VHLL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VHLL
Entrez Gene ID	391104
Full Name	VHL like
Synonyms	VHLP,VLP
General protein information	Preferred Names VHL like Names von Hippel-Lindau-like protein VHL pseudogene VHL-like protein von Hippel-Lindau tumor suppressor like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004319.2	NP_001004319.1	von Hippel-Lindau-like protein
NM_001004319.3	NP_001004319.1	von Hippel-Lindau-like protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VHLL	XP_001144433.1
Homo sapiens (human)	VHLL	NP_001004319.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study of hematological and biochemical traits in a Japanese population.
Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N
Nature genetics42(3)210-5(2010 Mar)

Molecular cloning and characterization of the von Hippel-Lindau-like protein.
Qi H, Gervais ML, Li W, DeCaprio JA, Challis JR, Ohh M
Molecular cancer research : MCR2(1)43-52(2004 Jan)

Processed pseudogene from the von Hippel-Lindau disease gene is located on human chromosome 1.
Bradley JF, Rothberg PG
Diagnostic molecular pathology : the American journal of surgical pathology, part B8(2)101-6(1999 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following VHLL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VHLL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21555	NM_001004319.3 Latest version!	Homo sapiens VHL like (VHLL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21555	NM_001004319.2	Homo sapiens VHL like (VHLL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VHLL ( NM_001004319.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004319.1 Homo sapiens VHL like (VHLL), mRNA.

Price & Availability↑

CloneID	OHu21555
Clone ID Related Accession (Same CDS sequence)	NM_001004319.2 , NM_001004319.3
Accession Version	NM_001004319.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	von Hippel-Lindau-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA324790.1, AL589685.17 and AY494836.1. On Jul 15, 2009 this sequence version replaced NM_001004319.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCTGGA GAGCGGGGAA CGGGGTGGGT TTAGAGGCCC AGGCGGGCAC CCAGGAGGCA 
GGCCCAGAAG AGTACTGCCA GGAAGAGTTG GGCGCCGAGG AGGAGATGGC AGCCAGAGCA 
GCATGGCCTG TGCTGCGCTC TGTGAACTCA CGCGAGCTCT CCCGGATCAT CATCTGCAAT 
CACAGCCCAC GAATCGTGCT GCCTGTGTGG CTCAACTACT ATGGCAAGCT GCTGCCCTAC 
CTGACGCTGC TGCCCGGCAG GGACTTCCGC ATCCACAACT TCCGAAGCCA CCCTTGGCTC 
TTCAGAGATG CAAGGACACA TGATAAGCTT CTGGTTAACC AAACTGAATT GTTTGTGCCA 
TCTTCCAATG TTAATGGACA GCCTGTTTTT GCCAACATCA CACTGCAGTG TATACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004319.1
CDS	449..868
Translation	MPWRAGNGVGLEAQAGTQEAGPEEYCQEELGAEEEMAARAAWPVLRSVNSRELSRIIICNHSPRIVLPVWLNYYGKLLPYLTLLPGRDFRIHNFRSHPWLFRDARTHDKLLVNQTELFVPSSNVNGQPVFANITLQCIP

Target ORF information:

RefSeq Version	NM_001004319.2
Organism	Homo sapiens(human)
Definition	Homo sapiens VHL like (VHLL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004319.2

ORF Insert Sequence:

ATGCCCTGGA GAGCGGGGAA CGGGGTGGGT TTAGAGGCCC AGGCGGGCAC CCAGGAGGCA 
GGCCCAGAAG AGTACTGCCA GGAAGAGTTG GGCGCCGAGG AGGAGATGGC AGCCAGAGCA 
GCATGGCCTG TGCTGCGCTC TGTGAACTCA CGCGAGCTCT CCCGGATCAT CATCTGCAAT 
CACAGCCCAC GAATCGTGCT GCCTGTGTGG CTCAACTACT ATGGCAAGCT GCTGCCCTAC 
CTGACGCTGC TGCCCGGCAG GGACTTCCGC ATCCACAACT TCCGAAGCCA CCCTTGGCTC 
TTCAGAGATG CAAGGACACA TGATAAGCTT CTGGTTAACC AAACTGAATT GTTTGTGCCA 
TCTTCCAATG TTAATGGACA GCCTGTTTTT GCCAACATCA CACTGCAGTG TATACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHLL ( NM_001004319.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004319.1 Homo sapiens VHL like (VHLL), mRNA.

Price & Availability↑

CloneID	OHu21555
Clone ID Related Accession (Same CDS sequence)	NM_001004319.2 , NM_001004319.3
Accession Version	NM_001004319.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	von Hippel-Lindau-like protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL589685.17. On Nov 27, 2019 this sequence version replaced NM_001004319.2. ##Evidence-Data-START## Transcript is intronless :: AY494836.1, BC130596.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCTGGA GAGCGGGGAA CGGGGTGGGT TTAGAGGCCC AGGCGGGCAC CCAGGAGGCA 
GGCCCAGAAG AGTACTGCCA GGAAGAGTTG GGCGCCGAGG AGGAGATGGC AGCCAGAGCA 
GCATGGCCTG TGCTGCGCTC TGTGAACTCA CGCGAGCTCT CCCGGATCAT CATCTGCAAT 
CACAGCCCAC GAATCGTGCT GCCTGTGTGG CTCAACTACT ATGGCAAGCT GCTGCCCTAC 
CTGACGCTGC TGCCCGGCAG GGACTTCCGC ATCCACAACT TCCGAAGCCA CCCTTGGCTC 
TTCAGAGATG CAAGGACACA TGATAAGCTT CTGGTTAACC AAACTGAATT GTTTGTGCCA 
TCTTCCAATG TTAATGGACA GCCTGTTTTT GCCAACATCA CACTGCAGTG TATACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004319.1
CDS	119..538
Translation	MPWRAGNGVGLEAQAGTQEAGPEEYCQEELGAEEEMAARAAWPVLRSVNSRELSRIIICNHSPRIVLPVWLNYYGKLLPYLTLLPGRDFRIHNFRSHPWLFRDARTHDKLLVNQTELFVPSSNVNGQPVFANITLQCIP

Target ORF information:

RefSeq Version	NM_001004319.3
Organism	Homo sapiens(human)
Definition	Homo sapiens VHL like (VHLL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004319.3

ORF Insert Sequence:

ATGCCCTGGA GAGCGGGGAA CGGGGTGGGT TTAGAGGCCC AGGCGGGCAC CCAGGAGGCA 
GGCCCAGAAG AGTACTGCCA GGAAGAGTTG GGCGCCGAGG AGGAGATGGC AGCCAGAGCA 
GCATGGCCTG TGCTGCGCTC TGTGAACTCA CGCGAGCTCT CCCGGATCAT CATCTGCAAT 
CACAGCCCAC GAATCGTGCT GCCTGTGTGG CTCAACTACT ATGGCAAGCT GCTGCCCTAC 
CTGACGCTGC TGCCCGGCAG GGACTTCCGC ATCCACAACT TCCGAAGCCA CCCTTGGCTC 
TTCAGAGATG CAAGGACACA TGATAAGCTT CTGGTTAACC AAACTGAATT GTTTGTGCCA 
TCTTCCAATG TTAATGGACA GCCTGTTTTT GCCAACATCA CACTGCAGTG TATACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study of hematological and biochemical traits in a Japanese population.
Nature genetics42(3)210-5(2010 Mar)
Kamatani Y,Matsuda K,Okada Y,Kubo M,Hosono N,Daigo Y,Nakamura Y,Kamatani N

Molecular cloning and characterization of the von Hippel-Lindau-like protein.
Molecular cancer research : MCR2(1)43-52(2004 Jan)
Qi H,Gervais ML,Li W,DeCaprio JA,Challis JR,Ohh M

Processed pseudogene from the von Hippel-Lindau disease gene is located on human chromosome 1.
Diagnostic molecular pathology : the American journal of surgical pathology, part B8(2)101-6(1999 Jun)
Bradley JF,Rothberg PG

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VHLL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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