Gene Symbol | IRF3 |
Entrez Gene ID | 3661 |
Full Name | interferon regulatory factor 3 |
Synonyms | IIAE7 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. |
Disorder MIM: | |
Disorder Html: | {?Herpes simplex encephalitis, susceptibility to, 7}, 616532 (3) |