IRAK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IRAK2
Entrez Gene ID	3656
Full Name	interleukin 1 receptor associated kinase 2
Synonyms	IRAK-2
General protein information	Preferred Names interleukin 1 receptor associated kinase 2 Names interleukin-1 receptor-associated kinase-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.3
Summary	IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008].
Disorder MIM:	603304

mRNA and Protein(s)

mRNA	Protein	Name
NM_001570.4	NP_001561.3	interleukin-1 receptor-associated kinase-like 2
NM_001570.3	NP_001561.3	interleukin-1 receptor-associated kinase-like 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IRAK2	NP_001069164.1
Mus musculus (house mouse)	Irak2	NP_751893.3
Rattus norvegicus (Norway rat)	Irak2	NP_001020593.1
Xenopus tropicalis (tropical clawed frog)	irak2	NP_001007501.1
Canis lupus familiaris (dog)	IRAK2	XP_005632225.1
	IRAK2	XP_001090790.1
Gallus gallus (chicken)	IRAK2	NP_001025776.1
Homo sapiens (human)	IRAK2	NP_001561.3
Pan troglodytes (chimpanzee)	IRAK2	XP_516275.4

Gene Ontology
Bibliography

Related articles in PubMed

IRAK2 is associated with susceptibility to rheumatoid arthritis.
Hassine HB, Sghiri R, Chabchoub E, Boumiza A, Slama F, Baccouche K, Shakoor Z, Almogren A, Mariaselvam C, Tamouza R, Bouajina E, Zemni R
Clinical rheumatology(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IRAK2 L392V showed intact binding to, but impaired ubiquitination of, tumor necrosis factor receptor-associated factor 6, a vital step in signal transduction
Title: A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.

Human miR-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 target genes.
Title: Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes.

This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.
Title: A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.

Results suggest that D431E-IRAK2 (interleukin-1 receptor-associated kinase-2) increases NF-kappaB activation by promoting TRAF6 ubiquitination by enhancing TNF Receptor-Associated Factor 6 (TRAF6)-IRAK2 interaction.
Title: Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-?B activity through promoting TRAF6 ubiquitination.

These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway.
Title: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling.

The following IRAK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRAK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02994	NM_001570.4 Latest version!	Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu02994	NM_001570.3	Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IRAK2 ( NM_001570.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001561.3 Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.

Price & Availability↑

CloneID	OHu02994
Clone ID Related Accession (Same CDS sequence)	NM_001570.4 , NM_001570.3
Accession Version	NM_001570.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	interleukin-1 receptor-associated kinase-like 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL538890.3, AF026273.1, AL556221.3, AC022384.5, AJ496794.1 and BG682610.1. On Nov 23, 2018 this sequence version replaced NM_001570.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.88999.1, SRR1660805.220225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256458.5/ ENSP00000256458.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGCTGG ACGACCTGTG CCGCAACATG 
GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC 
CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGTG TGAGCATCAC GCGGGAGCTG 
CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAAC TTGTGGACCT CCTGTGCCGC 
CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG 
TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AGCCTTTGGC AGCTTCTGTA 
AGAAAGGCTG AGGATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTTTCCAGGC 
CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT 
GCCCCTCATT CCTTGAGAAG CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC 
TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 
GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC GCAAAATCAG CCAGGGGACC 
TTTGCTGACG TCTACAGAGG GCACAGGCAC GGGAAGCCAT TCGTCTTCAA GAAGCTCAGA 
GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GTTGCAGATT 
TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG 
TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT 
CAGGGTGGCT CGGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC 
TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAACGTCAA GAGCTCTAAT 
GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA TCTGTGTCCT 
GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACC TGCTCCGGAC GTCAGCCGCG 
TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGAGTGGA CATCTTCAGC 
TGTGGAATAG TGTTGGCCGA GGTCCTCACG GGCATCCCTG CAATGGATAA CAACCGAAGC 
CCGGTTTACC TGAAGGACTT ACTCCTCAGT GATATTCCAA GCAGCACCGC CTCGCTCTGC 
TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG 
AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG 
TGCCTGCGGA GGCGTAACAC CAGCCTGCAG GAGGTGTGTG GCTCTGTGGC TGCTGTGGAA 
GAGCGGCTCC GAGGTCGGGA GACGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC 
TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC 
TCCTCCATGA GTGTGGCACC CTGGGCAGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT 
GGGGAAGGAA GGCTGCGGGT CATCGTGGGA AGGGAGGCTG ACTCCTCCTC TGAGGCCTGT 
GTTGGCCTGG AGCCTCCCCA GGATGTTACA GAAACTTCGT GGCAAATTGA GATCAATGAG 
GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAAAAAGT GGACAGCATT 
GAGCTCTTTG GCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001561.3
CDS	37..1914
Translation	MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP

Target ORF information:

RefSeq Version	NM_001570.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001570.4

ORF Insert Sequence:

ATGGCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGCTGG ACGACCTGTG CCGCAACATG 
GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC 
CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGTG TGAGCATCAC GCGGGAGCTG 
CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAAC TTGTGGACCT CCTGTGCCGC 
CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG 
TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AGCCTTTGGC AGCTTCTGTA 
AGAAAGGCTG AGGATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTTTCCAGGC 
CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT 
GCCCCTCATT CCTTGAGAAG CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC 
TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 
GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC GCAAAATCAG CCAGGGGACC 
TTTGCTGACG TCTACAGAGG GCACAGGCAC GGGAAGCCAT TCGTCTTCAA GAAGCTCAGA 
GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GTTGCAGATT 
TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG 
TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT 
CAGGGTGGCT CGGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC 
TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAACGTCAA GAGCTCTAAT 
GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA TCTGTGTCCT 
GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACC TGCTCCGGAC GTCAGCCGCG 
TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGAGTGGA CATCTTCAGC 
TGTGGAATAG TGTTGGCCGA GGTCCTCACG GGCATCCCTG CAATGGATAA CAACCGAAGC 
CCGGTTTACC TGAAGGACTT ACTCCTCAGT GATATTCCAA GCAGCACCGC CTCGCTCTGC 
TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG 
AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG 
TGCCTGCGGA GGCGTAACAC CAGCCTGCAG GAGGTGTGTG GCTCTGTGGC TGCTGTGGAA 
GAGCGGCTCC GAGGTCGGGA GACGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC 
TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC 
TCCTCCATGA GTGTGGCACC CTGGGCAGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT 
GGGGAAGGAA GGCTGCGGGT CATCGTGGGA AGGGAGGCTG ACTCCTCCTC TGAGGCCTGT 
GTTGGCCTGG AGCCTCCCCA GGATGTTACA GAAACTTCGT GGCAAATTGA GATCAATGAG 
GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAAAAAGT GGACAGCATT 
GAGCTCTTTG GCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IRAK2 ( NM_001570.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001561.3 Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.

Price & Availability↑

CloneID	OHu02994
Clone ID Related Accession (Same CDS sequence)	NM_001570.4 , NM_001570.3
Accession Version	NM_001570.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	interleukin-1 receptor-associated kinase-like 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL538890.3, AF026273.1, AL556221.3, AC022384.5, AJ496794.1 and BG682610.1. On Feb 2, 2005 this sequence version replaced NM_001570.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ496794.1, SRR1803613.166079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGCTGG ACGACCTGTG CCGCAACATG 
GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC 
CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGTG TGAGCATCAC GCGGGAGCTG 
CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAAC TTGTGGACCT CCTGTGCCGC 
CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG 
TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AGCCTTTGGC AGCTTCTGTA 
AGAAAGGCTG AGGATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTTTCCAGGC 
CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT 
GCCCCTCATT CCTTGAGAAG CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC 
TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 
GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC GCAAAATCAG CCAGGGGACC 
TTTGCTGACG TCTACAGAGG GCACAGGCAC GGGAAGCCAT TCGTCTTCAA GAAGCTCAGA 
GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GTTGCAGATT 
TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG 
TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT 
CAGGGTGGCT CGGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC 
TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAACGTCAA GAGCTCTAAT 
GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA TCTGTGTCCT 
GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACC TGCTCCGGAC GTCAGCCGCG 
TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGAGTGGA CATCTTCAGC 
TGTGGAATAG TGTTGGCCGA GGTCCTCACG GGCATCCCTG CAATGGATAA CAACCGAAGC 
CCGGTTTACC TGAAGGACTT ACTCCTCAGT GATATTCCAA GCAGCACCGC CTCGCTCTGC 
TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG 
AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG 
TGCCTGCGGA GGCGTAACAC CAGCCTGCAG GAGGTGTGTG GCTCTGTGGC TGCTGTGGAA 
GAGCGGCTCC GAGGTCGGGA GACGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC 
TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC 
TCCTCCATGA GTGTGGCACC CTGGGCAGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT 
GGGGAAGGAA GGCTGCGGGT CATCGTGGGA AGGGAGGCTG ACTCCTCCTC TGAGGCCTGT 
GTTGGCCTGG AGCCTCCCCA GGATGTTACA GAAACTTCGT GGCAAATTGA GATCAATGAG 
GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAAAAAGT GGACAGCATT 
GAGCTCTTTG GCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001561.3
CDS	77..1954
Translation	MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP

Target ORF information:

RefSeq Version	NM_001570.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001570.3

ORF Insert Sequence:

ATGGCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGCTGG ACGACCTGTG CCGCAACATG 
GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC 
CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGTG TGAGCATCAC GCGGGAGCTG 
CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAAC TTGTGGACCT CCTGTGCCGC 
CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG 
TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AGCCTTTGGC AGCTTCTGTA 
AGAAAGGCTG AGGATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTTTCCAGGC 
CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT 
GCCCCTCATT CCTTGAGAAG CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC 
TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 
GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC GCAAAATCAG CCAGGGGACC 
TTTGCTGACG TCTACAGAGG GCACAGGCAC GGGAAGCCAT TCGTCTTCAA GAAGCTCAGA 
GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GTTGCAGATT 
TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG 
TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT 
CAGGGTGGCT CGGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC 
TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAACGTCAA GAGCTCTAAT 
GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA TCTGTGTCCT 
GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACC TGCTCCGGAC GTCAGCCGCG 
TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGAGTGGA CATCTTCAGC 
TGTGGAATAG TGTTGGCCGA GGTCCTCACG GGCATCCCTG CAATGGATAA CAACCGAAGC 
CCGGTTTACC TGAAGGACTT ACTCCTCAGT GATATTCCAA GCAGCACCGC CTCGCTCTGC 
TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG 
AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG 
TGCCTGCGGA GGCGTAACAC CAGCCTGCAG GAGGTGTGTG GCTCTGTGGC TGCTGTGGAA 
GAGCGGCTCC GAGGTCGGGA GACGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC 
TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC 
TCCTCCATGA GTGTGGCACC CTGGGCAGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT 
GGGGAAGGAA GGCTGCGGGT CATCGTGGGA AGGGAGGCTG ACTCCTCCTC TGAGGCCTGT 
GTTGGCCTGG AGCCTCCCCA GGATGTTACA GAAACTTCGT GGCAAATTGA GATCAATGAG 
GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAAAAAGT GGACAGCATT 
GAGCTCTTTG GCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IRAK2 is associated with susceptibility to rheumatoid arthritis.
Clinical rheumatology(2017 Nov)
Hassine HB,Sghiri R,Chabchoub E,Boumiza A,Slama F,Baccouche K,Shakoor Z,Almogren A,Mariaselvam C,Tamouza R,Bouajina E,Zemni R

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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IRAK2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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