Gene Symbol | IRF4 |
Entrez Gene ID | 3662 |
Full Name | interferon regulatory factor 4 |
Synonyms | LSIRF,MUM1,NF-EM5,SHEP8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]. |
Disorder MIM: | |
Disorder Html: | [Skin/hair/eye pigmentation, variation in, 8], 611724 (3) |