AQP6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AQP6
Entrez Gene ID	363
Full Name	aquaporin 6
Synonyms	AQP2L,KID
General protein information	Preferred Names aquaporin 6 Names aquaporin-6 AQP-6 aquaporin 2-like, kidney specific aquaporin-6, kidney specific hKID kidney-specific aquaporin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.12
Summary	The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008].
Disorder MIM:	601383

mRNA and Protein(s)

mRNA	Protein	Name
NM_001652.3	NP_001643.2	aquaporin-6
NM_001652.4	NP_001643.2	aquaporin-6

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aqp6	NP_780296.1
Homo sapiens (human)	AQP6	NP_001643.2
Bos taurus (cattle)	AQP6	XP_002687325.1
Canis lupus familiaris (dog)	AQP6	XP_850452.1
Pan troglodytes (chimpanzee)	AQP6	XP_001157230.1
Rattus norvegicus (Norway rat)	Aqp6	NP_071517.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of AQP6 and AQP8 in epithelial ovarian tumor.
Ma J, Zhou C, Yang J, Ding X, Zhu Y, Chen X
Journal of molecular histology47(2)129-34(2016 Apr)

Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma.
Ishiyama G, Lopez IA, Beltran-Parrazal L, Ishiyama A
Cell and tissue research340(3)407-19(2010 Jun)

Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours.
Yusenko MV, Zubakov D, Kovacs G
International journal of biological sciences5(6)517-27(2009 Jul)

Aquaporin expression in developing human teeth and selected orofacial tissues.
Wang W, Hart PS, Piesco NP, Lu X, Gorry MC, Hart TC
Calcified tissue international72(3)222-7(2003 Mar)

Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.
Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M
The Journal of biological chemistry277(42)39873-9(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AQP6 and AQP8 had different expression degrees in epithelial ovarian tissues, which suggests that AQP6 and AQP8 may play certain roles in epithelial ovarian tumors.
Title: Expression of AQP6 and AQP8 in epithelial ovarian tumor.

Expression of AQP1, AQP4, or AQP6 mRNA did not differ in vestibular endorgans from patients with Meniere's disease.
Title: Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma.

Data have identified AQP6 s valuable markers for renal oncocytomas.
Title: Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours.

the primary role of AQP6 may be in cellular regulation
Title: Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.

The following AQP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AQP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03647	NM_001652.4 Latest version!	Homo sapiens aquaporin 6 (AQP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03647	NM_001652.3	Homo sapiens aquaporin 6 (AQP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AQP6 ( NM_001652.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001643.2 Homo sapiens aquaporin 6 (AQP6), mRNA.

Price & Availability↑

CloneID	OHu03647
Clone ID Related Accession (Same CDS sequence)	NM_001652.3 , NM_001652.4
Accession Version	NM_001652.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	aquaporin-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025154.31 and U48408.1. On Feb 7, 2006 this sequence version replaced NM_001652.2. ##Evidence-Data-START## Transcript exon combination :: U48408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGCAG TGGAGCCAGG GGGACGTGGC TGGGCCAGCA TGTTGGCGTG CAGGCTTTGG 
AAAGCCATCA GCAGGGCGCT GTTTGCAGAG TTCCTGGCCA CGGGGCTGTA TGTGTTCTTT 
GGCGTGGGCT CAGTCATGCG CTGGCCCACA GCACTTCCCT CCGTGCTACA GATTGCCATC 
ACCTTCAACC TGGTCACCGC CATGGCTGTG CAGGTCACCT GGAAGGCCAG CGGGGCCCAC 
GCCAACCCCG CCGTGACGCT GGCCTTCCTC GTAGGCTCCC ACATCTCTCT GCCCCGTGCT 
GTGGCCTATG TGGCTGCCCA GCTGGTGGGG GCCACGGTGG GGGCTGCTCT GCTTTATGGG 
GTCATGCCGG GAGACATCCG AGAGACCCTT GGGATCAACG TGGTCCGGAA CAGTGTCTCA 
ACTGGCCAGG CGGTGGCAGT GGAGCTGCTT CTGACCCTGC AGCTGGTGCT CTGTGTCTTC 
GCTTCCACCG ACAGCCGTCA GACATCAGGC TCCCCGGCCA CCATGATTGG GATCTCTGTG 
GCACTGGGCC ACCTCATTGG GATCCACTTC ACTGGCTGCT CCATGAATCC AGCCCGCTCC 
TTCGGCCCTG CCATCATCAT TGGGAAGTTC ACAGTCCACT GGGTCTTCTG GGTGGGGCCC 
CTGATGGGAG CCCTCCTGGC CTCACTGATC TACAACTTCG TCCTGTTCCC CGACACCAAG 
ACCCTGGCGC AGCGGCTGGC TATCCTCACA GGCACCGTAG AGGTGGGGAC AGGGGCAGGG 
GCAGGGGCGG AGCCCCTGAA GAAGGAATCC CAGCCGGGTT CGGGAGCCGT GGAGATGGAG 
AGTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001643.2
CDS	338..1186
Translation	MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV

Target ORF information:

RefSeq Version	NM_001652.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aquaporin 6 (AQP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001652.3

ORF Insert Sequence:

ATGGATGCAG TGGAGCCAGG GGGACGTGGC TGGGCCAGCA TGTTGGCGTG CAGGCTTTGG 
AAAGCCATCA GCAGGGCGCT GTTTGCAGAG TTCCTGGCCA CGGGGCTGTA TGTGTTCTTT 
GGCGTGGGCT CAGTCATGCG CTGGCCCACA GCACTTCCCT CCGTGCTACA GATTGCCATC 
ACCTTCAACC TGGTCACCGC CATGGCTGTG CAGGTCACCT GGAAGGCCAG CGGGGCCCAC 
GCCAACCCCG CCGTGACGCT GGCCTTCCTC GTAGGCTCCC ACATCTCTCT GCCCCGTGCT 
GTGGCCTATG TGGCTGCCCA GCTGGTGGGG GCCACGGTGG GGGCTGCTCT GCTTTATGGG 
GTCATGCCGG GAGACATCCG AGAGACCCTT GGGATCAACG TGGTCCGGAA CAGTGTCTCA 
ACTGGCCAGG CGGTGGCAGT GGAGCTGCTT CTGACCCTGC AGCTGGTGCT CTGTGTCTTC 
GCTTCCACCG ACAGCCGTCA GACATCAGGC TCCCCGGCCA CCATGATTGG GATCTCTGTG 
GCACTGGGCC ACCTCATTGG GATCCACTTC ACTGGCTGCT CCATGAATCC AGCCCGCTCC 
TTCGGCCCTG CCATCATCAT TGGGAAGTTC ACAGTCCACT GGGTCTTCTG GGTGGGGCCC 
CTGATGGGAG CCCTCCTGGC CTCACTGATC TACAACTTCG TCCTGTTCCC CGACACCAAG 
ACCCTGGCGC AGCGGCTGGC TATCCTCACA GGCACCGTAG AGGTGGGGAC AGGGGCAGGG 
GCAGGGGCGG AGCCCCTGAA GAAGGAATCC CAGCCGGGTT CGGGAGCCGT GGAGATGGAG 
AGTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AQP6 ( NM_001652.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001643.2 Homo sapiens aquaporin 6 (AQP6), mRNA.

Price & Availability↑

CloneID	OHu03647
Clone ID Related Accession (Same CDS sequence)	NM_001652.3 , NM_001652.4
Accession Version	NM_001652.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	aquaporin-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025154.31 and U48408.1. On Nov 23, 2018 this sequence version replaced NM_001652.3. ##Evidence-Data-START## Transcript exon combination :: U48408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000315520.10/ ENSP00000320247.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATGCAG TGGAGCCAGG GGGACGTGGC TGGGCCAGCA TGTTGGCGTG CAGGCTTTGG 
AAAGCCATCA GCAGGGCGCT GTTTGCAGAG TTCCTGGCCA CGGGGCTGTA TGTGTTCTTT 
GGCGTGGGCT CAGTCATGCG CTGGCCCACA GCACTTCCCT CCGTGCTACA GATTGCCATC 
ACCTTCAACC TGGTCACCGC CATGGCTGTG CAGGTCACCT GGAAGGCCAG CGGGGCCCAC 
GCCAACCCCG CCGTGACGCT GGCCTTCCTC GTAGGCTCCC ACATCTCTCT GCCCCGTGCT 
GTGGCCTATG TGGCTGCCCA GCTGGTGGGG GCCACGGTGG GGGCTGCTCT GCTTTATGGG 
GTCATGCCGG GAGACATCCG AGAGACCCTT GGGATCAACG TGGTCCGGAA CAGTGTCTCA 
ACTGGCCAGG CGGTGGCAGT GGAGCTGCTT CTGACCCTGC AGCTGGTGCT CTGTGTCTTC 
GCTTCCACCG ACAGCCGTCA GACATCAGGC TCCCCGGCCA CCATGATTGG GATCTCTGTG 
GCACTGGGCC ACCTCATTGG GATCCACTTC ACTGGCTGCT CCATGAATCC AGCCCGCTCC 
TTCGGCCCTG CCATCATCAT TGGGAAGTTC ACAGTCCACT GGGTCTTCTG GGTGGGGCCC 
CTGATGGGAG CCCTCCTGGC CTCACTGATC TACAACTTCG TCCTGTTCCC CGACACCAAG 
ACCCTGGCGC AGCGGCTGGC TATCCTCACA GGCACCGTAG AGGTGGGGAC AGGGGCAGGG 
GCAGGGGCGG AGCCCCTGAA GAAGGAATCC CAGCCGGGTT CGGGAGCCGT GGAGATGGAG 
AGTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001643.2
CDS	228..1076
Translation	MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV

Target ORF information:

RefSeq Version	NM_001652.4
Organism	Homo sapiens(human)
Definition	Homo sapiens aquaporin 6 (AQP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001652.4

ORF Insert Sequence:

ATGGATGCAG TGGAGCCAGG GGGACGTGGC TGGGCCAGCA TGTTGGCGTG CAGGCTTTGG 
AAAGCCATCA GCAGGGCGCT GTTTGCAGAG TTCCTGGCCA CGGGGCTGTA TGTGTTCTTT 
GGCGTGGGCT CAGTCATGCG CTGGCCCACA GCACTTCCCT CCGTGCTACA GATTGCCATC 
ACCTTCAACC TGGTCACCGC CATGGCTGTG CAGGTCACCT GGAAGGCCAG CGGGGCCCAC 
GCCAACCCCG CCGTGACGCT GGCCTTCCTC GTAGGCTCCC ACATCTCTCT GCCCCGTGCT 
GTGGCCTATG TGGCTGCCCA GCTGGTGGGG GCCACGGTGG GGGCTGCTCT GCTTTATGGG 
GTCATGCCGG GAGACATCCG AGAGACCCTT GGGATCAACG TGGTCCGGAA CAGTGTCTCA 
ACTGGCCAGG CGGTGGCAGT GGAGCTGCTT CTGACCCTGC AGCTGGTGCT CTGTGTCTTC 
GCTTCCACCG ACAGCCGTCA GACATCAGGC TCCCCGGCCA CCATGATTGG GATCTCTGTG 
GCACTGGGCC ACCTCATTGG GATCCACTTC ACTGGCTGCT CCATGAATCC AGCCCGCTCC 
TTCGGCCCTG CCATCATCAT TGGGAAGTTC ACAGTCCACT GGGTCTTCTG GGTGGGGCCC 
CTGATGGGAG CCCTCCTGGC CTCACTGATC TACAACTTCG TCCTGTTCCC CGACACCAAG 
ACCCTGGCGC AGCGGCTGGC TATCCTCACA GGCACCGTAG AGGTGGGGAC AGGGGCAGGG 
GCAGGGGCGG AGCCCCTGAA GAAGGAATCC CAGCCGGGTT CGGGAGCCGT GGAGATGGAG 
AGTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of AQP6 and AQP8 in epithelial ovarian tumor.
Journal of molecular histology47(2)129-34(2016 Apr)
Ma J,Zhou C,Yang J,Ding X,Zhu Y,Chen X

Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma.
Cell and tissue research340(3)407-19(2010 Jun)
Ishiyama G,Lopez IA,Beltran-Parrazal L,Ishiyama A

Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours.
International journal of biological sciences5(6)517-27(2009 Jul)
Yusenko MV,Zubakov D,Kovacs G

Aquaporin expression in developing human teeth and selected orofacial tissues.
Calcified tissue international72(3)222-7(2003 Mar)
Wang W,Hart PS,Piesco NP,Lu X,Gorry MC,Hart TC

Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.
The Journal of biological chemistry277(42)39873-9(2002 Oct)
Ikeda M,Beitz E,Kozono D,Guggino WB,Agre P,Yasui M

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AQP6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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