ARHGAP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGAP4
Entrez Gene ID	393
Full Name	Rho GTPase activating protein 4
Synonyms	C1,RGC1,RhoGAP4,SrGAP4,p115
General protein information	Preferred Names Rho GTPase activating protein 4 Names rho GTPase-activating protein 4 Rho-GAP hematopoietic protein C1 rho-type GTPase-activating protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Disorder MIM:	300023

mRNA and Protein(s)

mRNA	Protein	Name
NM_001164741.1	NP_001158213.1	rho GTPase-activating protein 4 isoform 1
NM_001164741.2	NP_001158213.1	rho GTPase-activating protein 4 isoform 1
NM_001666.4	NP_001657.3	rho GTPase-activating protein 4 isoform 2
NM_001666.5	NP_001657.3	rho GTPase-activating protein 4 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARHGAP4	XP_549365.3
	ARHGAP4	XP_002806496.1
Danio rerio (zebrafish)	arhgap4b	XP_689729.3
Danio rerio (zebrafish)	arhgap4a	NP_956738.1
Homo sapiens (human)	ARHGAP4	NP_001158213.1
Pan troglodytes (chimpanzee)	ARHGAP4	XP_003317822.1
Mus musculus (house mouse)	Arhgap4	NP_619536.2
Xenopus tropicalis (tropical clawed frog)	arhgap4	NP_001123805.1
Bos taurus (cattle)	ARHGAP4	NP_001096010.1
Rattus norvegicus (Norway rat)	Arhgap4	NP_653341.2

Gene Ontology
Bibliography

Related articles in PubMed

ARHGAP4 mutated in a Chinese intellectually challenged family.
Liu F, Guo H, Ou M, Hou X, Sun G, Gong W, Jing H, Tan Q, Xue W, Dai Y, Sui W
Gene578(2)205-9(2016 Mar)

Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
Wong EH, So HC, Li M, Wang Q, Butler AW, Paul B, Wu HM, Hui TC, Choi SC, So MT, Garcia-Barcelo MM, McAlonan GM, Chen EY, Cheung EF, Chan RC, Purcell SM, Cherny SS, Chen RR, Li T, Sham PC
Schizophrenia bulletin40(4)777-86(2014 Jul)

A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability.
Huang L, Poke G, Gecz J, Gibson K
American journal of medical genetics. Part A158A(10)2511-8(2012 Oct)

PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY
The Journal of biological chemistry286(49)42316-24(2011 Dec)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The relation between ARHGAP4 mutation and Mental retardation(MR) clinical characteristic is needed to be illuminated with participation of more MR patients
Title: ARHGAP4 mutated in a Chinese intellectually challenged family.

ARHGAP4 rs2269368 was associated with risk of schizophrenia in a Han Chinese population.
Title: Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.

X-linked nephrogenic diabetes insipidus (NDI) and intellectual disability in two dizygotic twin brothers was caused by a novel contiguous deletion of 17,905 bp of the entire AVPR2 gene and intron 7 of the ARHGAP4 gene.
Title: A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability.

PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

The following ARHGAP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGAP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13972	NM_001164741.2 Latest version!	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu18993	NM_001666.5 Latest version!	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$469.50-$657.30 $939.00
View Old Accession Versions >>
OHu13972	NM_001164741.1	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu18993	NM_001666.4	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$469.50-$657.30 $939.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGAP4 ( NM_001164741.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001158213.1 Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13972
Clone ID Related Accession (Same CDS sequence)	NM_001164741.1 , NM_001164741.2
Accession Version	NM_001164741.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2961bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052303.1, X78817.1 and AI249937.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCTCTGGCCC CCGCAGAGGC CTGTGGCCGC TTCCAGCTGT 
GCACCTGTGT GCTGGCTCCA AGCTGGGTTT CTCGTGCACC CTCCATGGTG GGGTGCCATG 
TGCGCACCTT CCACTCATCA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158213.1
CDS	59..3019
Translation	MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKLWPPQRPVAASSCAPVCWLQAGFLVHPPWWGAMCAPSTHQRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH

Target ORF information:

RefSeq Version	NM_001164741.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164741.1

ORF Insert Sequence:

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCTCTGGCCC CCGCAGAGGC CTGTGGCCGC TTCCAGCTGT 
GCACCTGTGT GCTGGCTCCA AGCTGGGTTT CTCGTGCACC CTCCATGGTG GGGTGCCATG 
TGCGCACCTT CCACTCATCA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP4 ( NM_001164741.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001158213.1 Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13972
Clone ID Related Accession (Same CDS sequence)	NM_001164741.1 , NM_001164741.2
Accession Version	NM_001164741.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2961bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U52112.2, BC052303.1, X78817.1 and AI249937.1. On Jun 2, 2019 this sequence version replaced NM_001164741.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCTCTGGCCC CCGCAGAGGC CTGTGGCCGC TTCCAGCTGT 
GCACCTGTGT GCTGGCTCCA AGCTGGGTTT CTCGTGCACC CTCCATGGTG GGGTGCCATG 
TGCGCACCTT CCACTCATCA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158213.1
CDS	63..3023
Translation	MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKLWPPQRPVAASSCAPVCWLQAGFLVHPPWWGAMCAPSTHQRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH

Target ORF information:

RefSeq Version	NM_001164741.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164741.2

ORF Insert Sequence:

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCTCTGGCCC CCGCAGAGGC CTGTGGCCGC TTCCAGCTGT 
GCACCTGTGT GCTGGCTCCA AGCTGGGTTT CTCGTGCACC CTCCATGGTG GGGTGCCATG 
TGCGCACCTT CCACTCATCA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP4 ( NM_001666.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001657.3 Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18993
Clone ID Related Accession (Same CDS sequence)	NM_001666.4 , NM_001666.5
Accession Version	NM_001666.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052303.1, D50921.1, X78817.1 and AI249937.1. This sequence is a reference standard in the RefSeqGene project. On Sep 17, 2009 this sequence version replaced NM_001666.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an alternate segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78817.1, D50921.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001657.3
CDS	59..2899
Translation	MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH

Target ORF information:

RefSeq Version	NM_001666.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001666.4

ORF Insert Sequence:

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP4 ( NM_001666.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001657.3 Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18993
Clone ID Related Accession (Same CDS sequence)	NM_001666.4 , NM_001666.5
Accession Version	NM_001666.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U52112.2, BC052303.1, D50921.1, X78817.1 and AI249937.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001666.4. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an alternate segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D50921.1, X78817.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001657.3
CDS	63..2903
Translation	MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH

Target ORF information:

RefSeq Version	NM_001666.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001666.5

ORF Insert Sequence:

ATGGCCGCTC ACGGGAAGCT GCGGCGGGAG CGGGGGCTGC AGGCTGAGTA TGAGACGCAA 
GTCAAAGAGA TGCGCTGGCA GCTGAGCGAG CAGCTGCGCT GCCTGGAGCT GCAGGGCGAG 
CTGCGGCGGG AGTTGCTGCA GGAGCTGGCA GAGTTCATGC GGCGCCGCGC TGAGGTGGAG 
CTGGAATACT CCCGGGGCCT GGAAAAGCTG GCCGAGCGCT TCTCCAGCCG TGGAGGCCGC 
CTGGGGAGCA GCCGGGAGCA CCAAAGCTTC CGGAAGGAGC CGTCCCTCCT GTCGCCCTTG 
CACTGCTGGG CGGTGCTGCT GCAGCACACG CGGCAGCAGA GCCGGGAGAG CGCGGCCCTG 
AGTGAGGTGC TGGCCGGGCC CCTGGCCCAG CGCCTGAGTC ACATTGCAGA GGACGTGGGG 
CGCCTGGTCA AGAAGAGCAG GGATCTGGAG CAGCAGCTGC AGGATGAGCT CCTGGAGGTG 
GTCTCAGAGC TCCAGACGGC CAAGAAGACG TACCAGGCAT ATCACATGGA GAGCGTGAAT 
GCCGAGGCCA AGCTCCGGGA GGCCGAGCGG CAGGAGGAGA AGCGGGCAGG CCGGAGTGTC 
CCCACCACCA CCGCTGGTGC CACTGAGGCA GGGCCCCTCC GCAAGAGCTC CCTCAAGAAG 
GGAGGGAGGC TGGTGGAGAA GCGGCAGGCC AAGTTCATGG AGCACAAACT CAAGTGCACA 
AAGGCGCGCA ACGAGTACCT GCTTAGCCTG GCTAGTGTCA ACGCTGCTGT CAGTAACTAC 
TACCTGCATG ACGTCTTGGA CCTCATGGAC TGCTGTGACA CAGGGTTCCA CCTGGCCCTG 
GGGCAGGTGC TCCGGAGCTA CACGGCCGCT GAGAGCCGCA CCCAAGCCTC CCAAGTGCAG 
GGCCTGGGCA GCCTGGAAGA AGCTGTGGAG GCCCTGGATC CTCCAGGGGA CAAAGCCAAG 
GTTCTCGAGG TGCATGCTAC CGTCTTCTGT CCCCCGCTGC GCTTTGACTA CCACCCCCAT 
GATGGGGATG AGGTGGCTGA GATCTGCGTT GAAATGGAGC TGCGGGACGA GATTCTGCCC 
AGAGCCCAGA ACATCCAGAG CCGCCTGGAC CGACAGACCA TTGAGACAGA GGAGGTGAAC 
AAGACTCTGA AGGCGACACT GCAGGCCCTG CTGGAGGTGG TGGCCTCGGA TGACGGGGAT 
GTGCTTGATT CCTTCCAGAC CAGCCCCTCC ACCGAGTCCC TCAAGTCCAC CAGCTCAGAC 
CCAGGCAGCC GGCAGGCGGG CCGGAGGCGC GGCCAGCAGC AGGAGACCGA AACCTTCTAC 
CTCACGAAGC TCCAGGAGTA TCTGAGTGGA CGGAGCATCC TCGCCAAGCT GCAGGCCAAG 
CACGAGAAGC TGCAGGAGGC CCTTCAGCGA GGTGACAAGG AGGAGCAGGA GGTGTCTTGG 
ACCCAGTACA CACAGAGAAA ATTCCAGAAG AGCCGCCAGC CCCGCCCCAG CTCCCAGTAT 
AACCAGAGAC TCTTTGGGGG AGACATGGAG AAGTTTATCC AGAGCTCAGG CCAGCCTGTG 
CCCCTGGTGG TGGAGAGCTG CATTCGCTTC ATCAACCTCA ATGGCCTGCA GCATGAAGGC 
ATCTTCCGGG TATCGGGTGC CCAGCTCCGG GTCTCAGAGA TCCGTGATGC CTTCGAGAGA 
GGGGAGGACC CACTGGTGGA GGGCTGCACT GCCCATGACC TGGACTCGGT GGCCGGGGTG 
CTGAAGCTCT ACTTCCGGAG CCTGGAGCCC CCACTCTTCC CCCCAGACCT GTTCGGCGAG 
CTGCTGGCTT CTTCGGAGCT GGAGGCCACA GCGGAGAGGG TGGAGCACGT GAGCCGCCTG 
CTGTGGCGGC TGCCCGCGCC GGTGCTGGTG GTTCTGCGCT ACCTCTTCAC CTTCCTCAAC 
CACCTGGCCC AGTACAGCGA TGAGAACATG ATGGACCCCT ACAACCTGGC CGTGTGCTTC 
GGGCCCACGC TGCTACCGGT GCCCGCTGGG CAGGACCCGG TGGCGCTGCA GGGCCGGGTG 
AACCAGCTGG TGCAGACGCT CATAGTGCAG CCCGATCGGG TCTTCCCGCC CCTGACCTCG 
CTGCCTGGCC CCGTCTACGA GAAGTGCATG GCACCGCCTT CCGCCAGCTG CCTGGGGGAC 
GCCCAGCTGG AGAGCCTGGG GGCGGACAAT GAGCCGGAGC TGGAAGCCGA GATGCCCGCA 
CAGGAGGATG ACCTGGAGGG GGTCGTGGAG GCTGTGGCCT GCTTTGCCTA CACGGGCCGC 
ACAGCCCAGG AGCTGAGCTT CCGGCGGGGG GACGTACTGC GGCTGCACGA GAGGGCCTCG 
AGCGACTGGT GGCGGGGGGA GCACAACGGC ATGCGGGGCC TCATCCCCCA CAAGTATATC 
ACGCTGCCCG CCGGGACGGA GAAGCAGGTG GTGGGCGCAG GGCTGCAGAC TGCAGGGGAG 
TCTGGGAGCA GTCCCGAGGG CCTCCTGGCA TCGGAGCTGG TCCACCGGCC AGAGCCATGC 
ACCTCACCTG AGGCCATGGG ACCCTCTGGA CACAGACGAC GCTGCTTGGT CCCAGCCTCC 
CCAGAGCAAC ACGTGGAGGT GGATAAGGCT GTGGCACAGA ACATGGACTC TGTGTTTAAG 
GAGCTCTTGG GAAAGACCTC TGTCCGCCAG GGCCTTGGGC CAGCATCTAC CACCTCTCCC 
AGTCCTGGGC CCCGAAGCCC AAAGGCCCCG CCCAGCAGCC GCCTGGGCAG GAACAAAGGC 
TTCTCCCGGG GCCCTGGGGC CCCAGCCTCA CCCTCAGCTT CCCACCCCCA GGGCCTAGAC 
ACGACCCCCA AGCCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ARHGAP4 mutated in a Chinese intellectually challenged family.
Gene578(2)205-9(2016 Mar)
Liu F,Guo H,Ou M,Hou X,Sun G,Gong W,Jing H,Tan Q,Xue W,Dai Y,Sui W

Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
Schizophrenia bulletin40(4)777-86(2014 Jul)
Wong EH,So HC,Li M,Wang Q,Butler AW,Paul B,Wu HM,Hui TC,Choi SC,So MT,Garcia-Barcelo MM,McAlonan GM,Chen EY,Cheung EF,Chan RC,Purcell SM,Cherny SS,Chen RR,Li T,Sham PC

A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability.
American journal of medical genetics. Part A158A(10)2511-8(2012 Oct)
Huang L,Poke G,Gecz J,Gibson K

PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
The Journal of biological chemistry286(49)42316-24(2011 Dec)
Bai Y,Luo Y,Liu S,Zhang L,Shen K,Dong Y,Walls CD,Quilliam LA,Wells CD,Cao Y,Zhang ZY

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

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ARHGAP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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