KCNA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA1
Entrez Gene ID	3736
Full Name	potassium voltage-gated channel subfamily A member 1
Synonyms	AEMK,EA1,HBK1,HUK1,KV1.1,MBK1,MK1,RBK1
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 1 Names potassium voltage-gated channel subfamily A member 1 potassium channel, voltage gated shaker related subfamily A, member 1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) voltage-gated K(+) channel HuKI voltage-gated potassium channel HBK1 voltage-gated potassium channel subunit Kv1.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Summary	This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008].
Disorder MIM:	176260
Disorder Html:	Episodic ataxia/myokymia syndrome, 160120 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000217.2	NP_000208.2	potassium voltage-gated channel subfamily A member 1
NM_000217.3	NP_000208.2	potassium voltage-gated channel subfamily A member 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNA1	NP_000208.2
	KCNA1	XP_001102027.2
Danio rerio (zebrafish)	LOC795942	XP_005163101.1
Pan troglodytes (chimpanzee)	KCNA1	XP_003313484.1
Bos taurus (cattle)	KCNA1	XP_005207261.1
Rattus norvegicus (Norway rat)	Kcna1	NP_775118.1
Xenopus tropicalis (tropical clawed frog)	LOC100492822	XP_004912859.1
Gallus gallus (chicken)	KCNA1	XP_004938130.1
Canis lupus familiaris (dog)	KCNA1	XP_005637320.1
Mus musculus (house mouse)	Kcna1	NP_034725.3

Gene Ontology
Bibliography

Related articles in PubMed

Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
Qu J, Lu SH, Lu ZL, Xu P, Xiang DX, Qu Q
Medicine96(26)e7321(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1, KCNA2, and KCNV2 in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1, KCNA2, and KCNV2 genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.
Title: Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.

Mutation p.Arg324Thr in the KCNA1 gene is pathogenic and results in episodic ataxia type 1 through a dominant-negative effect.
Title: Dominant-negative mutation p.Arg324Thr in KCNA1 impairs Kv1.1 channel function in episodic ataxia.

Herein, we critically evaluate the molecular and biophysical characteristics of the KV1.1 protein in comparison with others and discuss their role in the greater penetrance of KCNA1 mutations in humans leading to the neurological signs of episodic ataxia type 1
Title: Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.

we demonstrate that the pathophysiological impact of the I262T mutation entails altered channel gating and defective protein biosynthesis, both of which raise imperative questions that call for further elucidation of the structural and functional roles of the S3 transmembrane segment in Kv1.1 channels.
Title: The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels.

KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia is not present.
Title: Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations.

The following KCNA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25897	NM_000217.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25897	NM_000217.2	Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA1 ( NM_000217.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000208.2 Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.

Price & Availability↑

CloneID	OHu25897
Clone ID Related Accession (Same CDS sequence)	NM_000217.2 , NM_000217.3
Accession Version	NM_000217.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA236475.1 and AC006063.1. This sequence is a reference standard in the RefSeqGene project. On or before Dec 16, 2006 this sequence version replaced XM_001133050.1, NM_000217.1. Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA236475.1, SRR1803621.9971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGGTGA TGTCTGGGGA GAACGTGGAC GAGGCTTCGG CCGCCCCGGG CCACCCCCAG 
GATGGCAGCT ACCCCCGGCA GGCCGACCAC GACGACCACG AGTGCTGCGA GCGCGTGGTG 
ATCAACATCT CCGGGCTGCG CTTCGAGACG CAGCTCAAGA CCCTGGCGCA GTTCCCCAAC 
ACGCTGCTGG GCAACCCTAA GAAACGCATG CGCTACTTCG ACCCCCTGAG GAACGAGTAC 
TTCTTCGACC GCAACCGGCC CAGCTTCGAC GCCATCCTCT ACTACTACCA GTCCGGCGGC 
CGCCTGCGGA GGCCGGTCAA CGTGCCCCTG GACATGTTCT CCGAGGAGAT CAAGTTTTAC 
GAGTTGGGCG AGGAGGCCAT GGAGAAGTTC CGGGAGGACG AGGGCTTCAT CAAGGAGGAG 
GAGCGCCCTC TGCCCGAGAA GGAGTACCAG CGCCAGGTGT GGCTGCTCTT CGAGTACCCC 
GAGAGCTCGG GGCCCGCCAG GGTCATCGCC ATCGTCTCCG TCATGGTCAT CCTCATCTCC 
ATCGTCATCT TTTGCCTGGA GACGCTCCCC GAGCTGAAGG ATGACAAGGA CTTCACGGGC 
ACCGTCCACC GCATCGACAA CACCACGGTC ATCTACAATT CCAACATCTT CACAGACCCC 
TTCTTCATCG TGGAAACGCT GTGTATCATC TGGTTCTCCT TCGAGCTGGT GGTGCGCTTC 
TTCGCCTGCC CCAGCAAGAC GGACTTCTTC AAAAACATCA TGAACTTCAT AGACATTGTG 
GCCATCATTC CTTATTTCAT CACGCTGGGC ACCGAGATAG CTGAGCAGGA AGGAAACCAG 
AAGGGCGAGC AGGCCACCTC CCTGGCCATC CTCAGGGTCA TCCGCTTGGT AAGGGTTTTT 
AGAATCTTCA AGCTCTCCCG CCACTCTAAG GGCCTCCAGA TCCTGGGCCA GACCCTCAAA 
GCTAGTATGA GAGAGCTAGG GCTGCTCATC TTTTTCCTCT TCATCGGGGT CATCCTGTTT 
TCTAGTGCAG TGTACTTTGC CGAGGCGGAA GAAGCTGAGT CGCACTTCTC CAGTATCCCC 
GATGCTTTCT GGTGGGCGGT GGTGTCCATG ACCACTGTAG GATACGGTGA CATGTACCCT 
GTGACAATTG GAGGCAAGAT CGTGGGCTCC TTGTGTGCCA TCGCTGGTGT GCTAACAATT 
GCCCTGCCCG TACCTGTCAT TGTGTCCAAT TTCAACTATT TCTACCACCG AGAAACTGAG 
GGGGAAGAGC AGGCTCAGTT GCTCCACGTC AGTTCCCCTA ACTTAGCCTC TGACAGTGAC 
CTCAGTCGCC GCAGTTCCTC TACTATGAGC AAGTCTGAGT ACATGGAGAT CGAAGAGGAT 
ATGAATAATA GCATAGCCCA TTATAGACAG GTCAATATCA GAACTGCCAA TTGCACCACT 
GCTAACCAAA ACTGCGTTAA TAAGAGCAAG CTACTGACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000208.2
CDS	1106..2593
Translation	MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV

Target ORF information:

RefSeq Version	NM_000217.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000217.2

ORF Insert Sequence:

ATGACGGTGA TGTCTGGGGA GAACGTGGAC GAGGCTTCGG CCGCCCCGGG CCACCCCCAG 
GATGGCAGCT ACCCCCGGCA GGCCGACCAC GACGACCACG AGTGCTGCGA GCGCGTGGTG 
ATCAACATCT CCGGGCTGCG CTTCGAGACG CAGCTCAAGA CCCTGGCGCA GTTCCCCAAC 
ACGCTGCTGG GCAACCCTAA GAAACGCATG CGCTACTTCG ACCCCCTGAG GAACGAGTAC 
TTCTTCGACC GCAACCGGCC CAGCTTCGAC GCCATCCTCT ACTACTACCA GTCCGGCGGC 
CGCCTGCGGA GGCCGGTCAA CGTGCCCCTG GACATGTTCT CCGAGGAGAT CAAGTTTTAC 
GAGTTGGGCG AGGAGGCCAT GGAGAAGTTC CGGGAGGACG AGGGCTTCAT CAAGGAGGAG 
GAGCGCCCTC TGCCCGAGAA GGAGTACCAG CGCCAGGTGT GGCTGCTCTT CGAGTACCCC 
GAGAGCTCGG GGCCCGCCAG GGTCATCGCC ATCGTCTCCG TCATGGTCAT CCTCATCTCC 
ATCGTCATCT TTTGCCTGGA GACGCTCCCC GAGCTGAAGG ATGACAAGGA CTTCACGGGC 
ACCGTCCACC GCATCGACAA CACCACGGTC ATCTACAATT CCAACATCTT CACAGACCCC 
TTCTTCATCG TGGAAACGCT GTGTATCATC TGGTTCTCCT TCGAGCTGGT GGTGCGCTTC 
TTCGCCTGCC CCAGCAAGAC GGACTTCTTC AAAAACATCA TGAACTTCAT AGACATTGTG 
GCCATCATTC CTTATTTCAT CACGCTGGGC ACCGAGATAG CTGAGCAGGA AGGAAACCAG 
AAGGGCGAGC AGGCCACCTC CCTGGCCATC CTCAGGGTCA TCCGCTTGGT AAGGGTTTTT 
AGAATCTTCA AGCTCTCCCG CCACTCTAAG GGCCTCCAGA TCCTGGGCCA GACCCTCAAA 
GCTAGTATGA GAGAGCTAGG GCTGCTCATC TTTTTCCTCT TCATCGGGGT CATCCTGTTT 
TCTAGTGCAG TGTACTTTGC CGAGGCGGAA GAAGCTGAGT CGCACTTCTC CAGTATCCCC 
GATGCTTTCT GGTGGGCGGT GGTGTCCATG ACCACTGTAG GATACGGTGA CATGTACCCT 
GTGACAATTG GAGGCAAGAT CGTGGGCTCC TTGTGTGCCA TCGCTGGTGT GCTAACAATT 
GCCCTGCCCG TACCTGTCAT TGTGTCCAAT TTCAACTATT TCTACCACCG AGAAACTGAG 
GGGGAAGAGC AGGCTCAGTT GCTCCACGTC AGTTCCCCTA ACTTAGCCTC TGACAGTGAC 
CTCAGTCGCC GCAGTTCCTC TACTATGAGC AAGTCTGAGT ACATGGAGAT CGAAGAGGAT 
ATGAATAATA GCATAGCCCA TTATAGACAG GTCAATATCA GAACTGCCAA TTGCACCACT 
GCTAACCAAA ACTGCGTTAA TAAGAGCAAG CTACTGACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNA1 ( NM_000217.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000208.2 Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.

Price & Availability↑

CloneID	OHu25897
Clone ID Related Accession (Same CDS sequence)	NM_000217.2 , NM_000217.3
Accession Version	NM_000217.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA336089.1, DA236475.1 and AC006063.1. This sequence is a reference standard in the RefSeqGene project. On Oct 22, 2018 this sequence version replaced NM_000217.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.830717.1, SRR1803621.9971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382545.5/ ENSP00000371985.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGTGA TGTCTGGGGA GAACGTGGAC GAGGCTTCGG CCGCCCCGGG CCACCCCCAG 
GATGGCAGCT ACCCCCGGCA GGCCGACCAC GACGACCACG AGTGCTGCGA GCGCGTGGTG 
ATCAACATCT CCGGGCTGCG CTTCGAGACG CAGCTCAAGA CCCTGGCGCA GTTCCCCAAC 
ACGCTGCTGG GCAACCCTAA GAAACGCATG CGCTACTTCG ACCCCCTGAG GAACGAGTAC 
TTCTTCGACC GCAACCGGCC CAGCTTCGAC GCCATCCTCT ACTACTACCA GTCCGGCGGC 
CGCCTGCGGA GGCCGGTCAA CGTGCCCCTG GACATGTTCT CCGAGGAGAT CAAGTTTTAC 
GAGTTGGGCG AGGAGGCCAT GGAGAAGTTC CGGGAGGACG AGGGCTTCAT CAAGGAGGAG 
GAGCGCCCTC TGCCCGAGAA GGAGTACCAG CGCCAGGTGT GGCTGCTCTT CGAGTACCCC 
GAGAGCTCGG GGCCCGCCAG GGTCATCGCC ATCGTCTCCG TCATGGTCAT CCTCATCTCC 
ATCGTCATCT TTTGCCTGGA GACGCTCCCC GAGCTGAAGG ATGACAAGGA CTTCACGGGC 
ACCGTCCACC GCATCGACAA CACCACGGTC ATCTACAATT CCAACATCTT CACAGACCCC 
TTCTTCATCG TGGAAACGCT GTGTATCATC TGGTTCTCCT TCGAGCTGGT GGTGCGCTTC 
TTCGCCTGCC CCAGCAAGAC GGACTTCTTC AAAAACATCA TGAACTTCAT AGACATTGTG 
GCCATCATTC CTTATTTCAT CACGCTGGGC ACCGAGATAG CTGAGCAGGA AGGAAACCAG 
AAGGGCGAGC AGGCCACCTC CCTGGCCATC CTCAGGGTCA TCCGCTTGGT AAGGGTTTTT 
AGAATCTTCA AGCTCTCCCG CCACTCTAAG GGCCTCCAGA TCCTGGGCCA GACCCTCAAA 
GCTAGTATGA GAGAGCTAGG GCTGCTCATC TTTTTCCTCT TCATCGGGGT CATCCTGTTT 
TCTAGTGCAG TGTACTTTGC CGAGGCGGAA GAAGCTGAGT CGCACTTCTC CAGTATCCCC 
GATGCTTTCT GGTGGGCGGT GGTGTCCATG ACCACTGTAG GATACGGTGA CATGTACCCT 
GTGACAATTG GAGGCAAGAT CGTGGGCTCC TTGTGTGCCA TCGCTGGTGT GCTAACAATT 
GCCCTGCCCG TACCTGTCAT TGTGTCCAAT TTCAACTATT TCTACCACCG AGAAACTGAG 
GGGGAAGAGC AGGCTCAGTT GCTCCACGTC AGTTCCCCTA ACTTAGCCTC TGACAGTGAC 
CTCAGTCGCC GCAGTTCCTC TACTATGAGC AAGTCTGAGT ACATGGAGAT CGAAGAGGAT 
ATGAATAATA GCATAGCCCA TTATAGACAG GTCAATATCA GAACTGCCAA TTGCACCACT 
GCTAACCAAA ACTGCGTTAA TAAGAGCAAG CTACTGACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000208.2
CDS	1108..2595
Translation	MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV

Target ORF information:

RefSeq Version	NM_000217.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000217.3

ORF Insert Sequence:

ATGACGGTGA TGTCTGGGGA GAACGTGGAC GAGGCTTCGG CCGCCCCGGG CCACCCCCAG 
GATGGCAGCT ACCCCCGGCA GGCCGACCAC GACGACCACG AGTGCTGCGA GCGCGTGGTG 
ATCAACATCT CCGGGCTGCG CTTCGAGACG CAGCTCAAGA CCCTGGCGCA GTTCCCCAAC 
ACGCTGCTGG GCAACCCTAA GAAACGCATG CGCTACTTCG ACCCCCTGAG GAACGAGTAC 
TTCTTCGACC GCAACCGGCC CAGCTTCGAC GCCATCCTCT ACTACTACCA GTCCGGCGGC 
CGCCTGCGGA GGCCGGTCAA CGTGCCCCTG GACATGTTCT CCGAGGAGAT CAAGTTTTAC 
GAGTTGGGCG AGGAGGCCAT GGAGAAGTTC CGGGAGGACG AGGGCTTCAT CAAGGAGGAG 
GAGCGCCCTC TGCCCGAGAA GGAGTACCAG CGCCAGGTGT GGCTGCTCTT CGAGTACCCC 
GAGAGCTCGG GGCCCGCCAG GGTCATCGCC ATCGTCTCCG TCATGGTCAT CCTCATCTCC 
ATCGTCATCT TTTGCCTGGA GACGCTCCCC GAGCTGAAGG ATGACAAGGA CTTCACGGGC 
ACCGTCCACC GCATCGACAA CACCACGGTC ATCTACAATT CCAACATCTT CACAGACCCC 
TTCTTCATCG TGGAAACGCT GTGTATCATC TGGTTCTCCT TCGAGCTGGT GGTGCGCTTC 
TTCGCCTGCC CCAGCAAGAC GGACTTCTTC AAAAACATCA TGAACTTCAT AGACATTGTG 
GCCATCATTC CTTATTTCAT CACGCTGGGC ACCGAGATAG CTGAGCAGGA AGGAAACCAG 
AAGGGCGAGC AGGCCACCTC CCTGGCCATC CTCAGGGTCA TCCGCTTGGT AAGGGTTTTT 
AGAATCTTCA AGCTCTCCCG CCACTCTAAG GGCCTCCAGA TCCTGGGCCA GACCCTCAAA 
GCTAGTATGA GAGAGCTAGG GCTGCTCATC TTTTTCCTCT TCATCGGGGT CATCCTGTTT 
TCTAGTGCAG TGTACTTTGC CGAGGCGGAA GAAGCTGAGT CGCACTTCTC CAGTATCCCC 
GATGCTTTCT GGTGGGCGGT GGTGTCCATG ACCACTGTAG GATACGGTGA CATGTACCCT 
GTGACAATTG GAGGCAAGAT CGTGGGCTCC TTGTGTGCCA TCGCTGGTGT GCTAACAATT 
GCCCTGCCCG TACCTGTCAT TGTGTCCAAT TTCAACTATT TCTACCACCG AGAAACTGAG 
GGGGAAGAGC AGGCTCAGTT GCTCCACGTC AGTTCCCCTA ACTTAGCCTC TGACAGTGAC 
CTCAGTCGCC GCAGTTCCTC TACTATGAGC AAGTCTGAGT ACATGGAGAT CGAAGAGGAT 
ATGAATAATA GCATAGCCCA TTATAGACAG GTCAATATCA GAACTGCCAA TTGCACCACT 
GCTAACCAAA ACTGCGTTAA TAAGAGCAAG CTACTGACCG ATGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
Medicine96(26)e7321(2017 Jun)
Qu J,Lu SH,Lu ZL,Xu P,Xiang DX,Qu Q

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KCNA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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