_452034.1
Neurospora crassa	NCU03217	XP_965317.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003296	XP_003436436.1
Caenorhabditis elegans (roundworm)	letm-1	NP_506381.1
Saccharomyces cerevisiae (baker's yeast)	YLH47	NP_015450.1
Eremothecium gossypii	AGOS_AAR032W	NP_982573.2
Xenopus tropicalis (tropical clawed frog)	letm1	NP_001072793.1
Canis lupus familiaris (dog)	LETM1	XP_545925.2
Rattus norvegicus (Norway rat)	Letm1	NP_001005884.1
Magnaporthe oryzae (rice blast fungus)	MGG_03684	XP_003716197.1
Homo sapiens (human)	LETM1	NP_036450.1
Gallus gallus (chicken)	LETM1	NP_001006461.2
Pan troglodytes (chimpanzee)	LETM1	XP_003310276.1
	LETM1	XP_002802216.1
Schizosaccharomyces pombe (fission yeast)	mdm28	NP_593648.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of LETM1 by siRNA inhibits cell proliferation and invasion of bladder cancer cells.
Huang B, Zhang J, Zhang X, Huang C, Hu G, Li S, Xie T, Liu M, Xu Y
Oncology reports38(5)2935-2940(2017 Nov)

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation.
Lee J, Lee WK, Seol MY, Lee SG, Kim D, Kim H, Park J, Jung SG, Chung WY, Lee EJ, Jo YS
Oncotarget7(41)66728-66739(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.
Title: Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer.

LETM1 plays an important role in the progression of breast cancer
Title: LETM1 overexpression is correlated with the clinical features and survival outcome of breast cancer.

Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics
Title: LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes.
Title: NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.

LETM1 plays an important role in the progression of head and neck squamous cell carcinoma.
Title: High expression of leucine zipper-EF-hand containing transmembrane protein 1 predicts poor prognosis in head and neck squamous cell carcinoma.

The following LETM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LETM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu95172	XM_017008187.1 Latest version!	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu18027	NM_012318.3 Latest version!	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu38342	XM_006713884.1 Latest version!	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu18027	NM_012318.2	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LETM1 ( XM_017008187.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863676.1 Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X2, mRNA.

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CloneID	OHu95172
Clone ID Related Accession (Same CDS sequence)	XM_017008187.1
Accession Version	XM_017008187.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863676.1
CDS	959..2638
Translation	MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS

Target ORF information:

RefSeq Version	XM_017008187.1
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008187.1

ORF Insert Sequence:

ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LETM1 ( NM_012318.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036450.1 Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.

Price & Availability↑

CloneID	OHu18027
Clone ID Related Accession (Same CDS sequence)	NM_012318.2 , NM_012318.3
Accession Version	NM_012318.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	mitochondrial proton/calcium exchanger protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF061025.1 and AC105448.5. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2008 this sequence version replaced NM_012318.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF061025.1, SRR1803612.244606.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036450.1
CDS	298..2517
Translation	MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS

Target ORF information:

RefSeq Version	NM_012318.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012318.2

ORF Insert Sequence:

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LETM1 ( NM_012318.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036450.1 Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.

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CloneID	OHu18027
Clone ID Related Accession (Same CDS sequence)	NM_012318.2 , NM_012318.3
Accession Version	NM_012318.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	mitochondrial proton/calcium exchanger protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF061025.1 and AC105448.5. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_012318.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.244606.1, SRR1660809.61502.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000302787.3/ ENSP00000305653.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036450.1
CDS	207..2426
Translation	MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS

Target ORF information:

RefSeq Version	NM_012318.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012318.3

ORF Insert Sequence:

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGAAGG ATTTTGAGCC CGAACGTGTG 
GTAGCTGCTC CCCAAAGGCC GGGGACCGAG CCACAGCCAG AAATGCCTGA CACAGTCCTG 
CAGTCAGAGA CCTTGAAGGA CACTGCCCCG GTGCTGGAGG GCTTGAAGGA GGAAGAGATC 
ACGAAGGAGG AAATCGACAT CCTCAGCGAT GCCTGCTCTA AGCTGCAGGA GCAGAAGAAG 
TCACTCACCA AGGAGAAGGA GGAGCTGGAG CTGCTGAAGG AGGATGTGCA GGACTACAGC 
GAGGACTTGC AGGAGATCAA GAAGGAACTT TCAAAGACTG GTGAAGAAAA GTACGTGGAA 
GAATCTAAAG CCAGCAAGAG ATTGACAAAA AGGGTGCAGC AAATGATCGG GCAGATCGAT 
GGCTTGATCT CGCAGCTGGA GATGGACCAG CAGGCTGGCA AGCTGGCCCC GGCCAACGGC 
ATGCCCACGG GGGAGAACGT CATCAGTGTC GCTGAGCTCA TCAACGCCAT GAAGCAAGTC 
AAGCACATTC CCGAAAGCAA GCTCACCAGC CTGGCCGCAG CACTGGATGA AAACAAGGAT 
GGCAAGGTCA ACATCGACGA CCTCGTCAAG GTGATTGAGC TGGTGGACAA AGAAGATGTT 
CACATCTCCA CCAGCCAGGT GGCTGAGATT GTAGCAACAC TGGAAAAAGA GGAGAAGGTG 
GAGGAGAAGG AGAAGGCCAA AGAGAAGGCA GAGAAGGAGG TCGCAGAGGT GAAGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LETM1 ( XM_006713884.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006713947.1 Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X1, mRNA.

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CloneID	OHu38342
Clone ID Related Accession (Same CDS sequence)	XM_006713884.1
Accession Version	XM_006713884.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	mitochondrial proton/calcium exchanger protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGGATT TTGAGCCCGA ACGTGTGGTA 
GCTGCTCCCC AAAGGCCGGG GACCGAGCCA CAGCCAGAAA TGCCTGACAC AGTCCTGCAG 
TCAGAGACCT TGAAGGACAC TGCCCCGGTG CTGGAGGGCT TGAAGGAGGA AGAGATCACG 
AAGGAGGAAA TCGACATCCT CAGCGATGCC TGCTCTAAGC TGCAGGAGCA GAAGAAGTCA 
CTCACCAAGG AGAAGGAGGA GCTGGAGCTG CTGAAGGAGG ATGTGCAGGA CTACAGCGAG 
GACTTGCAGG AGATCAAGAA GGAACTTTCA AAGACTGGTG AAGAAAAGTA CGTGGAAGAA 
TCTAAAGCCA GCAAGAGATT GACAAAAAGG GTGCAGCAAA TGATCGGGCA GATCGATGGC 
TTGATCTCGC AGCTGGAGAT GGACCAGCAG GCTGGCAAGC TGGCCCCGGC CAACGGCATG 
CCCACGGGGG AGAACGTCAT CAGTGTCGCT GAGCTCATCA ACGCCATGAA GCAAGTCAAG 
CACATTCCCG AAAGCAAGCT CACCAGCCTG GCCGCAGCAC TGGATGAAAA CAAGGATGGC 
AAGGTCAACA TCGACGACCT CGTCAAGGTG ATTGAGCTGG TGGACAAAGA AGATGTTCAC 
ATCTCCACCA GCCAGGTGGC TGAGATTGTA GCAACACTGG AAAAAGAGGA GAAGGTGGAG 
GAGAAGGAGA AGGCCAAAGA GAAGGCAGAG AAGGAGGTCG CAGAGGTGAA GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006713947.1
CDS	6..2222
Translation	MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVADFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS

Target ORF information:

RefSeq Version	XM_006713884.1
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine zipper and EF-hand containing transmembrane protein 1 (LETM1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006713884.1

ORF Insert Sequence:

ATGGCGTCCA TCTTACTGAG GAGCTGCCGC GGCCGGGCGC CCGCCCGCCT CCCGCCGCCG 
CCTCGGTACA CCGTCCCGCG GGGTAGTCCA GGGGATCCTG CTCATCTCAG CTGTGCCAGC 
ACCCTGGGGT TGAGGAACTG CCTGAATGTT CCATTTGGCT GCTGCACTCC CATCCACCCT 
GTGTACACAT CCTCCAGAGG CGATCACCTC GGCTGTTGGG CTCTGAGGCC CGAGTGCCTT 
CGCATAGTGT CGAGAGCGCC ATGGACCTCT ACCTCTGTGG GTTTTGTGGC TGTGGGACCT 
CAGTGCCTTC CTGTGCGTGG CTGGCACTCT TCGCGCCCTG TTCGCGATGA CTCGGTAGTA 
GAGAAGTCCC TCAAGTCCTT GAAGGACAAG AACAAGAAGC TGGAGGAAGG CGGCCCGGTG 
TACAGCCCCC CCGCAGAGGT GGTGGTGAAG AAGTCCCTGG GGCAGCGGGT GCTGGACGAG 
CTGAAGCACT ACTACCATGG CTTCCGCCTG CTATGGATCG ACACCAAGAT CGCGGCACGC 
ATGCTCTGGC GCATCCTCAA CGGCCACAGC CTGACCCGCC GGGAGCGCAG GCAGTTTCTC 
CGGATCTGCG CTGACCTCTT CCGCCTGGTG CCGTTCCTTG TGTTCGTGGT GGTGCCGTTC 
ATGGAGTTTC TGCTGCCTGT TGCTGTGAAG CTCTTCCCCA ACATGTTGCC ATCCACATTT 
GAGACTCAGT CACTCAAGGA GGAGAGGCTG AAGAAGGAGC TTCGGGTCAA GCTGGAGCTG 
GCCAAGTTCC TCCAGGACAC CATCGAGGAG ATGGCCTTGA AGAACAAGGC AGCCAAGGGC 
AGCGCCACCA AAGACTTCTC TGTGTTTTTC CAGAAGATCC GGGAAACAGG GGAGAGGCCC 
AGCAATGAGG AAATCATGCG TTTTTCCAAA TTATTTGAGG ATGAGCTGAC CCTGGACAAC 
CTGACACGGC CGCAGCTGGT GGCCCTGTGC AAGCTGCTGG AGCTACAGTC CATCGGCACC 
AACAACTTCC TGCGCTTCCA GCTTACCATG CGGCTGCGCT CCATAAAGGC AGACGACAAG 
CTGATTGCTG AGGAAGGGGT GGACAGCCTG AATGTCAAGG AGCTGCAGGC AGCGTGTCGG 
GCACGAGGCA TGCGGGCCCT GGGCGTCACG GAAGACCGCC TGAGGGGTCA GCTGAAGCAG 
TGGCTGGACC TGCACCTGCA TCAGGAGATC CCCACATCGC TGCTCATCCT GTCCCGGGCC 
ATGTACCTCC CGGACACCCT CTCTCCAGCC GACCAGCTCA AGTCCACACT GCAGACCCTC 
CCAGAGATTG TGGCAAAGGA AGCACAGGTG AAAGTGGCCG AGGTGGAGGG CGAGCAGGTG 
GACAACAAGG CCAAGCTGGA GGCCACGCTG CAGGAGGAGG CGGCCATCCA GCAGGAGCAC 
CGTGAGAAGG AGCTGCAGAA GCGCTCGGAG GTGGCGGATT TTGAGCCCGA ACGTGTGGTA 
GCTGCTCCCC AAAGGCCGGG GACCGAGCCA CAGCCAGAAA TGCCTGACAC AGTCCTGCAG 
TCAGAGACCT TGAAGGACAC TGCCCCGGTG CTGGAGGGCT TGAAGGAGGA AGAGATCACG 
AAGGAGGAAA TCGACATCCT CAGCGATGCC TGCTCTAAGC TGCAGGAGCA GAAGAAGTCA 
CTCACCAAGG AGAAGGAGGA GCTGGAGCTG CTGAAGGAGG ATGTGCAGGA CTACAGCGAG 
GACTTGCAGG AGATCAAGAA GGAACTTTCA AAGACTGGTG AAGAAAAGTA CGTGGAAGAA 
TCTAAAGCCA GCAAGAGATT GACAAAAAGG GTGCAGCAAA TGATCGGGCA GATCGATGGC 
TTGATCTCGC AGCTGGAGAT GGACCAGCAG GCTGGCAAGC TGGCCCCGGC CAACGGCATG 
CCCACGGGGG AGAACGTCAT CAGTGTCGCT GAGCTCATCA ACGCCATGAA GCAAGTCAAG 
CACATTCCCG AAAGCAAGCT CACCAGCCTG GCCGCAGCAC TGGATGAAAA CAAGGATGGC 
AAGGTCAACA TCGACGACCT CGTCAAGGTG ATTGAGCTGG TGGACAAAGA AGATGTTCAC 
ATCTCCACCA GCCAGGTGGC TGAGATTGTA GCAACACTGG AAAAAGAGGA GAAGGTGGAG 
GAGAAGGAGA AGGCCAAAGA GAAGGCAGAG AAGGAGGTCG CAGAGGTGAA GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of LETM1 by siRNA inhibits cell proliferation and invasion of bladder cancer cells.
Oncology reports38(5)2935-2940(2017 Nov)
Huang B,Zhang J,Zhang X,Huang C,Hu G,Li S,Xie T,Liu M,Xu Y

Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation.
Oncotarget7(41)66728-66739(2016 Oct)
Lee J,Lee WK,Seol MY,Lee SG,Kim D,Kim H,Park J,Jung SG,Chung WY,Lee EJ,Jo YS

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LETM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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