GRXCR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRXCR1
Entrez Gene ID	389207
Full Name	glutaredoxin and cysteine rich domain containing 1
Synonyms	DFNB25,PPP1R88
General protein information	Preferred Names glutaredoxin and cysteine rich domain containing 1 Names glutaredoxin domain-containing cysteine-rich protein 1 glutaredoxin, cysteine rich 1 protein phosphatase 1, regulatory subunit 88
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p13
Summary	This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010].
Disorder MIM:	613283
Disorder Html:	Deafness, autosomal recessive 25, 613285 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001080476.2	NP_001073945.1	glutaredoxin domain-containing cysteine-rich protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GRXCR1	XP_517170.2
Mus musculus (house mouse)	Grxcr1	NP_001018019.2
Xenopus tropicalis (tropical clawed frog)	grxcr1	XP_002933496.2
Canis lupus familiaris (dog)	GRXCR1	XP_003431852.1
Rattus norvegicus (Norway rat)	Grxcr1	NP_001178864.1
Homo sapiens (human)	GRXCR1	NP_001073945.1
	GRXCR1	XP_001099443.1
Gallus gallus (chicken)	GRXCR1	XP_004936128.1
Danio rerio (zebrafish)	LOC100332873	XP_002664501.1
Caenorhabditis elegans (roundworm)	Y46E12A.3	NP_497453.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel mutation in GRXCR1 at DFNB25 lead to progressive hearing loss and dizziness.
Mori K, Miyanohara I, Moteki H, Nishio SY, Kurono Y, Usami S
The Annals of otology, rhinology, and laryngology124 Suppl 1129S-34S(2015 May)

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
Kariuki SN, Ghodke-Puranik Y, Dorschner JM, Chrabot BS, Kelly JA, Tsao BP, Kimberly RP, Alarc?n-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB
Genes and immunity16(1)15-23(2015 Jan-Feb)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.
Schraders M, Lee K, Oostrik J, Huygen PL, Ali G, Hoefsloot LH, Veltman JA, Cremers FP, Basit S, Ansar M, Cremers CW, Kunst HP, Ahmad W, Admiraal RJ, Leal SM, Kremer H
American journal of human genetics86(2)138-47(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel mutations in GRXCR1 at DFNB25 leading to progressive hearing loss are identified in a Japanese family.
Title: Novel mutation in GRXCR1 at DFNB25 lead to progressive hearing loss and dizziness.

Quantitative analysis of GRXCR1 transcripts in fetal and adult human tissues revealed a preferential expression of the gene in fetal cochlea, which may explain the nonsyndromic nature of the hearing impairment.
Title: Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.

The following GRXCR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRXCR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu28084	NM_001080476.2 Latest version!	Homo sapiens glutaredoxin and cysteine rich domain containing 1 (GRXCR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRXCR1 ( NM_001080476.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073945.1 Homo sapiens glutaredoxin and cysteine rich domain containing 1 (GRXCR1), mRNA.

Price & Availability↑

CloneID	OHu28084
Clone ID Related Accession (Same CDS sequence)	NM_001080476.2
Accession Version	NM_001080476.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	glutaredoxin domain-containing cysteine-rich protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC108035.3, DT932651.1, DY654338.1, AA588868.1 and BG213384.1. This sequence is a reference standard in the RefSeqGene project. On Sep 11, 2010 this sequence version replaced NM_001080476.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DY654338.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTTAAAA GGGAGATGAA GCCAGAAAGT GACAGGCCAC GGAAAGTCCG GTTTCGGATC 
GCGTCCTCTC ACAGTGGGCG AGTTCTGAAG GAAGTGTATG AAGATGGGCA ACCGTCAGGC 
TCTCTGGATT CTGAATGTGC CAGTATCTGT GGGATAGATG GACTAGGTGA TTCCGATGGA 
CAGCAGAATG GCCACATAGA GTCAGAAGGT GATGAGAATG AGAATGACCA GGATAGCTTG 
CTGGTGTTAG CAAGGGCTGC CAGTGAGAAG GGTTTTGGTA CAAGAAGAGT CAACATTTTA 
AGCAAAAATG GCACAGTCAG AGGCGTCAAA TACAAAGTGA GTGCTGGCCA GGCTCTATTT 
AACAATTTGA CCAAAGTATT ACAGCAACCA TCAACTGATC TAGAATTTGA CCGTGTAGTG 
ATTTATACCA CCTGCCTTCG TGTGGTCCGG ACAACCTTTG AAAGATGTGA ACTGGTTAGA 
AAGATTTTCC AAAACCATCG CGTAAAATTT GAAGAGAAAA ACATAGCCCT GAATGGTGAA 
TATGGAAAAG AGTTAGACGA ACGATGCCGA CGAGTTTCTG AAGCTCCTTC CCTCCCTGTT 
GTGTTCATTG ATGGCCATTA CCTTGGGGGT GCTGAGAAAA TTTTGTCAAT GAATGAATCA 
GGAGAACTGC AAGACATCCT AACCAAAATT GAGAGAGTAC AGCATCCACA TGAGTGTCCC 
TCTTGTGGAG GCTTTGGCTT TCTTCCATGC TCCGTGTGCC ATGGGAGCAA GATGTCCATG 
TTTCGAAACT GCTTCACAGA CTCTTTCAAA GCCCTGAAGT GTACGGCTTG CAATGAAAAT 
GGTCTTCAGC GTTGTAAGAA CTGTGCTGGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073945.1
CDS	2..874
Translation	MLKREMKPESDRPRKVRFRIASSHSGRVLKEVYEDGQPSGSLDSECASICGIDGLGDSDGQQNGHIESEGDENENDQDSLLVLARAASEKGFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGEYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDILTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSMFRNCFTDSFKALKCTACNENGLQRCKNCAG

Target ORF information:

RefSeq Version	NM_001080476.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin and cysteine rich domain containing 1 (GRXCR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080476.2

ORF Insert Sequence:

ATGCTTAAAA GGGAGATGAA GCCAGAAAGT GACAGGCCAC GGAAAGTCCG GTTTCGGATC 
GCGTCCTCTC ACAGTGGGCG AGTTCTGAAG GAAGTGTATG AAGATGGGCA ACCGTCAGGC 
TCTCTGGATT CTGAATGTGC CAGTATCTGT GGGATAGATG GACTAGGTGA TTCCGATGGA 
CAGCAGAATG GCCACATAGA GTCAGAAGGT GATGAGAATG AGAATGACCA GGATAGCTTG 
CTGGTGTTAG CAAGGGCTGC CAGTGAGAAG GGTTTTGGTA CAAGAAGAGT CAACATTTTA 
AGCAAAAATG GCACAGTCAG AGGCGTCAAA TACAAAGTGA GTGCTGGCCA GGCTCTATTT 
AACAATTTGA CCAAAGTATT ACAGCAACCA TCAACTGATC TAGAATTTGA CCGTGTAGTG 
ATTTATACCA CCTGCCTTCG TGTGGTCCGG ACAACCTTTG AAAGATGTGA ACTGGTTAGA 
AAGATTTTCC AAAACCATCG CGTAAAATTT GAAGAGAAAA ACATAGCCCT GAATGGTGAA 
TATGGAAAAG AGTTAGACGA ACGATGCCGA CGAGTTTCTG AAGCTCCTTC CCTCCCTGTT 
GTGTTCATTG ATGGCCATTA CCTTGGGGGT GCTGAGAAAA TTTTGTCAAT GAATGAATCA 
GGAGAACTGC AAGACATCCT AACCAAAATT GAGAGAGTAC AGCATCCACA TGAGTGTCCC 
TCTTGTGGAG GCTTTGGCTT TCTTCCATGC TCCGTGTGCC ATGGGAGCAA GATGTCCATG 
TTTCGAAACT GCTTCACAGA CTCTTTCAAA GCCCTGAAGT GTACGGCTTG CAATGAAAAT 
GGTCTTCAGC GTTGTAAGAA CTGTGCTGGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel mutation in GRXCR1 at DFNB25 lead to progressive hearing loss and dizziness.
The Annals of otology, rhinology, and laryngology124 Suppl 1129S-34S(2015 May)
Mori K,Miyanohara I,Moteki H,Nishio SY,Kurono Y,Usami S

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
Genes and immunity16(1)15-23(2015 Jan-Feb)
Kariuki SN,Ghodke-Puranik Y,Dorschner JM,Chrabot BS,Kelly JA,Tsao BP,Kimberly RP,Alarc?n-Riquelme ME,Jacob CO,Criswell LA,Sivils KL,Langefeld CD,Harley JB,Skol AD,Niewold TB

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment.
American journal of human genetics86(2)138-47(2010 Feb)
Schraders M,Lee K,Oostrik J,Huygen PL,Ali G,Hoefsloot LH,Veltman JA,Cremers FP,Basit S,Ansar M,Cremers CW,Kunst HP,Ahmad W,Admiraal RJ,Leal SM,Kremer H

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GRXCR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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