KRT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT2
Entrez Gene ID	3849
Full Name	keratin 2
Synonyms	CK-2e,K2e,KRT2A,KRT2E,KRTE
General protein information	Preferred Names keratin 2 Names keratin, type II cytoskeletal 2 epidermal cytokeratin-2e epithelial keratin-2e keratin 2, type II keratin-2 epidermis keratin-2e type-II keratin Kb2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
Disorder MIM:	600194
Disorder Html:	Ichthyosis bullosa of Siemens, 146800 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000423.2	NP_000414.2	keratin, type II cytoskeletal 2 epidermal
NM_000423.3	NP_000414.2	keratin, type II cytoskeletal 2 epidermal

Pathways from BioSystems

Homologies

Homo sapiens (human)	KRT2	NP_000414.2
Pan troglodytes (chimpanzee)	KRT2	NP_001092039.1
	KRT2	XP_001098486.1
Bos taurus (cattle)	KRT2	XP_002687293.1

Gene Ontology
Bibliography

Related articles in PubMed

Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis.
Hotz A, Oji V, Bourrat E, Jonca N, Mazereeuw-Hautier J, Betz RC, Blume-Peytavi U, Stieler K, Morice-Picard F, Sch?nbuchner I, Markus S, Schlipf N, Fischer J
Acta dermato-venereologica96(4)473-8(2016 May)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Superficial epidermolytic ichthyosis: a report of two families.
Cervantes T, Pham C, Browning JC
Pediatric dermatology30(4)469-72(2013 Jul-Aug)

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report genetic/clinical spectrum of KRT2 mutations in keratinopathic ichthyosis.
Title: Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis.

We describe two children with superficial epidermolytic ichthyosis confirmed by genetic testing, including one with a novel mutation.
Title: Superficial epidermolytic ichthyosis: a report of two families.

novel H1 domain mutation in a family with icthyosis bullosa Siemens
Title: A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens.

influence of keratinocyte activation, proliferation, and keratinization on K2e expression in samples of cutaneous and oral lesions (keratin K2e)
Title: Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.

The following KRT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19819	NM_000423.3 Latest version!	Homo sapiens keratin 2 (KRT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19819	NM_000423.2	Homo sapiens keratin 2 (KRT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT2 ( NM_000423.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000414.2 Homo sapiens keratin 2 (KRT2), mRNA.

Price & Availability↑

CloneID	OHu19819
Clone ID Related Accession (Same CDS sequence)	NM_000423.2 , NM_000423.3
Accession Version	NM_000423.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1920bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 2 epidermal
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M99061.1, BC096294.4 and AL598277.1. This sequence is a reference standard in the RefSeqGene project. On May 12, 2004 this sequence version replaced NM_000423.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M99061.1, BC096294.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTTGTC AGATCTCTTG CAAATCTCGA GGAAGAGGAG GAGGTGGAGG AGGATTCCGG 
GGCTTCAGCA GCGGCTCAGC TGTGGTGTCT GGTGGAAGCC GGAGATCAAC TTCCAGCTTC 
TCCTGCTTGA GCCGCCATGG TGGTGGTGGC GGGGGCTTCG GTGGAGGCGG CTTTGGCAGT 
CGGAGTCTTG TTGGCCTTGG AGGGACCAAG AGCATCTCCA TTAGTGTGGC TGGAGGAGGT 
GGTGGCTTTG GCGCCGCTGG TGGATTTGGT GGCAGAGGAG GTGGTTTTGG AGGCGGCAGC 
AGCTTTGGAG GTGGCAGCGG CTTCAGTGGT GGTGGTTTCG GTGGAGGCGG CTTTGGTGGA 
GGCCGCTTTG GAGGTTTTGG GGGCCCTGGT GGTGTTGGAG GTTTAGGGGG TCCTGGTGGC 
TTTGGGCCTG GAGGATACCC TGGTGGCATC CACGAAGTCT CTGTCAACCA GAGCCTCCTG 
CAGCCTCTCA ACGTGAAAGT TGACCCAGAG ATCCAGAATG TGAAGGCCCA AGAGCGTGAG 
CAGATCAAAA CTCTCAACAA CAAATTTGCC TCCTTCATTG ACAAGGTGCG GTTCTTGGAG 
CAGCAGAACC AGGTGTTACA GACCAAATGG GAGCTGCTAC AACAAATGAA TGTTGGCACC 
CGCCCCATCA ACCTGGAGCC CATCTTCCAG GGGTATATCG ACAGCCTCAA GAGATATCTG 
GATGGGCTCA CTGCAGAAAG AACATCACAG AATTCAGAGC TGAATAACAT GCAGGATCTT 
GTGGAGGATT ATAAGAAGAA GTATGAGGAT GAAATCAATA AGCGCACAGC TGCTGAGAAT 
GATTTTGTGA CGCTTAAAAA GGACGTGGAC AATGCCTACA TGATAAAGGT GGAGTTGCAG 
TCCAAGGTGG ACCTGCTGAA CCAGGAAATT GAGTTTCTGA AAGTTCTCTA TGATGCGGAG 
ATATCCCAGA TACATCAGAG TGTCACTGAC ACCAACGTCA TCCTCTCCAT GGACAACAGC 
CGCAACCTGG ACTTGGATAG CATCATCGCC GAGGTCAAGG CCCAGTATGA GGAGATCGCC 
CAGAGGAGCA AGGAAGAAGC GGAGGCCCTG TACCACAGCA AGTATGAGGA GCTCCAGGTG 
ACTGTCGGGA GACATGGAGA CAGCCTGAAA GAGATCAAGA TAGAGATCAG CGAGCTGAAC 
CGCGTGATCC AGAGGCTGCA GGGGGAGATC GCACATGTGA AGAAGCAGTG TAAGAATGTG 
CAAGATGCCA TCGCAGATGC CGAGCAGCGT GGGGAGCATG CCCTCAAGGA TGCCAGGAAC 
AAGTTGAATG ACCTGGAGGA GGCCCTGCAG CAGGCCAAGG AGGACTTGGC GCGGCTGCTG 
CGTGACTACC AGGAGCTGAT GAACGTGAAG CTGGCCCTAG ATGTGGAGAT CGCCACCTAC 
CGCAAACTGC TGGAGGGCGA GGAGTGCAGG ATGTCTGGAG ACCTCAGCAG CAATGTGACT 
GTGTCTGTGA CAAGCAGCAC CATTTCATCA AATGTGGCAT CCAAGGCTGC CTTTGGAGGT 
TCTGGAGGTA GAGGGTCCAG TTCCGGAGGA GGATACAGCT CTGGAAGCAG CAGTTATGGC 
TCTGGAGGCC GACAGTCTGG CTCCAGAGGC GGTAGTGGAG GAGGAGGTTC TATCTCTGGA 
GGAGGATATG GCTCTGGCGG TGGTTCTGGA GGAAGATACG GATCTGGTGG TGGCTCTAAG 
GGAGGGTCCA TCTCTGGAGG AGGATATGGC TCTGGAGGTG GAAAACACAG CTCTGGAGGT 
GGCTCTAGAG GAGGCTCCAG CTCTGGAGGA GGATATGGCT CTGGAGGTGG GGGTTCTAGC 
TCTGTAAAGG GTAGCTCAGG TGAAGCTTTT GGTTCCAGCG TGACCTTCTC TTTTAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000414.2
CDS	34..1953
Translation	MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR

Target ORF information:

RefSeq Version	NM_000423.2
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 2 (KRT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000423.2

ORF Insert Sequence:

ATGAGTTGTC AGATCTCTTG CAAATCTCGA GGAAGAGGAG GAGGTGGAGG AGGATTCCGG 
GGCTTCAGCA GCGGCTCAGC TGTGGTGTCT GGTGGAAGCC GGAGATCAAC TTCCAGCTTC 
TCCTGCTTGA GCCGCCATGG TGGTGGTGGC GGGGGCTTCG GTGGAGGCGG CTTTGGCAGT 
CGGAGTCTTG TTGGCCTTGG AGGGACCAAG AGCATCTCCA TTAGTGTGGC TGGAGGAGGT 
GGTGGCTTTG GCGCCGCTGG TGGATTTGGT GGCAGAGGAG GTGGTTTTGG AGGCGGCAGC 
AGCTTTGGAG GTGGCAGCGG CTTCAGTGGT GGTGGTTTCG GTGGAGGCGG CTTTGGTGGA 
GGCCGCTTTG GAGGTTTTGG GGGCCCTGGT GGTGTTGGAG GTTTAGGGGG TCCTGGTGGC 
TTTGGGCCTG GAGGATACCC TGGTGGCATC CACGAAGTCT CTGTCAACCA GAGCCTCCTG 
CAGCCTCTCA ACGTGAAAGT TGACCCAGAG ATCCAGAATG TGAAGGCCCA AGAGCGTGAG 
CAGATCAAAA CTCTCAACAA CAAATTTGCC TCCTTCATTG ACAAGGTGCG GTTCTTGGAG 
CAGCAGAACC AGGTGTTACA GACCAAATGG GAGCTGCTAC AACAAATGAA TGTTGGCACC 
CGCCCCATCA ACCTGGAGCC CATCTTCCAG GGGTATATCG ACAGCCTCAA GAGATATCTG 
GATGGGCTCA CTGCAGAAAG AACATCACAG AATTCAGAGC TGAATAACAT GCAGGATCTT 
GTGGAGGATT ATAAGAAGAA GTATGAGGAT GAAATCAATA AGCGCACAGC TGCTGAGAAT 
GATTTTGTGA CGCTTAAAAA GGACGTGGAC AATGCCTACA TGATAAAGGT GGAGTTGCAG 
TCCAAGGTGG ACCTGCTGAA CCAGGAAATT GAGTTTCTGA AAGTTCTCTA TGATGCGGAG 
ATATCCCAGA TACATCAGAG TGTCACTGAC ACCAACGTCA TCCTCTCCAT GGACAACAGC 
CGCAACCTGG ACTTGGATAG CATCATCGCC GAGGTCAAGG CCCAGTATGA GGAGATCGCC 
CAGAGGAGCA AGGAAGAAGC GGAGGCCCTG TACCACAGCA AGTATGAGGA GCTCCAGGTG 
ACTGTCGGGA GACATGGAGA CAGCCTGAAA GAGATCAAGA TAGAGATCAG CGAGCTGAAC 
CGCGTGATCC AGAGGCTGCA GGGGGAGATC GCACATGTGA AGAAGCAGTG TAAGAATGTG 
CAAGATGCCA TCGCAGATGC CGAGCAGCGT GGGGAGCATG CCCTCAAGGA TGCCAGGAAC 
AAGTTGAATG ACCTGGAGGA GGCCCTGCAG CAGGCCAAGG AGGACTTGGC GCGGCTGCTG 
CGTGACTACC AGGAGCTGAT GAACGTGAAG CTGGCCCTAG ATGTGGAGAT CGCCACCTAC 
CGCAAACTGC TGGAGGGCGA GGAGTGCAGG ATGTCTGGAG ACCTCAGCAG CAATGTGACT 
GTGTCTGTGA CAAGCAGCAC CATTTCATCA AATGTGGCAT CCAAGGCTGC CTTTGGAGGT 
TCTGGAGGTA GAGGGTCCAG TTCCGGAGGA GGATACAGCT CTGGAAGCAG CAGTTATGGC 
TCTGGAGGCC GACAGTCTGG CTCCAGAGGC GGTAGTGGAG GAGGAGGTTC TATCTCTGGA 
GGAGGATATG GCTCTGGCGG TGGTTCTGGA GGAAGATACG GATCTGGTGG TGGCTCTAAG 
GGAGGGTCCA TCTCTGGAGG AGGATATGGC TCTGGAGGTG GAAAACACAG CTCTGGAGGT 
GGCTCTAGAG GAGGCTCCAG CTCTGGAGGA GGATATGGCT CTGGAGGTGG GGGTTCTAGC 
TCTGTAAAGG GTAGCTCAGG TGAAGCTTTT GGTTCCAGCG TGACCTTCTC TTTTAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT2 ( NM_000423.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000414.2 Homo sapiens keratin 2 (KRT2), mRNA.

Price & Availability↑

CloneID	OHu19819
Clone ID Related Accession (Same CDS sequence)	NM_000423.2 , NM_000423.3
Accession Version	NM_000423.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1920bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 2 epidermal
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC055716.24, M99061.1, BC096294.4 and AL598277.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000423.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M99061.1, BC096294.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309680.4/ ENSP00000310861.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTTGTC AGATCTCTTG CAAATCTCGA GGAAGAGGAG GAGGTGGAGG AGGATTCCGG 
GGCTTCAGCA GCGGCTCAGC TGTGGTGTCT GGTGGAAGCC GGAGATCAAC TTCCAGCTTC 
TCCTGCTTGA GCCGCCATGG TGGTGGTGGC GGGGGCTTCG GTGGAGGCGG CTTTGGCAGT 
CGGAGTCTTG TTGGCCTTGG AGGGACCAAG AGCATCTCCA TTAGTGTGGC TGGAGGAGGT 
GGTGGCTTTG GCGCCGCTGG TGGATTTGGT GGCAGAGGAG GTGGTTTTGG AGGCGGCAGC 
AGCTTTGGAG GTGGCAGCGG CTTCAGTGGT GGTGGTTTCG GTGGAGGCGG CTTTGGTGGA 
GGCCGCTTTG GAGGTTTTGG GGGCCCTGGT GGTGTTGGAG GTTTAGGGGG TCCTGGTGGC 
TTTGGGCCTG GAGGATACCC TGGTGGCATC CACGAAGTCT CTGTCAACCA GAGCCTCCTG 
CAGCCTCTCA ACGTGAAAGT TGACCCAGAG ATCCAGAATG TGAAGGCCCA AGAGCGTGAG 
CAGATCAAAA CTCTCAACAA CAAATTTGCC TCCTTCATTG ACAAGGTGCG GTTCTTGGAG 
CAGCAGAACC AGGTGTTACA GACCAAATGG GAGCTGCTAC AACAAATGAA TGTTGGCACC 
CGCCCCATCA ACCTGGAGCC CATCTTCCAG GGGTATATCG ACAGCCTCAA GAGATATCTG 
GATGGGCTCA CTGCAGAAAG AACATCACAG AATTCAGAGC TGAATAACAT GCAGGATCTT 
GTGGAGGATT ATAAGAAGAA GTATGAGGAT GAAATCAATA AGCGCACAGC TGCTGAGAAT 
GATTTTGTGA CGCTTAAAAA GGACGTGGAC AATGCCTACA TGATAAAGGT GGAGTTGCAG 
TCCAAGGTGG ACCTGCTGAA CCAGGAAATT GAGTTTCTGA AAGTTCTCTA TGATGCGGAG 
ATATCCCAGA TACATCAGAG TGTCACTGAC ACCAACGTCA TCCTCTCCAT GGACAACAGC 
CGCAACCTGG ACTTGGATAG CATCATCGCC GAGGTCAAGG CCCAGTATGA GGAGATCGCC 
CAGAGGAGCA AGGAAGAAGC GGAGGCCCTG TACCACAGCA AGTATGAGGA GCTCCAGGTG 
ACTGTCGGGA GACATGGAGA CAGCCTGAAA GAGATCAAGA TAGAGATCAG CGAGCTGAAC 
CGCGTGATCC AGAGGCTGCA GGGGGAGATC GCACATGTGA AGAAGCAGTG TAAGAATGTG 
CAAGATGCCA TCGCAGATGC CGAGCAGCGT GGGGAGCATG CCCTCAAGGA TGCCAGGAAC 
AAGTTGAATG ACCTGGAGGA GGCCCTGCAG CAGGCCAAGG AGGACTTGGC GCGGCTGCTG 
CGTGACTACC AGGAGCTGAT GAACGTGAAG CTGGCCCTAG ATGTGGAGAT CGCCACCTAC 
CGCAAACTGC TGGAGGGCGA GGAGTGCAGG ATGTCTGGAG ACCTCAGCAG CAATGTGACT 
GTGTCTGTGA CAAGCAGCAC CATTTCATCA AATGTGGCAT CCAAGGCTGC CTTTGGAGGT 
TCTGGAGGTA GAGGGTCCAG TTCCGGAGGA GGATACAGCT CTGGAAGCAG CAGTTATGGC 
TCTGGAGGCC GACAGTCTGG CTCCAGAGGC GGTAGTGGAG GAGGAGGTTC TATCTCTGGA 
GGAGGATATG GCTCTGGCGG TGGTTCTGGA GGAAGATACG GATCTGGTGG TGGCTCTAAG 
GGAGGGTCCA TCTCTGGAGG AGGATATGGC TCTGGAGGTG GAAAACACAG CTCTGGAGGT 
GGCTCTAGAG GAGGCTCCAG CTCTGGAGGA GGATATGGCT CTGGAGGTGG GGGTTCTAGC 
TCTGTAAAGG GTAGCTCAGG TGAAGCTTTT GGTTCCAGCG TGACCTTCTC TTTTAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000414.2
CDS	70..1989
Translation	MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR

Target ORF information:

RefSeq Version	NM_000423.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 2 (KRT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000423.3

ORF Insert Sequence:

ATGAGTTGTC AGATCTCTTG CAAATCTCGA GGAAGAGGAG GAGGTGGAGG AGGATTCCGG 
GGCTTCAGCA GCGGCTCAGC TGTGGTGTCT GGTGGAAGCC GGAGATCAAC TTCCAGCTTC 
TCCTGCTTGA GCCGCCATGG TGGTGGTGGC GGGGGCTTCG GTGGAGGCGG CTTTGGCAGT 
CGGAGTCTTG TTGGCCTTGG AGGGACCAAG AGCATCTCCA TTAGTGTGGC TGGAGGAGGT 
GGTGGCTTTG GCGCCGCTGG TGGATTTGGT GGCAGAGGAG GTGGTTTTGG AGGCGGCAGC 
AGCTTTGGAG GTGGCAGCGG CTTCAGTGGT GGTGGTTTCG GTGGAGGCGG CTTTGGTGGA 
GGCCGCTTTG GAGGTTTTGG GGGCCCTGGT GGTGTTGGAG GTTTAGGGGG TCCTGGTGGC 
TTTGGGCCTG GAGGATACCC TGGTGGCATC CACGAAGTCT CTGTCAACCA GAGCCTCCTG 
CAGCCTCTCA ACGTGAAAGT TGACCCAGAG ATCCAGAATG TGAAGGCCCA AGAGCGTGAG 
CAGATCAAAA CTCTCAACAA CAAATTTGCC TCCTTCATTG ACAAGGTGCG GTTCTTGGAG 
CAGCAGAACC AGGTGTTACA GACCAAATGG GAGCTGCTAC AACAAATGAA TGTTGGCACC 
CGCCCCATCA ACCTGGAGCC CATCTTCCAG GGGTATATCG ACAGCCTCAA GAGATATCTG 
GATGGGCTCA CTGCAGAAAG AACATCACAG AATTCAGAGC TGAATAACAT GCAGGATCTT 
GTGGAGGATT ATAAGAAGAA GTATGAGGAT GAAATCAATA AGCGCACAGC TGCTGAGAAT 
GATTTTGTGA CGCTTAAAAA GGACGTGGAC AATGCCTACA TGATAAAGGT GGAGTTGCAG 
TCCAAGGTGG ACCTGCTGAA CCAGGAAATT GAGTTTCTGA AAGTTCTCTA TGATGCGGAG 
ATATCCCAGA TACATCAGAG TGTCACTGAC ACCAACGTCA TCCTCTCCAT GGACAACAGC 
CGCAACCTGG ACTTGGATAG CATCATCGCC GAGGTCAAGG CCCAGTATGA GGAGATCGCC 
CAGAGGAGCA AGGAAGAAGC GGAGGCCCTG TACCACAGCA AGTATGAGGA GCTCCAGGTG 
ACTGTCGGGA GACATGGAGA CAGCCTGAAA GAGATCAAGA TAGAGATCAG CGAGCTGAAC 
CGCGTGATCC AGAGGCTGCA GGGGGAGATC GCACATGTGA AGAAGCAGTG TAAGAATGTG 
CAAGATGCCA TCGCAGATGC CGAGCAGCGT GGGGAGCATG CCCTCAAGGA TGCCAGGAAC 
AAGTTGAATG ACCTGGAGGA GGCCCTGCAG CAGGCCAAGG AGGACTTGGC GCGGCTGCTG 
CGTGACTACC AGGAGCTGAT GAACGTGAAG CTGGCCCTAG ATGTGGAGAT CGCCACCTAC 
CGCAAACTGC TGGAGGGCGA GGAGTGCAGG ATGTCTGGAG ACCTCAGCAG CAATGTGACT 
GTGTCTGTGA CAAGCAGCAC CATTTCATCA AATGTGGCAT CCAAGGCTGC CTTTGGAGGT 
TCTGGAGGTA GAGGGTCCAG TTCCGGAGGA GGATACAGCT CTGGAAGCAG CAGTTATGGC 
TCTGGAGGCC GACAGTCTGG CTCCAGAGGC GGTAGTGGAG GAGGAGGTTC TATCTCTGGA 
GGAGGATATG GCTCTGGCGG TGGTTCTGGA GGAAGATACG GATCTGGTGG TGGCTCTAAG 
GGAGGGTCCA TCTCTGGAGG AGGATATGGC TCTGGAGGTG GAAAACACAG CTCTGGAGGT 
GGCTCTAGAG GAGGCTCCAG CTCTGGAGGA GGATATGGCT CTGGAGGTGG GGGTTCTAGC 
TCTGTAAAGG GTAGCTCAGG TGAAGCTTTT GGTTCCAGCG TGACCTTCTC TTTTAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis.
Acta dermato-venereologica96(4)473-8(2016 May)
Hotz A,Oji V,Bourrat E,Jonca N,Mazereeuw-Hautier J,Betz RC,Blume-Peytavi U,Stieler K,Morice-Picard F,Sch?nbuchner I,Markus S,Schlipf N,Fischer J

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Superficial epidermolytic ichthyosis: a report of two families.
Pediatric dermatology30(4)469-72(2013 Jul-Aug)
Cervantes T,Pham C,Browning JC

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Molecular bioSystems9(6)1108-16(2013 Jun)
Pieragostino D,Agnifili L,Fasanella V,D'Aguanno S,Mastropasqua R,Di Ilio C,Sacchetta P,Urbani A,Del Boccio P

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

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KRT2 cDNA ORF clone, Homo sapiens(human)

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