NANOGP8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NANOGP8
Entrez Gene ID	388112
Full Name	Nanog homeobox retrogene P8
Synonyms	NANOGP1,PN8
General protein information	Preferred Names Nanog homeobox retrogene P8 Names putative homeobox protein NANOGP8 Nanog homeobox pseudogene 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q14
Summary	This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001355281.1	NP_001342210.1	homeobox protein NANOGP8
NM_001355281.2	NP_001342210.1	homeobox protein NANOGP8

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion.
Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Xia L, Ellis LM
Molecular oncology11(8)1023-1034(2017 Aug)

LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.
Wang B, Chen Q, Cao Y, Ma X, Yin C, Jia Y, Zang A, Fan W
PloS one11(12)e0168904(2016)

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells.
Kawamura N, Nimura K, Nagano H, Yamaguchi S, Nonomura N, Kaneda Y
Oncotarget6(26)22361-74(2015 Sep)

[The expression of retrogene Nanogp8 is related to the biological characteristics of human SGC-7901 gastric cancer cells].
Liu Y, Wang C, Jiang Z
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(6)763-8(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes
Title: LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.

Results indicate that NANOG and NANOGP8 proteins are expressed in prostate cancer cell lines, and NANOG and NANOGP8 equally contribute to the high malignant potential of prostate cancer.
Title: CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells.

NANOGP8 has a close relationship with the proliferation, cycle, apoptosis, migration and invasion of SGC-7901 gastric cancer cells
Title: [The expression of retrogene Nanogp8 is related to the biological characteristics of human SGC-7901 gastric cancer cells].

Unique biochemical properties of Nanog1 in embryonal carcinoma cells and NanogP8 in somatic cancer cells.
Title: Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

High levels of NanogP8 may disrupt normal developmental programs and inhibit tumor development by depleting stem cells.
Title: In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.

The following NANOGP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NANOGP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu103194	NM_001355281.2 Latest version!	Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu103194	NM_001355281.1	Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NANOGP8 ( NM_001355281.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001342210.1 Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.

Price & Availability↑

CloneID	OHu103194
Clone ID Related Accession (Same CDS sequence)	NM_001355281.1 , NM_001355281.2
Accession Version	NM_001355281.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	homeobox protein NANOGP8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC021231.8. On Dec 2, 2019 this sequence version replaced NM_001355281.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069807.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTGTGG ATCCAGCTTG TCCCCAAAGC TTGCCTTGCT TTGAAGAATC CGACTGTAAA 
GAATCTTCAC CTATGCCTGT GATTTGTGGG CCTGAAGAAA ACTATCCATC CTTGCAAATG 
TCTTCTGCTG AGATGCCTCA CACAGAGACT GTCTCTCCTC TTCCTTCCTC CATGGATCTG 
CTTATTCAGG ACAGCCCTGA TTCTTCCACC AGTCCCAAAG GCAAACAACC CACTTCTGCA 
GAGAATAGTG TCGCAAAAAA GGAAGACAAG GTCCCGGTCA AGAAACAGAA GACCAGAACT 
GTGTTCTCTT CCACCCAGCT GTGTGTACTC AATGATAGAT TTCAGAGACA GAAATACCTC 
AGCCTCCAGC AGATGCAAGA ACTCTCCAAC ATCCTGAACC TCAGCTACAA ACAGGTGAAG 
ACCTGGTTCC AGAACCAGAG AATGAAATCT AAGAGGTGGC AGAAAAACAA CTGGCCGAAG 
AATAGCAATG GTGTGACGCA GAAGGCCTCA GCACCTACCT ACCCCAGCCT CTACTCTTCC 
TACCACCAGG GATGCCTGGT GAACCCGACT GGGAACCTTC CAATGTGGAG CAACCAGACC 
TGGAACAATT CAACCTGGAG CAACCAGACC CAGAACATCC AGTCCTGGAG CAACCACTCC 
TGGAACACTC AGACCTGGTG CACCCAATCC TGGAACAATC AGGCCTGGAA CAGTCCCTTC 
TATAACTGTG GAGAGGAATC TCTGCAGTCC TGCATGCACT TCCAGCCAAA TTCTCCTGCC 
AGTGACTTGG AGGCTGCCTT GGAAGCTGCT GGGGAAGGCC TTAATGTAAT ACAGCAGACC 
ACTAGGTATT TTAGTACTCC ACAAACCATG GATTTATTCC TAAACTACTC CATGAACATG 
CAACCTGAAG ACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342210.1
CDS	186..1103
Translation	MSVDPACPQSLPCFEESDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAENSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMHFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV

Target ORF information:

RefSeq Version	NM_001355281.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355281.2

ORF Insert Sequence:

ATGAGTGTGG ATCCAGCTTG TCCCCAAAGC TTGCCTTGCT TTGAAGAATC CGACTGTAAA 
GAATCTTCAC CTATGCCTGT GATTTGTGGG CCTGAAGAAA ACTATCCATC CTTGCAAATG 
TCTTCTGCTG AGATGCCTCA CACAGAGACT GTCTCTCCTC TTCCTTCCTC CATGGATCTG 
CTTATTCAGG ACAGCCCTGA TTCTTCCACC AGTCCCAAAG GCAAACAACC CACTTCTGCA 
GAGAATAGTG TCGCAAAAAA GGAAGACAAG GTCCCGGTCA AGAAACAGAA GACCAGAACT 
GTGTTCTCTT CCACCCAGCT GTGTGTACTC AATGATAGAT TTCAGAGACA GAAATACCTC 
AGCCTCCAGC AGATGCAAGA ACTCTCCAAC ATCCTGAACC TCAGCTACAA ACAGGTGAAG 
ACCTGGTTCC AGAACCAGAG AATGAAATCT AAGAGGTGGC AGAAAAACAA CTGGCCGAAG 
AATAGCAATG GTGTGACGCA GAAGGCCTCA GCACCTACCT ACCCCAGCCT CTACTCTTCC 
TACCACCAGG GATGCCTGGT GAACCCGACT GGGAACCTTC CAATGTGGAG CAACCAGACC 
TGGAACAATT CAACCTGGAG CAACCAGACC CAGAACATCC AGTCCTGGAG CAACCACTCC 
TGGAACACTC AGACCTGGTG CACCCAATCC TGGAACAATC AGGCCTGGAA CAGTCCCTTC 
TATAACTGTG GAGAGGAATC TCTGCAGTCC TGCATGCACT TCCAGCCAAA TTCTCCTGCC 
AGTGACTTGG AGGCTGCCTT GGAAGCTGCT GGGGAAGGCC TTAATGTAAT ACAGCAGACC 
ACTAGGTATT TTAGTACTCC ACAAACCATG GATTTATTCC TAAACTACTC CATGAACATG 
CAACCTGAAG ACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NANOGP8 ( NM_001355281.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001342210.1 Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.

Price & Availability↑

CloneID	OHu103194
Clone ID Related Accession (Same CDS sequence)	NM_001355281.1 , NM_001355281.2
Accession Version	NM_001355281.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	homeobox protein NANOGP8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC021231.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTGTGG ATCCAGCTTG TCCCCAAAGC TTGCCTTGCT TTGAAGAATC CGACTGTAAA 
GAATCTTCAC CTATGCCTGT GATTTGTGGG CCTGAAGAAA ACTATCCATC CTTGCAAATG 
TCTTCTGCTG AGATGCCTCA CACAGAGACT GTCTCTCCTC TTCCTTCCTC CATGGATCTG 
CTTATTCAGG ACAGCCCTGA TTCTTCCACC AGTCCCAAAG GCAAACAACC CACTTCTGCA 
GAGAATAGTG TCGCAAAAAA GGAAGACAAG GTCCCGGTCA AGAAACAGAA GACCAGAACT 
GTGTTCTCTT CCACCCAGCT GTGTGTACTC AATGATAGAT TTCAGAGACA GAAATACCTC 
AGCCTCCAGC AGATGCAAGA ACTCTCCAAC ATCCTGAACC TCAGCTACAA ACAGGTGAAG 
ACCTGGTTCC AGAACCAGAG AATGAAATCT AAGAGGTGGC AGAAAAACAA CTGGCCGAAG 
AATAGCAATG GTGTGACGCA GAAGGCCTCA GCACCTACCT ACCCCAGCCT CTACTCTTCC 
TACCACCAGG GATGCCTGGT GAACCCGACT GGGAACCTTC CAATGTGGAG CAACCAGACC 
TGGAACAATT CAACCTGGAG CAACCAGACC CAGAACATCC AGTCCTGGAG CAACCACTCC 
TGGAACACTC AGACCTGGTG CACCCAATCC TGGAACAATC AGGCCTGGAA CAGTCCCTTC 
TATAACTGTG GAGAGGAATC TCTGCAGTCC TGCATGCACT TCCAGCCAAA TTCTCCTGCC 
AGTGACTTGG AGGCTGCCTT GGAAGCTGCT GGGGAAGGCC TTAATGTAAT ACAGCAGACC 
ACTAGGTATT TTAGTACTCC ACAAACCATG GATTTATTCC TAAACTACTC CATGAACATG 
CAACCTGAAG ACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342210.1
CDS	299..1216
Translation	MSVDPACPQSLPCFEESDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAENSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMHFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV

Target ORF information:

RefSeq Version	NM_001355281.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Nanog homeobox retrogene P8 (NANOGP8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355281.1

ORF Insert Sequence:

ATGAGTGTGG ATCCAGCTTG TCCCCAAAGC TTGCCTTGCT TTGAAGAATC CGACTGTAAA 
GAATCTTCAC CTATGCCTGT GATTTGTGGG CCTGAAGAAA ACTATCCATC CTTGCAAATG 
TCTTCTGCTG AGATGCCTCA CACAGAGACT GTCTCTCCTC TTCCTTCCTC CATGGATCTG 
CTTATTCAGG ACAGCCCTGA TTCTTCCACC AGTCCCAAAG GCAAACAACC CACTTCTGCA 
GAGAATAGTG TCGCAAAAAA GGAAGACAAG GTCCCGGTCA AGAAACAGAA GACCAGAACT 
GTGTTCTCTT CCACCCAGCT GTGTGTACTC AATGATAGAT TTCAGAGACA GAAATACCTC 
AGCCTCCAGC AGATGCAAGA ACTCTCCAAC ATCCTGAACC TCAGCTACAA ACAGGTGAAG 
ACCTGGTTCC AGAACCAGAG AATGAAATCT AAGAGGTGGC AGAAAAACAA CTGGCCGAAG 
AATAGCAATG GTGTGACGCA GAAGGCCTCA GCACCTACCT ACCCCAGCCT CTACTCTTCC 
TACCACCAGG GATGCCTGGT GAACCCGACT GGGAACCTTC CAATGTGGAG CAACCAGACC 
TGGAACAATT CAACCTGGAG CAACCAGACC CAGAACATCC AGTCCTGGAG CAACCACTCC 
TGGAACACTC AGACCTGGTG CACCCAATCC TGGAACAATC AGGCCTGGAA CAGTCCCTTC 
TATAACTGTG GAGAGGAATC TCTGCAGTCC TGCATGCACT TCCAGCCAAA TTCTCCTGCC 
AGTGACTTGG AGGCTGCCTT GGAAGCTGCT GGGGAAGGCC TTAATGTAAT ACAGCAGACC 
ACTAGGTATT TTAGTACTCC ACAAACCATG GATTTATTCC TAAACTACTC CATGAACATG 
CAACCTGAAG ACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion.
Molecular oncology11(8)1023-1034(2017 Aug)
Wang R,Bhattacharya R,Ye X,Fan F,Boulbes DR,Xia L,Ellis LM

LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.
PloS one11(12)e0168904(2016)
Wang B,Chen Q,Cao Y,Ma X,Yin C,Jia Y,Zang A,Fan W

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells.
Oncotarget6(26)22361-74(2015 Sep)
Kawamura N,Nimura K,Nagano H,Yamaguchi S,Nonomura N,Kaneda Y

[The expression of retrogene Nanogp8 is related to the biological characteristics of human SGC-7901 gastric cancer cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(6)763-8(2015 Jun)
Liu Y,Wang C,Jiang Z

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NANOGP8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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