Gene Symbol | IMPDH2 |
Entrez Gene ID | 3615 |
Full Name | inosine monophosphate dehydrogenase 2 |
Synonyms | IMPD2,IMPDH-II |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | [IMPDH2 enzyme activity, variation in] (3) |