KRT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT1
Entrez Gene ID	3848
Full Name	keratin 1
Synonyms	CK1,EHK,EHK1,EPPK,K1,KRT1A,NEPPK
General protein information	Preferred Names keratin 1 Names keratin, type II cytoskeletal 1 67 kDa cytokeratin CK-1 cytokeratin 1 epidermolytic hyperkeratosis 1 hair alpha protein keratin 1, type II type-II keratin Kb1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
Disorder MIM:	139350
Disorder Html:	Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with epidermolytic hyperkeratosis, 607602 (3); Ichthyosis histrix, Curth-Macklin type, 146590 (3); Palmoplantar keratoderma, nonepidermolytic, 600962 (3); Palmoplantar keratoderma, epidermolytic, 144200 (3); Keratosis palmoplantaris striata III, 607654 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006121.3	NP_006112.3	keratin, type II cytoskeletal 1
NM_006121.4	NP_006112.3	keratin, type II cytoskeletal 1

Pathways from BioSystems

Homologies

	KRT1	XP_001098082.2
Bos taurus (cattle)	KRT1	XP_002687292.1
Pan troglodytes (chimpanzee)	KRT1	NP_001104288.1
Homo sapiens (human)	KRT1	NP_006112.3
Mus musculus (house mouse)	Krt1	NP_032499.2
Rattus norvegicus (Norway rat)	Krt1	NP_001008802.2
Canis lupus familiaris (dog)	KRT1	NP_001003392.1

Gene Ontology
Bibliography

Related articles in PubMed

Polymorphism of keratin 1 associates with systemic lupus erythematosus and systemic sclerosis in a south Chinese population.
Luo W, Zhou B, Luo Q, Fang H, Zuo X, Zou Y
PloS one12(10)e0186409(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Title: Critical role of Keratin 1 in maintaining epithelial barrier and correlation of its down-regulation with the progression of inflammatory bowel disease.

Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis.
Title: Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider-molytic Ichthyosis.

KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc
Title: Polymorphism of keratin 1 associates with systemic lupus erythematosus and systemic sclerosis in a south Chinese population.

Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis.
Title: Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis.

These findings indicate that exogenous FABP4 interacts with plasma membrane proteins, specifically CK1.
Title: New insights into circulating FABP4: Interaction with cytokeratin 1 on endothelial cell membranes.

The following KRT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu107234	NM_006121.4 Latest version!	Homo sapiens keratin 1 (KRT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu19449	NM_006121.3 Latest version!	Homo sapiens keratin 1 (KRT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT1 ( NM_006121.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006112.3 Homo sapiens keratin 1 (KRT1), mRNA.

Price & Availability↑

CloneID	OHu107234
Clone ID Related Accession (Same CDS sequence)	NM_006121.4
Accession Version	NM_006121.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from AC055716.24. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006121.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063697.1, ERR279845.9858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252244.3/ ENSP00000252244.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTCGAC AGTTTAGTTC CAGGTCTGGG TACCGAAGTG GAGGGGGCTT CAGCTCTGGC 
TCTGCTGGGA TCATCAACTA CCAGCGCAGG ACCACCAGCA GCTCCACACG CCGCAGTGGA 
GGAGGTGGTG GGAGATTTTC AAGCTGTGGT GGTGGTGGTG GTAGCTTTGG TGCTGGTGGT 
GGATTTGGAA GTCGGAGTCT TGTTAACCTT GGTGGCAGTA AAAGCATCTC CATAAGTGTG 
GCTAGAGGAG GTGGACGTGG TAGTGGCTTT GGTGGTGGTT ATGGTGGTGG TGGCTTTGGT 
GGTGGTGGCT TTGGTGGTGG TGGCTTTGGT GGAGGTGGCA TTGGGGGTGG TGGCTTTGGT 
GGTTTTGGCA GTGGTGGTGG TGGTTTTGGT GGAGGTGGCT TTGGGGGTGG TGGATATGGG 
GGTGGTTATG GTCCTGTCTG CCCTCCTGGT GGCATACAAG AAGTCACTAT CAACCAGAGC 
CTTCTTCAGC CCCTCAATGT GGAGATTGAC CCTGAGATCC AAAAGGTGAA GTCTCGAGAA 
AGGGAGCAAA TCAAGTCACT CAACAACCAA TTTGCCTCCT TCATTGACAA GGTGAGGTTC 
CTGGAGCAGC AGAACCAGGT ACTGCAAACA AAATGGGAGC TGCTGCAGCA GGTAGATACC 
TCCACTAGAA CCCATAATTT AGAGCCCTAC TTTGAGTCAT TCATCAACAA TCTCCGAAGG 
AGAGTGGACC AACTGAAGAG TGATCAATCT CGGTTGGATT CGGAACTGAA GAACATGCAG 
GACATGGTGG AGGATTACCG GAACAAGTAT GAGGATGAAA TCAACAAGCG GACAAATGCA 
GAGAATGAAT TTGTGACCAT CAAGAAGGAT GTGGATGGTG CTTATATGAC CAAGGTGGAC 
CTTCAGGCCA AACTTGACAA CTTGCAGCAG GAAATTGATT TCCTTACAGC ACTCTACCAA 
GCAGAGTTGT CTCAGATGCA GACTCAAATC AGTGAAACTA ATGTCATCCT CTCTATGGAC 
AACAACCGCA GTCTCGACCT GGACAGCATC ATTGCTGAGG TCAAGGCCCA GTACGAGGAT 
ATAGCCCAGA AGAGCAAAGC TGAGGCCGAG TCCTTGTACC AGAGCAAGTA TGAAGAGCTG 
CAGATCACTG CTGGCAGACA TGGGGATAGT GTGAGAAATT CAAAGATAGA AATTTCTGAG 
CTGAATCGTG TGATCCAGAG ACTTAGATCT GAAATCGACA ATGTCAAGAA GCAGATCTCC 
AACTTGCAGC AGTCCATCAG TGATGCAGAG CAGCGTGGCG AGAATGCCCT CAAGGATGCC 
AAGAACAAGC TGAATGACCT GGAGGATGCC CTGCAGCAGG CCAAGGAAGA CCTGGCCCGC 
CTGCTGCGCG ACTACCAGGA GCTGATGAAC ACAAAGCTGG CCCTGGATCT GGAGATTGCC 
ACCTACAGGA CCCTCCTGGA GGGAGAAGAA AGCAGGATGT CTGGAGAATG TGCCCCGAAC 
GTGAGTGTGT CTGTGAGCAC AAGCCACACC ACCATCAGTG GAGGTGGCAG CCGAGGAGGT 
GGCGGCGGTG GCTACGGCTC TGGAGGTAGC AGCTATGGCT CCGGAGGTGG TAGCTATGGT 
TCTGGAGGTG GCGGCGGCGG CGGCCGTGGC AGCTATGGCT CCGGAGGTAG CAGCTACGGC 
TCCGGAGGTG GCAGCTATGG CTCTGGAGGT GGCGGCGGCG GCCATGGCAG CTACGGCTCC 
GGAAGCAGCA GTGGGGGCTA CAGAGGTGGC TCTGGAGGCG GCGGCGGCGG CAGCTCTGGC 
GGCCGGGGCT CTGGCGGCGG GAGCTCTGGA GGCTCCATAG GAGGCCGGGG ATCCAGCTCT 
GGGGGTGTCA AGTCCTCTGG TGGCAGTTCC AGCGTGAAGT TTGTTTCTAC CACTTATTCC 
GGAGTAACCA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006112.3
CDS	60..1994
Translation	MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR

Target ORF information:

RefSeq Version	NM_006121.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 1 (KRT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006121.4

ORF Insert Sequence:

ATGAGTCGAC AGTTTAGTTC CAGGTCTGGG TACCGAAGTG GAGGGGGCTT CAGCTCTGGC 
TCTGCTGGGA TCATCAACTA CCAGCGCAGG ACCACCAGCA GCTCCACACG CCGCAGTGGA 
GGAGGTGGTG GGAGATTTTC AAGCTGTGGT GGTGGTGGTG GTAGCTTTGG TGCTGGTGGT 
GGATTTGGAA GTCGGAGTCT TGTTAACCTT GGTGGCAGTA AAAGCATCTC CATAAGTGTG 
GCTAGAGGAG GTGGACGTGG TAGTGGCTTT GGTGGTGGTT ATGGTGGTGG TGGCTTTGGT 
GGTGGTGGCT TTGGTGGTGG TGGCTTTGGT GGAGGTGGCA TTGGGGGTGG TGGCTTTGGT 
GGTTTTGGCA GTGGTGGTGG TGGTTTTGGT GGAGGTGGCT TTGGGGGTGG TGGATATGGG 
GGTGGTTATG GTCCTGTCTG CCCTCCTGGT GGCATACAAG AAGTCACTAT CAACCAGAGC 
CTTCTTCAGC CCCTCAATGT GGAGATTGAC CCTGAGATCC AAAAGGTGAA GTCTCGAGAA 
AGGGAGCAAA TCAAGTCACT CAACAACCAA TTTGCCTCCT TCATTGACAA GGTGAGGTTC 
CTGGAGCAGC AGAACCAGGT ACTGCAAACA AAATGGGAGC TGCTGCAGCA GGTAGATACC 
TCCACTAGAA CCCATAATTT AGAGCCCTAC TTTGAGTCAT TCATCAACAA TCTCCGAAGG 
AGAGTGGACC AACTGAAGAG TGATCAATCT CGGTTGGATT CGGAACTGAA GAACATGCAG 
GACATGGTGG AGGATTACCG GAACAAGTAT GAGGATGAAA TCAACAAGCG GACAAATGCA 
GAGAATGAAT TTGTGACCAT CAAGAAGGAT GTGGATGGTG CTTATATGAC CAAGGTGGAC 
CTTCAGGCCA AACTTGACAA CTTGCAGCAG GAAATTGATT TCCTTACAGC ACTCTACCAA 
GCAGAGTTGT CTCAGATGCA GACTCAAATC AGTGAAACTA ATGTCATCCT CTCTATGGAC 
AACAACCGCA GTCTCGACCT GGACAGCATC ATTGCTGAGG TCAAGGCCCA GTACGAGGAT 
ATAGCCCAGA AGAGCAAAGC TGAGGCCGAG TCCTTGTACC AGAGCAAGTA TGAAGAGCTG 
CAGATCACTG CTGGCAGACA TGGGGATAGT GTGAGAAATT CAAAGATAGA AATTTCTGAG 
CTGAATCGTG TGATCCAGAG ACTTAGATCT GAAATCGACA ATGTCAAGAA GCAGATCTCC 
AACTTGCAGC AGTCCATCAG TGATGCAGAG CAGCGTGGCG AGAATGCCCT CAAGGATGCC 
AAGAACAAGC TGAATGACCT GGAGGATGCC CTGCAGCAGG CCAAGGAAGA CCTGGCCCGC 
CTGCTGCGCG ACTACCAGGA GCTGATGAAC ACAAAGCTGG CCCTGGATCT GGAGATTGCC 
ACCTACAGGA CCCTCCTGGA GGGAGAAGAA AGCAGGATGT CTGGAGAATG TGCCCCGAAC 
GTGAGTGTGT CTGTGAGCAC AAGCCACACC ACCATCAGTG GAGGTGGCAG CCGAGGAGGT 
GGCGGCGGTG GCTACGGCTC TGGAGGTAGC AGCTATGGCT CCGGAGGTGG TAGCTATGGT 
TCTGGAGGTG GCGGCGGCGG CGGCCGTGGC AGCTATGGCT CCGGAGGTAG CAGCTACGGC 
TCCGGAGGTG GCAGCTATGG CTCTGGAGGT GGCGGCGGCG GCCATGGCAG CTACGGCTCC 
GGAAGCAGCA GTGGGGGCTA CAGAGGTGGC TCTGGAGGCG GCGGCGGCGG CAGCTCTGGC 
GGCCGGGGCT CTGGCGGCGG GAGCTCTGGA GGCTCCATAG GAGGCCGGGG ATCCAGCTCT 
GGGGGTGTCA AGTCCTCTGG TGGCAGTTCC AGCGTGAAGT TTGTTTCTAC CACTTATTCC 
GGAGTAACCA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT1 ( NM_006121.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006112.3 Homo sapiens keratin 1 (KRT1), mRNA.

Price & Availability↑

CloneID	OHu19449
Clone ID Related Accession (Same CDS sequence)	NM_006121.3
Accession Version	NM_006121.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from DB112126.1, BC063697.1 and AC055716.24. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced NM_006121.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063697.1, ERR279845.9858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCGAC AGTTTAGTTC CAGGTCTGGG TACCGAAGTG GAGGGGGCTT CAGCTCTGGC 
TCTGCTGGGA TCATCAACTA CCAGCGCAGG ACCACCAGCA GCTCCACACG CCGCAGTGGA 
GGAGGTGGTG GGAGATTTTC AAGCTGTGGT GGTGGTGGTG GTAGCTTTGG TGCTGGTGGT 
GGATTTGGAA GTCGGAGTCT TGTTAACCTT GGTGGCAGTA AAAGCATCTC CATAAGTGTG 
GCTAGAGGAG GTGGACGTGG TAGTGGCTTT GGTGGTGGTT ATGGTGGTGG TGGCTTTGGT 
GGTGGTGGCT TTGGTGGTGG TGGCTTTGGT GGAGGTGGCA TTGGGGGTGG TGGCTTTGGT 
GGTTTTGGCA GTGGTGGTGG TGGTTTTGGT GGAGGTGGCT TTGGGGGTGG TGGATATGGG 
GGTGGTTATG GTCCTGTCTG CCCTCCTGGT GGCATACAAG AAGTCACTAT CAACCAGAGC 
CTTCTTCAGC CCCTCAATGT GGAGATTGAC CCTGAGATCC AAAAGGTGAA GTCTCGAGAA 
AGGGAGCAAA TCAAGTCACT CAACAACCAA TTTGCCTCCT TCATTGACAA GGTGAGGTTC 
CTGGAGCAGC AGAACCAGGT ACTGCAAACA AAATGGGAGC TGCTGCAGCA GGTAGATACC 
TCCACTAGAA CCCATAATTT AGAGCCCTAC TTTGAGTCAT TCATCAACAA TCTCCGAAGG 
AGAGTGGACC AACTGAAGAG TGATCAATCT CGGTTGGATT CGGAACTGAA GAACATGCAG 
GACATGGTGG AGGATTACCG GAACAAGTAT GAGGATGAAA TCAACAAGCG GACAAATGCA 
GAGAATGAAT TTGTGACCAT CAAGAAGGAT GTGGATGGTG CTTATATGAC CAAGGTGGAC 
CTTCAGGCCA AACTTGACAA CTTGCAGCAG GAAATTGATT TCCTTACAGC ACTCTACCAA 
GCAGAGTTGT CTCAGATGCA GACTCAAATC AGTGAAACTA ATGTCATCCT CTCTATGGAC 
AACAACCGCA GTCTCGACCT GGACAGCATC ATTGCTGAGG TCAAGGCCCA GTACGAGGAT 
ATAGCCCAGA AGAGCAAAGC TGAGGCCGAG TCCTTGTACC AGAGCAAGTA TGAAGAGCTG 
CAGATCACTG CTGGCAGACA TGGGGATAGT GTGAGAAATT CAAAGATAGA AATTTCTGAG 
CTGAATCGTG TGATCCAGAG ACTTAGATCT GAAATCGACA ATGTCAAGAA GCAGATCTCC 
AACTTGCAGC AGTCCATCAG TGATGCAGAG CAGCGTGGCG AGAATGCCCT CAAGGATGCC 
AAGAACAAGC TGAATGACCT GGAGGATGCC CTGCAGCAGG CCAAGGAAGA CCTGGCCCGC 
CTGCTGCGCG ACTACCAGGA GCTGATGAAC ACCAAGCTGG CCCTGGATCT GGAGATTGCC 
ACCTACAGGA CCCTCCTGGA GGGAGAAGAA AGCAGGATGT CTGGAGAATG TGCCCCGAAC 
GTGAGTGTGT CTGTGAGCAC AAGCCACACC ACCATCAGTG GAGGTGGCAG CCGAGGAGGT 
GGCGGCGGTG GCTACGGCTC TGGAGGTAGC AGCTATGGCT CCGGAGGTGG TAGCTATGGT 
TCTGGAGGTG GCGGCGGCGG CGGCCGTGGC AGCTATGGCT CCGGAGGTAG CAGCTACGGC 
TCCGGAGGTG GCAGCTATGG CTCTGGAGGT GGCGGCGGCG GCCATGGCAG CTACGGCTCC 
GGAAGCAGCA GTGGGGGCTA CAGAGGTGGC TCTGGAGGCG GCGGCGGCGG CAGCTCTGGC 
GGCCGGGGCT CTGGCGGCGG GAGCTCTGGA GGCTCCATAG GAGGCCGGGG ATCCAGCTCT 
GGGGGTGTCA AGTCCTCTGG TGGCAGTTCC AGCGTGAAGT TTGTTTCTAC CACTTATTCC 
GGAGTAACCA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006112.3
CDS	60..1994
Translation	MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR

Target ORF information:

RefSeq Version	NM_006121.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 1 (KRT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006121.3

ORF Insert Sequence:

ATGAGTCGAC AGTTTAGTTC CAGGTCTGGG TACCGAAGTG GAGGGGGCTT CAGCTCTGGC 
TCTGCTGGGA TCATCAACTA CCAGCGCAGG ACCACCAGCA GCTCCACACG CCGCAGTGGA 
GGAGGTGGTG GGAGATTTTC AAGCTGTGGT GGTGGTGGTG GTAGCTTTGG TGCTGGTGGT 
GGATTTGGAA GTCGGAGTCT TGTTAACCTT GGTGGCAGTA AAAGCATCTC CATAAGTGTG 
GCTAGAGGAG GTGGACGTGG TAGTGGCTTT GGTGGTGGTT ATGGTGGTGG TGGCTTTGGT 
GGTGGTGGCT TTGGTGGTGG TGGCTTTGGT GGAGGTGGCA TTGGGGGTGG TGGCTTTGGT 
GGTTTTGGCA GTGGTGGTGG TGGTTTTGGT GGAGGTGGCT TTGGGGGTGG TGGATATGGG 
GGTGGTTATG GTCCTGTCTG CCCTCCTGGT GGCATACAAG AAGTCACTAT CAACCAGAGC 
CTTCTTCAGC CCCTCAATGT GGAGATTGAC CCTGAGATCC AAAAGGTGAA GTCTCGAGAA 
AGGGAGCAAA TCAAGTCACT CAACAACCAA TTTGCCTCCT TCATTGACAA GGTGAGGTTC 
CTGGAGCAGC AGAACCAGGT ACTGCAAACA AAATGGGAGC TGCTGCAGCA GGTAGATACC 
TCCACTAGAA CCCATAATTT AGAGCCCTAC TTTGAGTCAT TCATCAACAA TCTCCGAAGG 
AGAGTGGACC AACTGAAGAG TGATCAATCT CGGTTGGATT CGGAACTGAA GAACATGCAG 
GACATGGTGG AGGATTACCG GAACAAGTAT GAGGATGAAA TCAACAAGCG GACAAATGCA 
GAGAATGAAT TTGTGACCAT CAAGAAGGAT GTGGATGGTG CTTATATGAC CAAGGTGGAC 
CTTCAGGCCA AACTTGACAA CTTGCAGCAG GAAATTGATT TCCTTACAGC ACTCTACCAA 
GCAGAGTTGT CTCAGATGCA GACTCAAATC AGTGAAACTA ATGTCATCCT CTCTATGGAC 
AACAACCGCA GTCTCGACCT GGACAGCATC ATTGCTGAGG TCAAGGCCCA GTACGAGGAT 
ATAGCCCAGA AGAGCAAAGC TGAGGCCGAG TCCTTGTACC AGAGCAAGTA TGAAGAGCTG 
CAGATCACTG CTGGCAGACA TGGGGATAGT GTGAGAAATT CAAAGATAGA AATTTCTGAG 
CTGAATCGTG TGATCCAGAG ACTTAGATCT GAAATCGACA ATGTCAAGAA GCAGATCTCC 
AACTTGCAGC AGTCCATCAG TGATGCAGAG CAGCGTGGCG AGAATGCCCT CAAGGATGCC 
AAGAACAAGC TGAATGACCT GGAGGATGCC CTGCAGCAGG CCAAGGAAGA CCTGGCCCGC 
CTGCTGCGCG ACTACCAGGA GCTGATGAAC ACCAAGCTGG CCCTGGATCT GGAGATTGCC 
ACCTACAGGA CCCTCCTGGA GGGAGAAGAA AGCAGGATGT CTGGAGAATG TGCCCCGAAC 
GTGAGTGTGT CTGTGAGCAC AAGCCACACC ACCATCAGTG GAGGTGGCAG CCGAGGAGGT 
GGCGGCGGTG GCTACGGCTC TGGAGGTAGC AGCTATGGCT CCGGAGGTGG TAGCTATGGT 
TCTGGAGGTG GCGGCGGCGG CGGCCGTGGC AGCTATGGCT CCGGAGGTAG CAGCTACGGC 
TCCGGAGGTG GCAGCTATGG CTCTGGAGGT GGCGGCGGCG GCCATGGCAG CTACGGCTCC 
GGAAGCAGCA GTGGGGGCTA CAGAGGTGGC TCTGGAGGCG GCGGCGGCGG CAGCTCTGGC 
GGCCGGGGCT CTGGCGGCGG GAGCTCTGGA GGCTCCATAG GAGGCCGGGG ATCCAGCTCT 
GGGGGTGTCA AGTCCTCTGG TGGCAGTTCC AGCGTGAAGT TTGTTTCTAC CACTTATTCC 
GGAGTAACCA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polymorphism of keratin 1 associates with systemic lupus erythematosus and systemic sclerosis in a south Chinese population.
PloS one12(10)e0186409(2017)
Luo W,Zhou B,Luo Q,Fang H,Zuo X,Zou Y

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KRT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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