KRT6B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT6B
Entrez Gene ID	3854
Full Name	keratin 6B
Synonyms	CK-6B,CK6B,K6B,KRTL1,PC2,PC4
General protein information	Preferred Names keratin 6B Names keratin, type II cytoskeletal 6B cytokeratin 6B keratin 6B, type II keratin, epidermal, type II, K6B keratin-like 1 (a type II keratin sequence) type-II keratin Kb10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
Disorder MIM:	148042
Disorder Html:	Pachyonychia congenita 4, 615728 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005555.4	NP_005546.2	keratin, type II cytoskeletal 6B
NM_005555.3	NP_005546.2	keratin, type II cytoskeletal 6B

Pathways from BioSystems

Homologies

Homo sapiens (human)	KRT6B	NP_005546.2
Mus musculus (house mouse)	Krt6a	NP_032502.3
Mus musculus (house mouse)	Krt6b	NP_034799.2
Pan troglodytes (chimpanzee)	KRT6C	XP_001143340.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.
Duverger O, Carlson JC, Karacz CM, Schwartz ME, Cross MA, Marazita ML, Shaffer JR, Morasso MI
PLoS genetics14(1)e1007168(2018 Jan)

KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro.
Hu J, Zhang LC, Song X, Lu JR, Jin Z
International journal of clinical and experimental pathology8(8)9182-8(2015)

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.
Eliason MJ, Leachman SA, Feng BJ, Schwartz ME, Hansen CD
Journal of the American Academy of Dermatology67(4)680-6(2012 Oct)

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.
Hyun TS, Barnes M, Tabatabai ZL
Acta cytologica56(5)527-32(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggested that the upregulation of notch1 and KRT6B might be involved in the development, progression and prognosis of human renal cell carcinoma
Title: KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro.

We found that the KRT16 mutation carriers developed plantar keratoderma at a similar age to KRT6a carriers wheras KRT6B and KRT17 carriers were significantly more likely to report later onset.
Title: A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.

Data show that calretinin and CK5/6 were positive in 100 and 64% of mesotheliomas, and 92 and 31% of reactive effusions, respectively, and desmin was negative in all malignant cases and positive in 85% of reactive effusions.
Title: The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

Studies show that the intrinsic molecular signature of five markers, ER, PR, HER-2, CK 5/6, and EGFR, demonstrated specificity of 100% and sensitivity of 75%, compared with classification by gene expression profiling.
Title: Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.

The following KRT6B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT6B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17785	NM_005555.4 Latest version!	Homo sapiens keratin 6B (KRT6B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu17785	NM_005555.3	Homo sapiens keratin 6B (KRT6B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT6B ( NM_005555.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005546.2 Homo sapiens keratin 6B (KRT6B), mRNA.

Price & Availability↑

CloneID	OHu17785
Clone ID Related Accession (Same CDS sequence)	NM_005555.4 , NM_005555.3
Accession Version	NM_005555.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 6B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from AC055736.20, BC034535.1 and BG679927.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005555.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034535.1, ERR279831.6271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252252.4/ ENSP00000252252.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGCGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACTGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG 
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAA CATCGTGGGG GAACGGGGTC GTCTGGACTC GGAGCTGAGA 
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTTACAGATG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG GAGCAGGGCT GAGGCTGAGT CCTGGTACCA GACAAAGTAC 
GAGGAGCTGC AGATCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGTGCCA ACCTACAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTAGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGCGGCTT TAGTTCCAGC AGCGGCAGAG CCACTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTACAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005546.2
CDS	69..1763
Translation	MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRATGGGLSSVGGGSSTIKYTTTSSSSRKSYKH

Target ORF information:

RefSeq Version	NM_005555.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 6B (KRT6B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005555.4

ORF Insert Sequence:

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGCGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACTGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG 
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAA CATCGTGGGG GAACGGGGTC GTCTGGACTC GGAGCTGAGA 
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTTACAGATG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG GAGCAGGGCT GAGGCTGAGT CCTGGTACCA GACAAAGTAC 
GAGGAGCTGC AGATCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGTGCCA ACCTACAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTAGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGCGGCTT TAGTTCCAGC AGCGGCAGAG CCACTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTACAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT6B ( NM_005555.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005546.2 Homo sapiens keratin 6B (KRT6B), mRNA.

Price & Availability↑

CloneID	OHu17785
Clone ID Related Accession (Same CDS sequence)	NM_005555.4 , NM_005555.3
Accession Version	NM_005555.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 6B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from BC034535.1 and BG679927.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2006 this sequence version replaced NM_005555.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034535.1, ERR279831.6271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGCGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACTGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG 
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAA CATCGTGGGG GAACGGGGTC GTCTGGACTC GGAGCTGAGA 
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTTACAGATG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG GAGCAGGGCT GAGGCTGAGT CCTGGTACCA GACAAAGTAC 
GAGGAGCTGC AGATCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGTGCCA ACCTACAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTAGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGCGGCTT TAGTTCCAGC AGCGGCAGAG CCACTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTACAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005546.2
CDS	49..1743
Translation	MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRATGGGLSSVGGGSSTIKYTTTSSSSRKSYKH

Target ORF information:

RefSeq Version	NM_005555.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 6B (KRT6B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005555.3

ORF Insert Sequence:

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGCGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACTGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG 
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAA CATCGTGGGG GAACGGGGTC GTCTGGACTC GGAGCTGAGA 
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTTACAGATG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG GAGCAGGGCT GAGGCTGAGT CCTGGTACCA GACAAAGTAC 
GAGGAGCTGC AGATCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGTGCCA ACCTACAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTAGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGCGGCTT TAGTTCCAGC AGCGGCAGAG CCACTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTACAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.
PLoS genetics14(1)e1007168(2018 Jan)
Duverger O,Carlson JC,Karacz CM,Schwartz ME,Cross MA,Marazita ML,Shaffer JR,Morasso MI

KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro.
International journal of clinical and experimental pathology8(8)9182-8(2015)
Hu J,Zhang LC,Song X,Lu JR,Jin Z

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.
Journal of the American Academy of Dermatology67(4)680-6(2012 Oct)
Eliason MJ,Leachman SA,Feng BJ,Schwartz ME,Hansen CD

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.
Acta cytologica56(5)527-32(2012)
Hyun TS,Barnes M,Tabatabai ZL

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KRT6B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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