KCNA7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA7
Entrez Gene ID	3743
Full Name	potassium voltage-gated channel subfamily A member 7
Synonyms	HAK6,KV1.7
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 7 Names potassium voltage-gated channel subfamily A member 7 potassium channel, voltage gated shaker related subfamily A, member 7 potassium voltage-gated channel, shaker-related subfamily, member 7 voltage-dependent potassium channel Kv1.7 voltage-gated potassium channel KCNA7 voltage-gated potassium channel subunit Kv1.7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008].
Disorder MIM:	176268

mRNA and Protein(s)

mRNA	Protein	Name
NM_031886.2	NP_114092.2	potassium voltage-gated channel subfamily A member 7

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNA7	XP_002695249.2
Homo sapiens (human)	KCNA7	NP_114092.2
Mus musculus (house mouse)	Kcna7	NP_034726.2
Pan troglodytes (chimpanzee)	KCNA7	XP_003316537.1
Rattus norvegicus (Norway rat)	Kcna7	NP_001102384.1

Gene Ontology
Bibliography

Related articles in PubMed

Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.
Atsem S, Reichenbach J, Potabattula R, Dittrich M, Nava C, Depienne C, B?hm L, Rost S, Hahn T, Schorsch M, Haaf T, El Hajj N
Human molecular genetics25(22)4996-5005(2016 11)

Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.
Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Str?ver N, Pavlov E, Nichols CG, French RJ, Terlau H
EMBO molecular medicine4(5)424-34(2012 May)

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, St?hmer W, Wang X
Pharmacological reviews57(4)473-508(2005 Dec)

[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China].
Ding Q, Zhao YY, Dong LY, Sun ZJ, Guo L
Yi chuan = Hereditas25(2)129-32(2003 Mar)

Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V
European journal of human genetics : EJHG10(1)36-43(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors conclude that K(v) 1.7 contributes to the membrane-repolarizing current of beta cells during glucose-stimulated insulin.
Title: Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.

Observational study of genotype prevalence. (HuGE Navigator)
Title: [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China].

Expressed in heart, but not the cause of progressive familial heart block I.
Title: Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).

The following KCNA7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31225	NM_031886.2 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 7 (KCNA7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA7 ( NM_031886.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_114092.2 Homo sapiens potassium voltage-gated channel subfamily A member 7 (KCNA7), mRNA.

Price & Availability↑

CloneID	OHu31225
Clone ID Related Accession (Same CDS sequence)	NM_031886.2
Accession Version	NM_031886.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ310479.1. On Nov 29, 2002 this sequence version replaced NM_031886.1. ##Evidence-Data-START## Transcript exon combination :: AJ310479.1, BC140906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 5' end.

ATGGAGCCGC GGTGCCCGCC GCCGTGCGGC TGCTGCGAGC GGCTGGTGCT CAACGTGGCC 
GGGCTGCGCT TCGAGACGCG GGCGCGCACG CTGGGCCGCT TCCCGGACAC TCTGCTAGGG 
GACCCAGCGC GCCGCGGCCG CTTCTACGAC GACGCGCGCC GCGAGTATTT CTTCGACCGG 
CACCGGCCCA GCTTCGACGC CGTGCTCTAC TACTACCAGT CCGGTGGGCG GCTGCGGCGG 
CCGGCGCACG TGCCGCTCGA CGTCTTCCTG GAAGAGGTGG CCTTCTACGG GCTGGGCGCG 
GCGGCCCTGG CACGCCTGCG CGAGGACGAG GGCTGCCCGG TGCCGCCCGA GCGCCCCCTG 
CCCCGCCGCG CCTTCGCCCG CCAGCTGTGG CTGCTTTTCG AGTTTCCCGA GAGCTCTCAG 
GCCGCGCGCG TGCTCGCCGT AGTCTCCGTG CTGGTCATCC TCGTCTCCAT CGTCGTCTTC 
TGCCTCGAGA CGCTGCCTGA CTTCCGCGAC GACCGCGACG GCACGGGGCT TGCTGCTGCA 
GCCGCAGCCG GCCCGTTCCC CGCTCCGCTG AATGGCTCCA GCCAAATGCC TGGAAATCCA 
CCCCGCCTGC CCTTCAATGA CCCGTTCTTC GTGGTGGAGA CGCTGTGTAT TTGTTGGTTC 
TCCTTTGAGC TGCTGGTACG CCTCCTGGTC TGTCCAAGCA AGGCTATCTT CTTCAAGAAC 
GTGATGAACC TCATCGATTT TGTGGCTATC CTTCCCTACT TTGTGGCACT GGGCACCGAG 
CTGGCCCGGC AGCGAGGGGT GGGCCAGCAG GCCATGTCAC TGGCCATCCT GAGAGTCATC 
CGATTGGTGC GTGTCTTCCG CATCTTCAAG CTGTCCCGGC ACTCAAAGGG CCTGCAAATC 
TTGGGCCAGA CGCTTCGGGC CTCCATGCGT GAGCTGGGCC TCCTCATCTT TTTCCTCTTC 
ATCGGTGTGG TCCTCTTTTC CAGCGCCGTC TACTTTGCCG AAGTTGACCG GGTGGACTCC 
CATTTCACTA GCATCCCTGA GTCCTTCTGG TGGGCGGTAG TCACCATGAC TACAGTTGGC 
TATGGAGACA TGGCACCCGT CACTGTGGGT GGCAAGATAG TGGGCTCTCT GTGTGCCATT 
GCGGGCGTGC TGACTATTTC CCTGCCAGTG CCCGTCATTG TCTCCAATTT CAGCTACTTT 
TATCACCGGG AGACAGAGGG CGAAGAGGCT GGGATGTTCA GCCATGTGGA CATGCAGCCT 
TGTGGCCCAC TGGAGGGCAA GGCCAATGGG GGGCTGGTGG ACGGGGAGGT ACCTGAGCTA 
CCACCTCCAC TCTGGGCACC CCCAGGGAAA CACCTGGTCA CCGAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114092.2
CDS	357..1727
Translation	MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV

Target ORF information:

RefSeq Version	NM_031886.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 7 (KCNA7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031886.2

ORF Insert Sequence:

ATGGAGCCGC GGTGCCCGCC GCCGTGCGGC TGCTGCGAGC GGCTGGTGCT CAACGTGGCC 
GGGCTGCGCT TCGAGACGCG GGCGCGCACG CTGGGCCGCT TCCCGGACAC TCTGCTAGGG 
GACCCAGCGC GCCGCGGCCG CTTCTACGAC GACGCGCGCC GCGAGTATTT CTTCGACCGG 
CACCGGCCCA GCTTCGACGC CGTGCTCTAC TACTACCAGT CCGGTGGGCG GCTGCGGCGG 
CCGGCGCACG TGCCGCTCGA CGTCTTCCTG GAAGAGGTGG CCTTCTACGG GCTGGGCGCG 
GCGGCCCTGG CACGCCTGCG CGAGGACGAG GGCTGCCCGG TGCCGCCCGA GCGCCCCCTG 
CCCCGCCGCG CCTTCGCCCG CCAGCTGTGG CTGCTTTTCG AGTTTCCCGA GAGCTCTCAG 
GCCGCGCGCG TGCTCGCCGT AGTCTCCGTG CTGGTCATCC TCGTCTCCAT CGTCGTCTTC 
TGCCTCGAGA CGCTGCCTGA CTTCCGCGAC GACCGCGACG GCACGGGGCT TGCTGCTGCA 
GCCGCAGCCG GCCCGTTCCC CGCTCCGCTG AATGGCTCCA GCCAAATGCC TGGAAATCCA 
CCCCGCCTGC CCTTCAATGA CCCGTTCTTC GTGGTGGAGA CGCTGTGTAT TTGTTGGTTC 
TCCTTTGAGC TGCTGGTACG CCTCCTGGTC TGTCCAAGCA AGGCTATCTT CTTCAAGAAC 
GTGATGAACC TCATCGATTT TGTGGCTATC CTTCCCTACT TTGTGGCACT GGGCACCGAG 
CTGGCCCGGC AGCGAGGGGT GGGCCAGCAG GCCATGTCAC TGGCCATCCT GAGAGTCATC 
CGATTGGTGC GTGTCTTCCG CATCTTCAAG CTGTCCCGGC ACTCAAAGGG CCTGCAAATC 
TTGGGCCAGA CGCTTCGGGC CTCCATGCGT GAGCTGGGCC TCCTCATCTT TTTCCTCTTC 
ATCGGTGTGG TCCTCTTTTC CAGCGCCGTC TACTTTGCCG AAGTTGACCG GGTGGACTCC 
CATTTCACTA GCATCCCTGA GTCCTTCTGG TGGGCGGTAG TCACCATGAC TACAGTTGGC 
TATGGAGACA TGGCACCCGT CACTGTGGGT GGCAAGATAG TGGGCTCTCT GTGTGCCATT 
GCGGGCGTGC TGACTATTTC CCTGCCAGTG CCCGTCATTG TCTCCAATTT CAGCTACTTT 
TATCACCGGG AGACAGAGGG CGAAGAGGCT GGGATGTTCA GCCATGTGGA CATGCAGCCT 
TGTGGCCCAC TGGAGGGCAA GGCCAATGGG GGGCTGGTGG ACGGGGAGGT ACCTGAGCTA 
CCACCTCCAC TCTGGGCACC CCCAGGGAAA CACCTGGTCA CCGAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.
Human molecular genetics25(22)4996-5005(2016 11)
Atsem S,Reichenbach J,Potabattula R,Dittrich M,Nava C,Depienne C,B?hm L,Rost S,Hahn T,Schorsch M,Haaf T,El Hajj N

Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.
EMBO molecular medicine4(5)424-34(2012 May)
Finol-Urdaneta RK,Remedi MS,Raasch W,Becker S,Clark RB,Str?ver N,Pavlov E,Nichols CG,French RJ,Terlau H

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacological reviews57(4)473-508(2005 Dec)
Gutman GA,Chandy KG,Grissmer S,Lazdunski M,McKinnon D,Pardo LA,Robertson GA,Rudy B,Sanguinetti MC,St?hmer W,Wang X

[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China].
Yi chuan = Hereditas25(2)129-32(2003 Mar)
Ding Q,Zhao YY,Dong LY,Sun ZJ,Guo L

Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
European journal of human genetics : EJHG10(1)36-43(2002 Jan)
Bardien-Kruger S,Wulff H,Arieff Z,Brink P,Chandy KG,Corfield V

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KCNA7 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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