KCNA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA3
Entrez Gene ID	3738
Full Name	potassium voltage-gated channel subfamily A member 3
Synonyms	HGK5,HLK3,HPCN3,HUKIII,KV1.3,MK3,PCN3
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 3 Names potassium voltage-gated channel subfamily A member 3 potassium channel 3 potassium channel, voltage gated shaker related subfamily A, member 3 potassium voltage-gated channel, shaker-related subfamily, member 3 type n potassium channel voltage-gated K(+) channel HuKIII voltage-gated potassium channel protein Kv1.3 voltage-gated potassium channel subunit Kv1.3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.3
Summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008].
Disorder MIM:	176263

mRNA and Protein(s)

mRNA	Protein	Name
NM_002232.4	NP_002223.3	potassium voltage-gated channel subfamily A member 3
NM_002232.5	NP_002223.3	potassium voltage-gated channel subfamily A member 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNA3	XP_524797.1
Gallus gallus (chicken)	KCNA3	NP_001025549.1
Danio rerio (zebrafish)	LOC100150068	XP_005172172.1
Danio rerio (zebrafish)	LOC100330283	XP_005174156.1
Bos taurus (cattle)	KCNA3	XP_005204275.1
Drosophila melanogaster (fruit fly)	Sh	NP_523393.3
Xenopus tropicalis (tropical clawed frog)	kcna1	XP_004910792.1
Homo sapiens (human)	KCNA3	NP_002223.3
	KCNA3	XP_001101652.1
Rattus norvegicus (Norway rat)	Kcna3	NP_062143.3
Canis lupus familiaris (dog)	KCNA3	XP_003434878.2
Mus musculus (house mouse)	Kcna3	NP_032444.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000254	XP_310869.5
Caenorhabditis elegans (roundworm)	shk-1	NP_496104.2

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic regulation of voltage-gated potassium ion channel molecule Kv1.3 in mechanisms of colorectal cancer.
He T, Wang C, Zhang M, Zhang X, Zheng S, Linghu E, Guo M
Discovery medicine23(126)155-162(2017 Mar)

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL
Nature communications814644(2017 Mar)

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.
Sol? L, Roig SR, Vallejo-Gracia A, Serrano-Albarr?s A, Mart?nez-M?rmol R, Tamkun MM, Felipe A
Journal of cell science129(22)4265-4277(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.
Title: The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.

we report that Kv1.3-NPs reduced NFAT activation and CD40L expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.
Title: Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.

results identify a caveolin-binding domain in Kv1 channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes
Title: Caveolin interaction governs Kv1.3 lipid raft targeting.

concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK.
Title: Kv1.3 potassium channel mediates macrophage migration in atherosclerosis by regulating ERK activity.

Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr-447 by MAP kinase signal cascade appears crucial.
Title: Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation.

The following KCNA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12377	NM_002232.5 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu12377	NM_002232.4	Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA3 ( NM_002232.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002223.3 Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12377
Clone ID Related Accession (Same CDS sequence)	NM_002232.4 , NM_002232.5
Accession Version	NM_002232.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1728bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-28
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL365361.12, BC035059.1 and CA438434.1. On Dec 18, 2013 this sequence version replaced NM_002232.3. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGACGAGC GCCTCAGCCT TCTGCGCTCG CCGCCGCCGC CCTCAGCCCG CCACCGCGCC 
CACCCTCCTC AGCGCCCAGC GAGCAGCGGC GGTGCCCACA CGCTGGTGAA CCACGGCTAC 
GCGGAGCCCG CCGCAGGCCG CGAGCTGCCG CCCGACATGA CCGTGGTGCC CGGGGACCAC 
CTGCTGGAGC CGGAGGTGGC CGATGGTGGA GGGGCCCCGC CTCAAGGCGG CTGTGGCGGC 
GGCGGCTGCG ACCGCTACGA GCCGCTGCCG CCCTCACTGC CGGCCGCGGG CGAGCAGGAC 
TGCTGCGGGG AGCGCGTGGT CATCAACATC TCCGGGCTGC GCTTCGAGAC GCAGCTGAAG 
ACCCTTTGCC AGTTCCCCGA GACGCTGCTG GGCGACCCCA AGCGGCGCAT GAGGTACTTC 
GACCCGCTCC GCAACGAGTA CTTCTTCGAC CGCAACCGGC CCAGCTTCGA CGCCATCCTC 
TACTACTATC AGTCCGGGGG CCGCATCCGC CGGCCGGTCA ACGTGCCCAT CGACATTTTC 
TCCGAGGAGA TCCGCTTCTA CCAGCTGGGC GAGGAGGCCA TGGAGAAGTT CCGCGAGGAC 
GAGGGCTTCC TGCGGGAGGA GGAGCGGCCC TTGCCCCGCC GCGACTTCCA GCGCCAGGTG 
TGGCTGCTCT TCGAGTACCC CGAGAGCTCC GGGCCGGCCC GGGGCATCGC CATCGTGTCC 
GTGCTGGTCA TCCTCATCTC CATTGTCATC TTCTGCCTGG AGACGCTGCC GGAGTTCCGC 
GACGAGAAGG ACTACCCCGC CTCGACGTCG CAGGACTCAT TCGAAGCAGC CGGCAACAGC 
ACGTCGGGGT CCCGCGCAGG AGCCTCCAGC TTCTCCGATC CCTTCTTCGT GGTGGAGACG 
CTGTGCATCA TCTGGTTCTC CTTCGAACTG CTGGTGCGGT TCTTCGCTTG TCCTAGCAAA 
GCCACCTTCT CGCGAAACAT CATGAACCTG ATCGACATTG TGGCCATCAT TCCTTATTTT 
ATCACTCTGG GTACCGAGCT GGCCGAACGA CAGGGCAATG GACAGCAGGC CATGTCTCTG 
GCCATCCTGA GGGTCATCCG CCTGGTAAGG GTCTTCCGCA TCTTCAAGCT GTCGCGCCAC 
TCCAAGGGGC TGCAGATCCT CGGGCAAACG CTGAAGGCGT CCATGCGGGA GCTGGGATTG 
CTCATCTTCT TCCTCTTTAT TGGGGTCATC CTTTTCTCCA GCGCGGTCTA CTTTGCCGAG 
GCAGACGACC CCACTTCAGG TTTCAGCAGC ATCCCGGATG CCTTCTGGTG GGCAGTGGTA 
ACCATGACAA CAGTGGGTTA CGGCGATATG CACCCAGTGA CCATAGGGGG CAAGATTGTG 
GGATCTCTCT GTGCCATCGC CGGTGTCTTG ACCATCGCAT TGCCAGTTCC CGTGATTGTT 
TCCAACTTCA ATTACTTCTA CCACCGGGAG ACAGAAGGGG AAGAGCAATC CCAGTACATG 
CACGTGGGAA GTTGCCAGCA CCTCTCCTCT TCAGCCGAGG AGCTCCGAAA AGCAAGGAGT 
AACTCGACTC TGAGTAAGTC GGAGTATATG GTGATCGAAG AGGGGGGTAT GAACCATAGC 
GCTTTCCCCC AGACCCCTTT CAAAACGGGC AATTCCACTG CCACCTGCAC CACGAACAAT 
AATCCCAACT CTTGTGTCAA CATCAAAAAG ATATTCACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002223.3
CDS	225..1952
Translation	MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Target ORF information:

RefSeq Version	NM_002232.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002232.4

ORF Insert Sequence:

ATGGACGAGC GCCTCAGCCT TCTGCGCTCG CCGCCGCCGC CCTCAGCCCG CCACCGCGCC 
CACCCTCCTC AGCGCCCAGC GAGCAGCGGC GGTGCCCACA CGCTGGTGAA CCACGGCTAC 
GCGGAGCCCG CCGCAGGCCG CGAGCTGCCG CCCGACATGA CCGTGGTGCC CGGGGACCAC 
CTGCTGGAGC CGGAGGTGGC CGATGGTGGA GGGGCCCCGC CTCAAGGCGG CTGTGGCGGC 
GGCGGCTGCG ACCGCTACGA GCCGCTGCCG CCCTCACTGC CGGCCGCGGG CGAGCAGGAC 
TGCTGCGGGG AGCGCGTGGT CATCAACATC TCCGGGCTGC GCTTCGAGAC GCAGCTGAAG 
ACCCTTTGCC AGTTCCCCGA GACGCTGCTG GGCGACCCCA AGCGGCGCAT GAGGTACTTC 
GACCCGCTCC GCAACGAGTA CTTCTTCGAC CGCAACCGGC CCAGCTTCGA CGCCATCCTC 
TACTACTATC AGTCCGGGGG CCGCATCCGC CGGCCGGTCA ACGTGCCCAT CGACATTTTC 
TCCGAGGAGA TCCGCTTCTA CCAGCTGGGC GAGGAGGCCA TGGAGAAGTT CCGCGAGGAC 
GAGGGCTTCC TGCGGGAGGA GGAGCGGCCC TTGCCCCGCC GCGACTTCCA GCGCCAGGTG 
TGGCTGCTCT TCGAGTACCC CGAGAGCTCC GGGCCGGCCC GGGGCATCGC CATCGTGTCC 
GTGCTGGTCA TCCTCATCTC CATTGTCATC TTCTGCCTGG AGACGCTGCC GGAGTTCCGC 
GACGAGAAGG ACTACCCCGC CTCGACGTCG CAGGACTCAT TCGAAGCAGC CGGCAACAGC 
ACGTCGGGGT CCCGCGCAGG AGCCTCCAGC TTCTCCGATC CCTTCTTCGT GGTGGAGACG 
CTGTGCATCA TCTGGTTCTC CTTCGAACTG CTGGTGCGGT TCTTCGCTTG TCCTAGCAAA 
GCCACCTTCT CGCGAAACAT CATGAACCTG ATCGACATTG TGGCCATCAT TCCTTATTTT 
ATCACTCTGG GTACCGAGCT GGCCGAACGA CAGGGCAATG GACAGCAGGC CATGTCTCTG 
GCCATCCTGA GGGTCATCCG CCTGGTAAGG GTCTTCCGCA TCTTCAAGCT GTCGCGCCAC 
TCCAAGGGGC TGCAGATCCT CGGGCAAACG CTGAAGGCGT CCATGCGGGA GCTGGGATTG 
CTCATCTTCT TCCTCTTTAT TGGGGTCATC CTTTTCTCCA GCGCGGTCTA CTTTGCCGAG 
GCAGACGACC CCACTTCAGG TTTCAGCAGC ATCCCGGATG CCTTCTGGTG GGCAGTGGTA 
ACCATGACAA CAGTGGGTTA CGGCGATATG CACCCAGTGA CCATAGGGGG CAAGATTGTG 
GGATCTCTCT GTGCCATCGC CGGTGTCTTG ACCATCGCAT TGCCAGTTCC CGTGATTGTT 
TCCAACTTCA ATTACTTCTA CCACCGGGAG ACAGAAGGGG AAGAGCAATC CCAGTACATG 
CACGTGGGAA GTTGCCAGCA CCTCTCCTCT TCAGCCGAGG AGCTCCGAAA AGCAAGGAGT 
AACTCGACTC TGAGTAAGTC GGAGTATATG GTGATCGAAG AGGGGGGTAT GAACCATAGC 
GCTTTCCCCC AGACCCCTTT CAAAACGGGC AATTCCACTG CCACCTGCAC CACGAACAAT 
AATCCCAACT CTTGTGTCAA CATCAAAAAG ATATTCACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNA3 ( NM_002232.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002223.3 Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12377
Clone ID Related Accession (Same CDS sequence)	NM_002232.4 , NM_002232.5
Accession Version	NM_002232.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1728bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035059.1, AL365361.12 and CA438434.1. On Nov 23, 2018 this sequence version replaced NM_002232.4. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK314009.1, BC035059.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369769.4/ ENSP00000358784.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGAGC GCCTCAGCCT TCTGCGCTCG CCGCCGCCGC CCTCAGCCCG CCACCGCGCC 
CACCCTCCTC AGCGCCCAGC GAGCAGCGGC GGTGCCCACA CGCTGGTGAA CCACGGCTAC 
GCGGAGCCCG CCGCAGGCCG CGAGCTGCCG CCCGACATGA CCGTGGTGCC CGGGGACCAC 
CTGCTGGAGC CGGAGGTGGC CGATGGTGGA GGGGCCCCGC CTCAAGGCGG CTGTGGCGGC 
GGCGGCTGCG ACCGCTACGA GCCGCTGCCG CCCTCACTGC CGGCCGCGGG CGAGCAGGAC 
TGCTGCGGGG AGCGCGTGGT CATCAACATC TCCGGGCTGC GCTTCGAGAC GCAGCTGAAG 
ACCCTTTGCC AGTTCCCCGA GACGCTGCTG GGCGACCCCA AGCGGCGCAT GAGGTACTTC 
GACCCGCTCC GCAACGAGTA CTTCTTCGAC CGCAACCGGC CCAGCTTCGA CGCCATCCTC 
TACTACTATC AGTCCGGGGG CCGCATCCGC CGGCCGGTCA ACGTGCCCAT CGACATTTTC 
TCCGAGGAGA TCCGCTTCTA CCAGCTGGGC GAGGAGGCCA TGGAGAAGTT CCGCGAGGAC 
GAGGGCTTCC TGCGGGAGGA GGAGCGGCCC TTGCCCCGCC GCGACTTCCA GCGCCAGGTG 
TGGCTGCTCT TCGAGTACCC CGAGAGCTCC GGGCCGGCCC GGGGCATCGC CATCGTGTCC 
GTGCTGGTCA TCCTCATCTC CATTGTCATC TTCTGCCTGG AGACGCTGCC GGAGTTCCGC 
GACGAGAAGG ACTACCCCGC CTCGACGTCG CAGGACTCAT TCGAAGCAGC CGGCAACAGC 
ACGTCGGGGT CCCGCGCAGG AGCCTCCAGC TTCTCCGATC CCTTCTTCGT GGTGGAGACG 
CTGTGCATCA TCTGGTTCTC CTTCGAACTG CTGGTGCGGT TCTTCGCTTG TCCTAGCAAA 
GCCACCTTCT CGCGAAACAT CATGAACCTG ATCGACATTG TGGCCATCAT TCCTTATTTT 
ATCACTCTGG GTACCGAGCT GGCCGAACGA CAGGGCAATG GACAGCAGGC CATGTCTCTG 
GCCATCCTGA GGGTCATCCG CCTGGTAAGG GTCTTCCGCA TCTTCAAGCT GTCGCGCCAC 
TCCAAGGGGC TGCAGATCCT CGGGCAAACG CTGAAGGCGT CCATGCGGGA GCTGGGATTG 
CTCATCTTCT TCCTCTTTAT TGGGGTCATC CTTTTCTCCA GCGCGGTCTA CTTTGCCGAG 
GCAGACGACC CCACTTCAGG TTTCAGCAGC ATCCCGGATG CCTTCTGGTG GGCAGTGGTA 
ACCATGACAA CAGTGGGTTA CGGCGATATG CACCCAGTGA CCATAGGGGG CAAGATTGTG 
GGATCTCTCT GTGCCATCGC CGGTGTCTTG ACCATCGCAT TGCCAGTTCC CGTGATTGTT 
TCCAACTTCA ATTACTTCTA CCACCGGGAG ACAGAAGGGG AAGAGCAATC CCAGTACATG 
CACGTGGGAA GTTGCCAGCA CCTCTCCTCT TCAGCCGAGG AGCTCCGAAA AGCAAGGAGT 
AACTCGACTC TGAGTAAGTC GGAGTATATG GTGATCGAAG AGGGGGGTAT GAACCATAGC 
GCTTTCCCCC AGACCCCTTT CAAAACGGGC AATTCCACTG CCACCTGCAC CACGAACAAT 
AATCCCAACT CTTGTGTCAA CATCAAAAAG ATATTCACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002223.3
CDS	132..1859
Translation	MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Target ORF information:

RefSeq Version	NM_002232.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 3 (KCNA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002232.5

ORF Insert Sequence:

ATGGACGAGC GCCTCAGCCT TCTGCGCTCG CCGCCGCCGC CCTCAGCCCG CCACCGCGCC 
CACCCTCCTC AGCGCCCAGC GAGCAGCGGC GGTGCCCACA CGCTGGTGAA CCACGGCTAC 
GCGGAGCCCG CCGCAGGCCG CGAGCTGCCG CCCGACATGA CCGTGGTGCC CGGGGACCAC 
CTGCTGGAGC CGGAGGTGGC CGATGGTGGA GGGGCCCCGC CTCAAGGCGG CTGTGGCGGC 
GGCGGCTGCG ACCGCTACGA GCCGCTGCCG CCCTCACTGC CGGCCGCGGG CGAGCAGGAC 
TGCTGCGGGG AGCGCGTGGT CATCAACATC TCCGGGCTGC GCTTCGAGAC GCAGCTGAAG 
ACCCTTTGCC AGTTCCCCGA GACGCTGCTG GGCGACCCCA AGCGGCGCAT GAGGTACTTC 
GACCCGCTCC GCAACGAGTA CTTCTTCGAC CGCAACCGGC CCAGCTTCGA CGCCATCCTC 
TACTACTATC AGTCCGGGGG CCGCATCCGC CGGCCGGTCA ACGTGCCCAT CGACATTTTC 
TCCGAGGAGA TCCGCTTCTA CCAGCTGGGC GAGGAGGCCA TGGAGAAGTT CCGCGAGGAC 
GAGGGCTTCC TGCGGGAGGA GGAGCGGCCC TTGCCCCGCC GCGACTTCCA GCGCCAGGTG 
TGGCTGCTCT TCGAGTACCC CGAGAGCTCC GGGCCGGCCC GGGGCATCGC CATCGTGTCC 
GTGCTGGTCA TCCTCATCTC CATTGTCATC TTCTGCCTGG AGACGCTGCC GGAGTTCCGC 
GACGAGAAGG ACTACCCCGC CTCGACGTCG CAGGACTCAT TCGAAGCAGC CGGCAACAGC 
ACGTCGGGGT CCCGCGCAGG AGCCTCCAGC TTCTCCGATC CCTTCTTCGT GGTGGAGACG 
CTGTGCATCA TCTGGTTCTC CTTCGAACTG CTGGTGCGGT TCTTCGCTTG TCCTAGCAAA 
GCCACCTTCT CGCGAAACAT CATGAACCTG ATCGACATTG TGGCCATCAT TCCTTATTTT 
ATCACTCTGG GTACCGAGCT GGCCGAACGA CAGGGCAATG GACAGCAGGC CATGTCTCTG 
GCCATCCTGA GGGTCATCCG CCTGGTAAGG GTCTTCCGCA TCTTCAAGCT GTCGCGCCAC 
TCCAAGGGGC TGCAGATCCT CGGGCAAACG CTGAAGGCGT CCATGCGGGA GCTGGGATTG 
CTCATCTTCT TCCTCTTTAT TGGGGTCATC CTTTTCTCCA GCGCGGTCTA CTTTGCCGAG 
GCAGACGACC CCACTTCAGG TTTCAGCAGC ATCCCGGATG CCTTCTGGTG GGCAGTGGTA 
ACCATGACAA CAGTGGGTTA CGGCGATATG CACCCAGTGA CCATAGGGGG CAAGATTGTG 
GGATCTCTCT GTGCCATCGC CGGTGTCTTG ACCATCGCAT TGCCAGTTCC CGTGATTGTT 
TCCAACTTCA ATTACTTCTA CCACCGGGAG ACAGAAGGGG AAGAGCAATC CCAGTACATG 
CACGTGGGAA GTTGCCAGCA CCTCTCCTCT TCAGCCGAGG AGCTCCGAAA AGCAAGGAGT 
AACTCGACTC TGAGTAAGTC GGAGTATATG GTGATCGAAG AGGGGGGTAT GAACCATAGC 
GCTTTCCCCC AGACCCCTTT CAAAACGGGC AATTCCACTG CCACCTGCAC CACGAACAAT 
AATCCCAACT CTTGTGTCAA CATCAAAAAG ATATTCACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic regulation of voltage-gated potassium ion channel molecule Kv1.3 in mechanisms of colorectal cancer.
Discovery medicine23(126)155-162(2017 Mar)
He T,Wang C,Zhang M,Zhang X,Zheng S,Linghu E,Guo M

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
Nature communications814644(2017 Mar)
Chiang EY,Li T,Jeet S,Peng I,Zhang J,Lee WP,DeVoss J,Caplazi P,Chen J,Warming S,Hackos DH,Mukund S,Koth CM,Grogan JL

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.
Journal of cell science129(22)4265-4277(2016 11)
Sol? L,Roig SR,Vallejo-Gracia A,Serrano-Albarr?s A,Mart?nez-M?rmol R,Tamkun MM,Felipe A

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KCNA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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