RHOG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RHOG
Entrez Gene ID	391
Full Name	ras homolog family member G
Synonyms	ARHG
General protein information	Preferred Names ras homolog family member G Names rho-related GTP-binding protein RhoG ras homolog gene family, member G (rho G)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
Disorder MIM:	179505

mRNA and Protein(s)

mRNA	Protein	Name
XM_005252916.2	XP_005252973.1	rho-related GTP-binding protein RhoG isoform X1
NM_001665.3	NP_001656.2	rho-related GTP-binding protein RhoG precursor
NM_001665.4	NP_001656.2	rho-related GTP-binding protein RhoG precursor
XM_017017719.1	XP_016873208.1	rho-related GTP-binding protein RhoG isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rhog	NP_062512.1
Danio rerio (zebrafish)	rhogb	NP_956334.1
Homo sapiens (human)	RHOG	NP_001656.2
	RHOG	XP_001113546.1
Bos taurus (cattle)	RHOG	NP_001073774.1
Gallus gallus (chicken)	LOC100859599	XP_004939037.1
Xenopus tropicalis (tropical clawed frog)	LOC100489878	XP_004920315.1
Canis lupus familiaris (dog)	RHOG	XP_542335.2
Rattus norvegicus (Norway rat)	Rhog	NP_001032272.1

Gene Ontology
Bibliography

Related articles in PubMed

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
Goicoechea SM, Zinn A, Awadia SS, Snyder K, Garcia-Mata R
Journal of cell science130(6)1064-1077(2017 03)

Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.
Peotter JL, Phillips J, Tong T, Dimeo K, Gonzalez JM Jr, Peters DM
Experimental cell research347(2)301-11(2016 10)

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
de Le?n-Bautista MP, Cardenas-Aguayo MD, Casique-Aguirre D, Almaraz-Salinas M, Parraguirre-Martinez S, Olivo-Diaz A, Thompson-Bonilla MD, Vargas M
PloS one11(11)e0166370(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RhoG and SGEF modulate the phosphorylation of paxillin, which plays a key role during invadopodia disassembly.
Title: A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.

These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.
Title: Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.

This study describes the regulation of EMT in RPE cells by TGF-beta1/miR-124/RHOG signaling and suggests that the supplement of miR-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.
Title: MicroRNA-124 Controls Transforming Growth Factor ?1-Induced Epithelial-Mesenchymal Transition in the Retinal Pigment Epithelium by Targeting RHOG.

These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
Title: Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.

yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF
Title: Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.

The following RHOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu44864	NM_001665.4 Latest version!	Homo sapiens ras homolog family member G (RHOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu44864	XM_017017719.1 Latest version!	Homo sapiens ras homolog family member G (RHOG), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu44864	XM_005252916.2 Latest version!	Homo sapiens ras homolog family member G (RHOG), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu44864	NM_001665.3	Homo sapiens ras homolog family member G (RHOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RHOG ( NM_001665.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001656.2 Homo sapiens ras homolog family member G (RHOG), mRNA.

Price & Availability↑

CloneID	OHu44864
Clone ID Related Accession (Same CDS sequence)	XM_005252916.2 , NM_001665.3 , NM_001665.4 , XM_017017719.1
Accession Version	NM_001665.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoG precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB125569.1, BC104178.2 and AA424888.1. On May 22, 2007 this sequence version replaced NM_001665.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.483806.1, SRR1163655.53726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001656.2
CDS	159..734
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	NM_001665.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member G (RHOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001665.3

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOG ( NM_001665.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001656.2 Homo sapiens ras homolog family member G (RHOG), mRNA.

Price & Availability↑

CloneID	OHu44864
Clone ID Related Accession (Same CDS sequence)	XM_005252916.2 , NM_001665.3 , NM_001665.4 , XM_017017719.1
Accession Version	NM_001665.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoG precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB125569.1, BC104178.2 and AA424888.1. On Nov 22, 2018 this sequence version replaced NM_001665.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.483806.1, SRR1163655.53726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000351018.5/ ENSP00000339467.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001656.2
CDS	135..710
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	NM_001665.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member G (RHOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001665.4

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOG ( XM_005252916.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005252973.1 Homo sapiens ras homolog family member G (RHOG), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu44864
Clone ID Related Accession (Same CDS sequence)	XM_005252916.2 , NM_001665.3 , NM_001665.4 , XM_017017719.1
Accession Version	XM_005252916.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoG isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005252916.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005252973.1
CDS	339..914
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	XM_005252916.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member G (RHOG), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005252916.2

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOG ( XM_017017719.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873208.1 Homo sapiens ras homolog family member G (RHOG), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu44864
Clone ID Related Accession (Same CDS sequence)	XM_005252916.2 , NM_001665.3 , NM_001665.4 , XM_017017719.1
Accession Version	XM_017017719.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoG isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873208.1
CDS	186..761
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	XM_017017719.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member G (RHOG), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017719.1

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGCGT GGTGGTGGGT GATGGGGCTG TGGGCAAGAC GTGCCTGCTC 
ATCTGCTACA CAACTAACGC TTTCCCCAAA GAGTACATCC CCACCGTGTT CGACAATTAC 
AGCGCGCAGA GCGCAGTTGA CGGGCGCACA GTGAACCTGA ACCTGTGGGA CACTGCGGGC 
CAGGAGGAGT ATGACCGCCT CCGTACACTC TCCTACCCTC AGACCAACGT TTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC GCCGTCCTAT GAGAACGTGC GGCACAAGTG GCATCCAGAG 
GTGTGCCACC ACTGCCCTGA TGTGCCCATC CTGCTGGTGG GCACCAAGAA GGACCTGAGA 
GCCCAGCCTG ACACCCTACG GCGCCTCAAG GAGCAGGGCC AGGCGCCCAT CACACCGCAG 
CAGGGCCAGG CACTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAATG CTCAGCCCTG 
CAACAGGATG GTGTCAAGGA AGTGTTCGCC GAGGCTGTCC GGGCTGTGCT CAACCCCACG 
CCGATCAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
Journal of cell science130(6)1064-1077(2017 03)
Goicoechea SM,Zinn A,Awadia SS,Snyder K,Garcia-Mata R

Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.
Experimental cell research347(2)301-11(2016 10)
Peotter JL,Phillips J,Tong T,Dimeo K,Gonzalez JM Jr,Peters DM

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
PloS one11(11)e0166370(2016)
de Le?n-Bautista MP,Cardenas-Aguayo MD,Casique-Aguirre D,Almaraz-Salinas M,Parraguirre-Martinez S,Olivo-Diaz A,Thompson-Bonilla MD,Vargas M

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RHOG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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