ITGB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGB1
Entrez Gene ID	3688
Full Name	integrin subunit beta 1
Synonyms	CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB
General protein information	Preferred Names integrin subunit beta 1 Names integrin beta-1 glycoprotein IIa integrin VLA-4 beta subunit integrin beta 1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) very late activation protein, beta polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p11.22
Summary	Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	135630

mRNA and Protein(s)

mRNA	Protein	Name
NM_002211.3	NP_002202.2	integrin beta-1 isoform 1A precursor
NM_133376.2	NP_596867.1	integrin beta-1 isoform 1A precursor
NM_033668.2	NP_391988.1	integrin beta-1 isoform 1D precursor
NM_002211.4	NP_002202.2	integrin beta-1 isoform 1A precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ITGB1	NP_001034343.2
Pan troglodytes (chimpanzee)	ITGB1	XP_003312561.1
Mus musculus (house mouse)	Itgb1	NP_034708.1
Danio rerio (zebrafish)	itgb1b	NP_001030159.1
Anopheles gambiae (African malaria mosquito)	INTB	XP_311354.2
Xenopus tropicalis (tropical clawed frog)	itgb1	NP_989160.1
	ITGB1	XP_002805655.1
Homo sapiens (human)	ITGB1	NP_002202.2
Danio rerio (zebrafish)	itgb1a	NP_001030143.1
Drosophila melanogaster (fruit fly)	mys	NP_524793.2
Canis lupus familiaris (dog)	ITGB1	XP_005617006.1
Bos taurus (cattle)	ITGB1	NP_776793.1
Rattus norvegicus (Norway rat)	Itgb1	NP_058718.2
Caenorhabditis elegans (roundworm)	pat-3	NP_497787.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular dissection of protein-protein interactions between integrin ?5?1 and the Helicobacter pylori Cag type IV secretion system.
Koelblen T, Berg? C, Cherrier MV, Brillet K, Jimenez-Soto L, Ballut L, Takagi J, Montserret R, Rousselle P, Fischer W, Haas R, Fronzes R, Terradot L
The FEBS journal284(23)4143-4157(2017 Dec)

Galectin-3 alters the lateral mobility and clustering of ?1-integrin receptors.
Yang EH, Rode J, Howlader MA, Eckermann M, Santos JT, Hernandez Armada D, Zheng R, Zou C, Cairo CW
PloS one12(10)e0184378(2017)

Splice variants of human beta 1 integrins: origin, biosynthesis and functions.
Armulik A
Frontiers in bioscience : a journal and virtual library7d219-27(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA domain
Title: Integrin ?4?1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain.

Data show that beta1 integrins containing an extracellular pH-sensitive pHluorin tag allow direct visualization of integrin exocytosis in live cells and targeted delivery of integrin to focal adhesions.
Title: Novel ecto-tagged integrins reveal their trafficking in live cells.

These data outline a new signaling mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs).
Title: KCa1.1 channels regulate ?

Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 as a negative regulator of ILK activity.
Title: Tetraspanin 8 is a novel regulator of ILK-driven ?1 integrin adhesion and signaling in invasive melanoma cells.

Integrin beta1 appears to serve as a partner of Stathmin induction of ERK and Akt signaling by inhibiting apoptosis in the cholangiocarcinoma cell.
Title: Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.

The following ITGB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14087	NM_133376.2 Latest version!	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1E, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu14087	NM_002211.4 Latest version!	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu14082	NM_033668.2 Latest version!	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1D, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu14087	NM_002211.3	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGB1 ( NM_002211.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002202.2 Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.

Price & Availability↑

CloneID	OHu14087
Clone ID Related Accession (Same CDS sequence)	NM_002211.3 , NM_133376.2 , NM_002211.4
Accession Version	NM_002211.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	integrin beta-1 isoform 1A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB063946.1, DB292597.1, CX868374.1, BX537407.1, BM973433.1 and AI261443.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2008 this sequence version replaced NM_002211.2. Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.161545.1, SRR1660809.83546.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002202.2
CDS	222..2618
Translation	MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Target ORF information:

RefSeq Version	NM_002211.3
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002211.3

ORF Insert Sequence:

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGB1 ( NM_133376.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_596867.1 Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1E, mRNA.

Price & Availability↑

CloneID	OHu14087
Clone ID Related Accession (Same CDS sequence)	NM_002211.3 , NM_133376.2 , NM_002211.4
Accession Version	NM_133376.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	integrin beta-1 isoform 1A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL365203.19, DB292597.1, CX868374.1, BX537407.1, BM973433.1 and AI261443.1. On Apr 11, 2008 this sequence version replaced NM_133376.1. Transcript Variant: This variant (1E) differs in the 5' UTR compared to variant 1A. Both variants 1A and 1E encode the same isoform (1A). There are no publicly available full-length transcripts representing this variant; it is supported by partial transcript alignments and by full-length cloning and sequencing in PMID:8444890. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.168754.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_596867.1
CDS	137..2533
Translation	MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Target ORF information:

RefSeq Version	NM_133376.2
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1E, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133376.2

ORF Insert Sequence:

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGB1 ( NM_002211.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002202.2 Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.

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CloneID	OHu14087
Clone ID Related Accession (Same CDS sequence)	NM_002211.3 , NM_133376.2 , NM_002211.4
Accession Version	NM_002211.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	integrin beta-1 isoform 1A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB063946.1, DB292597.1, CX868374.1, BX537407.1, BM973433.1 and AI261443.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002211.3. Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.213013.1, SRR1660809.80543.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302278.8/ ENSP00000303351.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002202.2
CDS	87..2483
Translation	MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Target ORF information:

RefSeq Version	NM_002211.4
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002211.4

ORF Insert Sequence:

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GGGTGAAAAT 
CCTATTTATA AGAGTGCCGT AACAACTGTG GTCAATCCGA AGTATGAGGG AAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGB1 ( NM_033668.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_391988.1 Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1D, mRNA.

Price & Availability↑

CloneID	OHu14082
Clone ID Related Accession (Same CDS sequence)	NM_033668.2
Accession Version	NM_033668.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2406bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	integrin beta-1 isoform 1D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL710802.1, CX871886.1, BM791591.1, DA600874.1, AL365203.19, BX537407.1, BM973433.1 and AI261443.1. On Apr 11, 2008 this sequence version replaced NM_033668.1. Transcript Variant: This variant (1D) includes an alternate exon, known as exon D, which results in a frameshift in the 3' coding region, compared to variant 1A. The resulting isoform (1D) has a distinct and longer C-terminus, compared to isoform 1A. This variant lacks full-length transcript support; its exon combination is predicted based on partial human transcript alignments, homologous transcript alignments including full-length cow mRNA BC114107.1, and data in the literature, including PMIDs 7544298, 7545396, 8567725 and 11779688, which consider this to be a functionally significant variant. This variant lacks a 5' UTR due to alternative splicing choices upstream of the CDS, and uncertainty about which alternative promoter is used. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GCAAGAAAAT 
CCGATTTACA AGAGTCCTAT TAATAATTTC AAGAATCCAA ACTACGGACG TAAAGCTGGT 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_391988.1
CDS	1..2406
Translation	MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQENPIYKSPINNFKNPNYGRKAGL

Target ORF information:

RefSeq Version	NM_033668.2
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant 1D, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033668.2

ORF Insert Sequence:

ATGAATTTAC AACCAATTTT CTGGATTGGA CTGATCAGTT CAGTTTGCTG TGTGTTTGCT 
CAAACAGATG AAAATAGATG TTTAAAAGCA AATGCCAAAT CATGTGGAGA ATGTATACAA 
GCAGGGCCAA ATTGTGGGTG GTGCACAAAT TCAACATTTT TACAGGAAGG AATGCCTACT 
TCTGCACGAT GTGATGATTT AGAAGCCTTA AAAAAGAAGG GTTGCCCTCC AGATGACATA 
GAAAATCCCA GAGGCTCCAA AGATATAAAG AAAAATAAAA ATGTAACCAA CCGTAGCAAA 
GGAACAGCAG AGAAGCTCAA GCCAGAGGAT ATTACTCAGA TCCAACCACA GCAGTTGGTT 
TTGCGATTAA GATCAGGGGA GCCACAGACA TTTACATTAA AATTCAAGAG AGCTGAAGAC 
TATCCCATTG ACCTCTACTA CCTTATGGAC CTGTCTTACT CAATGAAAGA CGATTTGGAG 
AATGTAAAAA GTCTTGGAAC AGATCTGATG AATGAAATGA GGAGGATTAC TTCGGACTTC 
AGAATTGGAT TTGGCTCATT TGTGGAAAAG ACTGTGATGC CTTACATTAG CACAACACCA 
GCTAAGCTCA GGAACCCTTG CACAAGTGAA CAGAACTGCA CCAGCCCATT TAGCTACAAA 
AATGTGCTCA GTCTTACTAA TAAAGGAGAA GTATTTAATG AACTTGTTGG AAAACAGCGC 
ATATCTGGAA ATTTGGATTC TCCAGAAGGT GGTTTCGATG CCATCATGCA AGTTGCAGTT 
TGTGGATCAC TGATTGGCTG GAGGAATGTT ACACGGCTGC TGGTGTTTTC CACAGATGCC 
GGGTTTCACT TTGCTGGAGA TGGGAAACTT GGTGGCATTG TTTTACCAAA TGATGGACAA 
TGTCACCTGG AAAATAATAT GTACACAATG AGCCATTATT ATGATTATCC TTCTATTGCT 
CACCTTGTCC AGAAACTGAG TGAAAATAAT ATTCAGACAA TTTTTGCAGT TACTGAAGAA 
TTTCAGCCTG TTTACAAGGA GCTGAAAAAC TTGATCCCTA AGTCAGCAGT AGGAACATTA 
TCTGCAAATT CTAGCAATGT AATTCAGTTG ATCATTGATG CATACAATTC CCTTTCCTCA 
GAAGTCATTT TGGAAAACGG CAAATTGTCA GAAGGCGTAA CAATAAGTTA CAAATCTTAC 
TGCAAGAACG GGGTGAATGG AACAGGGGAA AATGGAAGAA AATGTTCCAA TATTTCCATT 
GGAGATGAGG TTCAATTTGA AATTAGCATA ACTTCAAATA AGTGTCCAAA AAAGGATTCT 
GACAGCTTTA AAATTAGGCC TCTGGGCTTT ACGGAGGAAG TAGAGGTTAT TCTTCAGTAC 
ATCTGTGAAT GTGAATGCCA AAGCGAAGGC ATCCCTGAAA GTCCCAAGTG TCATGAAGGA 
AATGGGACAT TTGAGTGTGG CGCGTGCAGG TGCAATGAAG GGCGTGTTGG TAGACATTGT 
GAATGCAGCA CAGATGAAGT TAACAGTGAA GACATGGATG CTTACTGCAG GAAAGAAAAC 
AGTTCAGAAA TCTGCAGTAA CAATGGAGAG TGCGTCTGCG GACAGTGTGT TTGTAGGAAG 
AGGGATAATA CAAATGAAAT TTATTCTGGC AAATTCTGCG AGTGTGATAA TTTCAACTGT 
GATAGATCCA ATGGCTTAAT TTGTGGAGGA AATGGTGTTT GCAAGTGTCG TGTGTGTGAG 
TGCAACCCCA ACTACACTGG CAGTGCATGT GACTGTTCTT TGGATACTAG TACTTGTGAA 
GCCAGCAACG GACAGATCTG CAATGGCCGG GGCATCTGCG AGTGTGGTGT CTGTAAGTGT 
ACAGATCCGA AGTTTCAAGG GCAAACGTGT GAGATGTGTC AGACCTGCCT TGGTGTCTGT 
GCTGAGCATA AAGAATGTGT TCAGTGCAGA GCCTTCAATA AAGGAGAAAA GAAAGACACA 
TGCACACAGG AATGTTCCTA TTTTAACATT ACCAAGGTAG AAAGTCGGGA CAAATTACCC 
CAGCCGGTCC AACCTGATCC TGTGTCCCAT TGTAAGGAGA AGGATGTTGA CGACTGTTGG 
TTCTATTTTA CGTATTCAGT GAATGGGAAC AACGAGGTCA TGGTTCATGT TGTGGAGAAT 
CCAGAGTGTC CCACTGGTCC AGACATCATT CCAATTGTAG CTGGTGTGGT TGCTGGAATT 
GTTCTTATTG GCCTTGCATT ACTGCTGATA TGGAAGCTTT TAATGATAAT TCATGACAGA 
AGGGAGTTTG CTAAATTTGA AAAGGAGAAA ATGAATGCCA AATGGGACAC GCAAGAAAAT 
CCGATTTACA AGAGTCCTAT TAATAATTTC AAGAATCCAA ACTACGGACG TAAAGCTGGT 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular dissection of protein-protein interactions between integrin ?5?1 and the Helicobacter pylori Cag type IV secretion system.
The FEBS journal284(23)4143-4157(2017 Dec)
Koelblen T,Berg? C,Cherrier MV,Brillet K,Jimenez-Soto L,Ballut L,Takagi J,Montserret R,Rousselle P,Fischer W,Haas R,Fronzes R,Terradot L

Galectin-3 alters the lateral mobility and clustering of ?1-integrin receptors.
PloS one12(10)e0184378(2017)
Yang EH,Rode J,Howlader MA,Eckermann M,Santos JT,Hernandez Armada D,Zheng R,Zou C,Cairo CW

Splice variants of human beta 1 integrins: origin, biosynthesis and functions.
Frontiers in bioscience : a journal and virtual library7d219-27(2002 Jan)
Armulik A

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ITGB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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