IMPA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IMPA1
Entrez Gene ID	3612
Full Name	inositol monophosphatase 1
Synonyms	IMP,IMPA,MRT59
General protein information	Preferred Names inositol monophosphatase 1 Names inositol monophosphatase 1 D-galactose 1-phosphate phosphatase IMP 1 IMPase 1 inositol(myo)-1(or 4)-monophosphatase 1 inositol-1(or 4)-monophosphatase 1 lithium-sensitive myo-inositol monophosphatase A1 myo-inositol monophosphatase 1 testicular tissue protein Li 94
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.13
Summary	This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014].
Disorder MIM:	602064
Disorder Html:	Mental retardation, autosomal recessive 59, 617323 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001144879.1	NP_001138351.1	inositol monophosphatase 1 isoform 3
NM_005536.3	NP_005527.1	inositol monophosphatase 1 isoform 1
NM_005536.4	NP_005527.1	inositol monophosphatase 1 isoform 1
NM_001144878.1	NP_001138350.1	inositol monophosphatase 1 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Impa1	NP_114446.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006570	XP_316595.4
Caenorhabditis elegans (roundworm)	ttx-7	NP_001122453.1
Saccharomyces cerevisiae (baker's yeast)	INM2	NP_010573.3
Magnaporthe oryzae (rice blast fungus)	MGG_06165	XP_003712046.1
Homo sapiens (human)	IMPA1	NP_001138350.1
Neurospora crassa	NCU06348	XP_962382.1
Xenopus tropicalis (tropical clawed frog)	impa1	NP_001017057.1
Drosophila melanogaster (fruit fly)	CG9391	NP_649294.1
Saccharomyces cerevisiae (baker's yeast)	INM1	NP_011912.1
Oryza sativa (rice)	Os03g0587000	NP_001050574.1
Pan troglodytes (chimpanzee)	LOC100613673	XP_003311833.1
	IMPA1	XP_001092596.2
Mus musculus (house mouse)	Impa1	NP_061352.2
Arabidopsis thaliana (thale cress)	VTC4	NP_186936.1
Canis lupus familiaris (dog)	IMPA1	XP_535114.1
Bos taurus (cattle)	IMPA1	NP_776786.1
Gallus gallus (chicken)	IMPA1	XP_418310.3
Danio rerio (zebrafish)	impa1	NP_001002745.1

Gene Ontology
Bibliography

Related articles in PubMed

A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.
Figueiredo T, Melo US, Pessoa AL, Nobrega PR, Kitajima JP, Rusch H, Vaz F, Lucato LT, Zatz M, Kok F, Santos S
Molecular psychiatry21(8)1125-9(2016 08)

Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.
Ferruz N, Tresadern G, Pineda-Lucena A, De Fabritiis G
Scientific reports630275(2016 Jul)

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, , , Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, D?rk T, du Bois A, D?rst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, H?gdall E, H?gdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubi?ski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM, Sellers TA
Nature genetics45(4)362-70, 370e1-2(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.
Title: A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.

Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A
Title: Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
Title: Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.

IMPA2 has a separate function in vivo from that of IMPA1
Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

No association between polymorphisms and bipolar disorder
Title: Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.

The following IMPA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IMPA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10957	NM_005536.4 Latest version!	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu11019	NM_001144879.1 Latest version!	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu22730	NM_001144878.1 Latest version!	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$202.30 $289.00
View Old Accession Versions >>
OHu10957	NM_005536.3	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IMPA1 ( NM_005536.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005527.1 Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10957
Clone ID Related Accession (Same CDS sequence)	NM_005536.3 , NM_005536.4
Accession Version	NM_005536.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	inositol monophosphatase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC375686.1, AF042729.2, BC008381.1, AI921211.1, AC090255.4 and DB299262.1. On Jan 27, 2009 this sequence version replaced NM_005536.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.109101.1, SRR1803611.119127.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGATA TTACCAAATC TCTCTTGGTG 
ACTGAGTTGG GCTCTTCCAG AACACCAGAG ACTGTGAGAA TGGTTCTTTC TAATATGGAA 
AAGCTTTTTT GCATTCCTGT TCATGGGATC CGGAGTGTTG GAACAGCAGC TGTTAATATG 
TGCCTTGTGG CAACTGGCGG AGCAGATGCA TATTATGAAA TGGGAATTCA CTGCTGGGAT 
GTTGCAGGAG CTGGCATTAT TGTTACTGAA GCTGGTGGCG TGCTAATGGA TGTTACAGGT 
GGACCATTTG ATTTGATGTC ACGAAGAGTA ATTGCTGCAA ATAATAGAAT ATTAGCAGAA 
AGGATAGCTA AAGAAATTCA GGTTATACCT TTGCAACGAG ACGACGAAGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005527.1
CDS	128..961
Translation	MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED

Target ORF information:

RefSeq Version	NM_005536.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005536.3

ORF Insert Sequence:

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGATA TTACCAAATC TCTCTTGGTG 
ACTGAGTTGG GCTCTTCCAG AACACCAGAG ACTGTGAGAA TGGTTCTTTC TAATATGGAA 
AAGCTTTTTT GCATTCCTGT TCATGGGATC CGGAGTGTTG GAACAGCAGC TGTTAATATG 
TGCCTTGTGG CAACTGGCGG AGCAGATGCA TATTATGAAA TGGGAATTCA CTGCTGGGAT 
GTTGCAGGAG CTGGCATTAT TGTTACTGAA GCTGGTGGCG TGCTAATGGA TGTTACAGGT 
GGACCATTTG ATTTGATGTC ACGAAGAGTA ATTGCTGCAA ATAATAGAAT ATTAGCAGAA 
AGGATAGCTA AAGAAATTCA GGTTATACCT TTGCAACGAG ACGACGAAGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IMPA1 ( NM_005536.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005527.1 Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10957
Clone ID Related Accession (Same CDS sequence)	NM_005536.3 , NM_005536.4
Accession Version	NM_005536.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	inositol monophosphatase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC375686.1, AF042729.2, BC008381.1, AI921211.1, AC090255.4 and DB299262.1. On Nov 24, 2018 this sequence version replaced NM_005536.3. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF042729.2, SRR1660805.82085.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256108.10/ ENSP00000256108.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGATA TTACCAAATC TCTCTTGGTG 
ACTGAGTTGG GCTCTTCCAG AACACCAGAG ACTGTGAGAA TGGTTCTTTC TAATATGGAA 
AAGCTTTTTT GCATTCCTGT TCATGGGATC CGGAGTGTTG GAACAGCAGC TGTTAATATG 
TGCCTTGTGG CAACTGGCGG AGCAGATGCA TATTATGAAA TGGGAATTCA CTGCTGGGAT 
GTTGCAGGAG CTGGCATTAT TGTTACTGAA GCTGGTGGCG TGCTAATGGA TGTTACAGGT 
GGACCATTTG ATTTGATGTC ACGAAGAGTA ATTGCTGCAA ATAATAGAAT ATTAGCAGAA 
AGGATAGCTA AAGAAATTCA GGTTATACCT TTGCAACGAG ACGACGAAGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005527.1
CDS	99..932
Translation	MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED

Target ORF information:

RefSeq Version	NM_005536.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005536.4

ORF Insert Sequence:

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGATA TTACCAAATC TCTCTTGGTG 
ACTGAGTTGG GCTCTTCCAG AACACCAGAG ACTGTGAGAA TGGTTCTTTC TAATATGGAA 
AAGCTTTTTT GCATTCCTGT TCATGGGATC CGGAGTGTTG GAACAGCAGC TGTTAATATG 
TGCCTTGTGG CAACTGGCGG AGCAGATGCA TATTATGAAA TGGGAATTCA CTGCTGGGAT 
GTTGCAGGAG CTGGCATTAT TGTTACTGAA GCTGGTGGCG TGCTAATGGA TGTTACAGGT 
GGACCATTTG ATTTGATGTC ACGAAGAGTA ATTGCTGCAA ATAATAGAAT ATTAGCAGAA 
AGGATAGCTA AAGAAATTCA GGTTATACCT TTGCAACGAG ACGACGAAGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IMPA1 ( NM_001144879.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138351.1 Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu11019
Clone ID Related Accession (Same CDS sequence)	NM_001144879.1
Accession Version	NM_001144879.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	inositol monophosphatase 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC375686.1, AK297078.1, AF042729.2, BC008381.1, AI921211.1, AC090255.4 and DB299262.1. Transcript Variant: This variant (3) is missing an internal coding exon compared to transcript variant 1. This results in a frame-shift and a shorter isoform (3) with a novel C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.62219.1, SRR1660809.97311.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGGAT CCGGAGTGTT GGAACAGCAG 
CTGTTAATAT GTGCCTTGTG GCAACTGGCG GAGCAGATGC ATATTATGAA ATGGGAATTC 
ACTGCTGGGA TGTTGCAGGA GCTGGCATTA TTGTTACTGA AGCTGGTGGC GTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138351.1
CDS	128..724
Translation	MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEGSGVLEQQLLICALWQLAEQMHIMKWEFTAGMLQELALLLLKLVAC

Target ORF information:

RefSeq Version	NM_001144879.1
Organism	Homo sapiens(human)
Definition	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001144879.1

ORF Insert Sequence:

ATGGCTGATC CTTGGCAGGA ATGCATGGAT TATGCAGTAA CTCTAGCAAG ACAAGCTGGA 
GAGGTAGTTT GTGAAGCTAT AAAAAATGAA ATGAATGTTA TGCTGAAAAG TTCTCCAGTT 
GATTTGGTAA CTGCTACGGA CCAAAAAGTT GAAAAAATGC TTATCTCTTC CATAAAGGAA 
AAGTATCCAT CTCACAGTTT CATTGGTGAA GAATCTGTGG CAGCTGGGGA AAAAAGTATC 
TTAACCGACA ACCCCACATG GATCATTGAC CCTATTGATG GAACAACTAA CTTTGTACAT 
AGATTTCCTT TTGTAGCTGT TTCAATTGGC TTTGCTGTAA ATAAAAAGAT AGAATTTGGA 
GTTGTGTACA GTTGTGTGGA AGGCAAGATG TACACTGCCA GAAAAGGAAA AGGTGCCTTT 
TGTAATGGTC AAAAACTACA AGTTTCACAA CAAGAAGGAT CCGGAGTGTT GGAACAGCAG 
CTGTTAATAT GTGCCTTGTG GCAACTGGCG GAGCAGATGC ATATTATGAA ATGGGAATTC 
ACTGCTGGGA TGTTGCAGGA GCTGGCATTA TTGTTACTGA AGCTGGTGGC GTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IMPA1 ( NM_001144878.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138350.1 Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22730
Clone ID Related Accession (Same CDS sequence)	NM_001144878.1
Accession Version	NM_001144878.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	inositol monophosphatase 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC375686.1, BP270804.1, AK300750.1, AF042729.2, BC008381.1, AI921211.1, AC090255.4 and DB299262.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to transcript variant 1, resulting in an isoform (2) with a longer and a novel N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005407.1, SRR1660805.78248.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCAGC GCCCAGGTCC TGTGCTGCCC GCAGTCGCGG TGCTGGGACA GGTGGCAAAA 
AGGAAGGTGG CCTGGCTCCT ACGCTGGAAG GCTGTGACCA GGACAGAAAC AGCAGGAAAC 
AGTTCAGGTG TTTATGGCTT TGGGAAAATG AAAATATTTG TCAAATATTT TCAGAAGATG 
GCTGATCCTT GGCAGGAATG CATGGATTAT GCAGTAACTC TAGCAAGACA AGCTGGAGAG 
GTAGTTTGTG AAGCTATAAA AAATGAAATG AATGTTATGC TGAAAAGTTC TCCAGTTGAT 
TTGGTAACTG CTACGGACCA AAAAGTTGAA AAAATGCTTA TCTCTTCCAT AAAGGAAAAG 
TATCCATCTC ACAGTTTCAT TGGTGAAGAA TCTGTGGCAG CTGGGGAAAA AAGTATCTTA 
ACCGACAACC CCACATGGAT CATTGACCCT ATTGATGGAA CAACTAACTT TGTACATAGA 
TTTCCTTTTG TAGCTGTTTC AATTGGCTTT GCTGTAAATA AAAAGATAGA ATTTGGAGTT 
GTGTACAGTT GTGTGGAAGG CAAGATGTAC ACTGCCAGAA AAGGAAAAGG TGCCTTTTGT 
AATGGTCAAA AACTACAAGT TTCACAACAA GAAGATATTA CCAAATCTCT CTTGGTGACT 
GAGTTGGGCT CTTCCAGAAC ACCAGAGACT GTGAGAATGG TTCTTTCTAA TATGGAAAAG 
CTTTTTTGCA TTCCTGTTCA TGGGATCCGG AGTGTTGGAA CAGCAGCTGT TAATATGTGC 
CTTGTGGCAA CTGGCGGAGC AGATGCATAT TATGAAATGG GAATTCACTG CTGGGATGTT 
GCAGGAGCTG GCATTATTGT TACTGAAGCT GGTGGCGTGC TAATGGATGT TACAGGTGGA 
CCATTTGATT TGATGTCACG AAGAGTAATT GCTGCAAATA ATAGAATATT AGCAGAAAGG 
ATAGCTAAAG AAATTCAGGT TATACCTTTG CAACGAGACG ACGAAGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138350.1
CDS	152..1162
Translation	MGQRPGPVLPAVAVLGQVAKRKVAWLLRWKAVTRTETAGNSSGVYGFGKMKIFVKYFQKMADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED

Target ORF information:

RefSeq Version	NM_001144878.1
Organism	Homo sapiens(human)
Definition	Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001144878.1

ORF Insert Sequence:

ATGGGGCAGC GCCCAGGTCC TGTGCTGCCC GCAGTCGCGG TGCTGGGACA GGTGGCAAAA 
AGGAAGGTGG CCTGGCTCCT ACGCTGGAAG GCTGTGACCA GGACAGAAAC AGCAGGAAAC 
AGTTCAGGTG TTTATGGCTT TGGGAAAATG AAAATATTTG TCAAATATTT TCAGAAGATG 
GCTGATCCTT GGCAGGAATG CATGGATTAT GCAGTAACTC TAGCAAGACA AGCTGGAGAG 
GTAGTTTGTG AAGCTATAAA AAATGAAATG AATGTTATGC TGAAAAGTTC TCCAGTTGAT 
TTGGTAACTG CTACGGACCA AAAAGTTGAA AAAATGCTTA TCTCTTCCAT AAAGGAAAAG 
TATCCATCTC ACAGTTTCAT TGGTGAAGAA TCTGTGGCAG CTGGGGAAAA AAGTATCTTA 
ACCGACAACC CCACATGGAT CATTGACCCT ATTGATGGAA CAACTAACTT TGTACATAGA 
TTTCCTTTTG TAGCTGTTTC AATTGGCTTT GCTGTAAATA AAAAGATAGA ATTTGGAGTT 
GTGTACAGTT GTGTGGAAGG CAAGATGTAC ACTGCCAGAA AAGGAAAAGG TGCCTTTTGT 
AATGGTCAAA AACTACAAGT TTCACAACAA GAAGATATTA CCAAATCTCT CTTGGTGACT 
GAGTTGGGCT CTTCCAGAAC ACCAGAGACT GTGAGAATGG TTCTTTCTAA TATGGAAAAG 
CTTTTTTGCA TTCCTGTTCA TGGGATCCGG AGTGTTGGAA CAGCAGCTGT TAATATGTGC 
CTTGTGGCAA CTGGCGGAGC AGATGCATAT TATGAAATGG GAATTCACTG CTGGGATGTT 
GCAGGAGCTG GCATTATTGT TACTGAAGCT GGTGGCGTGC TAATGGATGT TACAGGTGGA 
CCATTTGATT TGATGTCACG AAGAGTAATT GCTGCAAATA ATAGAATATT AGCAGAAAGG 
ATAGCTAAAG AAATTCAGGT TATACCTTTG CAACGAGACG ACGAAGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.
Molecular psychiatry21(8)1125-9(2016 08)
Figueiredo T,Melo US,Pessoa AL,Nobrega PR,Kitajima JP,Rusch H,Vaz F,Lucato LT,Zatz M,Kok F,Santos S

Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.
Scientific reports630275(2016 Jul)
Ferruz N,Tresadern G,Pineda-Lucena A,De Fabritiis G

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Nature genetics45(4)362-70, 370e1-2(2013 Apr)
Pharoah PD,Tsai YY,Ramus SJ,Phelan CM,Goode EL,Lawrenson K,Buckley M,Fridley BL,Tyrer JP,Shen H,Weber R,Karevan R,Larson MC,Song H,Tessier DC,Bacot F,Vincent D,Cunningham JM,Dennis J,Dicks E,,,Aben KK,Anton-Culver H,Antonenkova N,Armasu SM,Baglietto L,Bandera EV,Beckmann MW,Birrer MJ,Bloom G,Bogdanova N,Brenton JD,Brinton LA,Brooks-Wilson A,Brown R,Butzow R,Campbell I,Carney ME,Carvalho RS,Chang-Claude J,Chen YA,Chen Z,Chow WH,Cicek MS,Coetzee G,Cook LS,Cramer DW,Cybulski C,Dansonka-Mieszkowska A,Despierre E,Doherty JA,D?rk T,du Bois A,D?rst M,Eccles D,Edwards R,Ekici AB,Fasching PA,Fenstermacher D,Flanagan J,Gao YT,Garcia-Closas M,Gentry-Maharaj A,Giles G,Gjyshi A,Gore M,Gronwald J,Guo Q,Halle MK,Harter P,Hein A,Heitz F,Hillemanns P,Hoatlin M,H?gdall E,H?gdall CK,Hosono S,Jakubowska A,Jensen A,Kalli KR,Karlan BY,Kelemen LE,Kiemeney LA,Kjaer SK,Konecny GE,Krakstad C,Kupryjanczyk J,Lambrechts D,Lambrechts S,Le ND,Lee N,Lee J,Leminen A,Lim BK,Lissowska J,Lubi?ski J,Lundvall L,Lurie G,Massuger LF,Matsuo K,McGuire V,McLaughlin JR,Menon U,Modugno F,Moysich KB,Nakanishi T,Narod SA,Ness RB,Nevanlinna H,Nickels S,Noushmehr H,Odunsi K,Olson S,Orlow I,Paul J,Pejovic T,Pelttari LM,Permuth-Wey J,Pike MC,Poole EM,Qu X,Risch HA,Rodriguez-Rodriguez L,Rossing MA,Rudolph A,Runnebaum I,Rzepecka IK,Salvesen HB,Schwaab I,Severi G,Shen H,Shridhar V,Shu XO,Sieh W,Southey MC,Spellman P,Tajima K,Teo SH,Terry KL,Thompson PJ,Timorek A,Tworoger SS,van Altena AM,van den Berg D,Vergote I,Vierkant RA,Vitonis AF,Wang-Gohrke S,Wentzensen N,Whittemore AS,Wik E,Winterhoff B,Woo YL,Wu AH,Yang HP,Zheng W,Ziogas A,Zulkifli F,Goodman MT,Hall P,Easton DF,Pearce CL,Berchuck A,Chenevix-Trench G,Iversen E,Monteiro AN,Gayther SA,Schildkraut JM,Sellers TA

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IMPA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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