ITGA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGA1
Entrez Gene ID	3672
Full Name	integrin subunit alpha 1
Synonyms	CD49a,VLA1
General protein information	Preferred Names integrin subunit alpha 1 Names integrin alpha-1 CD49 antigen-like family member A VLA-1 laminin and collagen receptor very late activation protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q11.2
Summary	This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008].
Disorder MIM:	192968

mRNA and Protein(s)

mRNA	Protein	Name
NM_181501.2	NP_852478.1	integrin alpha-1 precursor
NM_181501.1	NP_852478.1	integrin alpha-1 precursor

Pathways from BioSystems

Homologies

	ITGA1	XP_001094788.1
Rattus norvegicus (Norway rat)	Itga1	NP_112256.1
Gallus gallus (chicken)	ITGA1	NP_990400.1
Pan troglodytes (chimpanzee)	ITGA1	XP_517769.2
Canis lupus familiaris (dog)	ITGA1	XP_005619392.1
Mus musculus (house mouse)	Itga1	NP_001028400.2
Danio rerio (zebrafish)	itga1	XP_699485.4
Xenopus tropicalis (tropical clawed frog)	itga1	XP_002933090.2
Homo sapiens (human)	ITGA1	NP_852478.1

Gene Ontology
Bibliography

Related articles in PubMed

A pivotal role for a conserved bulky residue at the ?1-helix of the ?I integrin domain in ligand binding.
Wang Z, Thinn AMM, Zhu J
The Journal of biological chemistry292(50)20756-20768(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10, Wnt5a, alpha1 integrin, and matrix metalloproteinase-3 in GS/BMP-4-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
Title: Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells.

ANGPTL1 inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 signaling pathway.

Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi.
Title: Liver-Resident NK Cells: The Human Factor.

A range of affinities from almost no interaction to the relatively high avidity that characterizes alphaIIbbeta3 is seen between various alpha subunits and beta1 transmembrane and cytosolic domains.
Title: Implications of the differing roles of the ?1 and ?3 transmembrane and cytoplasmic domains for integrin function.

a comparative study between the wild type integrin alpha1 I and a gain-of-function E317A mutant. NMR HDX results suggest a relationship between regions exhibiting a reduced local stability in the unbound I domain and those that undergo significant conformational changes upon binding.
Title: Intrinsic local destabilization of the C-terminus predisposes integrin ?1 I domain to a conformational switch induced by collagen binding.

The following ITGA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26020	NM_181501.2 Latest version!	Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
View Old Accession Versions >>
OHu26020	NM_181501.1	Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGA1 ( NM_181501.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852478.1 Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.

Price & Availability↑

CloneID	OHu26020
Clone ID Related Accession (Same CDS sequence)	NM_181501.2 , NM_181501.1
Accession Version	NM_181501.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	integrin alpha-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026230.5, AC027326.6, AC022133.7, KF510907.1, AC025180.6 and KF457900.1. On May 17, 2019 this sequence version replaced NM_181501.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.21043.1, SRR1803617.256505.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282588.7/ ENSP00000282588.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCTC GGCCCCGCGC CCGCCCAGGG GTCGCTGTCG CCTGCTGCTG GCTCCTCACT 
GTTGTTCTAC GCTGCTGCGT ATCATTCAAT GTTGATGTGA AAAATTCAAT GACTTTCAGC 
GGCCCGGTGG AAGACATGTT TGGATATACT GTTCAACAAT ATGAAAATGA AGAAGGAAAA 
TGGGTGCTTA TTGGTTCTCC GTTAGTTGGC CAACCCAAAA ACAGAACTGG AGATGTCTAT 
AAGTGTCCAG TTGGGAGAGG TGAATCATTA CCTTGTGTAA AGTTGGATCT ACCAGTTAAT 
ACATCAATTC CCAATGTCAC AGAAGTAAAG GAGAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCAA ATGGAGGATT TCTGGCTTGT GGGCCCTTAT ATGCCTATAG ATGTGGACAT 
TTGCATTACA CAACTGGAAT CTGTTCTGAC GTCAGCCCCA CATTTCAAGT CGTGAATTCC 
ATTGCCCCTG TACAAGAATG CAGCACTCAA CTGGACATAG TCATAGTGCT GGATGGTTCC 
AACAGTATTT ACCCATGGGA CAGTGTTACA GCTTTTTTAA ATGACCTTCT TGAAAGAATG 
GATATTGGTC CTAAACAGAC ACAGGTTGGA ATTGTACAGT ATGGAGAAAA CGTGACCCAT 
GAGTTCAACC TCAATAAGTA TTCTTCCACC GAAGAGGTAC TTGTTGCAGC AAAGAAAATA 
GTCCAGAGAG GTGGCCGCCA GACTATGACA GCTCTTGGAA TAGACACAGC AAGAAAGGAG 
GCATTCACGG AAGCCCGGGG TGCCCGAAGA GGAGTTAAAA AAGTCATGGT TATTGTGACA 
GATGGAGAGT CTCATGACAA TCATCGACTG AAGAAGGTCA TCCAAGACTG TGAAGATGAA 
AACATTCAAC GGTTTTCCAT AGCTATTCTT GGCAGCTATA ACCGAGGAAA TTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCAATT GCAAGTGAAC CCACTGAAAA GCATTTCTTC 
AATGTCTCTG ATGAATTGGC TCTAGTCACC ATTGTTAAAA CTCTGGGAGA AAGAATATTT 
GCCCTGGAAG CCACAGCTGA CCAGTCAGCA GCTTCATTTG AAATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCATTATTC ACAGGACTGG GTCATGCTTG GAGCAGTAGG AGCCTATGAT 
TGGAATGGAA CAGTTGTCAT GCAGAAGGCT AGTCAAATCA TAATCCCTCG AAACACAACC 
TTTAATGTTG AGTCTACCAA AAAGAATGAA CCGCTTGCTT CTTATTTAGG TTACACTGTA 
AACTCTGCTA CTGCTTCTTC TGGAGATGTG CTCTATATTG CTGGACAGCC TCGGTACAAT 
CATACAGGCC AGGTCATTAT CTACAGGATG GAAGATGGAA ACATCAAAAT TCTCCAGACG 
CTCAGTGGAG AACAGATTGG TTCCTACTTT GGCAGTATTT TAACAACAAC TGACATTGAC 
AAGGATTCTA ATACTGACAT TCTTCTAGTC GGAGCCCCTA TGTACATGGG AACAGAGAAG 
GAGGAGCAAG GAAAAGTGTA TGTGTATGCT CTCAATCAGA CAAGGTTTGA ATATCAAATG 
AGCCTGGAAC CTATTAAGCA GACGTGCTGT TCATCTCGGC AGCACAATTC ATGCACAACA 
GAAAACAAAA ATGAGCCATG CGGGGCTCGT TTTGGAACTG CAATTGCTGC TGTAAAAGAC 
CTCAATCTTG ATGGATTTAA TGACATCGTG ATAGGAGCTC CGCTGGAAGA TGATCACGGG 
GGAGCTGTGT ACATTTATCA TGGAAGTGGC AAGACTATAA GGAAAGAGTA TGCACAACGT 
ATTCCATCAG GTGGGGATGG TAAGACACTG AAATTTTTTG GCCAGTCTAT CCACGGAGAA 
ATGGATTTAA ATGGTGACGG TCTGACAGAT GTGACTATTG GGGGCCTTGG TGGTGCTGCC 
CTCTTCTGGT CCCGAGATGT GGCCGTAGTT AAAGTGACCA TGAATTTTGA GCCAAATAAA 
GTGAATATTC AAAAGAAAAA CTGCCATATG GAGGGAAAGG AAACAGTATG CATAAATGCT 
ACAGTGTGTT TTGATGTGAA ATTAAAGTCT AAAGAAGACA CGATTTATGA AGCTGATTTG 
CAGTACCGTG TCACCCTAGA TTCACTAAGA CAAATATCAC GAAGTTTTTT CTCTGGAACT 
CAAGAGAGAA AGGTTCAAAG GAACATCACA GTTCGAAAAT CAGAATGCAC TAAGCACTCC 
TTCTACATGT TGGACAAGCA TGACTTTCAG GACTCTGTGA GAATAACGTT GGACTTTAAT 
CTTACCGATC CAGAAAATGG GCCTGTTCTT GATGATTCTC TACCAAACTC AGTACATGAA 
TATATTCCCT TTGCCAAAGA TTGTGGAAAT AAGGAAAAAT GTATCTCAGA CCTCAGCCTG 
CATGTCGCCA CCACTGAAAA GGACCTGCTG ATTGTCCGAT CCCAGAATGA TAAGTTCAAC 
GTTAGCCTCA CAGTCAAAAA TACAAAGGAC AGTGCCTATA ACACCAGGAC AATAGTGCAT 
TATTCTCCAA ATCTAGTTTT TTCAGGAATT GAGGCTATCC AAAAAGACAG TTGTGAATCT 
AATCATAATA TCACATGTAA AGTTGGATAT CCCTTCCTGA GAAGAGGAGA GATGGTAACT 
TTCAAAATAT TGTTTCAGTT TAACACATCC TATCTCATGG AAAATGTGAC CATTTATTTA 
AGTGCAACAA GTGACAGCGA AGAACCTCCT GAAACCCTTT CTGATAATGT AGTAAACATT 
TCTATCCCGG TAAAATATGA AGTTGGACTA CAGTTTTACA GCTCTGCAAG TGAATACCAC 
ATTTCAATTG CTGCCAATGA GACAGTCCCT GAAGTTATTA ATTCTACTGA GGACATTGGA 
AATGAAATTA ATATCTTCTA CTTGATTAGA AAAAGTGGAT CTTTTCCAAT GCCAGAGCTT 
AAGCTGTCAA TTTCATTCCC CAATATGACA TCAAATGGTT ACCCTGTGCT GTACCCAACT 
GGATTGTCAT CTTCTGAGAA TGCAAACTGC AGACCCCATA TCTTTGAGGA TCCTTTCAGT 
ATCAACTCTG GAAAGAAAAT GACTACATCA ACTGACCATC TCAAACGAGG CACAATTCTG 
GACTGCAATA CATGTAAATT TGCTACCATC ACATGTAATC TCACTTCTTC TGACATCAGC 
CAAGTCAATG TTTCGCTTAT CTTGTGGAAA CCAACTTTTA TAAAATCATA TTTTTCCAGC 
TTAAATCTTA CTATAAGGGG AGAACTTCGG AGTGAAAATG CATCTCTGGT TTTAAGTAGC 
AGCAATCAAA AAAGAGAGCT TGCTATTCAA ATATCCAAAG ATGGGCTACC GGGCAGAGTG 
CCATTATGGG TCATCCTGCT GAGTGCTTTT GCCGGATTGT TGCTGTTAAT GCTGCTCATT 
TTAGCACTGT GGAAGATTGG ATTCTTCAAA AGACCACTGA AAAAGAAAAT GGAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852478.1
CDS	439..3978
Translation	MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK

Target ORF information:

RefSeq Version	NM_181501.2
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181501.2

ORF Insert Sequence:

ATGGCCCCTC GGCCCCGCGC CCGCCCAGGG GTCGCTGTCG CCTGCTGCTG GCTCCTCACT 
GTTGTTCTAC GCTGCTGCGT ATCATTCAAT GTTGATGTGA AAAATTCAAT GACTTTCAGC 
GGCCCGGTGG AAGACATGTT TGGATATACT GTTCAACAAT ATGAAAATGA AGAAGGAAAA 
TGGGTGCTTA TTGGTTCTCC GTTAGTTGGC CAACCCAAAA ACAGAACTGG AGATGTCTAT 
AAGTGTCCAG TTGGGAGAGG TGAATCATTA CCTTGTGTAA AGTTGGATCT ACCAGTTAAT 
ACATCAATTC CCAATGTCAC AGAAGTAAAG GAGAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCAA ATGGAGGATT TCTGGCTTGT GGGCCCTTAT ATGCCTATAG ATGTGGACAT 
TTGCATTACA CAACTGGAAT CTGTTCTGAC GTCAGCCCCA CATTTCAAGT CGTGAATTCC 
ATTGCCCCTG TACAAGAATG CAGCACTCAA CTGGACATAG TCATAGTGCT GGATGGTTCC 
AACAGTATTT ACCCATGGGA CAGTGTTACA GCTTTTTTAA ATGACCTTCT TGAAAGAATG 
GATATTGGTC CTAAACAGAC ACAGGTTGGA ATTGTACAGT ATGGAGAAAA CGTGACCCAT 
GAGTTCAACC TCAATAAGTA TTCTTCCACC GAAGAGGTAC TTGTTGCAGC AAAGAAAATA 
GTCCAGAGAG GTGGCCGCCA GACTATGACA GCTCTTGGAA TAGACACAGC AAGAAAGGAG 
GCATTCACGG AAGCCCGGGG TGCCCGAAGA GGAGTTAAAA AAGTCATGGT TATTGTGACA 
GATGGAGAGT CTCATGACAA TCATCGACTG AAGAAGGTCA TCCAAGACTG TGAAGATGAA 
AACATTCAAC GGTTTTCCAT AGCTATTCTT GGCAGCTATA ACCGAGGAAA TTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCAATT GCAAGTGAAC CCACTGAAAA GCATTTCTTC 
AATGTCTCTG ATGAATTGGC TCTAGTCACC ATTGTTAAAA CTCTGGGAGA AAGAATATTT 
GCCCTGGAAG CCACAGCTGA CCAGTCAGCA GCTTCATTTG AAATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCATTATTC ACAGGACTGG GTCATGCTTG GAGCAGTAGG AGCCTATGAT 
TGGAATGGAA CAGTTGTCAT GCAGAAGGCT AGTCAAATCA TAATCCCTCG AAACACAACC 
TTTAATGTTG AGTCTACCAA AAAGAATGAA CCGCTTGCTT CTTATTTAGG TTACACTGTA 
AACTCTGCTA CTGCTTCTTC TGGAGATGTG CTCTATATTG CTGGACAGCC TCGGTACAAT 
CATACAGGCC AGGTCATTAT CTACAGGATG GAAGATGGAA ACATCAAAAT TCTCCAGACG 
CTCAGTGGAG AACAGATTGG TTCCTACTTT GGCAGTATTT TAACAACAAC TGACATTGAC 
AAGGATTCTA ATACTGACAT TCTTCTAGTC GGAGCCCCTA TGTACATGGG AACAGAGAAG 
GAGGAGCAAG GAAAAGTGTA TGTGTATGCT CTCAATCAGA CAAGGTTTGA ATATCAAATG 
AGCCTGGAAC CTATTAAGCA GACGTGCTGT TCATCTCGGC AGCACAATTC ATGCACAACA 
GAAAACAAAA ATGAGCCATG CGGGGCTCGT TTTGGAACTG CAATTGCTGC TGTAAAAGAC 
CTCAATCTTG ATGGATTTAA TGACATCGTG ATAGGAGCTC CGCTGGAAGA TGATCACGGG 
GGAGCTGTGT ACATTTATCA TGGAAGTGGC AAGACTATAA GGAAAGAGTA TGCACAACGT 
ATTCCATCAG GTGGGGATGG TAAGACACTG AAATTTTTTG GCCAGTCTAT CCACGGAGAA 
ATGGATTTAA ATGGTGACGG TCTGACAGAT GTGACTATTG GGGGCCTTGG TGGTGCTGCC 
CTCTTCTGGT CCCGAGATGT GGCCGTAGTT AAAGTGACCA TGAATTTTGA GCCAAATAAA 
GTGAATATTC AAAAGAAAAA CTGCCATATG GAGGGAAAGG AAACAGTATG CATAAATGCT 
ACAGTGTGTT TTGATGTGAA ATTAAAGTCT AAAGAAGACA CGATTTATGA AGCTGATTTG 
CAGTACCGTG TCACCCTAGA TTCACTAAGA CAAATATCAC GAAGTTTTTT CTCTGGAACT 
CAAGAGAGAA AGGTTCAAAG GAACATCACA GTTCGAAAAT CAGAATGCAC TAAGCACTCC 
TTCTACATGT TGGACAAGCA TGACTTTCAG GACTCTGTGA GAATAACGTT GGACTTTAAT 
CTTACCGATC CAGAAAATGG GCCTGTTCTT GATGATTCTC TACCAAACTC AGTACATGAA 
TATATTCCCT TTGCCAAAGA TTGTGGAAAT AAGGAAAAAT GTATCTCAGA CCTCAGCCTG 
CATGTCGCCA CCACTGAAAA GGACCTGCTG ATTGTCCGAT CCCAGAATGA TAAGTTCAAC 
GTTAGCCTCA CAGTCAAAAA TACAAAGGAC AGTGCCTATA ACACCAGGAC AATAGTGCAT 
TATTCTCCAA ATCTAGTTTT TTCAGGAATT GAGGCTATCC AAAAAGACAG TTGTGAATCT 
AATCATAATA TCACATGTAA AGTTGGATAT CCCTTCCTGA GAAGAGGAGA GATGGTAACT 
TTCAAAATAT TGTTTCAGTT TAACACATCC TATCTCATGG AAAATGTGAC CATTTATTTA 
AGTGCAACAA GTGACAGCGA AGAACCTCCT GAAACCCTTT CTGATAATGT AGTAAACATT 
TCTATCCCGG TAAAATATGA AGTTGGACTA CAGTTTTACA GCTCTGCAAG TGAATACCAC 
ATTTCAATTG CTGCCAATGA GACAGTCCCT GAAGTTATTA ATTCTACTGA GGACATTGGA 
AATGAAATTA ATATCTTCTA CTTGATTAGA AAAAGTGGAT CTTTTCCAAT GCCAGAGCTT 
AAGCTGTCAA TTTCATTCCC CAATATGACA TCAAATGGTT ACCCTGTGCT GTACCCAACT 
GGATTGTCAT CTTCTGAGAA TGCAAACTGC AGACCCCATA TCTTTGAGGA TCCTTTCAGT 
ATCAACTCTG GAAAGAAAAT GACTACATCA ACTGACCATC TCAAACGAGG CACAATTCTG 
GACTGCAATA CATGTAAATT TGCTACCATC ACATGTAATC TCACTTCTTC TGACATCAGC 
CAAGTCAATG TTTCGCTTAT CTTGTGGAAA CCAACTTTTA TAAAATCATA TTTTTCCAGC 
TTAAATCTTA CTATAAGGGG AGAACTTCGG AGTGAAAATG CATCTCTGGT TTTAAGTAGC 
AGCAATCAAA AAAGAGAGCT TGCTATTCAA ATATCCAAAG ATGGGCTACC GGGCAGAGTG 
CCATTATGGG TCATCCTGCT GAGTGCTTTT GCCGGATTGT TGCTGTTAAT GCTGCTCATT 
TTAGCACTGT GGAAGATTGG ATTCTTCAAA AGACCACTGA AAAAGAAAAT GGAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGA1 ( NM_181501.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_852478.1 Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.

Price & Availability↑

CloneID	OHu26020
Clone ID Related Accession (Same CDS sequence)	NM_181501.2 , NM_181501.1
Accession Version	NM_181501.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	integrin alpha-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050277.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.21043.1, SRR1803611.277905.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCTC GGCCCCGCGC CCGCCCAGGG GTCGCTGTCG CCTGCTGCTG GCTCCTCACT 
GTTGTTCTAC GCTGCTGCGT ATCATTCAAT GTTGATGTGA AAAATTCAAT GACTTTCAGC 
GGCCCGGTGG AAGACATGTT TGGATATACT GTTCAACAAT ATGAAAATGA AGAAGGAAAA 
TGGGTGCTTA TTGGTTCTCC GTTAGTTGGC CAACCCAAAA ACAGAACTGG AGATGTCTAT 
AAGTGTCCAG TTGGGAGAGG TGAATCATTA CCTTGTGTAA AGTTGGATCT ACCAGTTAAT 
ACATCAATTC CCAATGTCAC AGAAGTAAAG GAGAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCAA ATGGAGGATT TCTGGCTTGT GGGCCCTTAT ATGCCTATAG ATGTGGACAT 
TTGCATTACA CAACTGGAAT CTGTTCTGAC GTCAGCCCCA CATTTCAAGT CGTGAATTCC 
ATTGCCCCTG TACAAGAATG CAGCACTCAA CTGGACATAG TCATAGTGCT GGATGGTTCC 
AACAGTATTT ACCCATGGGA CAGTGTTACA GCTTTTTTAA ATGACCTTCT TGAAAGAATG 
GATATTGGTC CTAAACAGAC ACAGGTTGGA ATTGTACAGT ATGGAGAAAA CGTGACCCAT 
GAGTTCAACC TCAATAAGTA TTCTTCCACC GAAGAGGTAC TTGTTGCAGC AAAGAAAATA 
GTCCAGAGAG GTGGCCGCCA GACTATGACA GCTCTTGGAA TAGACACAGC AAGAAAGGAG 
GCATTCACGG AAGCCCGGGG TGCCCGAAGA GGAGTTAAAA AAGTCATGGT TATTGTGACA 
GATGGAGAGT CTCATGACAA TCATCGACTG AAGAAGGTCA TCCAAGACTG TGAAGATGAA 
AACATTCAAC GGTTTTCCAT AGCTATTCTT GGCAGCTATA ACCGAGGAAA TTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCAATT GCAAGTGAAC CCACTGAAAA GCATTTCTTC 
AATGTCTCTG ATGAATTGGC TCTAGTCACC ATTGTTAAAA CTCTGGGAGA AAGAATATTT 
GCCCTGGAAG CCACAGCTGA CCAGTCAGCA GCTTCATTTG AAATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCATTATTC ACAGGACTGG GTCATGCTTG GAGCAGTAGG AGCCTATGAT 
TGGAATGGAA CAGTTGTCAT GCAGAAGGCT AGTCAAATCA TAATCCCTCG AAACACAACC 
TTTAATGTTG AGTCTACCAA AAAGAATGAA CCGCTTGCTT CTTATTTAGG TTACACTGTA 
AACTCTGCTA CTGCTTCTTC TGGAGATGTG CTCTATATTG CTGGACAGCC TCGGTACAAT 
CATACAGGCC AGGTCATTAT CTACAGGATG GAAGATGGAA ACATCAAAAT TCTCCAGACG 
CTCAGTGGAG AACAGATTGG TTCCTACTTT GGCAGTATTT TAACAACAAC TGACATTGAC 
AAGGATTCTA ATACTGACAT TCTTCTAGTC GGAGCCCCTA TGTACATGGG AACAGAGAAG 
GAGGAGCAAG GAAAAGTGTA TGTGTATGCT CTCAATCAGA CAAGGTTTGA ATATCAAATG 
AGCCTGGAAC CTATTAAGCA GACGTGCTGT TCATCTCGGC AGCACAATTC ATGCACAACA 
GAAAACAAAA ATGAGCCATG CGGGGCTCGT TTTGGAACTG CAATTGCTGC TGTAAAAGAC 
CTCAATCTTG ATGGATTTAA TGACATCGTG ATAGGAGCTC CGCTGGAAGA TGATCACGGG 
GGAGCTGTGT ACATTTATCA TGGAAGTGGC AAGACTATAA GGAAAGAGTA TGCACAACGT 
ATTCCATCAG GTGGGGATGG TAAGACACTG AAATTTTTTG GCCAGTCTAT CCACGGAGAA 
ATGGATTTAA ATGGTGACGG TCTGACAGAT GTGACTATTG GGGGCCTTGG TGGTGCTGCC 
CTCTTCTGGT CCCGAGATGT GGCCGTAGTT AAAGTGACCA TGAATTTTGA GCCAAATAAA 
GTGAATATTC AAAAGAAAAA CTGCCATATG GAGGGAAAGG AAACAGTATG CATAAATGCT 
ACAGTGTGTT TTGATGTGAA ATTAAAGTCT AAAGAAGACA CGATTTATGA AGCTGATTTG 
CAGTACCGTG TCACCCTAGA TTCACTAAGA CAAATATCAC GAAGTTTTTT CTCTGGAACT 
CAAGAGAGAA AGGTTCAAAG GAACATCACA GTTCGAAAAT CAGAATGCAC TAAGCACTCC 
TTCTACATGT TGGACAAGCA TGACTTTCAG GACTCTGTGA GAATAACGTT GGACTTTAAT 
CTTACCGATC CAGAAAATGG GCCTGTTCTT GATGATTCTC TACCAAACTC AGTACATGAA 
TATATTCCCT TTGCCAAAGA TTGTGGAAAT AAGGAAAAAT GTATCTCAGA CCTCAGCCTG 
CATGTCGCCA CCACTGAAAA GGACCTGCTG ATTGTCCGAT CCCAGAATGA TAAGTTCAAC 
GTTAGCCTCA CAGTCAAAAA TACAAAGGAC AGTGCCTATA ACACCAGGAC AATAGTGCAT 
TATTCTCCAA ATCTAGTTTT TTCAGGAATT GAGGCTATCC AAAAAGACAG TTGTGAATCT 
AATCATAATA TCACATGTAA AGTTGGATAT CCCTTCCTGA GAAGAGGAGA GATGGTAACT 
TTCAAAATAT TGTTTCAGTT TAACACATCC TATCTCATGG AAAATGTGAC CATTTATTTA 
AGTGCAACAA GTGACAGCGA AGAACCTCCT GAAACCCTTT CTGATAATGT AGTAAACATT 
TCTATCCCGG TAAAATATGA AGTTGGACTA CAGTTTTACA GCTCTGCAAG TGAATACCAC 
ATTTCAATTG CTGCCAATGA GACAGTCCCT GAAGTTATTA ATTCTACTGA GGACATTGGA 
AATGAAATTA ATATCTTCTA CTTGATTAGA AAAAGTGGAT CTTTTCCAAT GCCAGAGCTT 
AAGCTGTCAA TTTCATTCCC CAATATGACA TCAAATGGTT ACCCTGTGCT GTACCCAACT 
GGATTGTCAT CTTCTGAGAA TGCAAACTGC AGACCCCATA TCTTTGAGGA TCCTTTCAGT 
ATCAACTCTG GAAAGAAAAT GACTACATCA ACTGACCATC TCAAACGAGG CACAATTCTG 
GACTGCAATA CATGTAAATT TGCTACCATC ACATGTAATC TCACTTCTTC TGACATCAGC 
CAAGTCAATG TTTCGCTTAT CTTGTGGAAA CCAACTTTTA TAAAATCATA TTTTTCCAGC 
TTAAATCTTA CTATAAGGGG AGAACTTCGG AGTGAAAATG CATCTCTGGT TTTAAGTAGC 
AGCAATCAAA AAAGAGAGCT TGCTATTCAA ATATCCAAAG ATGGGCTACC GGGCAGAGTG 
CCATTATGGG TCATCCTGCT GAGTGCTTTT GCCGGATTGT TGCTGTTAAT GCTGCTCATT 
TTAGCACTGT GGAAGATTGG ATTCTTCAAA AGACCACTGA AAAAGAAAAT GGAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852478.1
CDS	53..3592
Translation	MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK

Target ORF information:

RefSeq Version	NM_181501.1
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181501.1

ORF Insert Sequence:

ATGGCCCCTC GGCCCCGCGC CCGCCCAGGG GTCGCTGTCG CCTGCTGCTG GCTCCTCACT 
GTTGTTCTAC GCTGCTGCGT ATCATTCAAT GTTGATGTGA AAAATTCAAT GACTTTCAGC 
GGCCCGGTGG AAGACATGTT TGGATATACT GTTCAACAAT ATGAAAATGA AGAAGGAAAA 
TGGGTGCTTA TTGGTTCTCC GTTAGTTGGC CAACCCAAAA ACAGAACTGG AGATGTCTAT 
AAGTGTCCAG TTGGGAGAGG TGAATCATTA CCTTGTGTAA AGTTGGATCT ACCAGTTAAT 
ACATCAATTC CCAATGTCAC AGAAGTAAAG GAGAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCAA ATGGAGGATT TCTGGCTTGT GGGCCCTTAT ATGCCTATAG ATGTGGACAT 
TTGCATTACA CAACTGGAAT CTGTTCTGAC GTCAGCCCCA CATTTCAAGT CGTGAATTCC 
ATTGCCCCTG TACAAGAATG CAGCACTCAA CTGGACATAG TCATAGTGCT GGATGGTTCC 
AACAGTATTT ACCCATGGGA CAGTGTTACA GCTTTTTTAA ATGACCTTCT TGAAAGAATG 
GATATTGGTC CTAAACAGAC ACAGGTTGGA ATTGTACAGT ATGGAGAAAA CGTGACCCAT 
GAGTTCAACC TCAATAAGTA TTCTTCCACC GAAGAGGTAC TTGTTGCAGC AAAGAAAATA 
GTCCAGAGAG GTGGCCGCCA GACTATGACA GCTCTTGGAA TAGACACAGC AAGAAAGGAG 
GCATTCACGG AAGCCCGGGG TGCCCGAAGA GGAGTTAAAA AAGTCATGGT TATTGTGACA 
GATGGAGAGT CTCATGACAA TCATCGACTG AAGAAGGTCA TCCAAGACTG TGAAGATGAA 
AACATTCAAC GGTTTTCCAT AGCTATTCTT GGCAGCTATA ACCGAGGAAA TTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCAATT GCAAGTGAAC CCACTGAAAA GCATTTCTTC 
AATGTCTCTG ATGAATTGGC TCTAGTCACC ATTGTTAAAA CTCTGGGAGA AAGAATATTT 
GCCCTGGAAG CCACAGCTGA CCAGTCAGCA GCTTCATTTG AAATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCATTATTC ACAGGACTGG GTCATGCTTG GAGCAGTAGG AGCCTATGAT 
TGGAATGGAA CAGTTGTCAT GCAGAAGGCT AGTCAAATCA TAATCCCTCG AAACACAACC 
TTTAATGTTG AGTCTACCAA AAAGAATGAA CCGCTTGCTT CTTATTTAGG TTACACTGTA 
AACTCTGCTA CTGCTTCTTC TGGAGATGTG CTCTATATTG CTGGACAGCC TCGGTACAAT 
CATACAGGCC AGGTCATTAT CTACAGGATG GAAGATGGAA ACATCAAAAT TCTCCAGACG 
CTCAGTGGAG AACAGATTGG TTCCTACTTT GGCAGTATTT TAACAACAAC TGACATTGAC 
AAGGATTCTA ATACTGACAT TCTTCTAGTC GGAGCCCCTA TGTACATGGG AACAGAGAAG 
GAGGAGCAAG GAAAAGTGTA TGTGTATGCT CTCAATCAGA CAAGGTTTGA ATATCAAATG 
AGCCTGGAAC CTATTAAGCA GACGTGCTGT TCATCTCGGC AGCACAATTC ATGCACAACA 
GAAAACAAAA ATGAGCCATG CGGGGCTCGT TTTGGAACTG CAATTGCTGC TGTAAAAGAC 
CTCAATCTTG ATGGATTTAA TGACATCGTG ATAGGAGCTC CGCTGGAAGA TGATCACGGG 
GGAGCTGTGT ACATTTATCA TGGAAGTGGC AAGACTATAA GGAAAGAGTA TGCACAACGT 
ATTCCATCAG GTGGGGATGG TAAGACACTG AAATTTTTTG GCCAGTCTAT CCACGGAGAA 
ATGGATTTAA ATGGTGACGG TCTGACAGAT GTGACTATTG GGGGCCTTGG TGGTGCTGCC 
CTCTTCTGGT CCCGAGATGT GGCCGTAGTT AAAGTGACCA TGAATTTTGA GCCAAATAAA 
GTGAATATTC AAAAGAAAAA CTGCCATATG GAGGGAAAGG AAACAGTATG CATAAATGCT 
ACAGTGTGTT TTGATGTGAA ATTAAAGTCT AAAGAAGACA CGATTTATGA AGCTGATTTG 
CAGTACCGTG TCACCCTAGA TTCACTAAGA CAAATATCAC GAAGTTTTTT CTCTGGAACT 
CAAGAGAGAA AGGTTCAAAG GAACATCACA GTTCGAAAAT CAGAATGCAC TAAGCACTCC 
TTCTACATGT TGGACAAGCA TGACTTTCAG GACTCTGTGA GAATAACGTT GGACTTTAAT 
CTTACCGATC CAGAAAATGG GCCTGTTCTT GATGATTCTC TACCAAACTC AGTACATGAA 
TATATTCCCT TTGCCAAAGA TTGTGGAAAT AAGGAAAAAT GTATCTCAGA CCTCAGCCTG 
CATGTCGCCA CCACTGAAAA GGACCTGCTG ATTGTCCGAT CCCAGAATGA TAAGTTCAAC 
GTTAGCCTCA CAGTCAAAAA TACAAAGGAC AGTGCCTATA ACACCAGGAC AATAGTGCAT 
TATTCTCCAA ATCTAGTTTT TTCAGGAATT GAGGCTATCC AAAAAGACAG TTGTGAATCT 
AATCATAATA TCACATGTAA AGTTGGATAT CCCTTCCTGA GAAGAGGAGA GATGGTAACT 
TTCAAAATAT TGTTTCAGTT TAACACATCC TATCTCATGG AAAATGTGAC CATTTATTTA 
AGTGCAACAA GTGACAGCGA AGAACCTCCT GAAACCCTTT CTGATAATGT AGTAAACATT 
TCTATCCCGG TAAAATATGA AGTTGGACTA CAGTTTTACA GCTCTGCAAG TGAATACCAC 
ATTTCAATTG CTGCCAATGA GACAGTCCCT GAAGTTATTA ATTCTACTGA GGACATTGGA 
AATGAAATTA ATATCTTCTA CTTGATTAGA AAAAGTGGAT CTTTTCCAAT GCCAGAGCTT 
AAGCTGTCAA TTTCATTCCC CAATATGACA TCAAATGGTT ACCCTGTGCT GTACCCAACT 
GGATTGTCAT CTTCTGAGAA TGCAAACTGC AGACCCCATA TCTTTGAGGA TCCTTTCAGT 
ATCAACTCTG GAAAGAAAAT GACTACATCA ACTGACCATC TCAAACGAGG CACAATTCTG 
GACTGCAATA CATGTAAATT TGCTACCATC ACATGTAATC TCACTTCTTC TGACATCAGC 
CAAGTCAATG TTTCGCTTAT CTTGTGGAAA CCAACTTTTA TAAAATCATA TTTTTCCAGC 
TTAAATCTTA CTATAAGGGG AGAACTTCGG AGTGAAAATG CATCTCTGGT TTTAAGTAGC 
AGCAATCAAA AAAGAGAGCT TGCTATTCAA ATATCCAAAG ATGGGCTACC GGGCAGAGTG 
CCATTATGGG TCATCCTGCT GAGTGCTTTT GCCGGATTGT TGCTGTTAAT GCTGCTCATT 
TTAGCACTGT GGAAGATTGG ATTCTTCAAA AGACCACTGA AAAAGAAAAT GGAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A pivotal role for a conserved bulky residue at the ?1-helix of the ?I integrin domain in ligand binding.
The Journal of biological chemistry292(50)20756-20768(2017 Dec)
Wang Z,Thinn AMM,Zhu J

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ITGA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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