KCNJ6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNJ6
Entrez Gene ID	3763
Full Name	potassium voltage-gated channel subfamily J member 6
Synonyms	BIR1,GIRK-2,GIRK2,KATP-2,KATP2,KCNJ7,KIR3.2,KPLBS,hiGIRK2
General protein information	Preferred Names potassium voltage-gated channel subfamily J member 6 Names G protein-activated inward rectifier potassium channel 2 inward rectifier K(+) channel Kir3.2 inward rectifier potassium channel KIR3.2 potassium channel, inwardly rectifying subfamily J, member 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.13
Summary	This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015].
Disorder MIM:	600877
Disorder Html:	Keppen-Lubinsky syndrome, 614098 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011529559.1	XP_011527861.1	G protein-activated inward rectifier potassium channel 2 isoform X1
XM_011529558.1	XP_011527860.1	G protein-activated inward rectifier potassium channel 2 isoform X1
NM_002240.4	NP_002231.1	G protein-activated inward rectifier potassium channel 2
NM_002240.5	NP_002231.1	G protein-activated inward rectifier potassium channel 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNJ6	XP_004934603.1
Mus musculus (house mouse)	Kcnj6	NP_034736.2
Homo sapiens (human)	KCNJ6	NP_002231.1
Rattus norvegicus (Norway rat)	Kcnj6	NP_037324.1
Danio rerio (zebrafish)	kcnj6	XP_697984.5
	KCNJ6	XP_001083031.1
Pan troglodytes (chimpanzee)	KCNJ6	XP_001170389.1
Canis lupus familiaris (dog)	KCNJ6	XP_544881.3
Bos taurus (cattle)	KCNJ6	XP_002685215.2
Xenopus tropicalis (tropical clawed frog)	kcnj9	NP_001096554.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic correlates of the development of theta event related oscillations?in adolescents and young adults.
Chorlian DB, Rangaswamy M, Manz N, Meyers JL, Kang SJ, Kamarajan C, Pandey AK, Wang JC, Wetherill L, Edenberg H, Porjesz B
International journal of psychophysiology : official journal of the International Organization of Psychophysiology11524-39(2017 May)

A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.
Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Edenberg HJ, Wetherill L, Schuckit M, Wang JC, Kuperman S, Kramer J, Tischfield JA, Porjesz B
International journal of psychophysiology : official journal of the International Organization of Psychophysiology11513-23(2017 May)

Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.
Masotti A, Uva P, Davis-Keppen L, Basel-Vanagaite L, Cohen L, Pisaneschi E, Celluzzi A, Bencivenga P, Fang M, Tian M, Xu X, Cappa M, Dallapiccola B
American journal of human genetics96(2)295-300(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta event related oscillations in adults.
Title: Genetic correlates of the development of theta event related oscillations?in adolescents and young adults.

The major findings of the current study are 1) an additive genotypic effect of the KCNJ6 SNP on the ERO theta power phenotype during reward processing, increasing significantly across genotypes.
Title: A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.

The KCNJ6 -1250A and COMT Val alleles are predisposing preterm newborns to diminished opioid-induced pain relief.
Title: Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation.

In this transgenic mouse model, GIRK2 plays a major role in the genesis of infantile spasms.
Title: The GIRK2 subunit is involved in IS-like seizures induced by GABA(B) receptor agonists.

Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.
Title: Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.

The following KCNJ6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNJ6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20323	NM_002240.5 Latest version!	Homo sapiens potassium inwardly rectifying channel subfamily J member 6 (KCNJ6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu20323	XM_011529559.1 Latest version!	Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu20323	XM_011529558.1 Latest version!	Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu20323	NM_002240.4	Homo sapiens potassium voltage-gated channel subfamily J member 6 (KCNJ6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNJ6 ( NM_002240.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002231.1 Homo sapiens potassium voltage-gated channel subfamily J member 6 (KCNJ6), mRNA.

Price & Availability↑

CloneID	OHu20323
Clone ID Related Accession (Same CDS sequence)	XM_011529559.1 , XM_011529558.1 , NM_002240.4 , NM_002240.5
Accession Version	NM_002240.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	G protein-activated inward rectifier potassium channel 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR000377.1, D87327.1, BC101547.1 and HY332424.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2015 this sequence version replaced NM_002240.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D87327.1, SRR1803613.209893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMN03465402 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002231.1
CDS	583..1854
Translation	MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

Target ORF information:

RefSeq Version	NM_002240.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily J member 6 (KCNJ6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002240.4

ORF Insert Sequence:

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNJ6 ( NM_002240.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002231.1 Homo sapiens potassium inwardly rectifying channel subfamily J member 6 (KCNJ6), mRNA.

Price & Availability↑

CloneID	OHu20323
Clone ID Related Accession (Same CDS sequence)	XM_011529559.1 , XM_011529558.1 , NM_002240.4 , NM_002240.5
Accession Version	NM_002240.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	G protein-activated inward rectifier potassium channel 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001427.1, DR000377.1, D87327.1, BC101547.1, HY332424.1, AP001407.1, AP001419.2 and KF457262.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002240.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.254086.1, SRR3476690.362903.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMN03465402 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000609713.2/ ENSP00000477437.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002231.1
CDS	602..1873
Translation	MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

Target ORF information:

RefSeq Version	NM_002240.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium inwardly rectifying channel subfamily J member 6 (KCNJ6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002240.5

ORF Insert Sequence:

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNJ6 ( XM_011529559.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527861.1 Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu20323
Clone ID Related Accession (Same CDS sequence)	XM_011529559.1 , XM_011529558.1 , NM_002240.4 , NM_002240.5
Accession Version	XM_011529559.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	G protein-activated inward rectifier potassium channel 2 isoform X1
Comment

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011527861.1

Translation

MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

Target ORF information:

RefSeq Version	XM_011529559.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011529559.1

ORF Insert Sequence:

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNJ6 ( XM_011529558.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527860.1 Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X1, mRNA.

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CloneID	OHu20323
Clone ID Related Accession (Same CDS sequence)	XM_011529559.1 , XM_011529558.1 , NM_002240.4 , NM_002240.5
Accession Version	XM_011529558.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	G protein-activated inward rectifier potassium channel 2 isoform X1
Comment

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011527860.1

Translation

MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

Target ORF information:

RefSeq Version	XM_011529558.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens potassium channel, inwardly rectifying subfamily J, member 6 (KCNJ6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011529558.1

ORF Insert Sequence:

ATGGCCAAGC TGACAGAATC CATGACTAAC GTCCTGGAGG GCGACTCCAT GGATCAGGAC 
GTCGAAAGCC CAGTGGCCAT TCACCAGCCA AAGTTGCCTA AGCAGGCCAG GGATGACCTG 
CCAAGACACA TCAGCCGAGA TCGGACCAAA AGGAAAATCC AGAGGTACGT GAGGAAAGAC 
GGAAAGTGCA ATGTTCATCA CGGCAACGTG AGGGAGACCT ATCGCTACCT GACCGATATC 
TTCACCACAT TAGTGGACCT GAAGTGGAGA TTCAACCTAT TGATTTTTGT CATGGTTTAC 
ACAGTGACCT GGCTCTTTTT TGGAATGATC TGGTGGTTGA TCGCATACAT ACGGGGAGAC 
ATGGACCACA TAGAGGACCC CTCCTGGACT CCTTGTGTTA CCAACCTCAA CGGGTTCGTC 
TCTGCTTTTT TATTCTCAAT AGAGACAGAA ACCACCATTG GTTATGGCTA CCGGGTCATC 
ACAGATAAAT GCCCAGAGGG AATTATTCTT CTCTTAATCC AATCTGTGTT GGGGTCCATT 
GTCAATGCAT TCATGGTGGG ATGCATGTTT GTAAAAATCT CTCAACCCAA GAAGAGGGCA 
GAGACCCTGG TCTTTTCCAC CCATGCAGTG ATCTCCATGC GGGATGGGAA ACTGTGCCTG 
ATGTTCCGGG TAGGGGACCT TAGGAATTCC CACATTGTGG AGGCTTCCAT CAGAGCCAAG 
TTGATCAAAT CCAAACAGAC CTCGGAGGGG GAGTTCATCC CGTTGAACCA GACGGATATC 
AACGTAGGGT ATTACACGGG GGATGACCGT CTGTTTCTGG TGTCACCGCT GATCATTAGC 
CATGAAATTA ACCAACAGAG TCCTTTCTGG GAGATCTCCA AAGCCCAGCT GCCCAAAGAG 
GAACTGGAAA TTGTGGTCAT CCTAGAAGGA ATGGTGGAAG CCACAGGGAT GACATGCCAA 
GCTCGAAGCT CCTACATCAC CAGTGAGATC CTGTGGGGTT ACCGGTTCAC ACCTGTCCTG 
ACCCTGGAGG ACGGGTTCTA CGAAGTTGAC TACAACAGCT TCCATGAGAC CTATGAGACC 
AGCACCCCAT CCCTTAGTGC CAAAGAGCTG GCCGAGTTAG CCAGCAGGGC AGAGCTGCCC 
CTGAGTTGGT CTGTATCCAG CAAACTCAAC CAACATGCAG AACTGGAGAC TGAAGAGGAA 
GAAAAGAACC TCGAAGAGCA AACAGAAAGA AATGGTGATG TGGCAAACCT GGAGAATGAA 
TCCAAAGTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic correlates of the development of theta event related oscillations?in adolescents and young adults.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology11524-39(2017 May)
Chorlian DB,Rangaswamy M,Manz N,Meyers JL,Kang SJ,Kamarajan C,Pandey AK,Wang JC,Wetherill L,Edenberg H,Porjesz B

A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology11513-23(2017 May)
Kamarajan C,Pandey AK,Chorlian DB,Manz N,Stimus AT,Edenberg HJ,Wetherill L,Schuckit M,Wang JC,Kuperman S,Kramer J,Tischfield JA,Porjesz B

Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.
American journal of human genetics96(2)295-300(2015 Feb)
Masotti A,Uva P,Davis-Keppen L,Basel-Vanagaite L,Cohen L,Pisaneschi E,Celluzzi A,Bencivenga P,Fang M,Tian M,Xu X,Cappa M,Dallapiccola B

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KCNJ6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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