KPNA2 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KPNA2
Entrez Gene ID	3838
Full Name	karyopherin subunit alpha 2
Synonyms	IPOA1,QIP2,RCH1,SRP1-alpha,SRP1alpha
General protein information	Preferred Names karyopherin subunit alpha 2 Names importin subunit alpha-1 RAG cohort protein 1 importin subunit alpha-2 importin-alpha-P1 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) pendulin
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 17 Map Location: 17q24.2
Summary	The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	600685

mRNA and Protein(s)

mRNA	Protein	Name
NM_001320611.1	NP_001307540.1	importin subunit alpha-1
NM_002266.2	NP_002257.1	importin subunit alpha-1
NM_002266.4	NP_002257.1	importin subunit alpha-1
NM_002266.3	NP_002257.1	importin subunit alpha-1
XM_011524783.1	XP_011523085.1	importin subunit alpha-1 isoform X1

Pathways from BioSystems

Homologies

	KPNA2	XP_002800621.1
Canis lupus familiaris (dog)	KPNA2	XP_861990.1
Mus musculus (house mouse)	Kpna2	NP_034785.1
Rattus norvegicus (Norway rat)	Kpna2	NP_001257731.1
Drosophila melanogaster (fruit fly)	Pen	NP_477041.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009792	XP_318886.3
Xenopus tropicalis (tropical clawed frog)	kpna2	NP_001008155.1
Pan troglodytes (chimpanzee)	KPNA2	XP_003315744.1
Rattus norvegicus (Norway rat)	LOC100359600	XP_002729642.1
Gallus gallus (chicken)	KPNA2	NP_001006209.1
Bos taurus (cattle)	KPNA2	NP_001029621.1
Danio rerio (zebrafish)	kpna2	NP_001002335.1
Homo sapiens (human)	KPNA2	NP_002257.1

Gene Ontology
Bibliography

Related articles in PubMed

Karyopherin ?-2 is a reliable marker for identification of patients with high-risk stage II colorectal cancer.
Jeong D, Kim H, Ban S, Oh S, Ji S, Kim D, Ahn TS, Kim HJ, Bae SB, Kwon HY, Im J, Lee MS, Cho HD, Kim CJ, Baek MJ
Journal of cancer research and clinical oncology143(12)2493-2503(2017 Dec)

Classical nuclear localization signals: definition, function, and interaction with importin alpha.
Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH
The Journal of biological chemistry282(8)5101-5(2007 Feb)

Importin KPNA2, NBS1, DNA repair and tumorigenesis.
Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L
Journal of molecular histology37(5-7)293-9(2006 Sep)

Genomic structure of karyopherin alpha2 ( KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome.
D?rr SN, Schlicker MN, Hansmann IN
Human genetics109(5)479-86(2001 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KPNA2 was associated with tumorigenesis and cancer progression in CRC cells; high KPNA2 expression was associated with increased cell proliferation, migration, invasion, and semisolid agar colony formation.
Title: Karyopherin ?-2 is a reliable marker for identification of patients with high-risk stage II colorectal cancer.

High serum karyopherin alpha 2 levels (>485 microg/mL) correlated with International Federation of Gynecology and Obstetrics stage ( p < 0.0001), lymphatic metastasis ( p = 0.045), overall survival ( p = 0.001), and disease-free progression ( p = 0.006). Serum karyopherin alpha 2 represents a potential diagnostic biomarker for epithelial ovarian carcinoma.
Title: KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis.

the crystal structure of the nuclear import adaptor importin-alpha1 bound to the nuclear localization signal (NLS) of EBNA-LP that shows EBNA-LP residues 44-RRVRRR-49 binding to the major NLS-binding site at the P0-P5 positions.
Title: Crystal structure of importin-? bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein.

The authors identified Importin-alpha1 to bind to Coxiella burnetii AnkG and concluded that binding of AnkG to p32 and Importin-alpha1 is essential for its migration into the nucleus.
Title: Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-?1.

that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities.
Title: Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha.

The following KPNA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KPNA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09638	NM_002266.4 Latest version!	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09638	NM_001320611.1 Latest version!	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09638	XM_011524783.1 Latest version!	Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09638	NM_002266.2	Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09638	NM_002266.3	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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Reference Sequences (Refseq)

KPNA2 ( NM_001320611.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001307540.1 Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09638
Clone ID Related Accession (Same CDS sequence)	NM_001320611.1 , NM_002266.2 , NM_002266.4 , NM_002266.3 , XM_011524783.1
Accession Version	NM_001320611.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	importin subunit alpha-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA636948.1, AC134407.6, BC067848.1, BC005978.1 and AA744568.1. On Mar 2, 2016 this sequence version replaced XM_011524783.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.122045.1, BC067848.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307540.1
CDS	621..2210
Translation	MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Target ORF information:

RefSeq Version	NM_001320611.1
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320611.1

ORF Insert Sequence:

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA2 ( NM_002266.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_002257.1 Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), mRNA.

Price & Availability↑

CloneID	OHu09638
Clone ID Related Accession (Same CDS sequence)	NM_001320611.1 , NM_002266.2 , NM_002266.4 , NM_002266.3 , XM_011524783.1
Accession Version	NM_002266.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	importin subunit alpha-1
Comment

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_002257.1

Translation

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Target ORF information:

RefSeq Version	NM_002266.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002266.2

ORF Insert Sequence:

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA2 ( NM_002266.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_002257.1 Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09638
Clone ID Related Accession (Same CDS sequence)	NM_001320611.1 , NM_002266.2 , NM_002266.4 , NM_002266.3 , XM_011524783.1
Accession Version	NM_002266.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Homo sapiens(human)
Product	importin subunit alpha-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U28386.1, AK024833.1 and AA744568.1. On Nov 23, 2018 this sequence version replaced NM_002266.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.868028.1, SRR5189652.250986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330459.8/ ENSP00000332455.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002257.1
CDS	130..1719
Translation	MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Target ORF information:

RefSeq Version	NM_002266.4
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002266.4

ORF Insert Sequence:

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA2 ( NM_002266.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_002257.1 Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.

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CloneID	OHu09638
Clone ID Related Accession (Same CDS sequence)	NM_001320611.1 , NM_002266.2 , NM_002266.4 , NM_002266.3 , XM_011524783.1
Accession Version	NM_002266.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	importin subunit alpha-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC134407.6, DC388846.1, U28386.1, AK024833.1 and AA744568.1. On Mar 2, 2016 this sequence version replaced NM_002266.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.286197.1, SRR1803616.141063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002257.1
CDS	263..1852
Translation	MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Target ORF information:

RefSeq Version	NM_002266.3
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002266.3

ORF Insert Sequence:

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA2 ( XM_011524783.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011523085.1 Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), transcript variant X1, mRNA.

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CloneID	OHu09638
Clone ID Related Accession (Same CDS sequence)	NM_001320611.1 , NM_002266.2 , NM_002266.4 , NM_002266.3 , XM_011524783.1
Accession Version	XM_011524783.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	importin subunit alpha-1 isoform X1
Comment

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011523085.1

Translation

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Target ORF information:

RefSeq Version	XM_011524783.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524783.1

ORF Insert Sequence:

ATGTCCACCA ACGAGAATGC TAATACACCA GCTGCCCGTC TTCACAGATT CAAGAACAAG 
GGAAAAGACA GTACAGAAAT GAGGCGTCGC AGAATAGAGG TCAATGTGGA GCTGAGGAAA 
GCTAAGAAGG ATGACCAGAT GCTGAAGAGG AGAAATGTAA GCTCATTTCC TGATGATGCT 
ACTTCTCCGC TGCAGGAAAA CCGCAACAAC CAGGGCACTG TAAATTGGTC TGTTGATGAC 
ATTGTCAAAG GCATAAATAG CAGCAATGTG GAAAATCAGC TCCAAGCTAC TCAAGCTGCC 
AGGAAACTAC TTTCCAGAGA AAAACAGCCC CCCATAGACA ACATAATCCG GGCTGGTTTG 
ATTCCGAAAT TTGTGTCCTT CTTGGGCAGA ACTGATTGTA GTCCCATTCA GTTTGAATCT 
GCTTGGGCAC TCACTAACAT TGCTTCTGGG ACATCAGAAC AAACCAAGGC TGTGGTAGAT 
GGAGGTGCCA TCCCAGCATT CATTTCTCTG TTGGCATCTC CCCATGCTCA CATCAGTGAA 
CAAGCTGTCT GGGCTCTAGG AAACATTGCA GGTGATGGCT CAGTGTTCCG AGACTTGGTT 
ATTAAGTACG GTGCAGTTGA CCCACTGTTG GCTCTCCTTG CAGTTCCTGA TATGTCATCT 
TTAGCATGTG GCTACTTACG TAATCTTACC TGGACACTTT CTAATCTTTG CCGCAACAAG 
AATCCTGCAC CCCCGATAGA TGCTGTTGAG CAGATTCTTC CTACCTTAGT TCGGCTCCTG 
CATCATGATG ATCCAGAAGT ATTAGCAGAT ACCTGCTGGG CTATTTCCTA CCTTACTGAT 
GGTCCAAATG AACGAATTGG CATGGTGGTG AAAACAGGAG TTGTGCCCCA ACTTGTGAAG 
CTTCTAGGAG CTTCTGAATT GCCAATTGTG ACTCCTGCCC TAAGAGCCAT AGGGAATATT 
GTCACTGGTA CAGATGAACA GACTCAGGTT GTGATTGATG CAGGAGCACT CGCCGTCTTT 
CCCAGCCTGC TCACCAACCC CAAAACTAAC ATTCAGAAGG AAGCTACGTG GACAATGTCA 
AACATCACAG CCGGCCGCCA GGACCAGATA CAGCAAGTTG TGAATCATGG ATTAGTCCCA 
TTCCTTGTCA GTGTTCTCTC TAAGGCAGAT TTTAAGACAC AAAAGGAAGC TGTGTGGGCC 
GTGACCAACT ATACCAGTGG TGGAACAGTT GAACAGATTG TGTACCTTGT TCACTGTGGC 
ATAATAGAAC CGTTGATGAA CCTCTTAACT GCAAAAGATA CCAAGATTAT TCTGGTTATC 
CTGGATGCCA TTTCAAATAT CTTTCAGGCT GCTGAGAAAC TAGGTGAAAC TGAGAAACTT 
AGTATAATGA TTGAAGAATG TGGAGGCTTA GACAAAATTG AAGCTCTACA AAACCATGAA 
AATGAGTCTG TGTATAAGGC TTCGTTAAGC TTAATTGAGA AGTATTTCTC TGTAGAGGAA 
GAGGAAGATC AAAACGTTGT ACCAGAAACT ACCTCTGAAG GCTACACTTT CCAAGTTCAG 
GATGGGGCTC CTGGGACCTT TAACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Karyopherin ?-2 is a reliable marker for identification of patients with high-risk stage II colorectal cancer.
Journal of cancer research and clinical oncology143(12)2493-2503(2017 Dec)
Jeong D,Kim H,Ban S,Oh S,Ji S,Kim D,Ahn TS,Kim HJ,Bae SB,Kwon HY,Im J,Lee MS,Cho HD,Kim CJ,Baek MJ

Classical nuclear localization signals: definition, function, and interaction with importin alpha.
The Journal of biological chemistry282(8)5101-5(2007 Feb)
Lange A,Mills RE,Lange CJ,Stewart M,Devine SE,Corbett AH

Importin KPNA2, NBS1, DNA repair and tumorigenesis.
Journal of molecular histology37(5-7)293-9(2006 Sep)
Teng SC,Wu KJ,Tseng SF,Wong CW,Kao L

Genomic structure of karyopherin alpha2 ( KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome.
Human genetics109(5)479-86(2001 Nov)
D?rr SN,Schlicker MN,Hansmann IN

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KPNA2 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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