Gene Symbol | KRAS |
Entrez Gene ID | 3845 |
Full Name | KRAS proto-oncogene, GTPase |
Synonyms | C-K-RAS,CFC2,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,K-Ras,KI-RAS,KRAS1,KRAS2,NS,NS3,RALD,RASK2,c-Ki-ras2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Lung cancer, somatic, 211980 (3); Bladder cancer, somatic, 109800 (3); Pancreatic carcinoma, somatic, 260350 (3); Gastric cancer, somatic, 137215 (3); Leukemia, acute myeloid, 601626 (3); Noonan syndrome 3, 609942 (3); Cardiofaciocutaneous syndrome 2, 615278 (3); Breast cancer, somatic, 114480 (3); Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic, 163200 (3); RAS-associated autoimmune leukoproliferative disorder, 614470 (3) |