CLEC2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLEC2A
Entrez Gene ID	387836
Full Name	C-type lectin domain family 2 member A
Synonyms	INPE5792,KACL,PILAR,UNQ5792
General protein information	Preferred Names C-type lectin domain family 2 member A Names C-type lectin domain family 2 member A keratinocyte-associated C-type lectin proliferation-induced lymphocyte-associated receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008].
Disorder MIM:	612087

mRNA and Protein(s)

mRNA	Protein	Name
XM_011520656.2	XP_011518958.1	C-type lectin domain family 2 member A isoform X2
NM_207375.2	NP_997258.1	C-type lectin domain family 2 member A isoform 2
XM_011520656.3	XP_011518958.1	C-type lectin domain family 2 member A isoform X2
NM_001130711.2	NP_001124183.1	C-type lectin domain family 2 member A isoform 1
XM_011520657.2	XP_011518959.1	C-type lectin domain family 2 member A isoform X3
NM_001130711.1	NP_001124183.1	C-type lectin domain family 2 member A isoform 1
NM_207375.3	NP_997258.1	C-type lectin domain family 2 member A isoform 2
XM_011520654.2	XP_011518956.1	C-type lectin domain family 2 member A isoform X1

Pathways from BioSystems

Homologies

	LOC722314	XP_001118475.1
Mus musculus (house mouse)	Clec2f	NP_001264131.1
Homo sapiens (human)	CLEC2A	NP_001124183.1
Pan troglodytes (chimpanzee)	CLEC2A	XP_001143480.2
Bos taurus (cattle)	CLEC2A	XP_003586183.2

Gene Ontology
Bibliography

Related articles in PubMed

Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.
Suzuki-Inoue K, Osada M, Ozaki Y
Journal of thrombosis and haemostasis : JTH15(2)219-229(2017 Feb)

PDGF upregulates CLEC-2 to induce T regulatory cells.
Agrawal S, Ganguly S, Hajian P, Cao JN, Agrawal A
Oncotarget6(30)28621-32(2015 Oct)

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.
Bauer B, Spreu J, Rohe C, Vogler I, Steinle A
Immunology145(1)114-23(2015 May)

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.
Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP
Blood124(14)2262-70(2014 Oct)

Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.
Spreu J, Kuttruff S, Stejfova V, Dennehy KM, Schittek B, Steinle A
Proceedings of the National Academy of Sciences of the United States of America107(11)5100-5(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PDGF upregulates the expression of CLEC-2 on dendritic cells to induce T regulatory cells.
Title: PDGF upregulates CLEC-2 to induce T regulatory cells.

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65
Title: Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.

CLEC-2, unlike platelet ITAM receptors, is not regulated by proteolysis and can be used to monitor platelet-derived microparticles
Title: CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

Keratinocytes express KACL and are capable of stimulating NKp65-expressing cells in a KACL-dependent manner.
Title: Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.

CLEC-2 is the receptor for podoplanin, a sialoglycoprotein implicated in tumor-induced platelet aggregation and tumor metastasis[review]
Title: Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI.

The following CLEC2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28649	NM_001130711.2 Latest version!	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28495	NM_207375.3 Latest version!	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu79872	XM_011520654.2 Latest version!	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu79874	XM_011520656.3 Latest version!	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu79875	XM_011520657.2 Latest version!	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu79874	XM_011520656.2	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu28649	NM_001130711.1	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28495	NM_207375.2	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLEC2A ( NM_001130711.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124183.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28649
Clone ID Related Accession (Same CDS sequence)	NM_001130711.2 , NM_001130711.1
Accession Version	NM_001130711.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EF127467.1. On May 17, 2019 this sequence version replaced NM_001130711.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: EF127467.1, EU095394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000455827.2/ ENSP00000396163.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GTTTGAAATT 
ATAGGGAACG GATCCTTTGC TTTCTTGAGT GCTGATGGAG TCCATAGTTC CAGAGGATTT 
ATTGATATCA AGTGGATTTG CAGCAAACCT AAATATTTTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124183.1
CDS	42..566
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL

Target ORF information:

RefSeq Version	NM_001130711.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130711.2

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GTTTGAAATT 
ATAGGGAACG GATCCTTTGC TTTCTTGAGT GCTGATGGAG TCCATAGTTC CAGAGGATTT 
ATTGATATCA AGTGGATTTG CAGCAAACCT AAATATTTTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( NM_001130711.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124183.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28649
Clone ID Related Accession (Same CDS sequence)	NM_001130711.2 , NM_001130711.1
Accession Version	NM_001130711.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EF127467.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: EF127467.1, EU095394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GTTTGAAATT 
ATAGGGAACG GATCCTTTGC TTTCTTGAGT GCTGATGGAG TCCATAGTTC CAGAGGATTT 
ATTGATATCA AGTGGATTTG CAGCAAACCT AAATATTTTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124183.1
CDS	53..577
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL

Target ORF information:

RefSeq Version	NM_001130711.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130711.1

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GTTTGAAATT 
ATAGGGAACG GATCCTTTGC TTTCTTGAGT GCTGATGGAG TCCATAGTTC CAGAGGATTT 
ATTGATATCA AGTGGATTTG CAGCAAACCT AAATATTTTT TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( NM_207375.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997258.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28495
Clone ID Related Accession (Same CDS sequence)	NM_207375.2 , NM_207375.3
Accession Version	NM_207375.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EF127467.1, AY359126.1 and AC091814.10. On or before Jun 25, 2014 this sequence version replaced XM_005253366.1, NM_207375.1. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AY359126.1, EU095393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GCCATCAAAC 
TCCAAATGGT CTTGCAACTG GAGCCTCCGA CAATGGCTTC TTCTGCTGGG ACCCCTTAGA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997258.1
CDS	53..535
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWPSNSKWSCNWSLRQWLLLLGPLR

Target ORF information:

RefSeq Version	NM_207375.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207375.2

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GCCATCAAAC 
TCCAAATGGT CTTGCAACTG GAGCCTCCGA CAATGGCTTC TTCTGCTGGG ACCCCTTAGA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( NM_207375.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997258.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28495
Clone ID Related Accession (Same CDS sequence)	NM_207375.2 , NM_207375.3
Accession Version	NM_207375.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EF127467.1, AY359126.1 and AC091814.10. On May 31, 2019 this sequence version replaced NM_207375.2. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AY359126.1, EU095393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GCCATCAAAC 
TCCAAATGGT CTTGCAACTG GAGCCTCCGA CAATGGCTTC TTCTGCTGGG ACCCCTTAGA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997258.1
CDS	42..524
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWPSNSKWSCNWSLRQWLLLLGPLR

Target ORF information:

RefSeq Version	NM_207375.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207375.3

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG GCCATCAAAC 
TCCAAATGGT CTTGCAACTG GAGCCTCCGA CAATGGCTTC TTCTGCTGGG ACCCCTTAGA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( XM_011520654.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518956.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu79872
Clone ID Related Accession (Same CDS sequence)	XM_011520654.2
Accession Version	XM_011520654.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520654.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGCCA TCAAACTCCA 
AATGGTCTTG CAACTGGAGC CTCCGACAAT GGCTTCTTCT GCTGGGACCC CTTAGATAGG 
CCTCTGAGGG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518956.1
CDS	102..599
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGHQTPNGLATGASDNGFFCWDPLDRPLREL

Target ORF information:

RefSeq Version	XM_011520654.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520654.2

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGCCA TCAAACTCCA 
AATGGTCTTG CAACTGGAGC CTCCGACAAT GGCTTCTTCT GCTGGGACCC CTTAGATAGG 
CCTCTGAGGG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( XM_011520656.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518958.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu79874
Clone ID Related Accession (Same CDS sequence)	XM_011520656.2 , XM_011520656.3
Accession Version	XM_011520656.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520656.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTT GAAATTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518958.1
CDS	102..521
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGLKL

Target ORF information:

RefSeq Version	XM_011520656.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520656.2

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTT GAAATTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( XM_011520656.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518958.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu79874
Clone ID Related Accession (Same CDS sequence)	XM_011520656.2 , XM_011520656.3
Accession Version	XM_011520656.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011520656.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTT GAAATTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518958.1
CDS	102..521
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGLKL

Target ORF information:

RefSeq Version	XM_011520656.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520656.3

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTT GAAATTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC2A ( XM_011520657.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518959.1 Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu79875
Clone ID Related Accession (Same CDS sequence)	XM_011520657.2
Accession Version	XM_011520657.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member A isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520657.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518959.1
CDS	101..511
Translation	MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNG

Target ORF information:

RefSeq Version	XM_011520657.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member A (CLEC2A), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520657.2

ORF Insert Sequence:

ATGATTAATC CAGAGCTGCG GGATGGCAGA GCTGATGGCT TCATACATCG GATAGTTCCC 
AAGTTGATAC AAAACTGGAA GATTGGCCTT ATGTGCTTCC TGAGTATTAT TATTACTACA 
GTTTGCATTA TTATGATAGC CACATGGTCC AAGCATGCTA AACCTGTGGC ATGTTCAGGG 
GACTGGCTTG GAGTGAGAGA TAAGTGTTTC TATTTTTCTG ATGATACCAG AAATTGGACA 
GCCAGTAAAA TATTTTGTAG TTTGCAGAAA GCAGAACTTG CTCAGATTGA TACACAAGAA 
GACATGGAAT TTTTGAAGAG GTACGCAGGA ACTGATATGC ACTGGATTGG ACTAAGCAGG 
AAACAAGGAG ATTCTTGGAA ATGGACAAAT GGCACCACAT TCAATGGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.
Journal of thrombosis and haemostasis : JTH15(2)219-229(2017 Feb)
Suzuki-Inoue K,Osada M,Ozaki Y

PDGF upregulates CLEC-2 to induce T regulatory cells.
Oncotarget6(30)28621-32(2015 Oct)
Agrawal S,Ganguly S,Hajian P,Cao JN,Agrawal A

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.
Immunology145(1)114-23(2015 May)
Bauer B,Spreu J,Rohe C,Vogler I,Steinle A

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.
Blood124(14)2262-70(2014 Oct)
Gitz E,Pollitt AY,Gitz-Francois JJ,Alshehri O,Mori J,Montague S,Nash GB,Douglas MR,Gardiner EE,Andrews RK,Buckley CD,Harrison P,Watson SP

Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America107(11)5100-5(2010 Mar)
Spreu J,Kuttruff S,Stejfova V,Dennehy KM,Schittek B,Steinle A

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CLEC2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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