KCNJ4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNJ4
Entrez Gene ID	3761
Full Name	potassium voltage-gated channel subfamily J member 4
Synonyms	HIR,HIRK2,HRK1,IRK-3,IRK3,Kir2.3
General protein information	Preferred Names potassium voltage-gated channel subfamily J member 4 Names inward rectifier potassium channel 4 hippocampal inward rectifier potassium channel inward rectifier K(+) channel Kir2.3 potassium channel, inwardly rectifying subfamily J, member 4 potassium inwardly-rectifying channel, subfamily J, member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	600504

mRNA and Protein(s)

mRNA	Protein	Name
NM_152868.2	NP_690607.1	inward rectifier potassium channel 4
NM_152868.3	NP_690607.1	inward rectifier potassium channel 4
NM_004981.1	NP_004972.1	inward rectifier potassium channel 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNJ4	XP_005625941.1
Rattus norvegicus (Norway rat)	Kcnj4	NP_446322.2
Pan troglodytes (chimpanzee)	KCNJ4	XP_525593.2
Gallus gallus (chicken)	KCNJ4	XP_416263.4
Xenopus tropicalis (tropical clawed frog)	kcnj4	XP_002934259.1
Danio rerio (zebrafish)	LOC100331864	XP_002667440.3
Homo sapiens (human)	KCNJ4	NP_004972.1
Mus musculus (house mouse)	Kcnj4	NP_032453.3

Gene Ontology
Bibliography

Related articles in PubMed

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.
Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM
Proceedings of the National Academy of Sciences of the United States of America111(7)2542-7(2014 Feb)

Genome-wide association study of maternal and inherited loci for conotruncal heart defects.
Agopian AJ, Mitchell LE, Glessner J, Bhalla AD, Sewda A, Hakonarson H, Goldmuntz E
PloS one9(5)e96057(2014)

Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.
Cazorla M, Shegda M, Ramesh B, Harrison NL, Kellendonk C
The Journal of neuroscience : the official journal of the Society for Neuroscience32(7)2398-409(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased excitability and decreased dendritic arborization are associated with downregulation of inward rectifier potassium channels (Kir2.1/2.3).
Title: Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.

Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3.
Title: Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.

The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes.
Title: Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.

possibility of intramolecular interactions of the residue Kir2.3(H117) with conserved cysteines in close proximity to the selectivity filter
Title: Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.

The following KCNJ4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNJ4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55985	NM_004981.1 Latest version!	Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu55985	NM_152868.3 Latest version!	Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu55985	NM_152868.2	Homo sapiens potassium voltage-gated channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNJ4 ( NM_152868.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_690607.1 Homo sapiens potassium voltage-gated channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55985
Clone ID Related Accession (Same CDS sequence)	NM_152868.2 , NM_152868.3 , NM_004981.1
Accession Version	NM_152868.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Homo sapiens(human)
Product	inward rectifier potassium channel 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC032562.1 and U07364.1. This sequence is a reference standard in the RefSeqGene project. On Jun 30, 2012 this sequence version replaced NM_152868.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24056.1, CR456507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690607.1
CDS	260..1597
Translation	MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI

Target ORF information:

RefSeq Version	NM_152868.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152868.2

ORF Insert Sequence:

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNJ4 ( NM_152868.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_690607.1 Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55985
Clone ID Related Accession (Same CDS sequence)	NM_152868.2 , NM_152868.3 , NM_004981.1
Accession Version	NM_152868.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	inward rectifier potassium channel 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z97056.1. On Aug 31, 2019 this sequence version replaced NM_152868.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24056.1, CR456507.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303592.3/ ENSP00000306497.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690607.1
CDS	260..1597
Translation	MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI

Target ORF information:

RefSeq Version	NM_152868.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152868.3

ORF Insert Sequence:

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNJ4 ( NM_004981.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_004972.1 Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55985
Clone ID Related Accession (Same CDS sequence)	NM_152868.2 , NM_152868.3 , NM_004981.1
Accession Version	NM_004981.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	inward rectifier potassium channel 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U07364.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U07364.1, BC113506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMN03465406 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004972.1
CDS	98..1435
Translation	MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI

Target ORF information:

RefSeq Version	NM_004981.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium inwardly rectifying channel subfamily J member 4 (KCNJ4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004981.1

ORF Insert Sequence:

ATGCACGGAC ACAGCCGCAA CGGCCAGGCC CACGTGCCCC GGCGGAAGCG CCGCAACCGC 
TTCGTCAAGA AGAACGGCCA ATGCAACGTG TACTTCGCCA ACCTGAGCAA CAAGTCGCAG 
CGCTACATGG CGGACATCTT CACCACCTGC GTGGACACGC GCTGGCGCTA CATGCTCATG 
ATCTTCTCCG CGGCCTTCCT TGTCTCCTGG CTCTTTTTCG GCCTCCTCTT CTGGTGTATC 
GCCTTCTTCC ACGGTGACCT GGAGGCCAGC CCAGGGGTGC CTGCGGCGGG GGGCCCGGCG 
GCGGGTGGTG GCGGAGCAGC CCCGGTGGCC CCCAAGCCCT GCATCATGCA CGTGAACGGC 
TTCCTGGGTG CCTTCCTGTT CTCGGTGGAG ACGCAGACGA CCATCGGCTA TGGGTTCCGG 
TGCGTGACAG AGGAGTGCCC GCTGGCAGTC ATCGCTGTGG TGGTCCAGTC CATCGTGGGC 
TGCGTCATCG ACTCCTTCAT GATTGGCACC ATCATGGCCA AGATGGCGCG GCCCAAGAAG 
CGGGCGCAGA CGTTGCTGTT CAGCCACCAC GCGGTCATTT CGGTGCGCGA CGGCAAGCTC 
TGCCTCATGT GGCGCGTGGG CAACCTGCGC AAGAGCCACA TTGTGGAGGC CCACGTGCGG 
GCCCAGCTCA TCAAGCCCTA CATGACCCAG GAGGGCGAGT ACCTGCCCCT GGACCAGCGG 
GACCTCAACG TGGGCTATGA CATCGGCCTG GACCGCATCT TCCTGGTGTC GCCCATCATC 
ATTGTCCACG AGATCGACGA GGACAGCCCG CTTTATGGCA TGGGCAAGGA GGAGCTGGAG 
TCGGAGGACT TTGAGATCGT GGTCATCCTG GAGGGCATGG TGGAGGCCAC GGCCATGACC 
ACCCAGGCCC GCAGCTCCTA CCTGGCCAGC GAGATCCTGT GGGGCCACCG CTTTGAGCCT 
GTGGTCTTCG AGGAGAAGAG CCACTACAAG GTGGACTACT CACGTTTTCA CAAGACCTAC 
GAGGTGGCCG GCACGCCCTG CTGCTCGGCC CGGGAGCTGC AGGAGAGTAA GATCACCGTG 
CTGCCCGCCC CACCGCCCCC TCCCAGTGCC TTCTGCTACG AGAACGAGCT GGCCCTTATG 
AGCCAGGAGG AAGAGGAGAT GGAGGAGGAG GCAGCTGCGG CGGCCGCGGT GGCCGCAGGC 
CTGGGCCTGG AGGCGGGTTC CAAGGAGGAG GCGGGCATCA TCCGGATGCT GGAGTTCGGC 
AGCCACCTGG ACCTGGAGCG CATGCAGGCT TCCCTCCCGC TGGACAACAT CTCCTACCGC 
AGGGAGTCTG CCATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.
Proceedings of the National Academy of Sciences of the United States of America111(7)2542-7(2014 Feb)
Ivarsson Y,Arnold R,McLaughlin M,Nim S,Joshi R,Ray D,Liu B,Teyra J,Pawson T,Moffat J,Li SS,Sidhu SS,Kim PM

Genome-wide association study of maternal and inherited loci for conotruncal heart defects.
PloS one9(5)e96057(2014)
Agopian AJ,Mitchell LE,Glessner J,Bhalla AD,Sewda A,Hakonarson H,Goldmuntz E

Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(7)2398-409(2012 Feb)
Cazorla M,Shegda M,Ramesh B,Harrison NL,Kellendonk C

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KCNJ4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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