KCNA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA4
Entrez Gene ID	3739
Full Name	potassium voltage-gated channel subfamily A member 4
Synonyms	HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 4 Names potassium voltage-gated channel subfamily A member 4 cardiac potassium channel fetal skeletal muscle potassium channel potassium channel 2 potassium channel, voltage gated shaker related subfamily A, member 4 rapidly inactivating potassium channel shaker-related potassium channel Kv1.4 type A potassium channel voltage-gated K(+) channel HuKII voltage-gated potassium channel HBK4 voltage-gated potassium channel HK1 voltage-gated potassium channel subunit Kv1.4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p14.1
Summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011].
Disorder MIM:	176266

mRNA and Protein(s)

mRNA	Protein	Name
NM_002233.4	NP_002224.1	potassium voltage-gated channel subfamily A member 4
NM_002233.3	NP_002224.1	potassium voltage-gated channel subfamily A member 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNA4	NP_776796.1
Gallus gallus (chicken)	KCNA4	NP_990230.1
Homo sapiens (human)	KCNA4	NP_002224.1
Pan troglodytes (chimpanzee)	KCNA4	XP_003313022.1
	KCNA4	XP_001088267.1
Canis lupus familiaris (dog)	KCNA4	XP_005633823.1
Mus musculus (house mouse)	Kcna4	NP_067250.2
Xenopus tropicalis (tropical clawed frog)	kcna4	XP_004913510.1
Rattus norvegicus (Norway rat)	Kcna4	NP_037103.1
Danio rerio (zebrafish)	kcna4	XP_005169006.1

Gene Ontology
Bibliography

Related articles in PubMed

Pore size matters for potassium channel conductance.
Naranjo D, Moldenhauer H, Pincuntureo M, D?az-Franulic I
The Journal of general physiology148(4)277-91(2016 Oct)

K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.
Jukkola PI, Lovett-Racke AE, Zamvil SS, Gu C
Neurobiology of disease47(2)280-93(2012 Aug)

Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.
Zheng Y, Chen L, Li J, Yu B, Su L, Chen X, Yu Y, Yan M, Liu B, Zhu Z
Clinical biochemistry44(17-18)1405-11(2011 Dec)

Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.
Imbrici P, D'Adamo MC, Grottesi A, Biscarini A, Pessia M
American journal of physiology. Cell physiology300(6)C1314-22(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of Kv1.4 appears to increase in the spinal cord of mice modelling remitting-relapsing experimental allergic encephalomyelitis (rrEAE) in peak and remitting phases.
Title: K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.

Detection of the methylation prevalence of KCNA4 and CYP26B1 together in serum demonstrated the good sensitivity and specificityin gastric cancer
Title: Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.

Data suggest that episodic ataxia type 1 mutations affect fast inactivation of Kv1.1/1.4 channels by a reduction in either subunit surface expression or altered affinity for the inactivation domain.
Title: Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.

Sialylated N-glycans uniquely impact gating of a mammalian Shaker family K(v) channel isoform, K(v)1.5, but have no effect on gating of a second Shaker isoform, K(v)1.4.
Title: N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating.

Both arachidonic acid and Trolox potently modulate Kv1.4 and Kv4.2 channel alpha-subunits, thereby presumably tuning presynaptic transmitter release and postsynaptic somatodendritic excitability in synaptic transmission and plasticity.
Title: Arachidonic acid potently inhibits both postsynaptic-type Kv4.2 and presynaptic-type Kv1.4 IA potassium channels.

The following KCNA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08590	NM_002233.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
View Old Accession Versions >>
OHu08590	NM_002233.3	Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA4 ( NM_002233.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002224.1 Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.

Price & Availability↑

CloneID	OHu08590
Clone ID Related Accession (Same CDS sequence)	NM_002233.4 , NM_002233.3
Accession Version	NM_002233.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA328650.1, AK311228.1, M60450.1, BE467209.1 and AC124657.5. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002233.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA328650.1, SRR1660803.27947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328224.7/ ENSP00000328511.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGTTG CAATGGTGAG TGCGGAGAGC TCAGGGTGCA ACAGTCACAT GCCTTATGGT 
TATGCTGCCC AGGCCCGGGC CCGGGAGCGG GAGAGGCTTG CTCACTCCAG GGCAGCTGCA 
GCAGCTGCTG TTGCAGCGGC CACAGCTGCT GTCGAAGGTA GCGGGGGTTC TGGTGGGGGC 
TCCCACCACC ACCACCAGTC ACGCGGGGCC TGTACCTCCC ATGACCCTCA GAGCAGCCGG 
GGTAGTCGGA GGAGGAGGCG ACAGCGGTCT GAGAAGAAGA AAGCCCACTA CCGGCAGAGC 
AGCTTCCCTC ATTGCTCTGA CCTGATGCCC AGTGGCTCTG AGGAGAAGAT CCTGAGGGAG 
CTGAGTGAGG AGGAGGAAGA TGAGGAGGAG GAGGAAGAGG AGGAAGAGGA GGGAAGGTTT 
TACTATAGTG AAGATGACCA TGGTGATGAG TGTTCCTACA CGGATCTGCT GCCTCAGGAT 
GAGGGCGGTG GCGGCTACAG TTCAGTCCGC TACAGTGACT GTTGTGAACG TGTGGTGATA 
AATGTGTCAG GCCTACGCTT TGAGACCCAA ATGAAAACTC TGGCCCAGTT TCCAGAGACT 
TTGTTGGGAG ACCCTGAAAA GAGGACTCAG TACTTTGACC CTTTGCGCAA TGAGTATTTT 
TTTGACAGGA ACCGCCCCAG CTTTGATGCC ATCTTGTATT ATTATCAATC AGGAGGCCGC 
CTGAAGAGGC CAGTCAATGT CCCCTTTGAT ATCTTCACTG AGGAGGTGAA GTTCTATCAG 
TTGGGGGAGG AGGCCCTGTT GAAGTTTCGG GAGGACGAGG GCTTTGTGAG AGAAGAGGAA 
GACAGGGCCC TCCCCGAGAA TGAATTTAAA AAGCAGATTT GGCTCCTCTT TGAATATCCA 
GAGAGCTCCA GTCCTGCAAG GGGCATAGCC ATTGTGTCCG TCCTGGTCAT CTTAATCTCC 
ATTGTCATCT TTTGCCTGGA AACCTTGCCT GAGTTTAGGG ACGACAGGGA TCTCGTCATG 
GCACTGAGTG CTGGCGGGCA TGGTGGGTTG TTGAATGATA CTTCAGCACC CCATCTGGAG 
AACTCAGGGC ACACAATATT CAATGACCCC TTCTTCATCG TGGAAACAGT CTGTATTGTA 
TGGTTTTCCT TTGAGTTTGT GGTTCGCTGC TTTGCTTGTC CCAGCCAAGC ACTCTTCTTC 
AAAAACATCA TGAACATCAT TGACATTGTC TCCATTTTGC CTTACTTCAT CACACTGGGC 
ACTGACCTGG CCCAGCAACA GGGGGGTGGC AATGGTCAGC AGCAGCAGGC CATGTCCTTT 
GCCATCCTCA GAATCATTCG TCTGGTCCGA GTATTCCGGA TCTTCAAACT CTCCAGGCAC 
TCCAAAGGCC TGCAGATCCT GGGCCACACC CTCAGAGCCA GCATGCGGGA ACTGGGCCTT 
CTGATCTTCT TCCTCTTCAT TGGGGTCATC CTCTTTTCTA GTGCTGTGTA TTTTGCAGAG 
GCGGATGAAC CTACTACCCA TTTCCAAAGC ATCCCAGATG CATTTTGGTG GGCTGTGGTG 
ACCATGACAA CTGTGGGCTA TGGGGACATG AAGCCCATCA CTGTAGGGGG CAAGATTGTC 
GGGTCCCTGT GTGCCATTGC GGGTGTCTTA ACCATTGCTT TGCCAGTGCC AGTGATTGTC 
TCTAACTTTA ACTATTTCTA CCACAGAGAG ACTGAAAATG AGGAACAGAC ACAGCTAACG 
CAGAATGCAG TCAGTTGTCC ATACCTCCCC TCTAATTTGC TCAAGAAATT TCGGAGCTCT 
ACTTCTTCTT CCCTGGGGGA CAAGTCAGAG TATCTAGAGA TGGAAGAAGG AGTTAAGGAA 
TCTCTGTGTG CAAAGGAGGA GAAGTGTCAG GGAAAGGGGG ATGACAGTGA GACAGATAAA 
AACAACTGTT CTAATGCAAA GGCTGTGGAG ACTGATGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002224.1
CDS	1242..3203
Translation	MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV

Target ORF information:

RefSeq Version	NM_002233.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002233.4

ORF Insert Sequence:

ATGGAGGTTG CAATGGTGAG TGCGGAGAGC TCAGGGTGCA ACAGTCACAT GCCTTATGGT 
TATGCTGCCC AGGCCCGGGC CCGGGAGCGG GAGAGGCTTG CTCACTCCAG GGCAGCTGCA 
GCAGCTGCTG TTGCAGCGGC CACAGCTGCT GTCGAAGGTA GCGGGGGTTC TGGTGGGGGC 
TCCCACCACC ACCACCAGTC ACGCGGGGCC TGTACCTCCC ATGACCCTCA GAGCAGCCGG 
GGTAGTCGGA GGAGGAGGCG ACAGCGGTCT GAGAAGAAGA AAGCCCACTA CCGGCAGAGC 
AGCTTCCCTC ATTGCTCTGA CCTGATGCCC AGTGGCTCTG AGGAGAAGAT CCTGAGGGAG 
CTGAGTGAGG AGGAGGAAGA TGAGGAGGAG GAGGAAGAGG AGGAAGAGGA GGGAAGGTTT 
TACTATAGTG AAGATGACCA TGGTGATGAG TGTTCCTACA CGGATCTGCT GCCTCAGGAT 
GAGGGCGGTG GCGGCTACAG TTCAGTCCGC TACAGTGACT GTTGTGAACG TGTGGTGATA 
AATGTGTCAG GCCTACGCTT TGAGACCCAA ATGAAAACTC TGGCCCAGTT TCCAGAGACT 
TTGTTGGGAG ACCCTGAAAA GAGGACTCAG TACTTTGACC CTTTGCGCAA TGAGTATTTT 
TTTGACAGGA ACCGCCCCAG CTTTGATGCC ATCTTGTATT ATTATCAATC AGGAGGCCGC 
CTGAAGAGGC CAGTCAATGT CCCCTTTGAT ATCTTCACTG AGGAGGTGAA GTTCTATCAG 
TTGGGGGAGG AGGCCCTGTT GAAGTTTCGG GAGGACGAGG GCTTTGTGAG AGAAGAGGAA 
GACAGGGCCC TCCCCGAGAA TGAATTTAAA AAGCAGATTT GGCTCCTCTT TGAATATCCA 
GAGAGCTCCA GTCCTGCAAG GGGCATAGCC ATTGTGTCCG TCCTGGTCAT CTTAATCTCC 
ATTGTCATCT TTTGCCTGGA AACCTTGCCT GAGTTTAGGG ACGACAGGGA TCTCGTCATG 
GCACTGAGTG CTGGCGGGCA TGGTGGGTTG TTGAATGATA CTTCAGCACC CCATCTGGAG 
AACTCAGGGC ACACAATATT CAATGACCCC TTCTTCATCG TGGAAACAGT CTGTATTGTA 
TGGTTTTCCT TTGAGTTTGT GGTTCGCTGC TTTGCTTGTC CCAGCCAAGC ACTCTTCTTC 
AAAAACATCA TGAACATCAT TGACATTGTC TCCATTTTGC CTTACTTCAT CACACTGGGC 
ACTGACCTGG CCCAGCAACA GGGGGGTGGC AATGGTCAGC AGCAGCAGGC CATGTCCTTT 
GCCATCCTCA GAATCATTCG TCTGGTCCGA GTATTCCGGA TCTTCAAACT CTCCAGGCAC 
TCCAAAGGCC TGCAGATCCT GGGCCACACC CTCAGAGCCA GCATGCGGGA ACTGGGCCTT 
CTGATCTTCT TCCTCTTCAT TGGGGTCATC CTCTTTTCTA GTGCTGTGTA TTTTGCAGAG 
GCGGATGAAC CTACTACCCA TTTCCAAAGC ATCCCAGATG CATTTTGGTG GGCTGTGGTG 
ACCATGACAA CTGTGGGCTA TGGGGACATG AAGCCCATCA CTGTAGGGGG CAAGATTGTC 
GGGTCCCTGT GTGCCATTGC GGGTGTCTTA ACCATTGCTT TGCCAGTGCC AGTGATTGTC 
TCTAACTTTA ACTATTTCTA CCACAGAGAG ACTGAAAATG AGGAACAGAC ACAGCTAACG 
CAGAATGCAG TCAGTTGTCC ATACCTCCCC TCTAATTTGC TCAAGAAATT TCGGAGCTCT 
ACTTCTTCTT CCCTGGGGGA CAAGTCAGAG TATCTAGAGA TGGAAGAAGG AGTTAAGGAA 
TCTCTGTGTG CAAAGGAGGA GAAGTGTCAG GGAAAGGGGG ATGACAGTGA GACAGATAAA 
AACAACTGTT CTAATGCAAA GGCTGTGGAG ACTGATGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNA4 ( NM_002233.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002224.1 Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.

Price & Availability↑

CloneID	OHu08590
Clone ID Related Accession (Same CDS sequence)	NM_002233.4 , NM_002233.3
Accession Version	NM_002233.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA328650.1, AK311228.1, M60450.1, BE467209.1 and AC124657.5. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2011 this sequence version replaced NM_002233.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA328650.1, SRR1660803.27947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGTTG CAATGGTGAG TGCGGAGAGC TCAGGGTGCA ACAGTCACAT GCCTTATGGT 
TATGCTGCCC AGGCCCGGGC CCGGGAGCGG GAGAGGCTTG CTCACTCCAG GGCAGCTGCA 
GCAGCTGCTG TTGCAGCGGC CACAGCTGCT GTCGAAGGTA GCGGGGGTTC TGGTGGGGGC 
TCCCACCACC ACCACCAGTC ACGCGGGGCC TGTACCTCCC ATGACCCTCA GAGCAGCCGG 
GGTAGTCGGA GGAGGAGGCG ACAGCGGTCT GAGAAGAAGA AAGCCCACTA CCGGCAGAGC 
AGCTTCCCTC ATTGCTCTGA CCTGATGCCC AGTGGCTCTG AGGAGAAGAT CCTGAGGGAG 
CTGAGTGAGG AGGAGGAAGA TGAGGAGGAG GAGGAAGAGG AGGAAGAGGA GGGAAGGTTT 
TACTATAGTG AAGATGACCA TGGTGATGAG TGTTCCTACA CGGATCTGCT GCCTCAGGAT 
GAGGGCGGTG GCGGCTACAG TTCAGTCCGC TACAGTGACT GTTGTGAACG TGTGGTGATA 
AATGTGTCAG GCCTACGCTT TGAGACCCAA ATGAAAACTC TGGCCCAGTT TCCAGAGACT 
TTGTTGGGAG ACCCTGAAAA GAGGACTCAG TACTTTGACC CTTTGCGCAA TGAGTATTTT 
TTTGACAGGA ACCGCCCCAG CTTTGATGCC ATCTTGTATT ATTATCAATC AGGAGGCCGC 
CTGAAGAGGC CAGTCAATGT CCCCTTTGAT ATCTTCACTG AGGAGGTGAA GTTCTATCAG 
TTGGGGGAGG AGGCCCTGTT GAAGTTTCGG GAGGACGAGG GCTTTGTGAG AGAAGAGGAA 
GACAGGGCCC TCCCCGAGAA TGAATTTAAA AAGCAGATTT GGCTCCTCTT TGAATATCCA 
GAGAGCTCCA GTCCTGCAAG GGGCATAGCC ATTGTGTCCG TCCTGGTCAT CTTAATCTCC 
ATTGTCATCT TTTGCCTGGA AACCTTGCCT GAGTTTAGGG ACGACAGGGA TCTCGTCATG 
GCACTGAGTG CTGGCGGGCA TGGTGGGTTG TTGAATGATA CTTCAGCACC CCATCTGGAG 
AACTCAGGGC ACACAATATT CAATGACCCC TTCTTCATCG TGGAAACAGT CTGTATTGTA 
TGGTTTTCCT TTGAGTTTGT GGTTCGCTGC TTTGCTTGTC CCAGCCAAGC ACTCTTCTTC 
AAAAACATCA TGAACATCAT TGACATTGTC TCCATTTTGC CTTACTTCAT CACACTGGGC 
ACTGACCTGG CCCAGCAACA GGGGGGTGGC AATGGTCAGC AGCAGCAGGC CATGTCCTTT 
GCCATCCTCA GAATCATTCG TCTGGTCCGA GTATTCCGGA TCTTCAAACT CTCCAGGCAC 
TCCAAAGGCC TGCAGATCCT GGGCCACACC CTCAGAGCCA GCATGCGGGA ACTGGGCCTT 
CTGATCTTCT TCCTCTTCAT TGGGGTCATC CTCTTTTCTA GTGCTGTGTA TTTTGCAGAG 
GCGGATGAAC CTACTACCCA TTTCCAAAGC ATCCCAGATG CATTTTGGTG GGCTGTGGTG 
ACCATGACAA CTGTGGGCTA TGGGGACATG AAGCCCATCA CTGTAGGGGG CAAGATTGTC 
GGGTCCCTGT GTGCCATTGC GGGTGTCTTA ACCATTGCTT TGCCAGTGCC AGTGATTGTC 
TCTAACTTTA ACTATTTCTA CCACAGAGAG ACTGAAAATG AGGAACAGAC ACAGCTAACG 
CAGAATGCAG TCAGTTGTCC ATACCTCCCC TCTAATTTGC TCAAGAAATT TCGGAGCTCT 
ACTTCTTCTT CCCTGGGGGA CAAGTCAGAG TATCTAGAGA TGGAAGAAGG AGTTAAGGAA 
TCTCTGTGTG CAAAGGAGGA GAAGTGTCAG GGAAAGGGGG ATGACAGTGA GACAGATAAA 
AACAACTGTT CTAATGCAAA GGCTGTGGAG ACTGATGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002224.1
CDS	1242..3203
Translation	MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV

Target ORF information:

RefSeq Version	NM_002233.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 4 (KCNA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002233.3

ORF Insert Sequence:

ATGGAGGTTG CAATGGTGAG TGCGGAGAGC TCAGGGTGCA ACAGTCACAT GCCTTATGGT 
TATGCTGCCC AGGCCCGGGC CCGGGAGCGG GAGAGGCTTG CTCACTCCAG GGCAGCTGCA 
GCAGCTGCTG TTGCAGCGGC CACAGCTGCT GTCGAAGGTA GCGGGGGTTC TGGTGGGGGC 
TCCCACCACC ACCACCAGTC ACGCGGGGCC TGTACCTCCC ATGACCCTCA GAGCAGCCGG 
GGTAGTCGGA GGAGGAGGCG ACAGCGGTCT GAGAAGAAGA AAGCCCACTA CCGGCAGAGC 
AGCTTCCCTC ATTGCTCTGA CCTGATGCCC AGTGGCTCTG AGGAGAAGAT CCTGAGGGAG 
CTGAGTGAGG AGGAGGAAGA TGAGGAGGAG GAGGAAGAGG AGGAAGAGGA GGGAAGGTTT 
TACTATAGTG AAGATGACCA TGGTGATGAG TGTTCCTACA CGGATCTGCT GCCTCAGGAT 
GAGGGCGGTG GCGGCTACAG TTCAGTCCGC TACAGTGACT GTTGTGAACG TGTGGTGATA 
AATGTGTCAG GCCTACGCTT TGAGACCCAA ATGAAAACTC TGGCCCAGTT TCCAGAGACT 
TTGTTGGGAG ACCCTGAAAA GAGGACTCAG TACTTTGACC CTTTGCGCAA TGAGTATTTT 
TTTGACAGGA ACCGCCCCAG CTTTGATGCC ATCTTGTATT ATTATCAATC AGGAGGCCGC 
CTGAAGAGGC CAGTCAATGT CCCCTTTGAT ATCTTCACTG AGGAGGTGAA GTTCTATCAG 
TTGGGGGAGG AGGCCCTGTT GAAGTTTCGG GAGGACGAGG GCTTTGTGAG AGAAGAGGAA 
GACAGGGCCC TCCCCGAGAA TGAATTTAAA AAGCAGATTT GGCTCCTCTT TGAATATCCA 
GAGAGCTCCA GTCCTGCAAG GGGCATAGCC ATTGTGTCCG TCCTGGTCAT CTTAATCTCC 
ATTGTCATCT TTTGCCTGGA AACCTTGCCT GAGTTTAGGG ACGACAGGGA TCTCGTCATG 
GCACTGAGTG CTGGCGGGCA TGGTGGGTTG TTGAATGATA CTTCAGCACC CCATCTGGAG 
AACTCAGGGC ACACAATATT CAATGACCCC TTCTTCATCG TGGAAACAGT CTGTATTGTA 
TGGTTTTCCT TTGAGTTTGT GGTTCGCTGC TTTGCTTGTC CCAGCCAAGC ACTCTTCTTC 
AAAAACATCA TGAACATCAT TGACATTGTC TCCATTTTGC CTTACTTCAT CACACTGGGC 
ACTGACCTGG CCCAGCAACA GGGGGGTGGC AATGGTCAGC AGCAGCAGGC CATGTCCTTT 
GCCATCCTCA GAATCATTCG TCTGGTCCGA GTATTCCGGA TCTTCAAACT CTCCAGGCAC 
TCCAAAGGCC TGCAGATCCT GGGCCACACC CTCAGAGCCA GCATGCGGGA ACTGGGCCTT 
CTGATCTTCT TCCTCTTCAT TGGGGTCATC CTCTTTTCTA GTGCTGTGTA TTTTGCAGAG 
GCGGATGAAC CTACTACCCA TTTCCAAAGC ATCCCAGATG CATTTTGGTG GGCTGTGGTG 
ACCATGACAA CTGTGGGCTA TGGGGACATG AAGCCCATCA CTGTAGGGGG CAAGATTGTC 
GGGTCCCTGT GTGCCATTGC GGGTGTCTTA ACCATTGCTT TGCCAGTGCC AGTGATTGTC 
TCTAACTTTA ACTATTTCTA CCACAGAGAG ACTGAAAATG AGGAACAGAC ACAGCTAACG 
CAGAATGCAG TCAGTTGTCC ATACCTCCCC TCTAATTTGC TCAAGAAATT TCGGAGCTCT 
ACTTCTTCTT CCCTGGGGGA CAAGTCAGAG TATCTAGAGA TGGAAGAAGG AGTTAAGGAA 
TCTCTGTGTG CAAAGGAGGA GAAGTGTCAG GGAAAGGGGG ATGACAGTGA GACAGATAAA 
AACAACTGTT CTAATGCAAA GGCTGTGGAG ACTGATGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pore size matters for potassium channel conductance.
The Journal of general physiology148(4)277-91(2016 Oct)
Naranjo D,Moldenhauer H,Pincuntureo M,D?az-Franulic I

K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.
Neurobiology of disease47(2)280-93(2012 Aug)
Jukkola PI,Lovett-Racke AE,Zamvil SS,Gu C

Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.
Clinical biochemistry44(17-18)1405-11(2011 Dec)
Zheng Y,Chen L,Li J,Yu B,Su L,Chen X,Yu Y,Yan M,Liu B,Zhu Z

Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.
American journal of physiology. Cell physiology300(6)C1314-22(2011 Jun)
Imbrici P,D'Adamo MC,Grottesi A,Biscarini A,Pessia M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

KCNA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報