IL17A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL17A
Entrez Gene ID	3605
Full Name	interleukin 17A
Synonyms	CTLA-8,CTLA8,IL-17,IL-17A,IL17
General protein information	Preferred Names interleukin 17A Names interleukin-17A cytotoxic T-lymphocyte-associated antigen 8 cytotoxic T-lymphocyte-associated protein 8 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.2
Summary	The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	603149

mRNA and Protein(s)

mRNA	Protein	Name
NM_002190.3	NP_002181.1	interleukin-17A precursor
NM_002190.2	NP_002181.1	interleukin-17A precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL17A	NP_002181.1
Canis lupus familiaris (dog)	IL17A	NP_001159350.1
Mus musculus (house mouse)	Il17a	NP_034682.1
Xenopus tropicalis (tropical clawed frog)	LOC101734167	XP_004915038.1
Pan troglodytes (chimpanzee)	IL17A	XP_527408.2
Bos taurus (cattle)	IL17A	NP_001008412.1
	IL17A	XP_001106391.1
Rattus norvegicus (Norway rat)	Il17a	NP_001100367.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-13 regulates IL-17C expression by suppressing NF-?B-mediated transcriptional activation in airway epithelial cells.
Yamanaka K, Fujisawa T, Kusagaya H, Mori K, Niwa M, Furuhashi K, Kono M, Hamada E, Suda T, Maekawa M
Biochemical and biophysical research communications495(1)1534-1540(2018 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings demonstrate that NF-kappaB-mediated transcriptional mechanisms are critically involved in the IL-1beta-mediated IL-17C induction, and that IL-13 negatively regulates this induction by suppressing NF-kappaB-based transcriptional activation.
Title: IL-13 regulates IL-17C expression by suppressing NF-?B-mediated transcriptional activation in airway epithelial cells.

Results showed that plasma and mRNA levels of IL-2, IFN-gamma, IL-4, and IL-17A in primary immune thrombocytopenia patients did not change significantly after TPO-RA treatment, whereas TGF-beta1 levels increased remarkably.
Title: Cytokine changes in response to TPO receptor agonist treatment in primary immune thrombocytopenia.

IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of acute bronchiolitis.
Title: IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis.

this study shows that miR-23a regulated IL-17-mediated proinflammatory mediators expression in rheumatoid arthritis by directly targeting IKKalpha
Title: MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKK? in articular chondrocytes.

The presence of IL-17 in the synovial fluid identifies a substantial subset of primary end-stage osteoarthritis patients with distinct biological and clinical features. Stratification of patients on the basis of IL-17 may identify those responsive to therapeutic targeting.
Title: Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype.

The following IL17A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL17A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25438	NM_002190.3 Latest version!	Homo sapiens interleukin 17A (IL17A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25438	NM_002190.2	Homo sapiens interleukin 17A (IL17A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL17A ( NM_002190.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002181.1 Homo sapiens interleukin 17A (IL17A), mRNA.

Price & Availability↑

CloneID	OHu25438
Clone ID Related Accession (Same CDS sequence)	NM_002190.3 , NM_002190.2
Accession Version	NM_002190.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	interleukin-17A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL391221.15 and U32659.1. This sequence is a reference standard in the RefSeqGene project. On May 29, 2018 this sequence version replaced NM_002190.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U32659.1, Z58820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000648244.1/ ENSP00000497968.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACTCCTG GGAAGACCTC ATTGGTGTCA CTGCTACTGC TGCTGAGCCT GGAGGCCATA 
GTGAAGGCAG GAATCACAAT CCCACGAAAT CCAGGATGCC CAAATTCTGA GGACAAGAAC 
TTCCCCCGGA CTGTGATGGT CAACCTGAAC ATCCATAACC GGAATACCAA TACCAATCCC 
AAAAGGTCCT CAGATTACTA CAACCGATCC ACCTCACCTT GGAATCTCCA CCGCAATGAG 
GACCCTGAGA GATATCCCTC TGTGATCTGG GAGGCAAAGT GCCGCCACTT GGGCTGCATC 
AACGCTGATG GGAACGTGGA CTACCACATG AACTCTGTCC CCATCCAGCA AGAGATCCTG 
GTCCTGCGCA GGGAGCCTCC ACACTGCCCC AACTCCTTCC GGCTGGAGAA GATACTGGTG 
TCCGTGGGCT GCACCTGTGT CACCCCGATT GTCCACCATG TGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002181.1
CDS	58..525
Translation	MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

Target ORF information:

RefSeq Version	NM_002190.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17A (IL17A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002190.3

ORF Insert Sequence:

ATGACTCCTG GGAAGACCTC ATTGGTGTCA CTGCTACTGC TGCTGAGCCT GGAGGCCATA 
GTGAAGGCAG GAATCACAAT CCCACGAAAT CCAGGATGCC CAAATTCTGA GGACAAGAAC 
TTCCCCCGGA CTGTGATGGT CAACCTGAAC ATCCATAACC GGAATACCAA TACCAATCCC 
AAAAGGTCCT CAGATTACTA CAACCGATCC ACCTCACCTT GGAATCTCCA CCGCAATGAG 
GACCCTGAGA GATATCCCTC TGTGATCTGG GAGGCAAAGT GCCGCCACTT GGGCTGCATC 
AACGCTGATG GGAACGTGGA CTACCACATG AACTCTGTCC CCATCCAGCA AGAGATCCTG 
GTCCTGCGCA GGGAGCCTCC ACACTGCCCC AACTCCTTCC GGCTGGAGAA GATACTGGTG 
TCCGTGGGCT GCACCTGTGT CACCCCGATT GTCCACCATG TGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17A ( NM_002190.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002181.1 Homo sapiens interleukin 17A (IL17A), mRNA.

Price & Availability↑

CloneID	OHu25438
Clone ID Related Accession (Same CDS sequence)	NM_002190.3 , NM_002190.2
Accession Version	NM_002190.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	interleukin-17A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U32659.1. This sequence is a reference standard in the RefSeqGene project. On Jan 3, 2003 this sequence version replaced NM_002190.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U32659.1, Z58820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END##

ATGACTCCTG GGAAGACCTC ATTGGTGTCA CTGCTACTGC TGCTGAGCCT GGAGGCCATA 
GTGAAGGCAG GAATCACAAT CCCACGAAAT CCAGGATGCC CAAATTCTGA GGACAAGAAC 
TTCCCCCGGA CTGTGATGGT CAACCTGAAC ATCCATAACC GGAATACCAA TACCAATCCC 
AAAAGGTCCT CAGATTACTA CAACCGATCC ACCTCACCTT GGAATCTCCA CCGCAATGAG 
GACCCTGAGA GATATCCCTC TGTGATCTGG GAGGCAAAGT GCCGCCACTT GGGCTGCATC 
AACGCTGATG GGAACGTGGA CTACCACATG AACTCTGTCC CCATCCAGCA AGAGATCCTG 
GTCCTGCGCA GGGAGCCTCC ACACTGCCCC AACTCCTTCC GGCTGGAGAA GATACTGGTG 
TCCGTGGGCT GCACCTGTGT CACCCCGATT GTCCACCATG TGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002181.1
CDS	46..513
Translation	MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

Target ORF information:

RefSeq Version	NM_002190.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17A (IL17A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002190.2

ORF Insert Sequence:

ATGACTCCTG GGAAGACCTC ATTGGTGTCA CTGCTACTGC TGCTGAGCCT GGAGGCCATA 
GTGAAGGCAG GAATCACAAT CCCACGAAAT CCAGGATGCC CAAATTCTGA GGACAAGAAC 
TTCCCCCGGA CTGTGATGGT CAACCTGAAC ATCCATAACC GGAATACCAA TACCAATCCC 
AAAAGGTCCT CAGATTACTA CAACCGATCC ACCTCACCTT GGAATCTCCA CCGCAATGAG 
GACCCTGAGA GATATCCCTC TGTGATCTGG GAGGCAAAGT GCCGCCACTT GGGCTGCATC 
AACGCTGATG GGAACGTGGA CTACCACATG AACTCTGTCC CCATCCAGCA AGAGATCCTG 
GTCCTGCGCA GGGAGCCTCC ACACTGCCCC AACTCCTTCC GGCTGGAGAA GATACTGGTG 
TCCGTGGGCT GCACCTGTGT CACCCCGATT GTCCACCATG TGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-13 regulates IL-17C expression by suppressing NF-?B-mediated transcriptional activation in airway epithelial cells.
Biochemical and biophysical research communications495(1)1534-1540(2018 01)
Yamanaka K,Fujisawa T,Kusagaya H,Mori K,Niwa M,Furuhashi K,Kono M,Hamada E,Suda T,Maekawa M

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IL17A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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