NRROS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NRROS
Entrez Gene ID	375387
Full Name	negative regulator of reactive oxygen species
Synonyms	ELLP3030,GARPL1,LRRC33,UNQ3030
General protein information	Preferred Names negative regulator of reactive oxygen species Names negative regulator of reactive oxygen species leucine-rich repeat-containing protein 33
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Disorder MIM:	615322

mRNA and Protein(s)

mRNA	Protein	Name
NM_198565.2	NP_940967.1	negative regulator of reactive oxygen species precursor
NM_198565.3	NP_940967.1	transforming growth factor beta activator LRRC33 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	nrros	NP_001231915.1
Pan troglodytes (chimpanzee)	LRRC33	XP_003310241.1
Rattus norvegicus (Norway rat)	Nrros	NP_001020166.1
Gallus gallus (chicken)	LRRC33	XP_004937053.1
Homo sapiens (human)	NRROS	NP_940967.1
Mus musculus (house mouse)	Nrros	NP_666181.2
Canis lupus familiaris (dog)	NRROS	XP_005639660.1
Bos taurus (cattle)	NRROS	NP_001029563.1
Danio rerio (zebrafish)	nrros	NP_001003775.1

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.
Su X, Mei S, Liang X, Wang S, Liu J, Zhang Y, Bao Y, Chen Y, Che Y, Chunhua Zhao R, Zhang Z, Yang R
Journal of leukocyte biology96(1)17-26(2014 Jul)

Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-?B activation.
Liu J, Zhang Z, Chai L, Che Y, Min S, Yang R
Biochemical and biophysical research communications434(1)28-34(2013 Apr)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis.
Title: Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.

LRRC33 represents the first identified LRR-containing protein that plays a critical role in desensitizing Toll-like receptor (TLR)-mediated innate immune responses.
Title: Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-?B activation.

The following NRROS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NRROS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu79749	NM_198565.3 Latest version!	Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu79749	NM_198565.2	Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NRROS ( NM_198565.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_940967.1 Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.

Price & Availability↑

CloneID	OHu79749
Clone ID Related Accession (Same CDS sequence)	NM_198565.2 , NM_198565.3
Accession Version	NM_198565.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	negative regulator of reactive oxygen species precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY084054.1, BC044233.1, BQ070837.1 and AA534416.1. On Dec 24, 2014 this sequence version replaced NM_198565.1. ##Evidence-Data-START## Transcript exon combination :: BC034704.1, AY358322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTGC TGCCTCTTTG GCTCTGCCTG GGTTTTCACT TCCTGACCGT GGGCTGGAGG 
AACAGAAGCG GAACAGCCAC AGCAGCCTCC CAAGGAGTCT GCAAGTTGGT GGGTGGAGCC 
GCTGACTGCC GAGGGCAGAG CCTCGCTTCG GTGCCCAGCA GCCTCCCGCC CCACGCCCGG 
ATGCTCACCC TGGATGCCAA CCCTCTCAAG ACCCTGTGGA ATCACTCCCT CCAGCCTTAC 
CCTCTCCTGG AGAGCCTCAG CCTGCACAGC TGCCACCTGG AGCGCATCAG CCGCGGCGCC 
TTCCAGGAGC AAGGTCACCT GCGCAGCCTG GTCCTGGGGG ACAACTGCCT CTCAGAGAAC 
TACGAAGAGA CGGCAGCCGC CCTCCACGCC CTGCCGGGCC TGCGGAGGCT GGACTTGTCA 
GGAAACGCCC TGACGGAGGA CATGGCAGCC CTCATGCTCC AGAACCTCTC CTCGCTGCGG 
TCCGTGTCCC TGGCGGGGAA CACCATCATG CGGCTGGACG ACTCCGTCTT CGAGGGCCTG 
GAGCGTCTCC GGGAGCTGGA TCTGCAGAGG AACTACATCT TCGAGATCGA GGGCGGCGCT 
TTCGACGGCC TGGCTGAGCT GAGGCACCTC AACCTGGCCT TCAACAACCT CCCCTGCATC 
GTGGACTTCG GGCTCACGCG GCTGCGGGTC CTCAACGTCA GCTACAACGT CCTGGAGTGG 
TTCCTCGCGA CCGGGGGAGA GGCTGCCTTC GAGCTGGAGA CGCTGGACCT GTCTCACAAC 
CAGCTGCTGT TCTTCCCGCT GCTGCCCCAG TACAGCAAGT TGCGGACCCT CCTGCTGCGC 
GACAACAACA TGGGCTTCTA CCGGGACCTG TACAACACCT CGTCGCCGAG GGAGATGGTG 
GCCCAGTTCC TCCTCGTGGA CGGCAACGTG ACCAACATCA CCACCGTCAG CCTCTGGGAA 
GAATTCTCCT CCAGCGACCT CGCAGATCTC CGCTTCCTGG ACATGAGCCA GAACCAGTTC 
CAGTACCTGC CAGACGGCTT CCTGAGGAAA ATGCCTTCCC TCTCCCACCT GAACCTCCAC 
CAGAATTGCC TGATGACGCT TCACATTCGG GAGCACGAGC CCCCCGGAGC GCTCACCGAG 
CTGGACCTGA GCCACAACCA GCTGTCGGAG CTGCACCTGG CTCCGGGGCT GGCCAGCTGC 
CTGGGCAGCC TGCGCTTGTT CAACCTGAGC TCCAACCAGC TCCTGGGCGT CCCCCCTGGC 
CTCTTCGCCA ATGCTAGGAA CATCACTACA CTTGACATGA GCCACAATCA GATCTCACTT 
TGTCCCCTGC CAGCTGCCTC GGACCGGGTG GGCCCCCCTA GCTGTGTGGA TTTCAGGAAT 
ATGGCATCTT TAAGGAGCCT GTCTCTGGAG GGCTGTGGCC TGGGGGCATT GCCAGACTGC 
CCATTCCAAG GGACCTCCCT GACCTACTTA GACCTCTCAA GCAACTGGGG GGTTCTGAAT 
GGGAGCCTCG CCCCACTCCA GGATGTTGCC CCCATGTTAC AGGTCCTGTC TCTCAGGAAC 
ATGGGCCTCC ACTCCAGCTT TATGGCGTTG GACTTCTCTG GGTTTGGGAA TCTCAGGGAC 
TTAGATCTGT CGGGGAATTG CTTGACCACC TTCCCAAGGT TTGGGGGCAG CCTGGCCCTG 
GAGACCCTGG ATCTCCGTAG AAACTCGCTC ACAGCCCTTC CCCAGAAGGC TGTGTCTGAG 
CAGCTCTCGA GAGGTCTGCG GACCATCTAC CTCAGTCAGA ATCCATATGA CTGCTGTGGG 
GTGGATGGCT GGGGGGCCCT GCAGCATGGG CAGACGGTGG CCGACTGGGC CATGGTCACC 
TGCAACCTCT CCTCCAAGAT CATCCGCGTG ACGGAGCTGC CCGGAGGTGT GCCTCGGGAC 
TGCAAGTGGG AGCGGCTGGA CCTGGGCCTG CTCTACCTCG TGCTCATCCT CCCCAGCTGC 
CTCACCCTGC TGGTGGCCTG CACTGTCATC GTCCTCACTT TTAAGAAGCC TCTGCTTCAG 
GTCATCAAGA GCCGCTGCCA CTGGTCCTCC GTTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940967.1
CDS	194..2272
Translation	MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY

Target ORF information:

RefSeq Version	NM_198565.2
Organism	Homo sapiens(human)
Definition	Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198565.2

ORF Insert Sequence:

ATGGAGTTGC TGCCTCTTTG GCTCTGCCTG GGTTTTCACT TCCTGACCGT GGGCTGGAGG 
AACAGAAGCG GAACAGCCAC AGCAGCCTCC CAAGGAGTCT GCAAGTTGGT GGGTGGAGCC 
GCTGACTGCC GAGGGCAGAG CCTCGCTTCG GTGCCCAGCA GCCTCCCGCC CCACGCCCGG 
ATGCTCACCC TGGATGCCAA CCCTCTCAAG ACCCTGTGGA ATCACTCCCT CCAGCCTTAC 
CCTCTCCTGG AGAGCCTCAG CCTGCACAGC TGCCACCTGG AGCGCATCAG CCGCGGCGCC 
TTCCAGGAGC AAGGTCACCT GCGCAGCCTG GTCCTGGGGG ACAACTGCCT CTCAGAGAAC 
TACGAAGAGA CGGCAGCCGC CCTCCACGCC CTGCCGGGCC TGCGGAGGCT GGACTTGTCA 
GGAAACGCCC TGACGGAGGA CATGGCAGCC CTCATGCTCC AGAACCTCTC CTCGCTGCGG 
TCCGTGTCCC TGGCGGGGAA CACCATCATG CGGCTGGACG ACTCCGTCTT CGAGGGCCTG 
GAGCGTCTCC GGGAGCTGGA TCTGCAGAGG AACTACATCT TCGAGATCGA GGGCGGCGCT 
TTCGACGGCC TGGCTGAGCT GAGGCACCTC AACCTGGCCT TCAACAACCT CCCCTGCATC 
GTGGACTTCG GGCTCACGCG GCTGCGGGTC CTCAACGTCA GCTACAACGT CCTGGAGTGG 
TTCCTCGCGA CCGGGGGAGA GGCTGCCTTC GAGCTGGAGA CGCTGGACCT GTCTCACAAC 
CAGCTGCTGT TCTTCCCGCT GCTGCCCCAG TACAGCAAGT TGCGGACCCT CCTGCTGCGC 
GACAACAACA TGGGCTTCTA CCGGGACCTG TACAACACCT CGTCGCCGAG GGAGATGGTG 
GCCCAGTTCC TCCTCGTGGA CGGCAACGTG ACCAACATCA CCACCGTCAG CCTCTGGGAA 
GAATTCTCCT CCAGCGACCT CGCAGATCTC CGCTTCCTGG ACATGAGCCA GAACCAGTTC 
CAGTACCTGC CAGACGGCTT CCTGAGGAAA ATGCCTTCCC TCTCCCACCT GAACCTCCAC 
CAGAATTGCC TGATGACGCT TCACATTCGG GAGCACGAGC CCCCCGGAGC GCTCACCGAG 
CTGGACCTGA GCCACAACCA GCTGTCGGAG CTGCACCTGG CTCCGGGGCT GGCCAGCTGC 
CTGGGCAGCC TGCGCTTGTT CAACCTGAGC TCCAACCAGC TCCTGGGCGT CCCCCCTGGC 
CTCTTCGCCA ATGCTAGGAA CATCACTACA CTTGACATGA GCCACAATCA GATCTCACTT 
TGTCCCCTGC CAGCTGCCTC GGACCGGGTG GGCCCCCCTA GCTGTGTGGA TTTCAGGAAT 
ATGGCATCTT TAAGGAGCCT GTCTCTGGAG GGCTGTGGCC TGGGGGCATT GCCAGACTGC 
CCATTCCAAG GGACCTCCCT GACCTACTTA GACCTCTCAA GCAACTGGGG GGTTCTGAAT 
GGGAGCCTCG CCCCACTCCA GGATGTTGCC CCCATGTTAC AGGTCCTGTC TCTCAGGAAC 
ATGGGCCTCC ACTCCAGCTT TATGGCGTTG GACTTCTCTG GGTTTGGGAA TCTCAGGGAC 
TTAGATCTGT CGGGGAATTG CTTGACCACC TTCCCAAGGT TTGGGGGCAG CCTGGCCCTG 
GAGACCCTGG ATCTCCGTAG AAACTCGCTC ACAGCCCTTC CCCAGAAGGC TGTGTCTGAG 
CAGCTCTCGA GAGGTCTGCG GACCATCTAC CTCAGTCAGA ATCCATATGA CTGCTGTGGG 
GTGGATGGCT GGGGGGCCCT GCAGCATGGG CAGACGGTGG CCGACTGGGC CATGGTCACC 
TGCAACCTCT CCTCCAAGAT CATCCGCGTG ACGGAGCTGC CCGGAGGTGT GCCTCGGGAC 
TGCAAGTGGG AGCGGCTGGA CCTGGGCCTG CTCTACCTCG TGCTCATCCT CCCCAGCTGC 
CTCACCCTGC TGGTGGCCTG CACTGTCATC GTCCTCACTT TTAAGAAGCC TCTGCTTCAG 
GTCATCAAGA GCCGCTGCCA CTGGTCCTCC GTTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NRROS ( NM_198565.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_940967.1 Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.

Price & Availability↑

CloneID	OHu79749
Clone ID Related Accession (Same CDS sequence)	NM_198565.2 , NM_198565.3
Accession Version	NM_198565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	transforming growth factor beta activator LRRC33 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC055725.22, HY084054.1, BC044233.1, BQ070837.1 and AA534416.1. On Nov 22, 2018 this sequence version replaced NM_198565.2. ##Evidence-Data-START## Transcript exon combination :: BC034704.1, AY358322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328557.5/ ENSP00000328625.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTTGC TGCCTCTTTG GCTCTGCCTG GGTTTTCACT TCCTGACCGT GGGCTGGAGG 
AACAGAAGCG GAACAGCCAC AGCAGCCTCC CAAGGAGTCT GCAAGTTGGT GGGTGGAGCC 
GCTGACTGCC GAGGGCAGAG CCTCGCTTCG GTGCCCAGCA GCCTCCCGCC CCACGCCCGG 
ATGCTCACCC TGGATGCCAA CCCTCTCAAG ACCCTGTGGA ATCACTCCCT CCAGCCTTAC 
CCTCTCCTGG AGAGCCTCAG CCTGCACAGC TGCCACCTGG AGCGCATCAG CCGCGGCGCC 
TTCCAGGAGC AAGGTCACCT GCGCAGCCTG GTCCTGGGGG ACAACTGCCT CTCAGAGAAC 
TACGAAGAGA CGGCAGCCGC CCTCCACGCC CTGCCGGGCC TGCGGAGGCT GGACTTGTCA 
GGAAACGCCC TGACGGAGGA CATGGCAGCC CTCATGCTCC AGAACCTCTC CTCGCTGCGG 
TCCGTGTCCC TGGCGGGGAA CACCATCATG CGGCTGGACG ACTCCGTCTT CGAGGGCCTG 
GAGCGTCTCC GGGAGCTGGA TCTGCAGAGG AACTACATCT TCGAGATCGA GGGCGGCGCT 
TTCGACGGCC TGGCTGAGCT GAGGCACCTC AACCTGGCCT TCAACAACCT CCCCTGCATC 
GTGGACTTCG GGCTCACGCG GCTGCGGGTC CTCAACGTCA GCTACAACGT CCTGGAGTGG 
TTCCTCGCGA CCGGGGGAGA GGCTGCCTTC GAGCTGGAGA CGCTGGACCT GTCTCACAAC 
CAGCTGCTGT TCTTCCCGCT GCTGCCCCAG TACAGCAAGT TGCGGACCCT CCTGCTGCGC 
GACAACAACA TGGGCTTCTA CCGGGACCTG TACAACACCT CGTCGCCGAG GGAGATGGTG 
GCCCAGTTCC TCCTCGTGGA CGGCAACGTG ACCAACATCA CCACCGTCAG CCTCTGGGAA 
GAATTCTCCT CCAGCGACCT CGCAGATCTC CGCTTCCTGG ACATGAGCCA GAACCAGTTC 
CAGTACCTGC CAGACGGCTT CCTGAGGAAA ATGCCTTCCC TCTCCCACCT GAACCTCCAC 
CAGAATTGCC TGATGACGCT TCACATTCGG GAGCACGAGC CCCCCGGAGC GCTCACCGAG 
CTGGACCTGA GCCACAACCA GCTGTCGGAG CTGCACCTGG CTCCGGGGCT GGCCAGCTGC 
CTGGGCAGCC TGCGCTTGTT CAACCTGAGC TCCAACCAGC TCCTGGGCGT CCCCCCTGGC 
CTCTTCGCCA ATGCTAGGAA CATCACTACA CTTGACATGA GCCACAATCA GATCTCACTT 
TGTCCCCTGC CAGCTGCCTC GGACCGGGTG GGCCCCCCTA GCTGTGTGGA TTTCAGGAAT 
ATGGCATCTT TAAGGAGCCT GTCTCTGGAG GGCTGTGGCC TGGGGGCATT GCCAGACTGC 
CCATTCCAAG GGACCTCCCT GACCTACTTA GACCTCTCAA GCAACTGGGG GGTTCTGAAT 
GGGAGCCTCG CCCCACTCCA GGATGTTGCC CCCATGTTAC AGGTCCTGTC TCTCAGGAAC 
ATGGGCCTCC ACTCCAGCTT TATGGCGTTG GACTTCTCTG GGTTTGGGAA TCTCAGGGAC 
TTAGATCTGT CGGGGAATTG CTTGACCACC TTCCCAAGGT TTGGGGGCAG CCTGGCCCTG 
GAGACCCTGG ATCTCCGTAG AAACTCGCTC ACAGCCCTTC CCCAGAAGGC TGTGTCTGAG 
CAGCTCTCGA GAGGTCTGCG GACCATCTAC CTCAGTCAGA ATCCATATGA CTGCTGTGGG 
GTGGATGGCT GGGGGGCCCT GCAGCATGGG CAGACGGTGG CCGACTGGGC CATGGTCACC 
TGCAACCTCT CCTCCAAGAT CATCCGCGTG ACGGAGCTGC CCGGAGGTGT GCCTCGGGAC 
TGCAAGTGGG AGCGGCTGGA CCTGGGCCTG CTCTACCTCG TGCTCATCCT CCCCAGCTGC 
CTCACCCTGC TGGTGGCCTG CACTGTCATC GTCCTCACTT TTAAGAAGCC TCTGCTTCAG 
GTCATCAAGA GCCGCTGCCA CTGGTCCTCC GTTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940967.1
CDS	196..2274
Translation	MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY

Target ORF information:

RefSeq Version	NM_198565.3
Organism	Homo sapiens(human)
Definition	Homo sapiens negative regulator of reactive oxygen species (NRROS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198565.3

ORF Insert Sequence:

ATGGAGTTGC TGCCTCTTTG GCTCTGCCTG GGTTTTCACT TCCTGACCGT GGGCTGGAGG 
AACAGAAGCG GAACAGCCAC AGCAGCCTCC CAAGGAGTCT GCAAGTTGGT GGGTGGAGCC 
GCTGACTGCC GAGGGCAGAG CCTCGCTTCG GTGCCCAGCA GCCTCCCGCC CCACGCCCGG 
ATGCTCACCC TGGATGCCAA CCCTCTCAAG ACCCTGTGGA ATCACTCCCT CCAGCCTTAC 
CCTCTCCTGG AGAGCCTCAG CCTGCACAGC TGCCACCTGG AGCGCATCAG CCGCGGCGCC 
TTCCAGGAGC AAGGTCACCT GCGCAGCCTG GTCCTGGGGG ACAACTGCCT CTCAGAGAAC 
TACGAAGAGA CGGCAGCCGC CCTCCACGCC CTGCCGGGCC TGCGGAGGCT GGACTTGTCA 
GGAAACGCCC TGACGGAGGA CATGGCAGCC CTCATGCTCC AGAACCTCTC CTCGCTGCGG 
TCCGTGTCCC TGGCGGGGAA CACCATCATG CGGCTGGACG ACTCCGTCTT CGAGGGCCTG 
GAGCGTCTCC GGGAGCTGGA TCTGCAGAGG AACTACATCT TCGAGATCGA GGGCGGCGCT 
TTCGACGGCC TGGCTGAGCT GAGGCACCTC AACCTGGCCT TCAACAACCT CCCCTGCATC 
GTGGACTTCG GGCTCACGCG GCTGCGGGTC CTCAACGTCA GCTACAACGT CCTGGAGTGG 
TTCCTCGCGA CCGGGGGAGA GGCTGCCTTC GAGCTGGAGA CGCTGGACCT GTCTCACAAC 
CAGCTGCTGT TCTTCCCGCT GCTGCCCCAG TACAGCAAGT TGCGGACCCT CCTGCTGCGC 
GACAACAACA TGGGCTTCTA CCGGGACCTG TACAACACCT CGTCGCCGAG GGAGATGGTG 
GCCCAGTTCC TCCTCGTGGA CGGCAACGTG ACCAACATCA CCACCGTCAG CCTCTGGGAA 
GAATTCTCCT CCAGCGACCT CGCAGATCTC CGCTTCCTGG ACATGAGCCA GAACCAGTTC 
CAGTACCTGC CAGACGGCTT CCTGAGGAAA ATGCCTTCCC TCTCCCACCT GAACCTCCAC 
CAGAATTGCC TGATGACGCT TCACATTCGG GAGCACGAGC CCCCCGGAGC GCTCACCGAG 
CTGGACCTGA GCCACAACCA GCTGTCGGAG CTGCACCTGG CTCCGGGGCT GGCCAGCTGC 
CTGGGCAGCC TGCGCTTGTT CAACCTGAGC TCCAACCAGC TCCTGGGCGT CCCCCCTGGC 
CTCTTCGCCA ATGCTAGGAA CATCACTACA CTTGACATGA GCCACAATCA GATCTCACTT 
TGTCCCCTGC CAGCTGCCTC GGACCGGGTG GGCCCCCCTA GCTGTGTGGA TTTCAGGAAT 
ATGGCATCTT TAAGGAGCCT GTCTCTGGAG GGCTGTGGCC TGGGGGCATT GCCAGACTGC 
CCATTCCAAG GGACCTCCCT GACCTACTTA GACCTCTCAA GCAACTGGGG GGTTCTGAAT 
GGGAGCCTCG CCCCACTCCA GGATGTTGCC CCCATGTTAC AGGTCCTGTC TCTCAGGAAC 
ATGGGCCTCC ACTCCAGCTT TATGGCGTTG GACTTCTCTG GGTTTGGGAA TCTCAGGGAC 
TTAGATCTGT CGGGGAATTG CTTGACCACC TTCCCAAGGT TTGGGGGCAG CCTGGCCCTG 
GAGACCCTGG ATCTCCGTAG AAACTCGCTC ACAGCCCTTC CCCAGAAGGC TGTGTCTGAG 
CAGCTCTCGA GAGGTCTGCG GACCATCTAC CTCAGTCAGA ATCCATATGA CTGCTGTGGG 
GTGGATGGCT GGGGGGCCCT GCAGCATGGG CAGACGGTGG CCGACTGGGC CATGGTCACC 
TGCAACCTCT CCTCCAAGAT CATCCGCGTG ACGGAGCTGC CCGGAGGTGT GCCTCGGGAC 
TGCAAGTGGG AGCGGCTGGA CCTGGGCCTG CTCTACCTCG TGCTCATCCT CCCCAGCTGC 
CTCACCCTGC TGGTGGCCTG CACTGTCATC GTCCTCACTT TTAAGAAGCC TCTGCTTCAG 
GTCATCAAGA GCCGCTGCCA CTGGTCCTCC GTTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.
Journal of leukocyte biology96(1)17-26(2014 Jul)
Su X,Mei S,Liang X,Wang S,Liu J,Zhang Y,Bao Y,Chen Y,Che Y,Chunhua Zhao R,Zhang Z,Yang R

Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-?B activation.
Biochemical and biophysical research communications434(1)28-34(2013 Apr)
Liu J,Zhang Z,Chai L,Che Y,Min S,Yang R

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

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NRROS cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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