KRT6A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT6A
Entrez Gene ID	3853
Full Name	keratin 6A
Synonyms	CK-6C,CK-6E,CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D,PC3
General protein information	Preferred Names keratin 6A Names keratin, type II cytoskeletal 6C cytokeratin 6A cytokeratin 6C cytokeratin 6D keratin 6A, , type II keratin 6A, type II keratin, epidermal type II, K6A keratin, type II cytoskeletal 6A type-II keratin Kb6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014].
Disorder MIM:	148041
Disorder Html:	Pachyonychia congenita 3, 615726 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005554.3	NP_005545.1	keratin, type II cytoskeletal 6C
NM_005554.4	NP_005545.1	keratin, type II cytoskeletal 6A

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KRT3	XP_004949798.1
	LOC100424162	XP_002798640.1
Homo sapiens (human)	KRT6A	NP_005545.1
Pan troglodytes (chimpanzee)	KRT6A	XP_509078.2
Canis lupus familiaris (dog)	KRT6B	XP_003433560.1
Bos taurus (cattle)	KRT6A	NP_001076979.1
Bos taurus (cattle)	KRT6B	NP_001244333.1
Canis lupus familiaris (dog)	KRT6A	XP_005636851.1
Bos taurus (cattle)	KRT6C	XP_002687296.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.
Duverger O, Carlson JC, Karacz CM, Schwartz ME, Cross MA, Marazita ML, Shaffer JR, Morasso MI
PLoS genetics14(1)e1007168(2018 Jan)

Pachyonychia Congenita: A Spectrum of KRT6a Mutations in Australian Patients.
Forrest CE, Casey G, Mordaunt DA, Thompson EM, Gordon L
Pediatric dermatology33(3)337-42(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia.
Title: Pachyonychia Congenita: A Spectrum of KRT6a Mutations in Australian Patients.

we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis.
Title: Impaired wound healing and cheilitis in a Pachyonychia congenita K6a family.

CK5/6, but not c-Met expression, seems to be important in lymphatic metastasis
Title: Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.

Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens.
Title: Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

Data show that calretinin and CK5/6 were positive in 100 and 64% of mesotheliomas, and 92 and 31% of reactive effusions, respectively, and desmin was negative in all malignant cases and positive in 85% of reactive effusions.
Title: The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

The following KRT6A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT6A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19164	NM_005554.4 Latest version!	Homo sapiens keratin 6A (KRT6A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu19164	NM_005554.3	Homo sapiens keratin 6A (KRT6A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT6A ( NM_005554.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005545.1 Homo sapiens keratin 6A (KRT6A), mRNA.

Price & Availability↑

CloneID	OHu19164
Clone ID Related Accession (Same CDS sequence)	NM_005554.3 , NM_005554.4
Accession Version	NM_005554.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 6C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from DA451441.1, BC008807.2 and BG059253.1. This sequence is a reference standard in the RefSeqGene project. On or before Feb 27, 2007 this sequence version replaced NM_058242.1, NM_005554.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014152.2, BC008807.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23006328 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCGTCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATCGATC CCACCATCCA GCGGGTGCGG 
GCTGAGGAGC GTGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAGCAGCA GAACAAGGTT CTGGAAACAA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAG CATTGTCGGG GAACGGGGCC GCCTGGACTC AGAGCTCAGA 
GGCATGCAGG ACCTGGTGGA GGACTTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGACG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC TGTGGTGCTG 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG AAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC 
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGCGCCA ACCTGCAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCCA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGACGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGTGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTGGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGTGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTATAAGC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005545.1
CDS	210..1904
Translation	MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSRKSYKH

Target ORF information:

RefSeq Version	NM_005554.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 6A (KRT6A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005554.3

ORF Insert Sequence:

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCGTCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATCGATC CCACCATCCA GCGGGTGCGG 
GCTGAGGAGC GTGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAGCAGCA GAACAAGGTT CTGGAAACAA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAG CATTGTCGGG GAACGGGGCC GCCTGGACTC AGAGCTCAGA 
GGCATGCAGG ACCTGGTGGA GGACTTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGACG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC TGTGGTGCTG 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG AAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC 
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGCGCCA ACCTGCAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCCA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGACGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGTGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTGGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGTGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTATAAGC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT6A ( NM_005554.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005545.1 Homo sapiens keratin 6A (KRT6A), mRNA.

Price & Availability↑

CloneID	OHu19164
Clone ID Related Accession (Same CDS sequence)	NM_005554.3 , NM_005554.4
Accession Version	NM_005554.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1695bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 6A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from DA451441.1 and BC008807.2. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2018 this sequence version replaced NM_005554.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008807.2, ERR279848.4870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330722.7/ ENSP00000369317.3 Protein has antimicrobial activity :: PMID: 23006328 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCGTCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATCGATC CCACCATCCA GCGGGTGCGG 
GCTGAGGAGC GTGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAGCAGCA GAACAAGGTT CTGGAAACAA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAG CATTGTCGGG GAACGGGGCC GCCTGGACTC AGAGCTCAGA 
GGCATGCAGG ACCTGGTGGA GGACTTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGACG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC TGTGGTGCTG 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG AAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC 
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGCGCCA ACCTGCAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCCA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGACGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGTGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTGGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGTGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTATAAGC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005545.1
CDS	70..1764
Translation	MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSRKSYKH

Target ORF information:

RefSeq Version	NM_005554.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 6A (KRT6A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005554.4

ORF Insert Sequence:

ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCGTCTC CGTGTCCCGC 
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT 
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT 
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT 
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT 
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC 
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATCGATC CCACCATCCA GCGGGTGCGG 
GCTGAGGAGC GTGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAGCAGCA GAACAAGGTT CTGGAAACAA AGTGGACCCT GCTGCAGGAG 
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC 
CTCAGGAGGC AGCTGGACAG CATTGTCGGG GAACGGGGCC GCCTGGACTC AGAGCTCAGA 
GGCATGCAGG ACCTGGTGGA GGACTTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC 
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC 
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGACG AGATCAACTT CCTGAGAGCC 
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC TGTGGTGCTG 
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA 
TATGAGGAGA TTGCTCAGAG AAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC 
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG 
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA CGTCAAGAAG 
CAGTGCGCCA ACCTGCAGGC CGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCCCTC 
AAGGATGCCA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC 
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGACGTG 
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGTGAGGAGT GCAGGCTGAA TGGCGAAGGC 
GTTGGACAAG TCAACATCTC TGTGGTGCAG TCCACCGTCT CCAGTGGCTA TGGCGGTGCC 
AGTGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT 
CTTGGCGTTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC 
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG 
AGCTATAAGC ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.
PLoS genetics14(1)e1007168(2018 Jan)
Duverger O,Carlson JC,Karacz CM,Schwartz ME,Cross MA,Marazita ML,Shaffer JR,Morasso MI

Pachyonychia Congenita: A Spectrum of KRT6a Mutations in Australian Patients.
Pediatric dermatology33(3)337-42(2016 May)
Forrest CE,Casey G,Mordaunt DA,Thompson EM,Gordon L

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KRT6A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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