RGS9BP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS9BP
Entrez Gene ID	388531
Full Name	regulator of G protein signaling 9 binding protein
Synonyms	PERRS,R9AP,RGS9
General protein information	Preferred Names regulator of G protein signaling 9 binding protein Names regulator of G-protein signaling 9-binding protein RGS9 anchor protein RGS9-anchoring protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.11
Summary	The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	607814
Disorder Html:	Bradyopsia, 608415 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_207391.2	NP_997274.2	regulator of G-protein signaling 9-binding protein
NM_207391.3	NP_997274.2	regulator of G-protein signaling 9-binding protein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rgs9bp	NP_001102612.1
Canis lupus familiaris (dog)	RGS9BP	XP_005616832.1
Mus musculus (house mouse)	Rgs9bp	NP_665839.1
Danio rerio (zebrafish)	LOC559232	XP_005169975.1
Xenopus tropicalis (tropical clawed frog)	LOC100491544	XP_004913611.1
Homo sapiens (human)	RGS9BP	NP_997274.2
Pan troglodytes (chimpanzee)	RGS9BP	XP_512566.2
	RGS9BP	XP_001087093.1
Bos taurus (cattle)	RGS9BP	NP_001159988.1
Gallus gallus (chicken)	RGS9BP	NP_989836.1

Gene Ontology
Bibliography

Related articles in PubMed

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
, ,
The American journal of psychiatry170(2)207-17(2013 Feb)

Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).
Michaelides M, Li Z, Rana NA, Richardson EC, Hykin PG, Moore AT, Holder GE, Webster AR
Ophthalmology117(1)120-127.e1(2010 Jan)

Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation120(24)2448-54(2009 Dec)

The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels.
Stockman A, Smithson HE, Webster AR, Holder GE, Rana NA, Ripamonti C, Sharpe LT
Journal of vision8(1)10.1-10(2008 Jan)

Bradyopsia in an Asian man.
Cheng JY, Luu CD, Yong VH, Mathur R, Aung T, Vithana EN
Archives of ophthalmology (Chicago, Ill. : 1960)125(8)1138-40(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first report describing a nonsense mutation in RGS9.
Title: Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).

Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
Title: Integrative predictive model of coronary artery calcification in atherosclerosis.

As the light level is increased and the PDE6* concentration in the normal rises relative to that in the observer lacking RGS9-1, the temporal advantage of the latter is soon lost, leaving only the deficit due to delayed deactivation.
Title: The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels.

homozygous mutations in R9AP gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia.
Title: Bradyopsia in an Asian man.

five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones
Title: Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.

The following RGS9BP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS9BP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19327	NM_207391.3 Latest version!	Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu19327	NM_207391.2	Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS9BP ( NM_207391.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997274.2 Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.

Price & Availability↑

CloneID	OHu19327
Clone ID Related Accession (Same CDS sequence)	NM_207391.2 , NM_207391.3
Accession Version	NM_207391.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 9-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008474.9. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2006 this sequence version replaced NM_207391.1. COMPLETENESS: complete on the 3' end.

ATGGCGAGGG AGGAGTGCAA GGCGCTGCTG GACGGGCTCA ACAAGACGAC TGCGTGCTAC 
CACCACCTGG TGCTGACCGT CGGTGGCTCG GCGGACTCGC AGAACCTGCG GCAGGAGCTG 
CAAAAGACGC GCCAGAAGGC GCAGGAGCTG GCGGTGTCCA CCTGCGCCCG GCTGACTGCT 
GTGCTGCGCG ACCGGGGCCT GGCCGCCGAC GAGCGCGCCG AGTTCGAGCG GCTCTGGGTG 
GCCTTCTCGG GCTGCCTGGA CCTGCTGGAA GCGGACATGC GACGCGCGCT GGAGCTGGGC 
GCCGCGTTCC CGCTGCACGC GCCGCGGCGG CCGCTGGTGC GCACAGGTGT GGCTGGCGCC 
TCCTCCGGCG TGGCGGCGCG CGCGCTGAGC ACCCGCAGCC TGCGGCTCGA GGCGGAGGGC 
GACTTCGACG TCGCGGACCT GCGGGAGCTG GAGCGCGAGG TCCTTCAGGT GGGCGAGATG 
ATCGACAACA TGGAGATGAA GGTCAACGTG CCCCGCTGGA CCGTGCAAGC CCGGCAGGCG 
GCGGGCGCCG AGCTCCTGTC CACGGTCAGC GCCGGCCCCT CCTCGGTCGT GTCCTTGCAG 
GAGCGCGGGG GGGGTTGCGA CCCCAGGAAG GCCCTGGCCG CCATCCTTTT CGGCGCCGTG 
CTGCTGGCGG CTGTGGCCCT AGCCGTGTGC GTGGCGAAGC TGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997274.2
CDS	858..1565
Translation	MAREECKALLDGLNKTTACYHHLVLTVGGSADSQNLRQELQKTRQKAQELAVSTCARLTAVLRDRGLAADERAEFERLWVAFSGCLDLLEADMRRALELGAAFPLHAPRRPLVRTGVAGASSGVAARALSTRSLRLEAEGDFDVADLRELEREVLQVGEMIDNMEMKVNVPRWTVQARQAAGAELLSTVSAGPSSVVSLQERGGGCDPRKALAAILFGAVLLAAVALAVCVAKLS

Target ORF information:

RefSeq Version	NM_207391.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207391.2

ORF Insert Sequence:

ATGGCGAGGG AGGAGTGCAA GGCGCTGCTG GACGGGCTCA ACAAGACGAC TGCGTGCTAC 
CACCACCTGG TGCTGACCGT CGGTGGCTCG GCGGACTCGC AGAACCTGCG GCAGGAGCTG 
CAAAAGACGC GCCAGAAGGC GCAGGAGCTG GCGGTGTCCA CCTGCGCCCG GCTGACTGCT 
GTGCTGCGCG ACCGGGGCCT GGCCGCCGAC GAGCGCGCCG AGTTCGAGCG GCTCTGGGTG 
GCCTTCTCGG GCTGCCTGGA CCTGCTGGAA GCGGACATGC GACGCGCGCT GGAGCTGGGC 
GCCGCGTTCC CGCTGCACGC GCCGCGGCGG CCGCTGGTGC GCACAGGTGT GGCTGGCGCC 
TCCTCCGGCG TGGCGGCGCG CGCGCTGAGC ACCCGCAGCC TGCGGCTCGA GGCGGAGGGC 
GACTTCGACG TCGCGGACCT GCGGGAGCTG GAGCGCGAGG TCCTTCAGGT GGGCGAGATG 
ATCGACAACA TGGAGATGAA GGTCAACGTG CCCCGCTGGA CCGTGCAAGC CCGGCAGGCG 
GCGGGCGCCG AGCTCCTGTC CACGGTCAGC GCCGGCCCCT CCTCGGTCGT GTCCTTGCAG 
GAGCGCGGGG GGGGTTGCGA CCCCAGGAAG GCCCTGGCCG CCATCCTTTT CGGCGCCGTG 
CTGCTGGCGG CTGTGGCCCT AGCCGTGTGC GTGGCGAAGC TGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS9BP ( NM_207391.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997274.2 Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.

Price & Availability↑

CloneID	OHu19327
Clone ID Related Accession (Same CDS sequence)	NM_207391.2 , NM_207391.3
Accession Version	NM_207391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 9-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008474.9. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_207391.2. ##Evidence-Data-START## Transcript is intronless :: AK127646.1, ERR279851.285.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334176.4/ ENSP00000334134.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGGG AGGAGTGCAA GGCGCTGCTG GACGGGCTCA ACAAGACGAC TGCGTGCTAC 
CACCACCTGG TGCTGACCGT CGGTGGCTCG GCGGACTCGC AGAACCTGCG GCAGGAGCTG 
CAAAAGACGC GCCAGAAGGC GCAGGAGCTG GCGGTGTCCA CCTGCGCCCG GCTGACTGCT 
GTGCTGCGCG ACCGGGGCCT GGCCGCCGAC GAGCGCGCCG AGTTCGAGCG GCTCTGGGTG 
GCCTTCTCGG GCTGCCTGGA CCTGCTGGAA GCGGACATGC GACGCGCGCT GGAGCTGGGC 
GCCGCGTTCC CGCTGCACGC GCCGCGGCGG CCGCTGGTGC GCACAGGTGT GGCTGGCGCC 
TCCTCCGGCG TGGCGGCGCG CGCGCTGAGC ACCCGCAGCC TGCGGCTCGA GGCGGAGGGC 
GACTTCGACG TCGCGGACCT GCGGGAGCTG GAGCGCGAGG TCCTTCAGGT GGGCGAGATG 
ATCGACAACA TGGAGATGAA GGTCAACGTG CCCCGCTGGA CCGTGCAAGC CCGGCAGGCG 
GCGGGCGCCG AGCTCCTGTC CACGGTCAGC GCCGGCCCCT CCTCGGTCGT GTCCTTGCAG 
GAGCGCGGGG GGGGTTGCGA CCCCAGGAAG GCCCTGGCCG CCATCCTTTT CGGCGCCGTG 
CTGCTGGCGG CTGTGGCCCT AGCCGTGTGC GTGGCGAAGC TGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997274.2
CDS	417..1124
Translation	MAREECKALLDGLNKTTACYHHLVLTVGGSADSQNLRQELQKTRQKAQELAVSTCARLTAVLRDRGLAADERAEFERLWVAFSGCLDLLEADMRRALELGAAFPLHAPRRPLVRTGVAGASSGVAARALSTRSLRLEAEGDFDVADLRELEREVLQVGEMIDNMEMKVNVPRWTVQARQAAGAELLSTVSAGPSSVVSLQERGGGCDPRKALAAILFGAVLLAAVALAVCVAKLS

Target ORF information:

RefSeq Version	NM_207391.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 9 binding protein (RGS9BP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207391.3

ORF Insert Sequence:

ATGGCGAGGG AGGAGTGCAA GGCGCTGCTG GACGGGCTCA ACAAGACGAC TGCGTGCTAC 
CACCACCTGG TGCTGACCGT CGGTGGCTCG GCGGACTCGC AGAACCTGCG GCAGGAGCTG 
CAAAAGACGC GCCAGAAGGC GCAGGAGCTG GCGGTGTCCA CCTGCGCCCG GCTGACTGCT 
GTGCTGCGCG ACCGGGGCCT GGCCGCCGAC GAGCGCGCCG AGTTCGAGCG GCTCTGGGTG 
GCCTTCTCGG GCTGCCTGGA CCTGCTGGAA GCGGACATGC GACGCGCGCT GGAGCTGGGC 
GCCGCGTTCC CGCTGCACGC GCCGCGGCGG CCGCTGGTGC GCACAGGTGT GGCTGGCGCC 
TCCTCCGGCG TGGCGGCGCG CGCGCTGAGC ACCCGCAGCC TGCGGCTCGA GGCGGAGGGC 
GACTTCGACG TCGCGGACCT GCGGGAGCTG GAGCGCGAGG TCCTTCAGGT GGGCGAGATG 
ATCGACAACA TGGAGATGAA GGTCAACGTG CCCCGCTGGA CCGTGCAAGC CCGGCAGGCG 
GCGGGCGCCG AGCTCCTGTC CACGGTCAGC GCCGGCCCCT CCTCGGTCGT GTCCTTGCAG 
GAGCGCGGGG GGGGTTGCGA CCCCAGGAAG GCCCTGGCCG CCATCCTTTT CGGCGCCGTG 
CTGCTGGCGG CTGTGGCCCT AGCCGTGTGC GTGGCGAAGC TGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
The American journal of psychiatry170(2)207-17(2013 Feb)
,,

Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).
Ophthalmology117(1)120-127.e1(2010 Jan)
Michaelides M,Li Z,Rana NA,Richardson EC,Hykin PG,Moore AT,Holder GE,Webster AR

Integrative predictive model of coronary artery calcification in atherosclerosis.
Circulation120(24)2448-54(2009 Dec)
McGeachie M,Ramoni RL,Mychaleckyj JC,Furie KL,Dreyfuss JM,Liu Y,Herrington D,Guo X,Lima JA,Post W,Rotter JI,Rich S,Sale M,Ramoni MF

The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels.
Journal of vision8(1)10.1-10(2008 Jan)
Stockman A,Smithson HE,Webster AR,Holder GE,Rana NA,Ripamonti C,Sharpe LT

Bradyopsia in an Asian man.
Archives of ophthalmology (Chicago, Ill. : 1960)125(8)1138-40(2007 Aug)
Cheng JY,Luu CD,Yong VH,Mathur R,Aung T,Vithana EN

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RGS9BP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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