RHOC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RHOC
Entrez Gene ID	389
Full Name	ras homolog family member C
Synonyms	ARH9,ARHC,H9,RHOH9
General protein information	Preferred Names ras homolog family member C Names rho-related GTP-binding protein RhoC RAS-related homolog 9 oncogene RHO H9 ras homolog gene family, member C rho cDNA clone 9 rhoC GTPase small GTP binding protein RhoC
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Summary	This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	165380

mRNA and Protein(s)

mRNA	Protein	Name
NM_175744.5	NP_786886.1	rho-related GTP-binding protein RhoC precursor
NM_175744.4	NP_786886.1	rho-related GTP-binding protein RhoC precursor
NM_001042679.1	NP_001036144.1	rho-related GTP-binding protein RhoC precursor
NM_001042678.1	NP_001036143.1	rho-related GTP-binding protein RhoC precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RHOC	XP_540336.2
Danio rerio (zebrafish)	rhoad	NP_001002445.1
Danio rerio (zebrafish)	rhoac	NP_998515.1
Danio rerio (zebrafish)	rhoae	NP_957444.1
Bos taurus (cattle)	RHOC	NP_001039603.1
Xenopus tropicalis (tropical clawed frog)	rhoc	NP_001016569.1
Homo sapiens (human)	RHOC	NP_001036143.1
Pan troglodytes (chimpanzee)	RHOC	XP_003339043.1
Mus musculus (house mouse)	Rhoc	NP_031510.2
Rattus norvegicus (Norway rat)	Rhoc	NP_001099931.1
Gallus gallus (chicken)	RHOC	NP_001025020.1
Danio rerio (zebrafish)	rhoaa	NP_998302.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005160	XP_001688510.1
Caenorhabditis elegans (roundworm)	rho-1	NP_502959.1
Eremothecium gossypii	AGOS_ABR182W	NP_983130.1
Drosophila melanogaster (fruit fly)	Rho1	NP_995851.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Chen S, Wang LL, Sun KX, Xiu YL, Zong ZH, Chen X, Zhao Y
Molecular carcinogenesis57(2)225-234(2018 Feb)

RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.
Luo J, Li D, Wei D, Wang X, Wang L, Zeng X
Molecular and cellular biochemistry436(1-2)13-21(2017 Dec)

Role of the lncRNA ABHD11-AS
Wu DD, Chen X, Sun KX, Wang LL, Chen S, Zhao Y
Molecular cancer16(1)138(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

E2F transcription factor 1 (E2F1) downregulated micrRNA miR-519d directly and miR-519d downregulated Ras homolog gene family member C (RhoC) directly.
Title: E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.

HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.
Title: Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.

These results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3- and MST3- and MST4-dependent manner.
Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells.
Title: Effects and mechanism of RhoC downregulation in suppressing ovarian cancer stem cell proliferation, drug resistance, invasion and metastasis.

During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1, upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro.
Title: Effect of RhoC on the epithelial-mesenchymal transition process induced by TGF-?1 in lung adenocarcinoma cells.

The following RHOC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHOC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02165	NM_001042679.1 Latest version!	Homo sapiens ras homolog family member C (RHOC), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu02165	NM_001042678.1 Latest version!	Homo sapiens ras homolog family member C (RHOC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu02165	NM_175744.5 Latest version!	Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu02165	NM_175744.4	Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RHOC ( NM_175744.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_786886.1 Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02165
Clone ID Related Accession (Same CDS sequence)	NM_175744.5 , NM_175744.4 , NM_001042679.1 , NM_001042678.1
Accession Version	NM_175744.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoC precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX872299.1, BC009177.2 and CB851337.1. On Aug 8, 2006 this sequence version replaced NM_175744.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279873.3030.1, SRR1163655.225082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786886.1
CDS	403..984
Translation	MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL

Target ORF information:

RefSeq Version	NM_175744.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175744.4

ORF Insert Sequence:

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOC ( NM_001042679.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001036144.1 Homo sapiens ras homolog family member C (RHOC), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu02165
Clone ID Related Accession (Same CDS sequence)	NM_175744.5 , NM_175744.4 , NM_001042679.1 , NM_001042678.1
Accession Version	NM_001042679.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoC precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN289691.1, BQ231012.1, BC009177.2 and CB851337.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.441361.1, BQ231012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153733 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036144.1
CDS	301..882
Translation	MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL

Target ORF information:

RefSeq Version	NM_001042679.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member C (RHOC), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042679.1

ORF Insert Sequence:

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOC ( NM_001042678.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001036143.1 Homo sapiens ras homolog family member C (RHOC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02165
Clone ID Related Accession (Same CDS sequence)	NM_175744.5 , NM_175744.4 , NM_001042679.1 , NM_001042678.1
Accession Version	NM_001042678.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoC precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX872299.1, BC052808.1 and CB851337.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279824.29.1, SRR1163655.659163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036143.1
CDS	334..915
Translation	MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL

Target ORF information:

RefSeq Version	NM_001042678.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member C (RHOC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042678.1

ORF Insert Sequence:

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOC ( NM_175744.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_786886.1 Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02165
Clone ID Related Accession (Same CDS sequence)	NM_175744.5 , NM_175744.4 , NM_001042679.1 , NM_001042678.1
Accession Version	NM_175744.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoC precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX872299.1 and BC009177.2. On Nov 30, 2019 this sequence version replaced NM_175744.4. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ900972.1, BC009177.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786886.1
CDS	127..708
Translation	MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL

Target ORF information:

RefSeq Version	NM_175744.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ras homolog family member C (RHOC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175744.5

ORF Insert Sequence:

ATGGCTGCAA TCCGAAAGAA GCTGGTGATC GTTGGGGATG GTGCCTGTGG GAAGACCTGC 
CTCCTCATCG TCTTCAGCAA GGATCAGTTT CCGGAGGTCT ACGTCCCTAC TGTCTTTGAG 
AACTATATTG CGGACATTGA GGTGGACGGC AAGCAGGTGG AGCTGGCTCT GTGGGACACA 
GCAGGGCAGG AAGACTATGA TCGACTGCGG CCTCTCTCCT ACCCGGACAC TGATGTCATC 
CTCATGTGCT TCTCCATCGA CAGCCCTGAC AGCCTGGAAA ACATTCCTGA GAAGTGGACC 
CCAGAGGTGA AGCACTTCTG CCCCAACGTG CCCATCATCC TGGTGGGGAA TAAGAAGGAC 
CTGAGGCAAG ACGAGCACAC CAGGAGAGAG CTGGCCAAGA TGAAGCAGGA GCCCGTTCGG 
TCTGAGGAAG GCCGGGACAT GGCGAACCGG ATCAGTGCCT TTGGCTACCT TGAGTGCTCA 
GCCAAGACCA AGGAGGGAGT GCGGGAGGTG TTTGAGATGG CCACTCGGGC TGGCCTCCAG 
GTCCGCAAGA ACAAGCGTCG GAGGGGCTGT CCCATTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Molecular carcinogenesis57(2)225-234(2018 Feb)
Chen S,Wang LL,Sun KX,Xiu YL,Zong ZH,Chen X,Zhao Y

RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.
Molecular and cellular biochemistry436(1-2)13-21(2017 Dec)
Luo J,Li D,Wei D,Wang X,Wang L,Zeng X

Role of the lncRNA ABHD11-AS
Molecular cancer16(1)138(2017 Aug)
Wu DD,Chen X,Sun KX,Wang LL,Chen S,Zhao Y

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RHOC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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