Gene Symbol | ITGA2 |
Entrez Gene ID | 3673 |
Full Name | integrin subunit alpha 2 |
Synonyms | BR,CD49B,GPIa,HPA-5,VLA-2,VLAA2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. |
Disorder MIM: | |
Disorder Html: | ?Glycoprotein Ia deficiency, 614200 (1) |