C2CD4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C2CD4B
Entrez Gene ID	388125
Full Name	C2 calcium dependent domain containing 4B
Synonyms	FAM148B,NLF2
General protein information	Preferred Names C2 calcium dependent domain containing 4B Names C2 calcium-dependent domain-containing protein 4B family with sequence similarity 148, member B nuclear localized factor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.2
Disorder MIM:	610344

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007595.2	NP_001007596.2	C2 calcium-dependent domain-containing protein 4B
XM_017022170.1	XP_016877659.1	C2 calcium-dependent domain-containing protein 4B isoform X1
NM_001007595.3	NP_001007596.2	C2 calcium-dependent domain-containing protein 4B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100688626	XP_005638753.1
Homo sapiens (human)	C2CD4B	NP_001007596.2
Rattus norvegicus (Norway rat)	C2cd4b	XP_576426.2
Bos taurus (cattle)	LOC529849	NP_001039772.1
Bos taurus (cattle)	C2CD4A	XP_005211804.1
	C2CD4B	XP_001101238.1
Pan troglodytes (chimpanzee)	C2CD4B	XP_001173432.1
Mus musculus (house mouse)	C2cd4b	NP_001074783.1

Gene Ontology
Bibliography

Related articles in PubMed

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the ?-cell are associated with glucose intolerance in humans and mice.
Mehta ZB, Fine N, Pullen TJ, Cane MC, Hu M, Chabosseau P, Meur G, Velayos-Baeza A, Monaco AP, Marselli L, Marchetti P, Rutter GA
American journal of physiology. Endocrinology and metabolism311(2)E488-507(2016 Aug)

Genome-wide association study identifies three novel loci for type 2 diabetes.
Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, Iwata M, Tsunoda T, Morizono T, Shojima N, So WY, Leung TF, Kwan P, Zhang R, Wang J, Yu W, Maegawa H, Hirose H, , Kaku K, Ito C, Watada H, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Jia W, Chan JC, Teo YY, Shyong TE, Kamatani N, Kubo M, Maeda S, Kadowaki T
Human molecular genetics23(1)239-46(2014 Jan)

NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment.
Turkyilmaz E, Guner H, Erdem M, Erdem A, Biri AA, Konac E, Alp E, Onen HI, Menevse S
Gene508(1)140-3(2012 Oct)

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJ, Luan J, Makrilakis K, Manning AK, Mart?nez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stanc?kov? A, Stirrups K, Swift AJ, Syv?nen AC, Tuomi T, van 't Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B, , , , , , Ongen H, M?larstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-R?os M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Watkins H, Froguel P, Johnson P, Deloukas P, Collins FS, Laakso M, Dermitzakis ET, Boehnke M, McCarthy MI, Wareham NJ, Groop L, Pattou F, Gloyn AL, Dedoussis GV, Lyssenko V, Meigs JB, Barroso I, Watanabe RM, Ingelsson E, Langenberg C, Hamsten A, Florez JC
Diabetes60(10)2624-34(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved.
Title: Changes in the expression of the type 2 diabetes-associated gene VPS13C in the ?-cell are associated with glucose intolerance in humans and mice.

Loss of NLF2 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment.
Title: NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.

Single nucleotide polymorphism in C2CD4B is associated with type 2 diabetes.
Title: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

Observational study of gene-disease association. (HuGE Navigator)
Title: Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.

The following C2CD4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C2CD4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09999	NM_001007595.3 Latest version!	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu09999	XM_017022170.1 Latest version!	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu09999	NM_001007595.2	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C2CD4B ( NM_001007595.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007596.2 Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.

Price & Availability↑

CloneID	OHu09999
Clone ID Related Accession (Same CDS sequence)	NM_001007595.2 , XM_017022170.1 , NM_001007595.3
Accession Version	NM_001007595.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	C2 calcium-dependent domain-containing protein 4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA584890.1, BM127548.1, BM023530.1, AW292865.1, BM974537.1 and BX109954.1. On Sep 15, 2007 this sequence version replaced NM_001007595.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279831.11469.1, BM023388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007596.2
CDS	130..1224
Translation	MRLLEKLCSSAAGSSAPKPAFAKVLTPNRIPEFCIPPRLPAPCTLESPIRAAAVPRRCAAESDLWPRAADEDAGRTDWDPRSQAALSLPHLPRVRTTYGFCALLESPHTRRKESLLLGGPPAPRPRAHSCGGGGGPDAPLGTLCGPRGPGPATPAAPGGPRLPQDALAAGPRRCRLLRVPDGLLSRALRAGRSRRLARVRSVSSGNEDEERRAGSESPARAPSSSPLSSRAPLPERLEAKGTVALGRAGDALRLAAEYCPGTRRLRLRLLRAESLFGGAPGPRAVRCRLSLVLRPPGTARWQCSAVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRDRGRLLGQGELSLGALLLL

Target ORF information:

RefSeq Version	NM_001007595.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007595.2

ORF Insert Sequence:

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C2CD4B ( NM_001007595.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007596.2 Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.

Price & Availability↑

CloneID	OHu09999
Clone ID Related Accession (Same CDS sequence)	NM_001007595.2 , XM_017022170.1 , NM_001007595.3
Accession Version	NM_001007595.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	C2 calcium-dependent domain-containing protein 4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC126323.6, DA584890.1, BM127548.1, BM023530.1, AW292865.1, BM974537.1 and BX109954.1. On Nov 22, 2018 this sequence version replaced NM_001007595.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279831.11469.1, BM023388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380392.4/ ENSP00000369755.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007596.2
CDS	132..1226
Translation	MRLLEKLCSSAAGSSAPKPAFAKVLTPNRIPEFCIPPRLPAPCTLESPIRAAAVPRRCAAESDLWPRAADEDAGRTDWDPRSQAALSLPHLPRVRTTYGFCALLESPHTRRKESLLLGGPPAPRPRAHSCGGGGGPDAPLGTLCGPRGPGPATPAAPGGPRLPQDALAAGPRRCRLLRVPDGLLSRALRAGRSRRLARVRSVSSGNEDEERRAGSESPARAPSSSPLSSRAPLPERLEAKGTVALGRAGDALRLAAEYCPGTRRLRLRLLRAESLFGGAPGPRAVRCRLSLVLRPPGTARWQCSAVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRDRGRLLGQGELSLGALLLL

Target ORF information:

RefSeq Version	NM_001007595.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007595.3

ORF Insert Sequence:

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C2CD4B ( XM_017022170.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877659.1 Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09999
Clone ID Related Accession (Same CDS sequence)	NM_001007595.2 , XM_017022170.1 , NM_001007595.3
Accession Version	XM_017022170.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C2 calcium-dependent domain-containing protein 4B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877659.1
CDS	471..1565
Translation	MRLLEKLCSSAAGSSAPKPAFAKVLTPNRIPEFCIPPRLPAPCTLESPIRAAAVPRRCAAESDLWPRAADEDAGRTDWDPRSQAALSLPHLPRVRTTYGFCALLESPHTRRKESLLLGGPPAPRPRAHSCGGGGGPDAPLGTLCGPRGPGPATPAAPGGPRLPQDALAAGPRRCRLLRVPDGLLSRALRAGRSRRLARVRSVSSGNEDEERRAGSESPARAPSSSPLSSRAPLPERLEAKGTVALGRAGDALRLAAEYCPGTRRLRLRLLRAESLFGGAPGPRAVRCRLSLVLRPPGTARWQCSAVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRDRGRLLGQGELSLGALLLL

Target ORF information:

RefSeq Version	XM_017022170.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C2 calcium dependent domain containing 4B (C2CD4B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022170.1

ORF Insert Sequence:

ATGCGGCTCC TCGAGAAACT CTGTTCCTCG GCCGCAGGCA GCTCCGCGCC GAAGCCCGCC 
TTCGCCAAAG TGCTCACGCC GAATCGCATC CCCGAATTCT GCATCCCGCC GCGGCTGCCG 
GCCCCTTGCA CGCTCGAGTC TCCAATCCGG GCCGCCGCCG TGCCCCGGCG CTGCGCCGCT 
GAAAGCGACC TGTGGCCCCG CGCGGCAGAC GAGGACGCCG GCCGCACGGA CTGGGACCCG 
CGCTCGCAGG CAGCGCTGTC ACTGCCGCAC CTGCCCCGTG TGCGCACCAC CTACGGCTTC 
TGCGCGCTGC TCGAGAGCCC GCACACGCGC CGCAAGGAGT CGCTCCTGCT CGGGGGCCCG 
CCCGCGCCCC GGCCCCGGGC CCACAGCTGC GGCGGCGGCG GAGGCCCGGA CGCCCCCCTG 
GGGACCCTGT GCGGCCCGCG AGGTCCGGGC CCGGCCACCC CCGCGGCCCC CGGCGGTCCC 
CGCCTGCCCC AGGACGCGCT CGCTGCGGGG CCCCGCCGCT GCCGCCTCCT GCGCGTCCCC 
GACGGGCTGC TGAGTCGCGC GCTGCGGGCT GGAAGGAGTC GCCGCCTGGC CCGCGTCCGC 
TCCGTCTCCA GCGGGAACGA GGACGAGGAG CGCCGCGCGG GATCCGAGTC CCCGGCCCGG 
GCCCCCTCCT CGAGCCCGCT GTCATCCAGG GCCCCGCTTC CTGAGCGCCT GGAGGCCAAG 
GGCACCGTGG CTCTGGGCCG CGCCGGCGAC GCCCTGCGCC TGGCTGCTGA GTACTGTCCG 
GGAACCCGGC GTCTCCGCCT CCGGCTGCTC CGCGCGGAGA GCCTGTTCGG AGGCGCCCCC 
GGGCCCCGCG CCGTCCGCTG CCGCCTCAGC CTCGTCCTGC GGCCGCCGGG CACTGCGCGT 
TGGCAATGCA GCGCTGTGGT GGGGCGCAGC CGCAAGGCCT CCTTTGACCA GGACTTTTGC 
TTCGACGGCC TCTCGGAAGA CGAGGTGCGC CGCCTGGCCG TTCGCGTCAA GGCCCGGGAT 
GAGGGTCGCG GCCGGGATCG GGGCCGCCTG CTGGGCCAGG GTGAGCTGTC CCTGGGCGCC 
CTCCTGCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the ?-cell are associated with glucose intolerance in humans and mice.
American journal of physiology. Endocrinology and metabolism311(2)E488-507(2016 Aug)
Mehta ZB,Fine N,Pullen TJ,Cane MC,Hu M,Chabosseau P,Meur G,Velayos-Baeza A,Monaco AP,Marselli L,Marchetti P,Rutter GA

Genome-wide association study identifies three novel loci for type 2 diabetes.
Human molecular genetics23(1)239-46(2014 Jan)
Hara K,Fujita H,Johnson TA,Yamauchi T,Yasuda K,Horikoshi M,Peng C,Hu C,Ma RC,Imamura M,Iwata M,Tsunoda T,Morizono T,Shojima N,So WY,Leung TF,Kwan P,Zhang R,Wang J,Yu W,Maegawa H,Hirose H,,Kaku K,Ito C,Watada H,Tanaka Y,Tobe K,Kashiwagi A,Kawamori R,Jia W,Chan JC,Teo YY,Shyong TE,Kamatani N,Kubo M,Maeda S,Kadowaki T

NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment.
Gene508(1)140-3(2012 Oct)
Turkyilmaz E,Guner H,Erdem M,Erdem A,Biri AA,Konac E,Alp E,Onen HI,Menevse S

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Diabetes60(10)2624-34(2011 Oct)
Strawbridge RJ,Dupuis J,Prokopenko I,Barker A,Ahlqvist E,Rybin D,Petrie JR,Travers ME,Bouatia-Naji N,Dimas AS,Nica A,Wheeler E,Chen H,Voight BF,Taneera J,Kanoni S,Peden JF,Turrini F,Gustafsson S,Zabena C,Almgren P,Barker DJ,Barnes D,Dennison EM,Eriksson JG,Eriksson P,Eury E,Folkersen L,Fox CS,Frayling TM,Goel A,Gu HF,Horikoshi M,Isomaa B,Jackson AU,Jameson KA,Kajantie E,Kerr-Conte J,Kuulasmaa T,Kuusisto J,Loos RJ,Luan J,Makrilakis K,Manning AK,Mart?nez-Larrad MT,Narisu N,Nastase Mannila M,Ohrvik J,Osmond C,Pascoe L,Payne F,Sayer AA,Sennblad B,Silveira A,Stanc?kov? A,Stirrups K,Swift AJ,Syv?nen AC,Tuomi T,van 't Hooft FM,Walker M,Weedon MN,Xie W,Zethelius B,,,,,,Ongen H,M?larstig A,Hopewell JC,Saleheen D,Chambers J,Parish S,Danesh J,Kooner J,Ostenson CG,Lind L,Cooper CC,Serrano-R?os M,Ferrannini E,Forsen TJ,Clarke R,Franzosi MG,Seedorf U,Watkins H,Froguel P,Johnson P,Deloukas P,Collins FS,Laakso M,Dermitzakis ET,Boehnke M,McCarthy MI,Wareham NJ,Groop L,Pattou F,Gloyn AL,Dedoussis GV,Lyssenko V,Meigs JB,Barroso I,Watanabe RM,Ingelsson E,Langenberg C,Hamsten A,Florez JC

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C2CD4B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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