INSL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	INSL3
Entrez Gene ID	3640
Full Name	insulin like 3
Synonyms	RLF,RLNL,ley-I-L
General protein information	Preferred Names insulin like 3 Names insulin-like 3 insulin-like 3 (Leydig cell) leydig insulin -like hormone leydig insulin-like peptide prepro-INSL3 relaxin-like factor b
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Disorder MIM:	146738
Disorder Html:	Cryptorchidism, 219050 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001265587.2	NP_001252516.1	insulin-like 3 isoform 1 precursor
NM_005543.3	NP_005534.2	insulin-like 3 isoform 2 precursor
NM_005543.4	NP_005534.2	insulin-like 3 isoform 2 precursor
NM_001265587.1	NP_001252516.1	insulin-like 3 isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	INSL3	NP_005534.2
Mus musculus (house mouse)	Insl3	NP_038592.3
Rattus norvegicus (Norway rat)	Insl3	NP_446132.1
Pan troglodytes (chimpanzee)	INSL3	NP_001171286.1
Canis lupus familiaris (dog)	INSL3	NP_001002962.1
Bos taurus (cattle)	INSL3	NP_776790.1

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent.
Seyam E, Hefzy E
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1-8(2017 Dec)

Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism.
Huang X, Jia J, Sun M, Li M, Liu N
Andrologia48(7)835-9(2016 Sep)

KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.
Tremblay MA, Mendoza-Villarroel RE, Robert NM, Bergeron F, Tremblay JJ
Journal of molecular endocrinology56(3)163-73(2016 04)

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells.
Adham IM, Burkhardt E, Benahmed M, Engel W
The Journal of biological chemistry268(35)26668-72(1993 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The INSL3 G178A polymorphism was not significantly associated with spermatozoa or no spermatozoa in the testes of males with a history of bilateral cryptorchidism. I The evidence suggests that mutations of INSL3 may not directly contribute to the damage of spermatogenesis in patients with bilateral cryptorchidism history.
Title: Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism.

KLF6-mediated activation of the human INSL3 promoter required an intact KLF element as well as Leydig/Sertoli-enriched factors. KLF6 transcriptionally cooperates with NUR77 and SF1. our results identify KLF6 as a regulator of human INSL3 transcription.
Title: KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.

hINSL3 seems to recruit Aund spermatogonia into differentiation, potentially mediating an Fsh effect on spermatogenesis.
Title: INSL3 stimulates spermatogonial differentiation in testis of adult zebrafish (Danio rerio).

rs6523 polymorphism and AGAG haplotype of INSL3 showed significant association with increased risk of polycystic ovary syndrome.
Title: Polymorphisms and haplotypes of insulin-like factor 3 gene are associated with risk of polycystic ovary syndrome in Indian women.

Healthy eumenorrheic late adolescent females with sporadic anovulation display higher INSL3 blood concentration.
Title: Anti-m?llerian hormone and insulin-like 3 levels in healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females: potential early biomarkers of ovarian dysfunction?

The following INSL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the INSL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20057	NM_005543.4 Latest version!	Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu21365	NM_001265587.2 Latest version!	Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu20057	NM_005543.3	Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu21365	NM_001265587.1	Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

INSL3 ( NM_005543.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005534.2 Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20057
Clone ID Related Accession (Same CDS sequence)	NM_005543.3 , NM_005543.4
Accession Version	NM_005543.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-01
Organism	Homo sapiens(human)
Product	insulin-like 3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY082014.1, BC106722.1 and BC040435.1. This sequence is a reference standard in the RefSeqGene project. On May 22, 2012 this sequence version replaced NM_005543.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279848.4192.1, ERR279856.1748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC GTGAGTTGCT ACAGTGGCTG GAGAGACGAC ATCTGCTCCA TGGGCTGGTG 
GCCGACAGTA ATCTCACGCT GGGACCTGGC CTGCAGCCCC TGCCCCAGAC CTCTCACCAT 
CACCGCCACC ACCGTGCAGC TGCCACCAAC CCTGCACGCT ACTGCTGCCT CAGTGGCTGT 
ACCCAACAAG ACCTGCTGAC CCTCTGTCCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005534.2
CDS	69..464
Translation	MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

Target ORF information:

RefSeq Version	NM_005543.3
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005543.3

ORF Insert Sequence:

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC GTGAGTTGCT ACAGTGGCTG GAGAGACGAC ATCTGCTCCA TGGGCTGGTG 
GCCGACAGTA ATCTCACGCT GGGACCTGGC CTGCAGCCCC TGCCCCAGAC CTCTCACCAT 
CACCGCCACC ACCGTGCAGC TGCCACCAAC CCTGCACGCT ACTGCTGCCT CAGTGGCTGT 
ACCCAACAAG ACCTGCTGAC CCTCTGTCCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INSL3 ( NM_005543.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005534.2 Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20057
Clone ID Related Accession (Same CDS sequence)	NM_005543.3 , NM_005543.4
Accession Version	NM_005543.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	insulin-like 3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY082014.1, BC106722.1, BC040435.1 and AC005952.2. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_005543.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG718760.1, BX359064.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC GTGAGTTGCT ACAGTGGCTG GAGAGACGAC ATCTGCTCCA TGGGCTGGTG 
GCCGACAGTA ATCTCACGCT GGGACCTGGC CTGCAGCCCC TGCCCCAGAC CTCTCACCAT 
CACCGCCACC ACCGTGCAGC TGCCACCAAC CCTGCACGCT ACTGCTGCCT CAGTGGCTGT 
ACCCAACAAG ACCTGCTGAC CCTCTGTCCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005534.2
CDS	14..409
Translation	MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

Target ORF information:

RefSeq Version	NM_005543.4
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 3 (INSL3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005543.4

ORF Insert Sequence:

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC GTGAGTTGCT ACAGTGGCTG GAGAGACGAC ATCTGCTCCA TGGGCTGGTG 
GCCGACAGTA ATCTCACGCT GGGACCTGGC CTGCAGCCCC TGCCCCAGAC CTCTCACCAT 
CACCGCCACC ACCGTGCAGC TGCCACCAAC CCTGCACGCT ACTGCTGCCT CAGTGGCTGT 
ACCCAACAAG ACCTGCTGAC CCTCTGTCCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INSL3 ( NM_001265587.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001252516.1 Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21365
Clone ID Related Accession (Same CDS sequence)	NM_001265587.2 , NM_001265587.1
Accession Version	NM_001265587.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	insulin-like 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY082014.1, AC005952.2 and BC040435.1. On Jun 2, 2019 this sequence version replaced NM_001265587.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY082014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC AGAGGGAGTC TCACTCTGTT TCCCAGGCTG GTCTCAAACT CCTGAGCTCA 
AGTAATCCTC CCACCTTGAC CTTCCAAAGT GTTGGGATTA GCGATGTGAG TTGCTACAGT 
GGCTGGAGAG ACGACATCTG CTCCATGGGC TGGTGGCCGA CAGTAATCTC ACGCTGGGAC 
CTGGCCTGCA GCCCCTGCCC CAGACCTCTC ACCATCACCG CCACCACCGT GCAGCTGCCA 
CCAACCCTGC ACGCTACTGC TGCCTCAGTG GCTGTACCCA ACAAGACCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001252516.1
CDS	14..487
Translation	MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDQRESHSVSQAGLKLLSSSNPPTLTFQSVGISDVSCYSGWRDDICSMGWWPTVISRWDLACSPCPRPLTITATTVQLPPTLHATAASVAVPNKTC

Target ORF information:

RefSeq Version	NM_001265587.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001265587.2

ORF Insert Sequence:

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC AGAGGGAGTC TCACTCTGTT TCCCAGGCTG GTCTCAAACT CCTGAGCTCA 
AGTAATCCTC CCACCTTGAC CTTCCAAAGT GTTGGGATTA GCGATGTGAG TTGCTACAGT 
GGCTGGAGAG ACGACATCTG CTCCATGGGC TGGTGGCCGA CAGTAATCTC ACGCTGGGAC 
CTGGCCTGCA GCCCCTGCCC CAGACCTCTC ACCATCACCG CCACCACCGT GCAGCTGCCA 
CCAACCCTGC ACGCTACTGC TGCCTCAGTG GCTGTACCCA ACAAGACCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INSL3 ( NM_001265587.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001252516.1 Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21365
Clone ID Related Accession (Same CDS sequence)	NM_001265587.2 , NM_001265587.1
Accession Version	NM_001265587.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-01
Organism	Homo sapiens(human)
Product	insulin-like 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY082014.1, AC005952.2 and BC040435.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY082014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC AGAGGGAGTC TCACTCTGTT TCCCAGGCTG GTCTCAAACT CCTGAGCTCA 
AGTAATCCTC CCACCTTGAC CTTCCAAAGT GTTGGGATTA GCGATGTGAG TTGCTACAGT 
GGCTGGAGAG ACGACATCTG CTCCATGGGC TGGTGGCCGA CAGTAATCTC ACGCTGGGAC 
CTGGCCTGCA GCCCCTGCCC CAGACCTCTC ACCATCACCG CCACCACCGT GCAGCTGCCA 
CCAACCCTGC ACGCTACTGC TGCCTCAGTG GCTGTACCCA ACAAGACCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001252516.1
CDS	69..542
Translation	MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDQRESHSVSQAGLKLLSSSNPPTLTFQSVGISDVSCYSGWRDDICSMGWWPTVISRWDLACSPCPRPLTITATTVQLPPTLHATAASVAVPNKTC

Target ORF information:

RefSeq Version	NM_001265587.1
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 3 (INSL3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001265587.1

ORF Insert Sequence:

ATGGACCCCC GTCTGCCCGC CTGGGCGCTG GTGCTGCTGG GCCCTGCCCT GGTGTTCGCG 
TTGGGCCCCG CGCCCACCCC AGAGATGCGT GAGAAGTTGT GCGGCCACCA CTTCGTACGC 
GCGCTAGTGC GCGTGTGCGG GGGCCCCCGC TGGTCCACCG AAGCCAGGAG GCCTGCGACC 
GGAGGCGACC AGAGGGAGTC TCACTCTGTT TCCCAGGCTG GTCTCAAACT CCTGAGCTCA 
AGTAATCCTC CCACCTTGAC CTTCCAAAGT GTTGGGATTA GCGATGTGAG TTGCTACAGT 
GGCTGGAGAG ACGACATCTG CTCCATGGGC TGGTGGCCGA CAGTAATCTC ACGCTGGGAC 
CTGGCCTGCA GCCCCTGCCC CAGACCTCTC ACCATCACCG CCACCACCGT GCAGCTGCCA 
CCAACCCTGC ACGCTACTGC TGCCTCAGTG GCTGTACCCA ACAAGACCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1-8(2017 Dec)
Seyam E,Hefzy E

Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism.
Andrologia48(7)835-9(2016 Sep)
Huang X,Jia J,Sun M,Li M,Liu N

KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.
Journal of molecular endocrinology56(3)163-73(2016 04)
Tremblay MA,Mendoza-Villarroel RE,Robert NM,Bergeron F,Tremblay JJ

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells.
The Journal of biological chemistry268(35)26668-72(1993 Dec)
Adham IM,Burkhardt E,Benahmed M,Engel W

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INSL3 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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