ARHGAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGAP1
Entrez Gene ID	392
Full Name	Rho GTPase activating protein 1
Synonyms	CDC42GAP,RHOGAP,RHOGAP1,p50rhoGAP
General protein information	Preferred Names Rho GTPase activating protein 1 Names rho GTPase-activating protein 1 CDC42 GTPase-activating protein GTPase-activating protein rhoGAP GTPase-activating protein rhoOGAP GTPase-activating protein, Rho, 1 rho-related small GTPase protein activator rho-type GTPase-activating protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p11.2
Summary	This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012].
Disorder MIM:	602732

mRNA and Protein(s)

mRNA	Protein	Name
XM_024448520.1	XP_024304288.1	rho GTPase-activating protein 1 isoform X1
XM_011520095.1	XP_011518397.1	rho GTPase-activating protein 1 isoform X2
XM_011520095.2	XP_011518397.1	rho GTPase-activating protein 1 isoform X2
NM_004308.5	NP_004299.1	rho GTPase-activating protein 1
XM_017017720.1	XP_016873209.1	rho GTPase-activating protein 1 isoform X1
NM_004308.3	NP_004299.1	rho GTPase-activating protein 1

Pathways from BioSystems

Homologies

	ARHGAP1	XP_002799610.1
Canis lupus familiaris (dog)	ARHGAP1	NP_001076836.1
Bos taurus (cattle)	ARHGAP1	NP_001179991.1
Mus musculus (house mouse)	Arhgap1	NP_001139374.1
Danio rerio (zebrafish)	arhgap1	NP_001017781.1
Drosophila melanogaster (fruit fly)	RhoGAP68F	NP_001261745.1
Schizosaccharomyces pombe (fission yeast)	SPAC1565.02c	NP_593281.1
Pan troglodytes (chimpanzee)	ARHGAP1	XP_508398.3
Xenopus tropicalis (tropical clawed frog)	arhgap1	NP_001008141.1
Homo sapiens (human)	ARHGAP1	NP_004299.1
Rattus norvegicus (Norway rat)	Arhgap1	NP_001101217.2
Gallus gallus (chicken)	ARHGAP1	XP_004941648.1
Caenorhabditis elegans (roundworm)	rga-1	NP_001022390.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.
Satterfield L, Shuck R, Kurenbekova L, Allen-Rhoades W, Edwards D, Huang S, Rajapakshe K, Coarfa C, Donehower LA, Yustein JT
International journal of cancer141(10)2062-2075(2017 Nov)

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.
Hsu YH, Li G, Liu CT, Brody JA, Karasik D, Chou WC, Demissie S, Nandakumar K, Zhou Y, Cheng CH, Gill R, Gibbs RA, Muzny D, Santibanez J, Estrada K, Rivadeneira F, Harris T, Gudnason V, Uitterlinden A, Psaty BM, Robbins JA, Adrienne Cupples L, Kiel DP
Human molecular genetics25(23)5234-5243(2016 12)

Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells.
Rauch L, Hennings K, Trasak C, R?der A, Schr?der B, Koch-Nolte F, Rivera-Molina F, Toomre D, Aepfelbacher M
Journal of cell science129(15)2937-49(2016 08)

Current knowledge of the large RhoGAP family of proteins.
Tcherkezian J, Lamarche-Vane N
Biology of the cell99(2)67-86(2007 Feb)

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ
Nature388(6643)693-7(1997 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified ARHGAP1, which is a negative regulator of CDC42, as a novel, direct target of miR-130b
Title: miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.

we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs.
Title: Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

to complete invasion of the endothelium, staphylococci reorient recycling endocytic vesicles to recruit Cdc42GAP.
Title: Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells.

The interaction of RhoGap protein stabilizes the tetrameric conformation of p53 and enhances its DNA-binding activity, thereby inducing cell-cycle arrest and apoptosis.
Title: RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain.

study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells
Title: The human minor histocompatibility antigen 1 is a RhoGAP.

The following ARHGAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04238	NM_004308.3 Latest version!	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu56355	NM_004308.5 Latest version!	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56354	XM_024448520.1 Latest version!	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56354	XM_017017720.1 Latest version!	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56355	XM_011520095.2 Latest version!	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu56355	XM_011520095.1	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGAP1 ( NM_004308.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004299.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.

Price & Availability↑

CloneID	OHu04238
Clone ID Related Accession (Same CDS sequence)	NM_004308.3
Accession Version	NM_004308.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY004921.1, BC018118.1 and AI640658.1. On Aug 4, 2012 this sequence version replaced NM_004308.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.4104.1, BC018118.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAGA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004299.1
CDS	165..1484
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	NM_004308.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004308.3

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAGA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP1 ( NM_004308.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004299.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.

Price & Availability↑

CloneID	OHu56355
Clone ID Related Accession (Same CDS sequence)	XM_011520095.1 , XM_011520095.2 , NM_004308.5
Accession Version	NM_004308.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC115088.6. On Nov 22, 2018 this sequence version replaced NM_004308.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.985744.1, SRR1803611.4104.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311956.9/ ENSP00000310491.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004299.1
CDS	119..1438
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	NM_004308.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004308.5

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP1 ( XM_024448520.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304288.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56354
Clone ID Related Accession (Same CDS sequence)	XM_024448520.1 , XM_017017720.1
Accession Version	XM_024448520.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CAAGAAAAAC ATCAAGGCCT TGTACATCGT GCATCCAACC 
ATGTTCATCA AAACTCTGCT CATCCTCTTC AAGCCCCTCA TCAGCTTCAA GTTCGGGCAG 
AAGATCTTCT ATGTGAATTA CCTGAGCGAG CTGAGCGAGC ACGTGAAGCT GGAGCAGCTG 
GGGATCCCTC GCCAAGTGCT CAAATATGAC GACTTCCTGA AATCCACACA GAAGAGCCCC 
GCGACAGCCC CCAAGCCCAT GCCCCCACGG CCCCCCCTGC CCAACCAGCA GTTTGGAGTC 
TCGCTGCAGC ACCTCCAGGA GAAGAATCCA GAGCAGGAGC CCATTCCCAT TGTACTCAGG 
GAGACTGTTG CCTACTTACA GGCCCACGCT CTCACCACCG AGGGCATCTT CCGGAGGTCG 
GCCAACACCC AAGTGGTCCG GGAAGTGCAG CAGAAGTACA ACATGGGGCT GCCTGTGGAT 
TTCGACCAGT ACAATGAGCT GCACCTGCCA GCAGTCATCC TCAAGACCTT CCTCCGGGAG 
CTTCCTGAGC CCCTGCTCAC CTTTGACCTC TACCCCCATG TGGTGGGCTT CCTCAACATT 
GATGAAAGCC AGAGGGTGCC AGCGACACTG CAGGTCCTCC AGACGCTGCC CGAGGAGAAC 
TACCAGGTGC TTCGTTTCCT GACTGCTTTC CTGGTGCAGA TTTCTGCACA CAGTGACCAG 
AACAAGATGA CCAACACTAA CCTGGCTGTT GTTTTCGGCC CTAACCTGCT GTGGGCCAAG 
GATGCGGCCA TCACCCTCAA GGCCATTAAT CCCATCAACA CCTTCACCAA GTTCCTTCTG 
GATCACCAAG GGGAGCTGTT CCCAAGCCCG GACCCCAGCG GGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304288.1
CDS	160..1347
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	XM_024448520.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448520.1

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CAAGAAAAAC ATCAAGGCCT TGTACATCGT GCATCCAACC 
ATGTTCATCA AAACTCTGCT CATCCTCTTC AAGCCCCTCA TCAGCTTCAA GTTCGGGCAG 
AAGATCTTCT ATGTGAATTA CCTGAGCGAG CTGAGCGAGC ACGTGAAGCT GGAGCAGCTG 
GGGATCCCTC GCCAAGTGCT CAAATATGAC GACTTCCTGA AATCCACACA GAAGAGCCCC 
GCGACAGCCC CCAAGCCCAT GCCCCCACGG CCCCCCCTGC CCAACCAGCA GTTTGGAGTC 
TCGCTGCAGC ACCTCCAGGA GAAGAATCCA GAGCAGGAGC CCATTCCCAT TGTACTCAGG 
GAGACTGTTG CCTACTTACA GGCCCACGCT CTCACCACCG AGGGCATCTT CCGGAGGTCG 
GCCAACACCC AAGTGGTCCG GGAAGTGCAG CAGAAGTACA ACATGGGGCT GCCTGTGGAT 
TTCGACCAGT ACAATGAGCT GCACCTGCCA GCAGTCATCC TCAAGACCTT CCTCCGGGAG 
CTTCCTGAGC CCCTGCTCAC CTTTGACCTC TACCCCCATG TGGTGGGCTT CCTCAACATT 
GATGAAAGCC AGAGGGTGCC AGCGACACTG CAGGTCCTCC AGACGCTGCC CGAGGAGAAC 
TACCAGGTGC TTCGTTTCCT GACTGCTTTC CTGGTGCAGA TTTCTGCACA CAGTGACCAG 
AACAAGATGA CCAACACTAA CCTGGCTGTT GTTTTCGGCC CTAACCTGCT GTGGGCCAAG 
GATGCGGCCA TCACCCTCAA GGCCATTAAT CCCATCAACA CCTTCACCAA GTTCCTTCTG 
GATCACCAAG GGGAGCTGTT CCCAAGCCCG GACCCCAGCG GGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP1 ( XM_017017720.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873209.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56354
Clone ID Related Accession (Same CDS sequence)	XM_024448520.1 , XM_017017720.1
Accession Version	XM_017017720.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CAAGAAAAAC ATCAAGGCCT TGTACATCGT GCATCCAACC 
ATGTTCATCA AAACTCTGCT CATCCTCTTC AAGCCCCTCA TCAGCTTCAA GTTCGGGCAG 
AAGATCTTCT ATGTGAATTA CCTGAGCGAG CTGAGCGAGC ACGTGAAGCT GGAGCAGCTG 
GGGATCCCTC GCCAAGTGCT CAAATATGAC GACTTCCTGA AATCCACACA GAAGAGCCCC 
GCGACAGCCC CCAAGCCCAT GCCCCCACGG CCCCCCCTGC CCAACCAGCA GTTTGGAGTC 
TCGCTGCAGC ACCTCCAGGA GAAGAATCCA GAGCAGGAGC CCATTCCCAT TGTACTCAGG 
GAGACTGTTG CCTACTTACA GGCCCACGCT CTCACCACCG AGGGCATCTT CCGGAGGTCG 
GCCAACACCC AAGTGGTCCG GGAAGTGCAG CAGAAGTACA ACATGGGGCT GCCTGTGGAT 
TTCGACCAGT ACAATGAGCT GCACCTGCCA GCAGTCATCC TCAAGACCTT CCTCCGGGAG 
CTTCCTGAGC CCCTGCTCAC CTTTGACCTC TACCCCCATG TGGTGGGCTT CCTCAACATT 
GATGAAAGCC AGAGGGTGCC AGCGACACTG CAGGTCCTCC AGACGCTGCC CGAGGAGAAC 
TACCAGGTGC TTCGTTTCCT GACTGCTTTC CTGGTGCAGA TTTCTGCACA CAGTGACCAG 
AACAAGATGA CCAACACTAA CCTGGCTGTT GTTTTCGGCC CTAACCTGCT GTGGGCCAAG 
GATGCGGCCA TCACCCTCAA GGCCATTAAT CCCATCAACA CCTTCACCAA GTTCCTTCTG 
GATCACCAAG GGGAGCTGTT CCCAAGCCCG GACCCCAGCG GGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873209.1
CDS	50..1237
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	XM_017017720.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017720.1

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CAAGAAAAAC ATCAAGGCCT TGTACATCGT GCATCCAACC 
ATGTTCATCA AAACTCTGCT CATCCTCTTC AAGCCCCTCA TCAGCTTCAA GTTCGGGCAG 
AAGATCTTCT ATGTGAATTA CCTGAGCGAG CTGAGCGAGC ACGTGAAGCT GGAGCAGCTG 
GGGATCCCTC GCCAAGTGCT CAAATATGAC GACTTCCTGA AATCCACACA GAAGAGCCCC 
GCGACAGCCC CCAAGCCCAT GCCCCCACGG CCCCCCCTGC CCAACCAGCA GTTTGGAGTC 
TCGCTGCAGC ACCTCCAGGA GAAGAATCCA GAGCAGGAGC CCATTCCCAT TGTACTCAGG 
GAGACTGTTG CCTACTTACA GGCCCACGCT CTCACCACCG AGGGCATCTT CCGGAGGTCG 
GCCAACACCC AAGTGGTCCG GGAAGTGCAG CAGAAGTACA ACATGGGGCT GCCTGTGGAT 
TTCGACCAGT ACAATGAGCT GCACCTGCCA GCAGTCATCC TCAAGACCTT CCTCCGGGAG 
CTTCCTGAGC CCCTGCTCAC CTTTGACCTC TACCCCCATG TGGTGGGCTT CCTCAACATT 
GATGAAAGCC AGAGGGTGCC AGCGACACTG CAGGTCCTCC AGACGCTGCC CGAGGAGAAC 
TACCAGGTGC TTCGTTTCCT GACTGCTTTC CTGGTGCAGA TTTCTGCACA CAGTGACCAG 
AACAAGATGA CCAACACTAA CCTGGCTGTT GTTTTCGGCC CTAACCTGCT GTGGGCCAAG 
GATGCGGCCA TCACCCTCAA GGCCATTAAT CCCATCAACA CCTTCACCAA GTTCCTTCTG 
GATCACCAAG GGGAGCTGTT CCCAAGCCCG GACCCCAGCG GGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP1 ( XM_011520095.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518397.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu56355
Clone ID Related Accession (Same CDS sequence)	XM_011520095.1 , XM_011520095.2 , NM_004308.5
Accession Version	XM_011520095.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518397.1
CDS	602..1921
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	XM_011520095.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520095.1

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP1 ( XM_011520095.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518397.1 Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu56355
Clone ID Related Accession (Same CDS sequence)	XM_011520095.1 , XM_011520095.2 , NM_004308.5
Accession Version	XM_011520095.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011520095.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518397.1
CDS	871..2190
Translation	MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL

Target ORF information:

RefSeq Version	XM_011520095.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520095.2

ORF Insert Sequence:

ATGGATCCGC TCTCAGAGCT GCAGGATGAT CTGACCTTGG ATGACACCAG CGAGGCTCTG 
AACCAGCTGA AGCTGGCCTC CATCGATGAG AAGAACTGGC CCTCGGATGA AATGCCTGAC 
TTCCCCAAGT CAGATGACTC CAAAAGCAGC TCCCCGGAAC TTGTCACACA CCTGAAGTGG 
GATGACCCAT ACTATGACAT CGCCCGGCAC CAGATCGTGG AGGTGGCAGG AGATGACAAG 
TATGGGCGGA AGATCATTGT GTTTAGTGCC TGTCGAATGC CCCCCAGCCA CCAGCTCGAC 
CACAGCAAGC TCCTGGGGTA CCTGAAGCAC ACCCTGGACC AGTACGTGGA GAGTGACTAC 
ACACTTCTGT ATCTGCACCA CGGCCTGACC AGCGACAACA AGCCCTCCCT CAGCTGGCTC 
CGTGATGCCT ACCGGGAGTT TGACCGCAAG TACAAGAAAA ACATCAAGGC CTTGTACATC 
GTGCATCCAA CCATGTTCAT CAAAACTCTG CTCATCCTCT TCAAGCCCCT CATCAGCTTC 
AAGTTCGGGC AGAAGATCTT CTATGTGAAT TACCTGAGCG AGCTGAGCGA GCACGTGAAG 
CTGGAGCAGC TGGGGATCCC TCGCCAAGTG CTCAAATATG ACGACTTCCT GAAATCCACA 
CAGAAGAGCC CCGCGACAGC CCCCAAGCCC ATGCCCCCAC GGCCCCCCCT GCCCAACCAG 
CAGTTTGGAG TCTCGCTGCA GCACCTCCAG GAGAAGAATC CAGAGCAGGA GCCCATTCCC 
ATTGTACTCA GGGAGACTGT TGCCTACTTA CAGGCCCACG CTCTCACCAC CGAGGGCATC 
TTCCGGAGGT CGGCCAACAC CCAAGTGGTC CGGGAAGTGC AGCAGAAGTA CAACATGGGG 
CTGCCTGTGG ATTTCGACCA GTACAATGAG CTGCACCTGC CAGCAGTCAT CCTCAAGACC 
TTCCTCCGGG AGCTTCCTGA GCCCCTGCTC ACCTTTGACC TCTACCCCCA TGTGGTGGGC 
TTCCTCAACA TTGATGAAAG CCAGAGGGTG CCAGCGACAC TGCAGGTCCT CCAGACGCTG 
CCCGAGGAGA ACTACCAGGT GCTTCGTTTC CTGACTGCTT TCCTGGTGCA GATTTCTGCA 
CACAGTGACC AGAACAAGAT GACCAACACT AACCTGGCTG TTGTTTTCGG CCCTAACCTG 
CTGTGGGCCA AGGATGCGGC CATCACCCTC AAGGCCATTA ATCCCATCAA CACCTTCACC 
AAGTTCCTTC TGGATCACCA AGGGGAGCTG TTCCCAAGCC CGGACCCCAG CGGGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.
International journal of cancer141(10)2062-2075(2017 Nov)
Satterfield L,Shuck R,Kurenbekova L,Allen-Rhoades W,Edwards D,Huang S,Rajapakshe K,Coarfa C,Donehower LA,Yustein JT

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.
Human molecular genetics25(23)5234-5243(2016 12)
Hsu YH,Li G,Liu CT,Brody JA,Karasik D,Chou WC,Demissie S,Nandakumar K,Zhou Y,Cheng CH,Gill R,Gibbs RA,Muzny D,Santibanez J,Estrada K,Rivadeneira F,Harris T,Gudnason V,Uitterlinden A,Psaty BM,Robbins JA,Adrienne Cupples L,Kiel DP

Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells.
Journal of cell science129(15)2937-49(2016 08)
Rauch L,Hennings K,Trasak C,R?der A,Schr?der B,Koch-Nolte F,Rivera-Molina F,Toomre D,Aepfelbacher M

Current knowledge of the large RhoGAP family of proteins.
Biology of the cell99(2)67-86(2007 Feb)
Tcherkezian J,Lamarche-Vane N

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature388(6643)693-7(1997 Aug)
Rittinger K,Walker PA,Eccleston JF,Nurmahomed K,Owen D,Laue E,Gamblin SJ,Smerdon SJ

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ARHGAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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