ITIH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITIH2
Entrez Gene ID	3698
Full Name	inter-alpha-trypsin inhibitor heavy chain 2
Synonyms	H2P,SHAP
General protein information	Preferred Names inter-alpha-trypsin inhibitor heavy chain 2 Names inter-alpha-trypsin inhibitor heavy chain H2 ITI heavy chain H2 ITI-HC2 inter-alpha (globulin) inhibitor H2 inter-alpha (globulin) inhibitor, H2 polypeptide inter-alpha-inhibitor heavy chain 2 inter-alpha-trypsin inhibitor complex component II serum-derived hyaluronan-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p14
Summary	The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].
Disorder MIM:	146640

mRNA and Protein(s)

mRNA	Protein	Name
NM_002216.3	NP_002207.2	inter-alpha-trypsin inhibitor heavy chain H2 precursor
NM_002216.2	NP_002207.2	inter-alpha-trypsin inhibitor heavy chain H2 precursor

Pathways from BioSystems

Homologies

	ITIH2	XP_001107718.1
Canis lupus familiaris (dog)	ITIH2	XP_535195.2
Homo sapiens (human)	ITIH2	NP_002207.2
Gallus gallus (chicken)	ITIH2	NP_001124213.1
Bos taurus (cattle)	ITIH2	NP_001091485.1
Mus musculus (house mouse)	Itih2	NP_034712.2
Xenopus tropicalis (tropical clawed frog)	itih2	NP_001039260.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Ragelle H, Naba A, Larson BL, Zhou F, Priji? M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG
Biomaterials128147-159(2017 06)

The Compact and Biologically Relevant Structure of Inter-?-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.
Scavenius C, Nikolajsen CL, Stenvang M, Th?gersen IB, Wyro?emski ?, Wisniewski HG, Otzen DE, Sanggaard KW, Enghild JJ
The Journal of biological chemistry291(9)4658-70(2016 Feb)

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO
BMC cancer14518(2014 Jul)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains.
Title: The Compact and Biologically Relevant Structure of Inter-?-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.

Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.
Title: Human inter-?-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.

It forms complex with hyaluronan and the comlex is a functional molecule involved in inflammation.
Title: [Covalent complex of hyaluronan and serum-derived protein, SHAP is a functional molecule involved in inflammation: finding, structure, formation mechanism, and function of the complex].

serum-derived hyaluronan-associated protein-hyaluronan complex has a role in progression of ovarian cancer
Title: Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer.

Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
Title: Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.

The following ITIH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITIH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30923	NM_002216.3 Latest version!	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu30923	NM_002216.2	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITIH2 ( NM_002216.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002207.2 Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.

Price & Availability↑

CloneID	OHu30923
Clone ID Related Accession (Same CDS sequence)	NM_002216.3 , NM_002216.2
Accession Version	NM_002216.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	inter-alpha-trypsin inhibitor heavy chain H2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG617651.1, X07173.1, AL158044.17, CB154170.1 and AA406494.1. On Nov 23, 2018 this sequence version replaced NM_002216.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225329.1, SRR1660809.121555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000358415.9/ ENSP00000351190.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAAGAC TCACGTGCTT TTTCATCTGC TTCTTTCTTT CTGAAGTATC AGGCTTCGAA 
ATCCCCATAA ATGGACTTTC TGAATTTGTA GACTATGAAG ATCTTGTGGA ACTGGCCCCA 
GGCAAATTTC AATTGGTGGC AGAGAACCGG AGATATCAGA GAAGCCTTCC AGGAGAATCG 
GAAGAAATGA TGGAAGAGGT TGATCAAGTA ACTCTTTATA GCTATAAAGT CCAGTCTACT 
ATTACTTCTC GGATGGCCAC CACCATGATC CAGAGCAAAG TGGTGAACAA TTCCCCGCAG 
CCTCAGAATG TCGTGTTTGA TGTTCAGATC CCCAAAGGAG CATTCATTTC CAACTTCTCC 
ATGACTGTGG ACGGCAAGAC ATTTAGGAGC TCTATTAAGG AGAAAACTGT GGGCCGAGCT 
CTTTATGCAC AGGCCAGAGC AAAAGGCAAG ACGGCTGGCT TGGTGAGGAG CAGCGCTCTT 
GATATGGAAA ACTTCAGAAC GGAAGTAAAT GTCCTCCCAG GAGCAAAGGT GCAGTTCGAA 
CTTCACTACC AGGAGGTGAA GTGGAGGAAG CTGGGCTCCT ATGAGCACAG GATCTATCTG 
CAACCTGGAC GGCTGGCCAA ACACTTAGAG GTAGATGTGT GGGTTATCGA ACCACAGGGA 
CTGAGATTTC TTCATGTTCC CGACACATTT GAAGGCCATT TCGATGGTGT TCCGGTCATT 
TCTAAAGGAC AACAGAAGGC GCACGTCTCC TTCAAGCCCA CGGTAGCACA GCAGAGAATA 
TGCCCTAACT GCCGGGAGAC TGCGGTAGAT GGGGAACTGG TGGTGCTGTA TGACGTGAAA 
AGAGAAGAGA AGGCTGGTGA ACTGGAGGTG TTTAATGGAT ATTTTGTCCA CTTCTTTGCT 
CCTGACAACC TGGACCCAAT TCCCAAAAAC ATCCTCTTTG TCATCGATGT GAGTGGCTCC 
ATGTGGGGAG TTAAAATGAA ACAAACTGTG GAAGCAATGA AGACCATATT GGATGACCTC 
AGAGCAGAAG ACCATTTCTC TGTGATTGAT TTCAACCAGA ACATTCGAAC TTGGAGAAAT 
GATTTAATTT CAGCTACAAA AACACAGGTT GCAGATGCCA AGAGGTATAT TGAGAAAATC 
CAGCCCAGTG GAGGCACAAA CATCAACGAA GCACTCCTAC GGGCAATCTT CATTTTGAAT 
GAAGCCAATA ACTTGGGACT GTTAGACCCC AACTCCGTCT CGCTGATCAT TTTGGTTTCT 
GATGGAGATC CAACAGTGGG CGAACTAAAA CTGTCAAAAA TTCAGAAAAA CGTTAAGGAG 
AACATCCAAG ACAATATCTC CTTGTTCAGT TTGGGCATGG GATTTGATGT GGACTATGAT 
TTTTTGAAGA GACTGTCCAA TGAAAACCAT GGAATTGCAC AAAGGATTTA TGGAAACCAG 
GACACGTCTT CCCAGCTTAA GAAATTCTAC AACCAGGTCT CCACTCCATT GCTCCGGAAT 
GTTCAGTTCA ACTATCCCCA TACATCAGTC ACGGACGTCA CTCAAAACAA TTTCCATAAC 
TACTTTGGAG GCTCAGAGAT TGTGGTGGCA GGAAAATTTG ACCCTGCTAA ATTGGATCAA 
ATAGAGAGCG TTATCACGGC GACTTCGGCT AACACGCAGT TAGTCTTGGA GACCCTGGCC 
CAGATGGACG ACTTGCAGGA TTTTCTATCG AAAGACAAGC ATGCAGATCC CGATTTCACC 
AGGAAACTGT GGGCCTATCT AACCATCAAC CAACTGCTAG CTGAACGAAG CCTGGCTCCT 
ACAGCTGCCG CCAAGAGAAG AATTACAAGA TCGATCCTGC AGATGTCTCT AGACCACCAC 
ATTGTGACTC CGCTGACCTC GCTGGTGATC GAGAACGAGG CTGGGGATGA GCGCATGCTG 
GCGGATGCCC CACCGCAGGA TCCCTCCTGC TGCTCAGGGG CCCTGTATTA CGGCAGCAAA 
GTGGTTCCAG ATTCCACCCC GTCTTGGGCC AATCCTTCAC CAACGCCCGT GATCTCCATG 
CTGGCACAAG GATCTCAGGT GCTAGAGTCC ACGCCACCCC CACATGTGAT GAGAGTTGAA 
AATGACCCAC ATTTCATCAT TTATCTACCA AAAAGCCAAA AGAACATTTG TTTCAATATT 
GACTCAGAAC CTGGAAAAAT CCTCAACCTG GTTTCTGACC CAGAATCAGG AATTGTAGTC 
AACGGTCAGC TTGTTGGTGC CAAGAAGCCC AACAATGGAA AACTAAGCAC CTATTTTGGA 
AAACTGGGAT TTTATTTCCA AAGTGAAGAC ATAAAAATAG AAATCAGCAC TGAGACCATC 
ACCCTGAGCC ATGGTTCTAG CACATTCTCC TTGTCCTGGT CCGACACGGC TCAAGTCACG 
AATCAGAGGG TGCAGATCTC AGTGAAGAAA GAAAAAGTGG TAACTATCAC CCTGGATAAA 
GAGATGTCCT TTTCTGTTTT ACTTCATCGT GTTTGGAAGA AGCATCCCGT CAATGTTGAC 
TTTCTGGGAA TCTACATACC CCCTACAAAC AAGTTCTCAC CTAAAGCCCA CGGACTAATA 
GGCCAGTTCA TGCAGGAACC AAAGATACAC ATCTTCAATG AGAGACCAGG AAAGGACCCT 
GAGAAGCCAG AGGCCAGCAT GGAAGTGAAG GGGCAGAAGC TGATCATCAC CAGGGGCTTA 
CAGAAAGACT ACAGAACGGA TCTAGTGTTT GGAACGGACG TTACCTGCTG GTTTGTGCAC 
AACAGTGGAA AAGGATTCAT TGACGGGCAT TACAAGGATT ACTTCGTGCC TCAGCTCTAC 
AGCTTTCTCA AACGGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002207.2
CDS	120..2960
Translation	MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP

Target ORF information:

RefSeq Version	NM_002216.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002216.3

ORF Insert Sequence:

ATGAAAAGAC TCACGTGCTT TTTCATCTGC TTCTTTCTTT CTGAAGTATC AGGCTTCGAA 
ATCCCCATAA ATGGACTTTC TGAATTTGTA GACTATGAAG ATCTTGTGGA ACTGGCCCCA 
GGCAAATTTC AATTGGTGGC AGAGAACCGG AGATATCAGA GAAGCCTTCC AGGAGAATCG 
GAAGAAATGA TGGAAGAGGT TGATCAAGTA ACTCTTTATA GCTATAAAGT CCAGTCTACT 
ATTACTTCTC GGATGGCCAC CACCATGATC CAGAGCAAAG TGGTGAACAA TTCCCCGCAG 
CCTCAGAATG TCGTGTTTGA TGTTCAGATC CCCAAAGGAG CATTCATTTC CAACTTCTCC 
ATGACTGTGG ACGGCAAGAC ATTTAGGAGC TCTATTAAGG AGAAAACTGT GGGCCGAGCT 
CTTTATGCAC AGGCCAGAGC AAAAGGCAAG ACGGCTGGCT TGGTGAGGAG CAGCGCTCTT 
GATATGGAAA ACTTCAGAAC GGAAGTAAAT GTCCTCCCAG GAGCAAAGGT GCAGTTCGAA 
CTTCACTACC AGGAGGTGAA GTGGAGGAAG CTGGGCTCCT ATGAGCACAG GATCTATCTG 
CAACCTGGAC GGCTGGCCAA ACACTTAGAG GTAGATGTGT GGGTTATCGA ACCACAGGGA 
CTGAGATTTC TTCATGTTCC CGACACATTT GAAGGCCATT TCGATGGTGT TCCGGTCATT 
TCTAAAGGAC AACAGAAGGC GCACGTCTCC TTCAAGCCCA CGGTAGCACA GCAGAGAATA 
TGCCCTAACT GCCGGGAGAC TGCGGTAGAT GGGGAACTGG TGGTGCTGTA TGACGTGAAA 
AGAGAAGAGA AGGCTGGTGA ACTGGAGGTG TTTAATGGAT ATTTTGTCCA CTTCTTTGCT 
CCTGACAACC TGGACCCAAT TCCCAAAAAC ATCCTCTTTG TCATCGATGT GAGTGGCTCC 
ATGTGGGGAG TTAAAATGAA ACAAACTGTG GAAGCAATGA AGACCATATT GGATGACCTC 
AGAGCAGAAG ACCATTTCTC TGTGATTGAT TTCAACCAGA ACATTCGAAC TTGGAGAAAT 
GATTTAATTT CAGCTACAAA AACACAGGTT GCAGATGCCA AGAGGTATAT TGAGAAAATC 
CAGCCCAGTG GAGGCACAAA CATCAACGAA GCACTCCTAC GGGCAATCTT CATTTTGAAT 
GAAGCCAATA ACTTGGGACT GTTAGACCCC AACTCCGTCT CGCTGATCAT TTTGGTTTCT 
GATGGAGATC CAACAGTGGG CGAACTAAAA CTGTCAAAAA TTCAGAAAAA CGTTAAGGAG 
AACATCCAAG ACAATATCTC CTTGTTCAGT TTGGGCATGG GATTTGATGT GGACTATGAT 
TTTTTGAAGA GACTGTCCAA TGAAAACCAT GGAATTGCAC AAAGGATTTA TGGAAACCAG 
GACACGTCTT CCCAGCTTAA GAAATTCTAC AACCAGGTCT CCACTCCATT GCTCCGGAAT 
GTTCAGTTCA ACTATCCCCA TACATCAGTC ACGGACGTCA CTCAAAACAA TTTCCATAAC 
TACTTTGGAG GCTCAGAGAT TGTGGTGGCA GGAAAATTTG ACCCTGCTAA ATTGGATCAA 
ATAGAGAGCG TTATCACGGC GACTTCGGCT AACACGCAGT TAGTCTTGGA GACCCTGGCC 
CAGATGGACG ACTTGCAGGA TTTTCTATCG AAAGACAAGC ATGCAGATCC CGATTTCACC 
AGGAAACTGT GGGCCTATCT AACCATCAAC CAACTGCTAG CTGAACGAAG CCTGGCTCCT 
ACAGCTGCCG CCAAGAGAAG AATTACAAGA TCGATCCTGC AGATGTCTCT AGACCACCAC 
ATTGTGACTC CGCTGACCTC GCTGGTGATC GAGAACGAGG CTGGGGATGA GCGCATGCTG 
GCGGATGCCC CACCGCAGGA TCCCTCCTGC TGCTCAGGGG CCCTGTATTA CGGCAGCAAA 
GTGGTTCCAG ATTCCACCCC GTCTTGGGCC AATCCTTCAC CAACGCCCGT GATCTCCATG 
CTGGCACAAG GATCTCAGGT GCTAGAGTCC ACGCCACCCC CACATGTGAT GAGAGTTGAA 
AATGACCCAC ATTTCATCAT TTATCTACCA AAAAGCCAAA AGAACATTTG TTTCAATATT 
GACTCAGAAC CTGGAAAAAT CCTCAACCTG GTTTCTGACC CAGAATCAGG AATTGTAGTC 
AACGGTCAGC TTGTTGGTGC CAAGAAGCCC AACAATGGAA AACTAAGCAC CTATTTTGGA 
AAACTGGGAT TTTATTTCCA AAGTGAAGAC ATAAAAATAG AAATCAGCAC TGAGACCATC 
ACCCTGAGCC ATGGTTCTAG CACATTCTCC TTGTCCTGGT CCGACACGGC TCAAGTCACG 
AATCAGAGGG TGCAGATCTC AGTGAAGAAA GAAAAAGTGG TAACTATCAC CCTGGATAAA 
GAGATGTCCT TTTCTGTTTT ACTTCATCGT GTTTGGAAGA AGCATCCCGT CAATGTTGAC 
TTTCTGGGAA TCTACATACC CCCTACAAAC AAGTTCTCAC CTAAAGCCCA CGGACTAATA 
GGCCAGTTCA TGCAGGAACC AAAGATACAC ATCTTCAATG AGAGACCAGG AAAGGACCCT 
GAGAAGCCAG AGGCCAGCAT GGAAGTGAAG GGGCAGAAGC TGATCATCAC CAGGGGCTTA 
CAGAAAGACT ACAGAACGGA TCTAGTGTTT GGAACGGACG TTACCTGCTG GTTTGTGCAC 
AACAGTGGAA AAGGATTCAT TGACGGGCAT TACAAGGATT ACTTCGTGCC TCAGCTCTAC 
AGCTTTCTCA AACGGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITIH2 ( NM_002216.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002207.2 Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.

Price & Availability↑

CloneID	OHu30923
Clone ID Related Accession (Same CDS sequence)	NM_002216.3 , NM_002216.2
Accession Version	NM_002216.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	inter-alpha-trypsin inhibitor heavy chain H2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG617651.1, X07173.1, AL158044.17, CB154170.1 and AA406494.1. On Jul 13, 2005 this sequence version replaced NM_002216.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225329.1, SRR1660809.121555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

ATGAAAAGAC TCACGTGCTT TTTCATCTGC TTCTTTCTTT CTGAAGTATC AGGCTTCGAA 
ATCCCCATAA ATGGACTTTC TGAATTTGTA GACTATGAAG ATCTTGTGGA ACTGGCCCCA 
GGCAAATTTC AATTGGTGGC AGAGAACCGG AGATATCAGA GAAGCCTTCC AGGAGAATCG 
GAAGAAATGA TGGAAGAGGT TGATCAAGTA ACTCTTTATA GCTATAAAGT CCAGTCTACT 
ATTACTTCTC GGATGGCCAC CACCATGATC CAGAGCAAAG TGGTGAACAA TTCCCCGCAG 
CCTCAGAATG TCGTGTTTGA TGTTCAGATC CCCAAAGGAG CATTCATTTC CAACTTCTCC 
ATGACTGTGG ACGGCAAGAC ATTTAGGAGC TCTATTAAGG AGAAAACTGT GGGCCGAGCT 
CTTTATGCAC AGGCCAGAGC AAAAGGCAAG ACGGCTGGCT TGGTGAGGAG CAGCGCTCTT 
GATATGGAAA ACTTCAGAAC GGAAGTAAAT GTCCTCCCAG GAGCAAAGGT GCAGTTCGAA 
CTTCACTACC AGGAGGTGAA GTGGAGGAAG CTGGGCTCCT ATGAGCACAG GATCTATCTG 
CAACCTGGAC GGCTGGCCAA ACACTTAGAG GTAGATGTGT GGGTTATCGA ACCACAGGGA 
CTGAGATTTC TTCATGTTCC CGACACATTT GAAGGCCATT TCGATGGTGT TCCGGTCATT 
TCTAAAGGAC AACAGAAGGC GCACGTCTCC TTCAAGCCCA CGGTAGCACA GCAGAGAATA 
TGCCCTAACT GCCGGGAGAC TGCGGTAGAT GGGGAACTGG TGGTGCTGTA TGACGTGAAA 
AGAGAAGAGA AGGCTGGTGA ACTGGAGGTG TTTAATGGAT ATTTTGTCCA CTTCTTTGCT 
CCTGACAACC TGGACCCAAT TCCCAAAAAC ATCCTCTTTG TCATCGATGT GAGTGGCTCC 
ATGTGGGGAG TTAAAATGAA ACAAACTGTG GAAGCAATGA AGACCATATT GGATGACCTC 
AGAGCAGAAG ACCATTTCTC TGTGATTGAT TTCAACCAGA ACATTCGAAC TTGGAGAAAT 
GATTTAATTT CAGCTACAAA AACACAGGTT GCAGATGCCA AGAGGTATAT TGAGAAAATC 
CAGCCCAGTG GAGGCACAAA CATCAACGAA GCACTCCTAC GGGCAATCTT CATTTTGAAT 
GAAGCCAATA ACTTGGGACT GTTAGACCCC AACTCCGTCT CGCTGATCAT TTTGGTTTCT 
GATGGAGATC CAACAGTGGG CGAACTAAAA CTGTCAAAAA TTCAGAAAAA CGTTAAGGAG 
AACATCCAAG ACAATATCTC CTTGTTCAGT TTGGGCATGG GATTTGATGT GGACTATGAT 
TTTTTGAAGA GACTGTCCAA TGAAAACCAT GGAATTGCAC AAAGGATTTA TGGAAACCAG 
GACACGTCTT CCCAGCTTAA GAAATTCTAC AACCAGGTCT CCACTCCATT GCTCCGGAAT 
GTTCAGTTCA ACTATCCCCA TACATCAGTC ACGGACGTCA CTCAAAACAA TTTCCATAAC 
TACTTTGGAG GCTCAGAGAT TGTGGTGGCA GGAAAATTTG ACCCTGCTAA ATTGGATCAA 
ATAGAGAGCG TTATCACGGC GACTTCGGCT AACACGCAGT TAGTCTTGGA GACCCTGGCC 
CAGATGGACG ACTTGCAGGA TTTTCTATCG AAAGACAAGC ATGCAGATCC CGATTTCACC 
AGGAAACTGT GGGCCTATCT AACCATCAAC CAACTGCTAG CTGAACGAAG CCTGGCTCCT 
ACAGCTGCCG CCAAGAGAAG AATTACAAGA TCGATCCTGC AGATGTCTCT AGACCACCAC 
ATTGTGACTC CGCTGACCTC GCTGGTGATC GAGAACGAGG CTGGGGATGA GCGCATGCTG 
GCGGATGCCC CACCGCAGGA TCCCTCCTGC TGCTCAGGGG CCCTGTATTA CGGCAGCAAA 
GTGGTTCCAG ATTCCACCCC GTCTTGGGCC AATCCTTCAC CAACGCCCGT GATCTCCATG 
CTGGCACAAG GATCTCAGGT GCTAGAGTCC ACGCCACCCC CACATGTGAT GAGAGTTGAA 
AATGACCCAC ATTTCATCAT TTATCTACCA AAAAGCCAAA AGAACATTTG TTTCAATATT 
GACTCAGAAC CTGGAAAAAT CCTCAACCTG GTTTCTGACC CAGAATCAGG AATTGTAGTC 
AACGGTCAGC TTGTTGGTGC CAAGAAGCCC AACAATGGAA AACTAAGCAC CTATTTTGGA 
AAACTGGGAT TTTATTTCCA AAGTGAAGAC ATAAAAATAG AAATCAGCAC TGAGACCATC 
ACCCTGAGCC ATGGTTCTAG CACATTCTCC TTGTCCTGGT CCGACACGGC TCAAGTCACG 
AATCAGAGGG TGCAGATCTC AGTGAAGAAA GAAAAAGTGG TAACTATCAC CCTGGATAAA 
GAGATGTCCT TTTCTGTTTT ACTTCATCGT GTTTGGAAGA AGCATCCCGT CAATGTTGAC 
TTTCTGGGAA TCTACATACC CCCTACAAAC AAGTTCTCAC CTAAAGCCCA CGGACTAATA 
GGCCAGTTCA TGCAGGAACC AAAGATACAC ATCTTCAATG AGAGACCAGG AAAGGACCCT 
GAGAAGCCAG AGGCCAGCAT GGAAGTGAAG GGGCAGAAGC TGATCATCAC CAGGGGCTTA 
CAGAAAGACT ACAGAACGGA TCTAGTGTTT GGAACGGACG TTACCTGCTG GTTTGTGCAC 
AACAGTGGAA AAGGATTCAT TGACGGGCAT TACAAGGATT ACTTCGTGCC TCAGCTCTAC 
AGCTTTCTCA AACGGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002207.2
CDS	163..3003
Translation	MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP

Target ORF information:

RefSeq Version	NM_002216.2
Organism	Homo sapiens(human)
Definition	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002216.2

ORF Insert Sequence:

ATGAAAAGAC TCACGTGCTT TTTCATCTGC TTCTTTCTTT CTGAAGTATC AGGCTTCGAA 
ATCCCCATAA ATGGACTTTC TGAATTTGTA GACTATGAAG ATCTTGTGGA ACTGGCCCCA 
GGCAAATTTC AATTGGTGGC AGAGAACCGG AGATATCAGA GAAGCCTTCC AGGAGAATCG 
GAAGAAATGA TGGAAGAGGT TGATCAAGTA ACTCTTTATA GCTATAAAGT CCAGTCTACT 
ATTACTTCTC GGATGGCCAC CACCATGATC CAGAGCAAAG TGGTGAACAA TTCCCCGCAG 
CCTCAGAATG TCGTGTTTGA TGTTCAGATC CCCAAAGGAG CATTCATTTC CAACTTCTCC 
ATGACTGTGG ACGGCAAGAC ATTTAGGAGC TCTATTAAGG AGAAAACTGT GGGCCGAGCT 
CTTTATGCAC AGGCCAGAGC AAAAGGCAAG ACGGCTGGCT TGGTGAGGAG CAGCGCTCTT 
GATATGGAAA ACTTCAGAAC GGAAGTAAAT GTCCTCCCAG GAGCAAAGGT GCAGTTCGAA 
CTTCACTACC AGGAGGTGAA GTGGAGGAAG CTGGGCTCCT ATGAGCACAG GATCTATCTG 
CAACCTGGAC GGCTGGCCAA ACACTTAGAG GTAGATGTGT GGGTTATCGA ACCACAGGGA 
CTGAGATTTC TTCATGTTCC CGACACATTT GAAGGCCATT TCGATGGTGT TCCGGTCATT 
TCTAAAGGAC AACAGAAGGC GCACGTCTCC TTCAAGCCCA CGGTAGCACA GCAGAGAATA 
TGCCCTAACT GCCGGGAGAC TGCGGTAGAT GGGGAACTGG TGGTGCTGTA TGACGTGAAA 
AGAGAAGAGA AGGCTGGTGA ACTGGAGGTG TTTAATGGAT ATTTTGTCCA CTTCTTTGCT 
CCTGACAACC TGGACCCAAT TCCCAAAAAC ATCCTCTTTG TCATCGATGT GAGTGGCTCC 
ATGTGGGGAG TTAAAATGAA ACAAACTGTG GAAGCAATGA AGACCATATT GGATGACCTC 
AGAGCAGAAG ACCATTTCTC TGTGATTGAT TTCAACCAGA ACATTCGAAC TTGGAGAAAT 
GATTTAATTT CAGCTACAAA AACACAGGTT GCAGATGCCA AGAGGTATAT TGAGAAAATC 
CAGCCCAGTG GAGGCACAAA CATCAACGAA GCACTCCTAC GGGCAATCTT CATTTTGAAT 
GAAGCCAATA ACTTGGGACT GTTAGACCCC AACTCCGTCT CGCTGATCAT TTTGGTTTCT 
GATGGAGATC CAACAGTGGG CGAACTAAAA CTGTCAAAAA TTCAGAAAAA CGTTAAGGAG 
AACATCCAAG ACAATATCTC CTTGTTCAGT TTGGGCATGG GATTTGATGT GGACTATGAT 
TTTTTGAAGA GACTGTCCAA TGAAAACCAT GGAATTGCAC AAAGGATTTA TGGAAACCAG 
GACACGTCTT CCCAGCTTAA GAAATTCTAC AACCAGGTCT CCACTCCATT GCTCCGGAAT 
GTTCAGTTCA ACTATCCCCA TACATCAGTC ACGGACGTCA CTCAAAACAA TTTCCATAAC 
TACTTTGGAG GCTCAGAGAT TGTGGTGGCA GGAAAATTTG ACCCTGCTAA ATTGGATCAA 
ATAGAGAGCG TTATCACGGC GACTTCGGCT AACACGCAGT TAGTCTTGGA GACCCTGGCC 
CAGATGGACG ACTTGCAGGA TTTTCTATCG AAAGACAAGC ATGCAGATCC CGATTTCACC 
AGGAAACTGT GGGCCTATCT AACCATCAAC CAACTGCTAG CTGAACGAAG CCTGGCTCCT 
ACAGCTGCCG CCAAGAGAAG AATTACAAGA TCGATCCTGC AGATGTCTCT AGACCACCAC 
ATTGTGACTC CGCTGACCTC GCTGGTGATC GAGAACGAGG CTGGGGATGA GCGCATGCTG 
GCGGATGCCC CACCGCAGGA TCCCTCCTGC TGCTCAGGGG CCCTGTATTA CGGCAGCAAA 
GTGGTTCCAG ATTCCACCCC GTCTTGGGCC AATCCTTCAC CAACGCCCGT GATCTCCATG 
CTGGCACAAG GATCTCAGGT GCTAGAGTCC ACGCCACCCC CACATGTGAT GAGAGTTGAA 
AATGACCCAC ATTTCATCAT TTATCTACCA AAAAGCCAAA AGAACATTTG TTTCAATATT 
GACTCAGAAC CTGGAAAAAT CCTCAACCTG GTTTCTGACC CAGAATCAGG AATTGTAGTC 
AACGGTCAGC TTGTTGGTGC CAAGAAGCCC AACAATGGAA AACTAAGCAC CTATTTTGGA 
AAACTGGGAT TTTATTTCCA AAGTGAAGAC ATAAAAATAG AAATCAGCAC TGAGACCATC 
ACCCTGAGCC ATGGTTCTAG CACATTCTCC TTGTCCTGGT CCGACACGGC TCAAGTCACG 
AATCAGAGGG TGCAGATCTC AGTGAAGAAA GAAAAAGTGG TAACTATCAC CCTGGATAAA 
GAGATGTCCT TTTCTGTTTT ACTTCATCGT GTTTGGAAGA AGCATCCCGT CAATGTTGAC 
TTTCTGGGAA TCTACATACC CCCTACAAAC AAGTTCTCAC CTAAAGCCCA CGGACTAATA 
GGCCAGTTCA TGCAGGAACC AAAGATACAC ATCTTCAATG AGAGACCAGG AAAGGACCCT 
GAGAAGCCAG AGGCCAGCAT GGAAGTGAAG GGGCAGAAGC TGATCATCAC CAGGGGCTTA 
CAGAAAGACT ACAGAACGGA TCTAGTGTTT GGAACGGACG TTACCTGCTG GTTTGTGCAC 
AACAGTGGAA AAGGATTCAT TGACGGGCAT TACAAGGATT ACTTCGTGCC TCAGCTCTAC 
AGCTTTCTCA AACGGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Biomaterials128147-159(2017 06)
Ragelle H,Naba A,Larson BL,Zhou F,Priji? M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

The Compact and Biologically Relevant Structure of Inter-?-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.
The Journal of biological chemistry291(9)4658-70(2016 Feb)
Scavenius C,Nikolajsen CL,Stenvang M,Th?gersen IB,Wyro?emski ?,Wisniewski HG,Otzen DE,Sanggaard KW,Enghild JJ

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
BMC cancer14518(2014 Jul)
Naba A,Clauser KR,Whittaker CA,Carr SA,Tanabe KK,Hynes RO

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM

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ITIH2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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