KPNA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KPNA3
Entrez Gene ID	3839
Full Name	karyopherin subunit alpha 3
Synonyms	IPOA4,SRP1,SRP1gamma,SRP4,hSRP1
General protein information	Preferred Names karyopherin subunit alpha 3 Names importin subunit alpha-4 SRP1-gamma importin alpha 4 importin alpha Q2 importin alpha-3 importin subunit alpha-3 karyopherin alpha 3 (importin alpha 4) qip2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.2
Summary	The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009].
Disorder MIM:	601892

mRNA and Protein(s)

mRNA	Protein	Name
NM_002267.4	NP_002258.2	importin subunit alpha-4
XM_017020561.1	XP_016876050.1	importin subunit alpha-4 isoform X1
NM_002267.3	NP_002258.2	importin subunit alpha-4

Pathways from BioSystems

Homologies

Homo sapiens (human)	KPNA3	NP_002258.2
Canis lupus familiaris (dog)	KPNA3	XP_005633904.1
Mus musculus (house mouse)	Kpna3	NP_032492.1
Gallus gallus (chicken)	KPNA3	NP_001180504.1
Xenopus tropicalis (tropical clawed frog)	kpna3	NP_001016060.1
Pan troglodytes (chimpanzee)	KPNA3	XP_001156682.1
	KPNA3	XP_002800805.1
Bos taurus (cattle)	KPNA3	NP_001179702.1
Rattus norvegicus (Norway rat)	Kpna3	NP_001014792.1
Danio rerio (zebrafish)	kpna3	NP_958477.2

Gene Ontology
Bibliography

Related articles in PubMed

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, Song Y, Deng C, Zhang B, Chen H, Cao S
Journal of virology91(8)(2017 Apr)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4.
Title: Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.

Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
Title: Karyopherin ? 3 and karyopherin ? 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.

SNP rs2273816 is significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level
Title: KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.

The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
Title: A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.

The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size.
Title: The KPNA3 gene may be a susceptibility candidate for schizophrenia.

The following KPNA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KPNA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03014	NM_002267.4 Latest version!	Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu84533	XM_017020561.1 Latest version!	Homo sapiens karyopherin subunit alpha 3 (KPNA3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu03014	NM_002267.3	Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KPNA3 ( NM_002267.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002258.2 Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.

Price & Availability↑

CloneID	OHu03014
Clone ID Related Accession (Same CDS sequence)	NM_002267.4 , NM_002267.3
Accession Version	NM_002267.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	importin subunit alpha-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035090.2, DN991804.1, AK291000.1, AU132188.1 and AI309735.1. On Nov 22, 2018 this sequence version replaced NM_002267.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.96763.1, BC035090.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261667.8/ ENSP00000261667.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGA ACCCCAGCTT GGAGAACCAC CGCATCAAGA GCTTCAAGAA CAAGGGCCGC 
GATGTGGAAA CAATGCGAAG ACATAGAAAT GAAGTGACAG TGGAACTGCG GAAGAACAAA 
AGAGATGAAC ACTTATTGAA AAAGAGAAAT GTTCCCCAAG AAGAAAGTCT AGAAGATTCA 
GATGTTGATG CTGATTTTAA AGCACAAAAT GTAACCCTAG AAGCTATATT GCAGAATGCC 
ACAAGTGATA ACCCAGTGGT CCAATTGAGT GCTGTCCAGG CAGCAAGAAA ACTGTTATCC 
AGTGACAGAA ATCCACCGAT TGATGACTTA ATAAAATCTG GGATTTTACC AATTCTAGTC 
AAATGTCTAG AAAGGGATGA TAATCCTTCA TTACAGTTTG AAGCTGCTTG GGCATTAACT 
AACATAGCAT CAGGAACTTC TGCACAGACT CAAGCTGTTG TGCAGTCTAA TGCAGTACCT 
CTTTTTCTGA GACTTCTTCG TTCACCACAT CAGAATGTTT GTGAACAAGC AGTATGGGCT 
TTGGGAAACA TTATAGGTGA TGGTCCTCAA TGTAGAGATT ATGTCATATC ACTGGGAGTT 
GTCAAACCTC TTCTGTCCTT CATCAGTCCC TCCATCCCCA TCACCTTCCT TCGGAACGTC 
ACATGGGTCA TTGTCAATCT CTGCAGGAAT AAGGATCCCC CGCCGCCTAT GGAGACAGTT 
CAGGAGATTT TGCCAGCTTT ATGTGTCCTC ATATACCATA CAGATATAAA CATTCTTGTA 
GACACTGTTT GGGCTCTGTC ATACTTGACA GATGGAGGTA ATGAACAGAT ACAGATGGTT 
ATTGATTCAG GAGTTGTGCC CTTTCTTGTG CCCCTTCTGA GCCATCAGGA AGTCAAAGTT 
CAAACAGCAG CCCTCAGAGC AGTTGGCAAC ATAGTGACTG GCACCGACGA GCAGACCCAG 
GTTGTTCTCA ATTGTGATGT CCTGTCACAC TTCCCAAATC TCTTATCACA CCCAAAAGAG 
AAGATAAATA AGGAAGCAGT GTGGTTCCTT TCCAACATAA CAGCAGGCAA CCAGCAACAA 
GTTCAAGCTG TAATAGATGC TGGATTAATT CCTATGATAA TTCATCAGCT TGCTAAGGGG 
GACTTTGGAA CACAAAAAGA AGCTGCTTGG GCAATCAGCA ACTTAACAAT AAGTGGCAGA 
AAAGATCAGG TTGAGTACCT TGTACAGCAG AATGTAATAC CACCGTTCTG TAATTTACTG 
TCAGTGAAAG ATTCTCAAGT GGTTCAGGTG GTTCTAGATG GTCTAAAAAA CATTCTGATA 
ATGGCCGGTG ATGAAGCAAG CACAATAGCT GAAATAATAG AGGAATGTGG AGGTTTGGAG 
AAAATTGAAG TTTTACAGCA ACATGAAAAT GAAGACATAT ATAAATTAGC ATTTGAAATC 
ATAGATCAGT ATTTCTCTGG TGATGATATT GATGAAGATC CCTGCCTCAT TCCTGAAGCA 
ACACAAGGAG GTACCTACAA TTTTGATCCA ACAGCCAACC TTCAAACAAA AGAATTTAAT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002258.2
CDS	177..1742
Translation	MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF

Target ORF information:

RefSeq Version	NM_002267.4
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002267.4

ORF Insert Sequence:

ATGGCCGAGA ACCCCAGCTT GGAGAACCAC CGCATCAAGA GCTTCAAGAA CAAGGGCCGC 
GATGTGGAAA CAATGCGAAG ACATAGAAAT GAAGTGACAG TGGAACTGCG GAAGAACAAA 
AGAGATGAAC ACTTATTGAA AAAGAGAAAT GTTCCCCAAG AAGAAAGTCT AGAAGATTCA 
GATGTTGATG CTGATTTTAA AGCACAAAAT GTAACCCTAG AAGCTATATT GCAGAATGCC 
ACAAGTGATA ACCCAGTGGT CCAATTGAGT GCTGTCCAGG CAGCAAGAAA ACTGTTATCC 
AGTGACAGAA ATCCACCGAT TGATGACTTA ATAAAATCTG GGATTTTACC AATTCTAGTC 
AAATGTCTAG AAAGGGATGA TAATCCTTCA TTACAGTTTG AAGCTGCTTG GGCATTAACT 
AACATAGCAT CAGGAACTTC TGCACAGACT CAAGCTGTTG TGCAGTCTAA TGCAGTACCT 
CTTTTTCTGA GACTTCTTCG TTCACCACAT CAGAATGTTT GTGAACAAGC AGTATGGGCT 
TTGGGAAACA TTATAGGTGA TGGTCCTCAA TGTAGAGATT ATGTCATATC ACTGGGAGTT 
GTCAAACCTC TTCTGTCCTT CATCAGTCCC TCCATCCCCA TCACCTTCCT TCGGAACGTC 
ACATGGGTCA TTGTCAATCT CTGCAGGAAT AAGGATCCCC CGCCGCCTAT GGAGACAGTT 
CAGGAGATTT TGCCAGCTTT ATGTGTCCTC ATATACCATA CAGATATAAA CATTCTTGTA 
GACACTGTTT GGGCTCTGTC ATACTTGACA GATGGAGGTA ATGAACAGAT ACAGATGGTT 
ATTGATTCAG GAGTTGTGCC CTTTCTTGTG CCCCTTCTGA GCCATCAGGA AGTCAAAGTT 
CAAACAGCAG CCCTCAGAGC AGTTGGCAAC ATAGTGACTG GCACCGACGA GCAGACCCAG 
GTTGTTCTCA ATTGTGATGT CCTGTCACAC TTCCCAAATC TCTTATCACA CCCAAAAGAG 
AAGATAAATA AGGAAGCAGT GTGGTTCCTT TCCAACATAA CAGCAGGCAA CCAGCAACAA 
GTTCAAGCTG TAATAGATGC TGGATTAATT CCTATGATAA TTCATCAGCT TGCTAAGGGG 
GACTTTGGAA CACAAAAAGA AGCTGCTTGG GCAATCAGCA ACTTAACAAT AAGTGGCAGA 
AAAGATCAGG TTGAGTACCT TGTACAGCAG AATGTAATAC CACCGTTCTG TAATTTACTG 
TCAGTGAAAG ATTCTCAAGT GGTTCAGGTG GTTCTAGATG GTCTAAAAAA CATTCTGATA 
ATGGCCGGTG ATGAAGCAAG CACAATAGCT GAAATAATAG AGGAATGTGG AGGTTTGGAG 
AAAATTGAAG TTTTACAGCA ACATGAAAAT GAAGACATAT ATAAATTAGC ATTTGAAATC 
ATAGATCAGT ATTTCTCTGG TGATGATATT GATGAAGATC CCTGCCTCAT TCCTGAAGCA 
ACACAAGGAG GTACCTACAA TTTTGATCCA ACAGCCAACC TTCAAACAAA AGAATTTAAT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA3 ( NM_002267.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002258.2 Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.

Price & Availability↑

CloneID	OHu03014
Clone ID Related Accession (Same CDS sequence)	NM_002267.4 , NM_002267.3
Accession Version	NM_002267.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	importin subunit alpha-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035090.2, DN991804.1, AK291000.1, AU132188.1 and AI309735.1. On Jan 24, 2009 this sequence version replaced NM_002267.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035090.2, SRR1660803.155588.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGA ACCCCAGCTT GGAGAACCAC CGCATCAAGA GCTTCAAGAA CAAGGGCCGC 
GATGTGGAAA CAATGCGAAG ACATAGAAAT GAAGTGACAG TGGAACTGCG GAAGAACAAA 
AGAGATGAAC ACTTATTGAA AAAGAGAAAT GTTCCCCAAG AAGAAAGTCT AGAAGATTCA 
GATGTTGATG CTGATTTTAA AGCACAAAAT GTAACCCTAG AAGCTATATT GCAGAATGCC 
ACAAGTGATA ACCCAGTGGT CCAATTGAGT GCTGTCCAGG CAGCAAGAAA ACTGTTATCC 
AGTGACAGAA ATCCACCGAT TGATGACTTA ATAAAATCTG GGATTTTACC AATTCTAGTC 
AAATGTCTAG AAAGGGATGA TAATCCTTCA TTACAGTTTG AAGCTGCTTG GGCATTAACT 
AACATAGCAT CAGGAACTTC TGCACAGACT CAAGCTGTTG TGCAGTCTAA TGCAGTACCT 
CTTTTTCTGA GACTTCTTCG TTCACCACAT CAGAATGTTT GTGAACAAGC AGTATGGGCT 
TTGGGAAACA TTATAGGTGA TGGTCCTCAA TGTAGAGATT ATGTCATATC ACTGGGAGTT 
GTCAAACCTC TTCTGTCCTT CATCAGTCCC TCCATCCCCA TCACCTTCCT TCGGAACGTC 
ACATGGGTCA TTGTCAATCT CTGCAGGAAT AAGGATCCCC CGCCGCCTAT GGAGACAGTT 
CAGGAGATTT TGCCAGCTTT ATGTGTCCTC ATATACCATA CAGATATAAA CATTCTTGTA 
GACACTGTTT GGGCTCTGTC ATACTTGACA GATGGAGGTA ATGAACAGAT ACAGATGGTT 
ATTGATTCAG GAGTTGTGCC CTTTCTTGTG CCCCTTCTGA GCCATCAGGA AGTCAAAGTT 
CAAACAGCAG CCCTCAGAGC AGTTGGCAAC ATAGTGACTG GCACCGACGA GCAGACCCAG 
GTTGTTCTCA ATTGTGATGT CCTGTCACAC TTCCCAAATC TCTTATCACA CCCAAAAGAG 
AAGATAAATA AGGAAGCAGT GTGGTTCCTT TCCAACATAA CAGCAGGCAA CCAGCAACAA 
GTTCAAGCTG TAATAGATGC TGGATTAATT CCTATGATAA TTCATCAGCT TGCTAAGGGG 
GACTTTGGAA CACAAAAAGA AGCTGCTTGG GCAATCAGCA ACTTAACAAT AAGTGGCAGA 
AAAGATCAGG TTGAGTACCT TGTACAGCAG AATGTAATAC CACCGTTCTG TAATTTACTG 
TCAGTGAAAG ATTCTCAAGT GGTTCAGGTG GTTCTAGATG GTCTAAAAAA CATTCTGATA 
ATGGCCGGTG ATGAAGCAAG CACAATAGCT GAAATAATAG AGGAATGTGG AGGTTTGGAG 
AAAATTGAAG TTTTACAGCA ACATGAAAAT GAAGACATAT ATAAATTAGC ATTTGAAATC 
ATAGATCAGT ATTTCTCTGG TGATGATATT GATGAAGATC CCTGCCTCAT TCCTGAAGCA 
ACACAAGGAG GTACCTACAA TTTTGATCCA ACAGCCAACC TTCAAACAAA AGAATTTAAT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002258.2
CDS	416..1981
Translation	MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF

Target ORF information:

RefSeq Version	NM_002267.3
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 3 (KPNA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002267.3

ORF Insert Sequence:

ATGGCCGAGA ACCCCAGCTT GGAGAACCAC CGCATCAAGA GCTTCAAGAA CAAGGGCCGC 
GATGTGGAAA CAATGCGAAG ACATAGAAAT GAAGTGACAG TGGAACTGCG GAAGAACAAA 
AGAGATGAAC ACTTATTGAA AAAGAGAAAT GTTCCCCAAG AAGAAAGTCT AGAAGATTCA 
GATGTTGATG CTGATTTTAA AGCACAAAAT GTAACCCTAG AAGCTATATT GCAGAATGCC 
ACAAGTGATA ACCCAGTGGT CCAATTGAGT GCTGTCCAGG CAGCAAGAAA ACTGTTATCC 
AGTGACAGAA ATCCACCGAT TGATGACTTA ATAAAATCTG GGATTTTACC AATTCTAGTC 
AAATGTCTAG AAAGGGATGA TAATCCTTCA TTACAGTTTG AAGCTGCTTG GGCATTAACT 
AACATAGCAT CAGGAACTTC TGCACAGACT CAAGCTGTTG TGCAGTCTAA TGCAGTACCT 
CTTTTTCTGA GACTTCTTCG TTCACCACAT CAGAATGTTT GTGAACAAGC AGTATGGGCT 
TTGGGAAACA TTATAGGTGA TGGTCCTCAA TGTAGAGATT ATGTCATATC ACTGGGAGTT 
GTCAAACCTC TTCTGTCCTT CATCAGTCCC TCCATCCCCA TCACCTTCCT TCGGAACGTC 
ACATGGGTCA TTGTCAATCT CTGCAGGAAT AAGGATCCCC CGCCGCCTAT GGAGACAGTT 
CAGGAGATTT TGCCAGCTTT ATGTGTCCTC ATATACCATA CAGATATAAA CATTCTTGTA 
GACACTGTTT GGGCTCTGTC ATACTTGACA GATGGAGGTA ATGAACAGAT ACAGATGGTT 
ATTGATTCAG GAGTTGTGCC CTTTCTTGTG CCCCTTCTGA GCCATCAGGA AGTCAAAGTT 
CAAACAGCAG CCCTCAGAGC AGTTGGCAAC ATAGTGACTG GCACCGACGA GCAGACCCAG 
GTTGTTCTCA ATTGTGATGT CCTGTCACAC TTCCCAAATC TCTTATCACA CCCAAAAGAG 
AAGATAAATA AGGAAGCAGT GTGGTTCCTT TCCAACATAA CAGCAGGCAA CCAGCAACAA 
GTTCAAGCTG TAATAGATGC TGGATTAATT CCTATGATAA TTCATCAGCT TGCTAAGGGG 
GACTTTGGAA CACAAAAAGA AGCTGCTTGG GCAATCAGCA ACTTAACAAT AAGTGGCAGA 
AAAGATCAGG TTGAGTACCT TGTACAGCAG AATGTAATAC CACCGTTCTG TAATTTACTG 
TCAGTGAAAG ATTCTCAAGT GGTTCAGGTG GTTCTAGATG GTCTAAAAAA CATTCTGATA 
ATGGCCGGTG ATGAAGCAAG CACAATAGCT GAAATAATAG AGGAATGTGG AGGTTTGGAG 
AAAATTGAAG TTTTACAGCA ACATGAAAAT GAAGACATAT ATAAATTAGC ATTTGAAATC 
ATAGATCAGT ATTTCTCTGG TGATGATATT GATGAAGATC CCTGCCTCAT TCCTGAAGCA 
ACACAAGGAG GTACCTACAA TTTTGATCCA ACAGCCAACC TTCAAACAAA AGAATTTAAT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA3 ( XM_017020561.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876050.1 Homo sapiens karyopherin subunit alpha 3 (KPNA3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu84533
Clone ID Related Accession (Same CDS sequence)	XM_017020561.1
Accession Version	XM_017020561.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	importin subunit alpha-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGAAGAC ATAGAAATGA AGTGACAGTG GAACTGCGGA AGAACAAAAG AGATGAACAC 
TTATTGAAAA AGAGAAATGT TCCCCAAGAA GAAAGTCTAG AAGATTCAGA TGTTGATGCT 
GATTTTAAAG CACAAAATGT AACCCTAGAA GCTATATTGC AGAATGCCAC AAGTGATAAC 
CCAGTGGTCC AATTGAGTGC TGTCCAGGCA GCAAGAAAAC TGTTATCCAG TGACAGAAAT 
CCACCGATTG ATGACTTAAT AAAATCTGGG ATTTTACCAA TTCTAGTCAA ATGTCTAGAA 
AGGGATGATA ATCCTTCATT ACAGTTTGAA GCTGCTTGGG CATTAACTAA CATAGCATCA 
GGAACTTCTG CACAGACTCA AGCTGTTGTG CAGTCTAATG CAGTACCTCT TTTTCTGAGA 
CTTCTTCGTT CACCACATCA GAATGTTTGT GAACAAGCAG TATGGGCTTT GGGAAACATT 
ATAGGTGATG GTCCTCAATG TAGAGATTAT GTCATATCAC TGGGAGTTGT CAAACCTCTT 
CTGTCCTTCA TCAGTCCCTC CATCCCCATC ACCTTCCTTC GGAACGTCAC ATGGGTCATT 
GTCAATCTCT GCAGGAATAA GGATCCCCCG CCGCCTATGG AGACAGTTCA GGAGATTTTG 
CCAGCTTTAT GTGTCCTCAT ATACCATACA GATATAAACA TTCTTGTAGA CACTGTTTGG 
GCTCTGTCAT ACTTGACAGA TGGAGGTAAT GAACAGATAC AGATGGTTAT TGATTCAGGA 
GTTGTGCCCT TTCTTGTGCC CCTTCTGAGC CATCAGGAAG TCAAAGTTCA AACAGCAGCC 
CTCAGAGCAG TTGGCAACAT AGTGACTGGC ACCGACGAGC AGACCCAGGT TGTTCTCAAT 
TGTGATGTCC TGTCACACTT CCCAAATCTC TTATCACACC CAAAAGAGAA GATAAATAAG 
GAAGCAGTGT GGTTCCTTTC CAACATAACA GCAGGCAACC AGCAACAAGT TCAAGCTGTA 
ATAGATGCTG GATTAATTCC TATGATAATT CATCAGCTTG CTAAGGGGGA CTTTGGAACA 
CAAAAAGAAG CTGCTTGGGC AATCAGCAAC TTAACAATAA GTGGCAGAAA AGATCAGGTT 
GAGTACCTTG TACAGCAGAA TGTAATACCA CCGTTCTGTA ATTTACTGTC AGTGAAAGAT 
TCTCAAGTGG TTCAGGTGGT TCTAGATGGT CTAAAAAACA TTCTGATAAT GGCCGGTGAT 
GAAGCAAGCA CAATAGCTGA AATAATAGAG GAATGTGGAG GTTTGGAGAA AATTGAAGTT 
TTACAGCAAC ATGAAAATGA AGACATATAT AAATTAGCAT TTGAAATCAT AGATCAGTAT 
TTCTCTGGTG ATGATATTGA TGAAGATCCC TGCCTCATTC CTGAAGCAAC ACAAGGAGGT 
ACCTACAATT TTGATCCAAC AGCCAACCTT CAAACAAAAG AATTTAATTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876050.1
CDS	171..1664
Translation	MRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF

Target ORF information:

RefSeq Version	XM_017020561.1
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 3 (KPNA3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020561.1

ORF Insert Sequence:

ATGCGAAGAC ATAGAAATGA AGTGACAGTG GAACTGCGGA AGAACAAAAG AGATGAACAC 
TTATTGAAAA AGAGAAATGT TCCCCAAGAA GAAAGTCTAG AAGATTCAGA TGTTGATGCT 
GATTTTAAAG CACAAAATGT AACCCTAGAA GCTATATTGC AGAATGCCAC AAGTGATAAC 
CCAGTGGTCC AATTGAGTGC TGTCCAGGCA GCAAGAAAAC TGTTATCCAG TGACAGAAAT 
CCACCGATTG ATGACTTAAT AAAATCTGGG ATTTTACCAA TTCTAGTCAA ATGTCTAGAA 
AGGGATGATA ATCCTTCATT ACAGTTTGAA GCTGCTTGGG CATTAACTAA CATAGCATCA 
GGAACTTCTG CACAGACTCA AGCTGTTGTG CAGTCTAATG CAGTACCTCT TTTTCTGAGA 
CTTCTTCGTT CACCACATCA GAATGTTTGT GAACAAGCAG TATGGGCTTT GGGAAACATT 
ATAGGTGATG GTCCTCAATG TAGAGATTAT GTCATATCAC TGGGAGTTGT CAAACCTCTT 
CTGTCCTTCA TCAGTCCCTC CATCCCCATC ACCTTCCTTC GGAACGTCAC ATGGGTCATT 
GTCAATCTCT GCAGGAATAA GGATCCCCCG CCGCCTATGG AGACAGTTCA GGAGATTTTG 
CCAGCTTTAT GTGTCCTCAT ATACCATACA GATATAAACA TTCTTGTAGA CACTGTTTGG 
GCTCTGTCAT ACTTGACAGA TGGAGGTAAT GAACAGATAC AGATGGTTAT TGATTCAGGA 
GTTGTGCCCT TTCTTGTGCC CCTTCTGAGC CATCAGGAAG TCAAAGTTCA AACAGCAGCC 
CTCAGAGCAG TTGGCAACAT AGTGACTGGC ACCGACGAGC AGACCCAGGT TGTTCTCAAT 
TGTGATGTCC TGTCACACTT CCCAAATCTC TTATCACACC CAAAAGAGAA GATAAATAAG 
GAAGCAGTGT GGTTCCTTTC CAACATAACA GCAGGCAACC AGCAACAAGT TCAAGCTGTA 
ATAGATGCTG GATTAATTCC TATGATAATT CATCAGCTTG CTAAGGGGGA CTTTGGAACA 
CAAAAAGAAG CTGCTTGGGC AATCAGCAAC TTAACAATAA GTGGCAGAAA AGATCAGGTT 
GAGTACCTTG TACAGCAGAA TGTAATACCA CCGTTCTGTA ATTTACTGTC AGTGAAAGAT 
TCTCAAGTGG TTCAGGTGGT TCTAGATGGT CTAAAAAACA TTCTGATAAT GGCCGGTGAT 
GAAGCAAGCA CAATAGCTGA AATAATAGAG GAATGTGGAG GTTTGGAGAA AATTGAAGTT 
TTACAGCAAC ATGAAAATGA AGACATATAT AAATTAGCAT TTGAAATCAT AGATCAGTAT 
TTCTCTGGTG ATGATATTGA TGAAGATCCC TGCCTCATTC CTGAAGCAAC ACAAGGAGGT 
ACCTACAATT TTGATCCAAC AGCCAACCTT CAAACAAAAG AATTTAATTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
Journal of virology91(8)(2017 Apr)
Ye J,Chen Z,Li Y,Zhao Z,He W,Zohaib A,Song Y,Deng C,Zhang B,Chen H,Cao S

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

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KPNA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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