KCNS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNS1
Entrez Gene ID	3787
Full Name	potassium voltage-gated channel modifier subfamily S member 1
Synonyms	Kv9.1
General protein information	Preferred Names potassium voltage-gated channel modifier subfamily S member 1 Names potassium voltage-gated channel subfamily S member 1 delayed-rectifier K(+) channel alpha subunit 1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 voltage-gated potassium channel subunit Kv9.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008].
Disorder MIM:	602905

mRNA and Protein(s)

mRNA	Protein	Name
NM_002251.5	NP_002242.2	potassium voltage-gated channel subfamily S member 1
NM_002251.4	NP_002242.2	potassium voltage-gated channel subfamily S member 1
XM_017027846.1	XP_016883335.1	potassium voltage-gated channel subfamily S member 1 isoform X1
NM_001322799.1	NP_001309728.1	potassium voltage-gated channel subfamily S member 1
NM_001322799.2	NP_001309728.1	potassium voltage-gated channel subfamily S member 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNS1	XP_543013.2
Mus musculus (house mouse)	Kcns1	NP_032461.2
Xenopus tropicalis (tropical clawed frog)	kcns1	XP_002938059.2
Danio rerio (zebrafish)	si:dkey-43k4.5	XP_001922193.1
	KCNS1	NP_001162097.1
Rattus norvegicus (Norway rat)	Kcns1	NP_446406.1
Bos taurus (cattle)	KCNS1	NP_001192813.1
Gallus gallus (chicken)	KCNS1	XP_004947085.1
Homo sapiens (human)	KCNS1	NP_002242.2
Pan troglodytes (chimpanzee)	KCNS1	NP_001129322.1

Gene Ontology
Bibliography

Related articles in PubMed

Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.
Langford DJ, West C, Elboim C, Cooper BA, Abrams G, Paul SM, Schmidt BL, Levine JD, Merriman JD, Dhruva A, Neuhaus J, Leutwyler H, Baggott C, Sullivan CW, Aouizerat BE, Miaskowski C
Journal of neurogenetics28(1-2)122-35(2014 Mar-Jun)

Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes.
George SZ, Parr JJ, Wallace MR, Wu SS, Borsa PA, Dai Y, Fillingim RB
The journal of pain : official journal of the American Pain Society15(1)68-80(2014 Jan)

KCNS1, but not GCH1, is associated with pain intensity in a black southern African population with HIV-associated sensory neuropathy: a genetic association study.
Hendry L, Lombard Z, Wadley A, Kamerman P
Journal of acquired immune deficiency syndromes (1999)63(1)27-30(2013 May)

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe JR
Journal of affective disorders145(2)200-7(2013 Feb)

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, M?nnikk? M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ
Brain : a journal of neurology133(9)2519-27(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

For KCNS1 rs4499491, individuals homozygous for the rare A allele (CC+ CA versus AA) had a 3.0-fold increase in the odds of reporting preoperative breast pain.
Title: Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.

There was moderate statistical evidence for interactions shoulder pain phenotypes between KCNS1 and depressive symptoms, pain catastrophizing, or kinesiophobia
Title: Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes.

Several haplotypes of population-specific tagSNPs correlated with pain intensity in black southern African population with HIV-associated sensory neuropathy.
Title: KCNS1, but not GCH1, is associated with pain intensity in a black southern African population with HIV-associated sensory neuropathy: a genetic association study.

Thia study presented the KCNS1 allele rs734784 as one of the first prognostic indicators of chronic pain risk.
Title: Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.

The following KCNS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03008	NM_002251.5 Latest version!	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03008	NM_001322799.2 Latest version!	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu93026	XM_017027846.1 Latest version!	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu03008	NM_002251.4	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03008	NM_001322799.1	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNS1 ( NM_002251.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002242.2 Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03008
Clone ID Related Accession (Same CDS sequence)	NM_002251.5 , NM_002251.4 , NM_001322799.1 , NM_001322799.2
Accession Version	NM_002251.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily S member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93016.2, AF043473.2 and CA449742.1. On May 31, 2019 this sequence version replaced NM_002251.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF043473.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002242.2
CDS	413..1993
Translation	MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Target ORF information:

RefSeq Version	NM_002251.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002251.5

ORF Insert Sequence:

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNS1 ( NM_002251.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002242.2 Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03008
Clone ID Related Accession (Same CDS sequence)	NM_002251.5 , NM_002251.4 , NM_001322799.1 , NM_001322799.2
Accession Version	NM_002251.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-21
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily S member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93016.2, AF043473.2 and CA449742.1. On Apr 13, 2016 this sequence version replaced NM_002251.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF043473.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002242.2
CDS	398..1978
Translation	MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Target ORF information:

RefSeq Version	NM_002251.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002251.4

ORF Insert Sequence:

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNS1 ( NM_001322799.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309728.1 Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03008
Clone ID Related Accession (Same CDS sequence)	NM_002251.5 , NM_002251.4 , NM_001322799.1 , NM_001322799.2
Accession Version	NM_001322799.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily S member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93016.2, AK289735.1 and CA449742.1. On Apr 13, 2016 this sequence version replaced XM_005260409.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC132957.1, AK289735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309728.1
CDS	196..1776
Translation	MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Target ORF information:

RefSeq Version	NM_001322799.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322799.1

ORF Insert Sequence:

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNS1 ( NM_001322799.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309728.1 Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.

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CloneID	OHu03008
Clone ID Related Accession (Same CDS sequence)	NM_002251.5 , NM_002251.4 , NM_001322799.1 , NM_001322799.2
Accession Version	NM_001322799.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily S member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93016.2, AK289735.1 and CA449742.1. On Nov 23, 2018 this sequence version replaced NM_001322799.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC132957.1, AK289735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000537075.3/ ENSP00000445595.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309728.1
CDS	211..1791
Translation	MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Target ORF information:

RefSeq Version	NM_001322799.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322799.2

ORF Insert Sequence:

ATGCTGATGC TGCTGGTCCG GGGAACACAC TATGAGAACC TCCGGTCTAA AGTGGTGCTG 
CCAACACCCC TAGGAGGGAG GAGCACTGAA ACCTTTGTGA GCGAGTTCCC GGGCCCCGAC 
ACCGGGATCC GCTGGCGGCG AAGCGACGAG GCGCTGCGCG TGAACGTGGG TGGCGTGCGG 
CGGCAGCTGA GCGCGCGCGC CCTGGCGCGC TTCCCGGGCA CGCGGCTGGG CCGCCTGCAG 
GCCGCGGCGT CGGAGGAGCA GGCGCGGCGC CTGTGCGACG ACTACGACGA GGCGGCGCGC 
GAATTCTACT TCGACCGGCA CCCGGGCTTC TTCCTGAGCC TGCTGCACTT CTACCGCACT 
GGCCACCTGC ACGTGCTCGA CGAGCTGTGC GTCTTCGCCT TTGGCCAGGA GGCCGACTAC 
TGGGGCCTAG GCGAGAACGC GCTTGCCGCG TGCTGCCGCG CGCGCTACCT GGAGAGGCGG 
CTGACCCAGC CGCACGCCTG GGACGAGGAC AGCGACACGC CGAGCAGCGT GGACCCGTGC 
CCCGACGAGA TCTCCGACGT GCAGCGAGAA CTGGCGCGCT ATGGCGCGGC GCGCTGTGGC 
CGCCTGCGCC GCCGCCTCTG GCTGACCATG GAGAACCCGG GCTACTCGCT GCCGAGCAAG 
CTCTTCAGCT GCGTCTCCAT CAGCGTGGTG CTCGCCTCCA TCGCCGCCAT GTGCATCCAC 
AGCCTGCCCG AGTACCAGGC CCGCGAGGCG GCGGCCGCCG TGGCTGCGGT GGCCGCGGGC 
CGCAGCCCGG AAGGCGTGCG CGACGACCCG GTGCTGCGAC GCCTCGAGTA CTTCTGCATC 
GCCTGGTTCA GCTTCGAGGT GTCGTCGCGC CTCCTGCTGG CGCCCAGTAC GCGCAACTTC 
TTCTGCCACC CGCTCAACCT CATCGACATT GTGTCTGTGC TGCCCTTCTA TCTCACGCTG 
CTGGCTGGTG TGGCACTGGG CGACCAGGGC GGCAAGGAGT TCGGCCACCT GGGCAAGGTG 
GTGCAGGTGT TCCGCCTCAT GCGCATCTTC CGCGTACTCA AGTTGGCGCG CCATTCCACC 
GGGCTGCGCT CGCTGGGAGC CACGCTCAAG CACAGCTACC GTGAGGTGGG CATCTTGCTG 
CTGTACCTGG CTGTGGGTGT GTCAGTGTTC TCTGGTGTGG CCTACACAGC TGAAAAGGAG 
GAGGACGTGG GCTTTAACAC CATCCCAGCC TGCTGGTGGT GGGGCACAGT GAGCATGACC 
ACCGTGGGCT ATGGGGATGT GGTGCCAGTG ACGGTGGCTG GCAAGCTGGC AGCCTCAGGC 
TGCATCCTAG GGGGCATCCT GGTGGTAGCA CTCCCCATCA CCATCATCTT CAACAAGTTC 
TCCCACTTCT ACCGGCGCCA GAAGGCTCTG GAGGCAGCCG TGCGCAACAG CAACCACCAA 
GAGTTTGAGG ACTTGCTGAG CAGCATTGAT GGGGTGTCGG AGGCATCTCT GGAGACATCC 
CGAGAAACCT CTCAGGAGGG ACAGTCTGCA GATCTAGAGA GCCAGGCCCC CAGTGAGCCT 
CCACACCCTC AGATGTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNS1 ( XM_017027846.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883335.1 Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu93026
Clone ID Related Accession (Same CDS sequence)	XM_017027846.1
Accession Version	XM_017027846.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily S member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGAGG GGATTTTAAC CTGGTCTTCC AGGAAGGGAA GCCCGGGAAC TCCTCAGCGC 
GCCCTTCTGG TGTCCGCAGG GAGGAGCACT GAAACCTTTG TGAGCGAGTT CCCGGGCCCC 
GACACCGGGA TCCGCTGGCG GCGAAGCGAC GAGGCGCTGC GCGTGAACGT GGGTGGCGTG 
CGGCGGCAGC TGAGCGCGCG CGCCCTGGCG CGCTTCCCGG GCACGCGGCT GGGCCGCCTG 
CAGGCCGCGG CGTCGGAGGA GCAGGCGCGG CGCCTGTGCG ACGACTACGA CGAGGCGGCG 
CGCGAATTCT ACTTCGACCG GCACCCGGGC TTCTTCCTGA GCCTGCTGCA CTTCTACCGC 
ACTGGCCACC TGCACGTGCT CGACGAGCTG TGCGTCTTCG CCTTTGGCCA GGAGGCCGAC 
TACTGGGGCC TAGGCGAGAA CGCGCTTGCC GCGTGCTGCC GCGCGCGCTA CCTGGAGAGG 
CGGCTGACCC AGCCGCACGC CTGGGACGAG GACAGCGACA CGCCGAGCAG CGTGGACCCG 
TGCCCCGACG AGATCTCCGA CGTGCAGCGA GAACTGGCGC GCTATGGCGC GGCGCGCTGT 
GGCCGCCTGC GCCGCCGCCT CTGGCTGACC ATGGAGAACC CGGGCTACTC GCTGCCGAGC 
AAGCTCTTCA GCTGCGTCTC CATCAGCGTG GTGCTCGCCT CCATCGCCGC CATGTGCATC 
CACAGCCTGC CCGAGTACCA GGCCCGCGAG GCGGCGGCCG CCGTGGCTGC GGTGGCCGCG 
GGCCGCAGCC CGGAAGGCGT GCGCGACGAC CCGGTGCTGC GACGCCTCGA GTACTTCTGC 
ATCGCCTGGT TCAGCTTCGA GGTGTCGTCG CGCCTCCTGC TGGCGCCCAG TACGCGCAAC 
TTCTTCTGCC ACCCGCTCAA CCTCATCGAC ATTGTGTCTG TGCTGCCCTT CTATCTCACG 
CTGCTGGCTG GTGTGGCACT GGGCGACCAG GGCGGCAAGG AGTTCGGCCA CCTGGGCAAG 
GTGGTGCAGG TGTTCCGCCT CATGCGCATC TTCCGCGTAC TCAAGTTGGC GCGCCATTCC 
ACCGGGCTGC GCTCGCTGGG AGCCACGCTC AAGCACAGCT ACCGTGAGGT GGGCATCTTG 
CTGCTGTACC TGGCTGTGGG TGTGTCAGTG TTCTCTGGTG TGGCCTACAC AGCTGAAAAG 
GAGGAGGACG TGGGCTTTAA CACCATCCCA GCCTGCTGGT GGTGGGGCAC AGTGAGCATG 
ACCACCGTGG GCTATGGGGA TGTGGTGCCA GTGACGGTGG CTGGCAAGCT GGCAGCCTCA 
GGCTGCATCC TAGGGGGCAT CCTGGTGGTA GCACTCCCCA TCACCATCAT CTTCAACAAG 
TTCTCCCACT TCTACCGGCG CCAGAAGGCT CTGGAGGCAG CCGTGCGCAA CAGCAACCAC 
CAAGAGTTTG AGGACTTGCT GAGCAGCATT GATGGGGTGT CGGAGGCATC TCTGGAGACA 
TCCCGAGAAA CCTCTCAGGA GGGACAGTCT GCAGATCTAG AGAGCCAGGC CCCCAGTGAG 
CCTCCACACC CTCAGATGTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883335.1
CDS	934..2517
Translation	MEEGILTWSSRKGSPGTPQRALLVSAGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Target ORF information:

RefSeq Version	XM_017027846.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027846.1

ORF Insert Sequence:

ATGGAGGAGG GGATTTTAAC CTGGTCTTCC AGGAAGGGAA GCCCGGGAAC TCCTCAGCGC 
GCCCTTCTGG TGTCCGCAGG GAGGAGCACT GAAACCTTTG TGAGCGAGTT CCCGGGCCCC 
GACACCGGGA TCCGCTGGCG GCGAAGCGAC GAGGCGCTGC GCGTGAACGT GGGTGGCGTG 
CGGCGGCAGC TGAGCGCGCG CGCCCTGGCG CGCTTCCCGG GCACGCGGCT GGGCCGCCTG 
CAGGCCGCGG CGTCGGAGGA GCAGGCGCGG CGCCTGTGCG ACGACTACGA CGAGGCGGCG 
CGCGAATTCT ACTTCGACCG GCACCCGGGC TTCTTCCTGA GCCTGCTGCA CTTCTACCGC 
ACTGGCCACC TGCACGTGCT CGACGAGCTG TGCGTCTTCG CCTTTGGCCA GGAGGCCGAC 
TACTGGGGCC TAGGCGAGAA CGCGCTTGCC GCGTGCTGCC GCGCGCGCTA CCTGGAGAGG 
CGGCTGACCC AGCCGCACGC CTGGGACGAG GACAGCGACA CGCCGAGCAG CGTGGACCCG 
TGCCCCGACG AGATCTCCGA CGTGCAGCGA GAACTGGCGC GCTATGGCGC GGCGCGCTGT 
GGCCGCCTGC GCCGCCGCCT CTGGCTGACC ATGGAGAACC CGGGCTACTC GCTGCCGAGC 
AAGCTCTTCA GCTGCGTCTC CATCAGCGTG GTGCTCGCCT CCATCGCCGC CATGTGCATC 
CACAGCCTGC CCGAGTACCA GGCCCGCGAG GCGGCGGCCG CCGTGGCTGC GGTGGCCGCG 
GGCCGCAGCC CGGAAGGCGT GCGCGACGAC CCGGTGCTGC GACGCCTCGA GTACTTCTGC 
ATCGCCTGGT TCAGCTTCGA GGTGTCGTCG CGCCTCCTGC TGGCGCCCAG TACGCGCAAC 
TTCTTCTGCC ACCCGCTCAA CCTCATCGAC ATTGTGTCTG TGCTGCCCTT CTATCTCACG 
CTGCTGGCTG GTGTGGCACT GGGCGACCAG GGCGGCAAGG AGTTCGGCCA CCTGGGCAAG 
GTGGTGCAGG TGTTCCGCCT CATGCGCATC TTCCGCGTAC TCAAGTTGGC GCGCCATTCC 
ACCGGGCTGC GCTCGCTGGG AGCCACGCTC AAGCACAGCT ACCGTGAGGT GGGCATCTTG 
CTGCTGTACC TGGCTGTGGG TGTGTCAGTG TTCTCTGGTG TGGCCTACAC AGCTGAAAAG 
GAGGAGGACG TGGGCTTTAA CACCATCCCA GCCTGCTGGT GGTGGGGCAC AGTGAGCATG 
ACCACCGTGG GCTATGGGGA TGTGGTGCCA GTGACGGTGG CTGGCAAGCT GGCAGCCTCA 
GGCTGCATCC TAGGGGGCAT CCTGGTGGTA GCACTCCCCA TCACCATCAT CTTCAACAAG 
TTCTCCCACT TCTACCGGCG CCAGAAGGCT CTGGAGGCAG CCGTGCGCAA CAGCAACCAC 
CAAGAGTTTG AGGACTTGCT GAGCAGCATT GATGGGGTGT CGGAGGCATC TCTGGAGACA 
TCCCGAGAAA CCTCTCAGGA GGGACAGTCT GCAGATCTAG AGAGCCAGGC CCCCAGTGAG 
CCTCCACACC CTCAGATGTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.
Journal of neurogenetics28(1-2)122-35(2014 Mar-Jun)
Langford DJ,West C,Elboim C,Cooper BA,Abrams G,Paul SM,Schmidt BL,Levine JD,Merriman JD,Dhruva A,Neuhaus J,Leutwyler H,Baggott C,Sullivan CW,Aouizerat BE,Miaskowski C

Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes.
The journal of pain : official journal of the American Pain Society15(1)68-80(2014 Jan)
George SZ,Parr JJ,Wallace MR,Wu SS,Borsa PA,Dai Y,Fillingim RB

KCNS1, but not GCH1, is associated with pain intensity in a black southern African population with HIV-associated sensory neuropathy: a genetic association study.
Journal of acquired immune deficiency syndromes (1999)63(1)27-30(2013 May)
Hendry L,Lombard Z,Wadley A,Kamerman P

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
Journal of affective disorders145(2)200-7(2013 Feb)
Lee HJ,Woo HG,Greenwood TA,Kripke DF,Kelsoe JR

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
Brain : a journal of neurology133(9)2519-27(2010 Sep)
Costigan M,Belfer I,Griffin RS,Dai F,Barrett LB,Coppola G,Wu T,Kiselycznyk C,Poddar M,Lu Y,Diatchenko L,Smith S,Cobos EJ,Zaykin D,Allchorne A,Gershon E,Livneh J,Shen PH,Nikolajsen L,Karppinen J,M?nnikk? M,Kelempisioti A,Goldman D,Maixner W,Geschwind DH,Max MB,Seltzer Z,Woolf CJ

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KCNS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

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