IGFL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGFL1
Entrez Gene ID	374918
Full Name	IGF like family member 1
Synonyms	APRG644,UNQ644
General protein information	Preferred Names IGF like family member 1 Names insulin growth factor-like family member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016].
Disorder MIM:	610544

mRNA and Protein(s)

mRNA	Protein	Name
NM_198541.2	NP_940943.1	insulin growth factor-like family member 1 precursor
NM_198541.1	NP_940943.1	insulin growth factor-like family member 1 precursor

Pathways from BioSystems

Homologies

	LOC717124	XP_001108346.2
Homo sapiens (human)	IGFL1	NP_940943.1
Pan troglodytes (chimpanzee)	IGFL1	XP_001167360.1
Bos taurus (cattle)	LOC512788	XP_002695222.1

Gene Ontology
Bibliography

Related articles in PubMed

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
Lobito AA, Ramani SR, Tom I, Bazan JF, Luis E, Fairbrother WJ, Ouyang W, Gonzalez LC
The Journal of biological chemistry286(21)18969-81(2011 May)

The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children.
Ester WA, van Meurs JB, Arends NJ, Uitterlinden AG, de Ridder MA, Hokken-Koelega AC
European journal of endocrinology160(4)549-55(2009 Apr)

IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily.
Emtage P, Vatta P, Arterburn M, Muller MW, Park E, Boyle B, Hazell S, Polizotto R, Funk WD, Tang YT
Genomics88(4)513-20(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
Title: Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.

The -1245 A-allele of the IGF1 promoter single nucleotide polymorphism is associated with a small head size and less brain sparing in small for gestational age born subjects
Title: The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children.

The following IGFL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGFL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29580	NM_198541.2 Latest version!	Homo sapiens IGF like family member 1 (IGFL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29580	NM_198541.1	Homo sapiens IGF like family member 1 (IGFL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGFL1 ( NM_198541.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_940943.1 Homo sapiens IGF like family member 1 (IGFL1), mRNA.

Price & Availability↑

CloneID	OHu29580
Clone ID Related Accession (Same CDS sequence)	NM_198541.2 , NM_198541.1
Accession Version	NM_198541.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	insulin growth factor-like family member 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006262.2 and AY359013.1. On Nov 22, 2018 this sequence version replaced NM_198541.1. ##Evidence-Data-START## Transcript exon combination :: AY359013.1, DN995474.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000437936.2/ ENSP00000415823.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCCCC GAGGCTGCAT CGTAGCTGTC TTTGCCATTT TCTGCATCTC CAGGCTCCTC 
TGCTCACACG GAGCCCCAGT GGCCCCCATG ACTCCTTACC TGATGCTGTG CCAGCCACAC 
AAGAGATGTG GGGACAAGTT CTACGACCCC CTGCAGCACT GTTGCTATGA TGATGCCGTC 
GTGCCCTTGG CCAGGACCCA GACGTGTGGA AACTGCACCT TCAGAGTCTG CTTTGAGCAG 
TGCTGCCCCT GGACCTTCAT GGTGAAGCTG ATAAACCAGA ACTGCGACTC AGCCCGGACC 
TCGGATGACA GGCTTTGTCG CAGTGTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940943.1
CDS	34..366
Translation	MAPRGCIVAVFAIFCISRLLCSHGAPVAPMTPYLMLCQPHKRCGDKFYDPLQHCCYDDAVVPLARTQTCGNCTFRVCFEQCCPWTFMVKLINQNCDSARTSDDRLCRSVS

Target ORF information:

RefSeq Version	NM_198541.2
Organism	Homo sapiens(human)
Definition	Homo sapiens IGF like family member 1 (IGFL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198541.2

ORF Insert Sequence:

ATGGCTCCCC GAGGCTGCAT CGTAGCTGTC TTTGCCATTT TCTGCATCTC CAGGCTCCTC 
TGCTCACACG GAGCCCCAGT GGCCCCCATG ACTCCTTACC TGATGCTGTG CCAGCCACAC 
AAGAGATGTG GGGACAAGTT CTACGACCCC CTGCAGCACT GTTGCTATGA TGATGCCGTC 
GTGCCCTTGG CCAGGACCCA GACGTGTGGA AACTGCACCT TCAGAGTCTG CTTTGAGCAG 
TGCTGCCCCT GGACCTTCAT GGTGAAGCTG ATAAACCAGA ACTGCGACTC AGCCCGGACC 
TCGGATGACA GGCTTTGTCG CAGTGTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFL1 ( NM_198541.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_940943.1 Homo sapiens IGF like family member 1 (IGFL1), mRNA.

Price & Availability↑

CloneID	OHu29580
Clone ID Related Accession (Same CDS sequence)	NM_198541.2 , NM_198541.1
Accession Version	NM_198541.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	insulin growth factor-like family member 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY359013.1. On Dec 17, 2003 this sequence version replaced XM_353187.1. ##Evidence-Data-START## Transcript exon combination :: AY359013.1, DN995474.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCCC GAGGCTGCAT CGTAGCTGTC TTTGCCATTT TCTGCATCTC CAGGCTCCTC 
TGCTCACACG GAGCCCCAGT GGCCCCCATG ACTCCTTACC TGATGCTGTG CCAGCCACAC 
AAGAGATGTG GGGACAAGTT CTACGACCCC CTGCAGCACT GTTGCTATGA TGATGCCGTC 
GTGCCCTTGG CCAGGACCCA GACGTGTGGA AACTGCACCT TCAGAGTCTG CTTTGAGCAG 
TGCTGCCCCT GGACCTTCAT GGTGAAGCTG ATAAACCAGA ACTGCGACTC AGCCCGGACC 
TCGGATGACA GGCTTTGTCG CAGTGTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940943.1
CDS	24..356
Translation	MAPRGCIVAVFAIFCISRLLCSHGAPVAPMTPYLMLCQPHKRCGDKFYDPLQHCCYDDAVVPLARTQTCGNCTFRVCFEQCCPWTFMVKLINQNCDSARTSDDRLCRSVS

Target ORF information:

RefSeq Version	NM_198541.1
Organism	Homo sapiens(human)
Definition	Homo sapiens IGF like family member 1 (IGFL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198541.1

ORF Insert Sequence:

ATGGCTCCCC GAGGCTGCAT CGTAGCTGTC TTTGCCATTT TCTGCATCTC CAGGCTCCTC 
TGCTCACACG GAGCCCCAGT GGCCCCCATG ACTCCTTACC TGATGCTGTG CCAGCCACAC 
AAGAGATGTG GGGACAAGTT CTACGACCCC CTGCAGCACT GTTGCTATGA TGATGCCGTC 
GTGCCCTTGG CCAGGACCCA GACGTGTGGA AACTGCACCT TCAGAGTCTG CTTTGAGCAG 
TGCTGCCCCT GGACCTTCAT GGTGAAGCTG ATAAACCAGA ACTGCGACTC AGCCCGGACC 
TCGGATGACA GGCTTTGTCG CAGTGTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
The Journal of biological chemistry286(21)18969-81(2011 May)
Lobito AA,Ramani SR,Tom I,Bazan JF,Luis E,Fairbrother WJ,Ouyang W,Gonzalez LC

The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children.
European journal of endocrinology160(4)549-55(2009 Apr)
Ester WA,van Meurs JB,Arends NJ,Uitterlinden AG,de Ridder MA,Hokken-Koelega AC

IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily.
Genomics88(4)513-20(2006 Oct)
Emtage P,Vatta P,Arterburn M,Muller MW,Park E,Boyle B,Hazell S,Polizotto R,Funk WD,Tang YT

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IGFL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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