ANXA2R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANXA2R
Entrez Gene ID	389289
Full Name	annexin A2 receptor
Synonyms	AX2R,AXIIR,C5orf39
General protein information	Preferred Names annexin A2 receptor Names annexin-2 receptor annexin II receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p12
Disorder MIM:	611296

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014279.2	NP_001014301.1	annexin-2 receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANXA2R	NP_001014301.1
Pan troglodytes (chimpanzee)	ANXA2R	XP_001136316.1
	LOC698994	XP_001089654.1

Gene Ontology
Bibliography

Related articles in PubMed

hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein translation.
Zhang J, Kong L, Guo S, Bu M, Guo Q, Xiong Y, Zhu N, Qiu C, Yan X, Chen Q, Zhang H, Zhuang J, Wang Q, Zhang SS, Shen Y, Chen M
Nucleic acids research(2016 Oct)

Overexpression of Annexin II Receptor-Induced Autophagy Protects Against Apoptosis in Uveal Melanoma Cells.
Zhang Y, Song H, Guo T, Zhu Y, Tang H, Qi Z, Zhao P, Zhao S
Cancer biotherapy & radiopharmaceuticals31(4)145-51(2016 May)

SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression.
Song H, Pan D, Sun W, Gu C, Zhang Y, Zhao P, Qi Z, Zhao S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology35(3)875-84(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data highlighted the crucial role of AXIIR in reducing Mum2C cell viability through inducing apoptosis, while autophagy played a protective role in this process.
Title: Overexpression of Annexin II Receptor-Induced Autophagy Protects Against Apoptosis in Uveal Melanoma Cells.

these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases
Title: SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression.

AXIIR acts as a novel inducer of apoptosis in human cells, partially through activating Caspase-8.
Title: Annexin II receptor induces apoptosis independent of Annexin II.

Results show that AXII and AXIIR play important roles in multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM.
Title: Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment.

annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche.
Title: Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer.

The following ANXA2R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANXA2R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31874	NM_001014279.2 Latest version!	Homo sapiens annexin A2 receptor (ANXA2R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANXA2R ( NM_001014279.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014301.1 Homo sapiens annexin A2 receptor (ANXA2R), mRNA.

Price & Availability↑

CloneID	OHu31874
Clone ID Related Accession (Same CDS sequence)	NM_001014279.2
Accession Version	NM_001014279.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	annexin-2 receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN261477.1, AY032883.1 and BQ670161.1. On Oct 4, 2008 this sequence version replaced NM_001014279.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 27789685 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAC ATTTTCTTGG CTGTGTGAAG CGGGCTTGGG ATTCCGCAGA GGTGGCGCCA 
GAGCCCCAGC CTCCACCTAT TGTGAGTTCA GAAGATCGTG GGCCGTGGCC TCTTCCTTTG 
TATCCAGTAC TAGGAGAGTA CTCACTGGAC AGCTGTGATT TGGGACTGCT TTCCAGCCCT 
TGCTGGCGGC TGCCCGGAGT CTACTGGCAA AACGGACTCT CTCCTGGAGT CCAGAGCACC 
TTGGAACCAA GTACAGCGAA GCCCACTGAG TTCAGTTGGC CGGGGACACA GAAGCAGCAA 
GAGGCACCCG TAGAAGAGGT GGGGCAGGCA GAGGAACCCG ACAGACTCAG GCTCCAGCAG 
CTTCCCTGGA GCAGTCCTCT CCATCCCTGG GACAGACAGC AGGACACCGA GGTCTGTGAC 
AGCGGGTGCC TTTTGGAACG CCGCCATCCT CCTGCCCTCC AGCCGTGGCG CCACCTCCCG 
GGTTTCTCAG ACTGCCTGGA GTGGATTCTT CGCGTTGGTT TTGCCGCGTT CTCTGTACTC 
TGGGCGTGCT GTTCACGGAT CTGTGGAGCT AAGCAGCCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014301.1
CDS	300..881
Translation	MEQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVLGEYSLDSCDLGLLSSPCWRLPGVYWQNGLSPGVQSTLEPSTAKPTEFSWPGTQKQQEAPVEEVGQAEEPDRLRLQQLPWSSPLHPWDRQQDTEVCDSGCLLERRHPPALQPWRHLPGFSDCLEWILRVGFAAFSVLWACCSRICGAKQP

Target ORF information:

RefSeq Version	NM_001014279.2
Organism	Homo sapiens(human)
Definition	Homo sapiens annexin A2 receptor (ANXA2R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014279.2

ORF Insert Sequence:

ATGGAGCAAC ATTTTCTTGG CTGTGTGAAG CGGGCTTGGG ATTCCGCAGA GGTGGCGCCA 
GAGCCCCAGC CTCCACCTAT TGTGAGTTCA GAAGATCGTG GGCCGTGGCC TCTTCCTTTG 
TATCCAGTAC TAGGAGAGTA CTCACTGGAC AGCTGTGATT TGGGACTGCT TTCCAGCCCT 
TGCTGGCGGC TGCCCGGAGT CTACTGGCAA AACGGACTCT CTCCTGGAGT CCAGAGCACC 
TTGGAACCAA GTACAGCGAA GCCCACTGAG TTCAGTTGGC CGGGGACACA GAAGCAGCAA 
GAGGCACCCG TAGAAGAGGT GGGGCAGGCA GAGGAACCCG ACAGACTCAG GCTCCAGCAG 
CTTCCCTGGA GCAGTCCTCT CCATCCCTGG GACAGACAGC AGGACACCGA GGTCTGTGAC 
AGCGGGTGCC TTTTGGAACG CCGCCATCCT CCTGCCCTCC AGCCGTGGCG CCACCTCCCG 
GGTTTCTCAG ACTGCCTGGA GTGGATTCTT CGCGTTGGTT TTGCCGCGTT CTCTGTACTC 
TGGGCGTGCT GTTCACGGAT CTGTGGAGCT AAGCAGCCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein translation.
Nucleic acids research(2016 Oct)
Zhang J,Kong L,Guo S,Bu M,Guo Q,Xiong Y,Zhu N,Qiu C,Yan X,Chen Q,Zhang H,Zhuang J,Wang Q,Zhang SS,Shen Y,Chen M

Overexpression of Annexin II Receptor-Induced Autophagy Protects Against Apoptosis in Uveal Melanoma Cells.
Cancer biotherapy & radiopharmaceuticals31(4)145-51(2016 May)
Zhang Y,Song H,Guo T,Zhu Y,Tang H,Qi Z,Zhao P,Zhao S

SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology35(3)875-84(2015)
Song H,Pan D,Sun W,Gu C,Zhang Y,Zhao P,Qi Z,Zhao S

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ANXA2R cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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