IL10RA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL10RA
Entrez Gene ID	3587
Full Name	interleukin 10 receptor subunit alpha
Synonyms	CD210,CD210a,CDW210A,HIL-10R,IL-10R1,IL10R
General protein information	Preferred Names interleukin 10 receptor subunit alpha Names interleukin-10 receptor subunit alpha IL-10 receptor subunit alpha IL-10R subunit 1 IL-10R subunit alpha IL-10RA interleukin 10 receptor, alpha interleukin-10 receptor alpha chain interleukin-10 receptor subunit 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].
Disorder MIM:	146933
Disorder Html:	Inflammatory bowel disease 28, early onset, autosomal recessive, 613148 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001558.4	NP_001549.2	interleukin-10 receptor subunit alpha precursor
XM_024448493.1	XP_024304261.1	interleukin-10 receptor subunit alpha isoform X1
NM_001558.3	NP_001549.2	interleukin-10 receptor subunit alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL10RA	NP_001549.2
Mus musculus (house mouse)	Il10ra	NP_032374.1
Gallus gallus (chicken)	IL10RA	NP_001034686.1
Pan troglodytes (chimpanzee)	IL10RA	XP_508785.2
	IL10RA	XP_001092736.1
Bos taurus (cattle)	IL10RA	NP_001192686.1
Canis lupus familiaris (dog)	IL10RA	XP_005620363.1
Rattus norvegicus (Norway rat)	Il10ra	NP_476541.2

Gene Ontology
Bibliography

Related articles in PubMed

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.
Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB
Inflammatory bowel diseases23(11)1950-1961(2017 Nov)

Impaired IL-10 Receptor Mediated Suppression in Monocyte from Patients with Crohn's Disease.
Nunberg MY, Werner L, Kopylov U, Haberman Y, Lahad A, Weiss B, Shouval DS
Journal of pediatric gastroenterology and nutrition(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA-dependent repression of claudin-2
Title: Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.

Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases.
Title: Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.

Interleukin 10 and interleukin 10 receptor expression was also enriched in interferon gamma-expressing activated CD8(+) T cells. Treatment of anti-CD3/CD28-stimulated, purified CD8(+) T cells with interleukin 10 alone could significantly enhance CD8(+) T cell survival, an effect dependent on interleukin 10 receptor expression
Title: Stimulatory role of interleukin 10 in CD8

These results suggest that S138G loss-of-function polymorphism of the IL-10R1 may be important risk factor in increasing susceptibility to multiple sclerosis.
Title: Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.

The IL-10RA rs9610 A allele was increased in rheumatoid arthritis (RA) patient group compared with control subjects. Interestingly, significant differences were detected both in the allele and genotype frequencies of rs9610 between anti-CCP (anti-cyclic citrullinated peptide) positive patients and anti-CCP negative patients. The findings suggest that IL-10RA rs9610 polymorphism might contribute to RA susceptibility.
Title: Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population.

The following IL10RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL10RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu106668	XM_024448493.1 Latest version!	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu22931	NM_001558.4 Latest version!	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu22931	NM_001558.3	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL10RA ( NM_001558.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001549.2 Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22931
Clone ID Related Accession (Same CDS sequence)	NM_001558.4 , NM_001558.3
Accession Version	NM_001558.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1737bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	interleukin-10 receptor subunit alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291645.1, BC028082.1, AP002962.2 and CA307153.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2009 this sequence version replaced NM_001558.2. Transcript Variant: This variant (1) is the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291645.1, BC028082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCGT GCCTCGTAGT GCTGCTGGCG GCGCTCCTCA GCCTCCGTCT TGGCTCAGAC 
GCTCATGGGA CAGAGCTGCC CAGCCCTCCG TCTGTGTGGT TTGAAGCAGA ATTTTTCCAC 
CACATCCTCC ACTGGACACC CATCCCAAAT CAGTCTGAAA GTACCTGCTA TGAAGTGGCG 
CTCCTGAGGT ATGGAATAGA GTCCTGGAAC TCCATCTCCA ACTGTAGCCA GACCCTGTCC 
TATGACCTTA CCGCAGTGAC CTTGGACCTG TACCACAGCA ATGGCTACCG GGCCAGAGTG 
CGGGCTGTGG ACGGCAGCCG GCACTCCAAC TGGACCGTCA CCAACACCCG CTTCTCTGTG 
GATGAAGTGA CTCTGACAGT TGGCAGTGTG AACCTAGAGA TCCACAATGG CTTCATCCTC 
GGGAAGATTC AGCTACCCAG GCCCAAGATG GCCCCCGCAA ATGACACATA TGAAAGCATC 
TTCAGTCACT TCCGAGAGTA TGAGATTGCC ATTCGCAAGG TGCCGGGAAA CTTCACGTTC 
ACACACAAGA AAGTAAAACA TGAAAACTTC AGCCTCCTAA CCTCTGGAGA AGTGGGAGAG 
TTCTGTGTCC AGGTGAAACC ATCTGTCGCT TCCCGAAGTA ACAAGGGGAT GTGGTCTAAA 
GAGGAGTGCA TCTCCCTCAC CAGGCAGTAT TTCACCGTGA CCAACGTCAT CATCTTCTTT 
GCCTTTGTCC TGCTGCTCTC CGGAGCCCTC GCCTACTGCC TGGCCCTCCA GCTGTATGTG 
CGGCGCCGAA AGAAGCTACC CAGTGTCCTG CTCTTCAAGA AGCCCAGCCC CTTCATCTTC 
ATCAGCCAGC GTCCCTCCCC AGAGACCCAA GACACCATCC ACCCGCTTGA TGAGGAGGCC 
TTTTTGAAGG TGTCCCCAGA GCTGAAGAAC TTGGACCTGC ACGGCAGCAC AGACAGTGGC 
TTTGGCAGCA CCAAGCCATC CCTGCAGACT GAAGAGCCCC AGTTCCTCCT CCCTGACCCT 
CACCCCCAGG CTGACAGAAC GCTGGGAAAC AGGGAGCCCC CTGTGCTGGG GGACAGCTGC 
AGTAGTGGCA GCAGCAATAG CACAGACAGC GGGATCTGCC TGCAGGAGCC CAGCCTGAGC 
CCCAGCACAG GGCCCACCTG GGAGCAACAG GTGGGGAGCA ACAGCAGGGG CCAGGATGAC 
AGTGGCATTG ACTTAGTTCA AAACTCTGAG GGCCGGGCTG GGGACACACA GGGTGGCTCG 
GCCTTGGGCC ACCACAGTCC CCCGGAGCCT GAGGTGCCTG GGGAAGAAGA CCCAGCTGCT 
GTGGCATTCC AGGGTTACCT GAGGCAGACC AGATGTGCTG AAGAGAAGGC AACCAAGACA 
GGCTGCCTGG AGGAAGAATC GCCCTTGACA GATGGCCTTG GCCCCAAATT CGGGAGATGC 
CTGGTTGATG AGGCAGGCTT GCATCCACCA GCCCTGGCCA AGGGCTATTT GAAACAGGAT 
CCTCTAGAAA TGACTCTGGC TTCCTCAGGG GCCCCAACGG GACAGTGGAA CCAGCCCACT 
GAGGAATGGT CACTCCTGGC CTTGAGCAGC TGCAGTGACC TGGGAATATC TGACTGGAGC 
TTTGCCCATG ACCTTGCCCC TCTAGGCTGT GTGGCAGCCC CAGGTGGTCT CCTGGGCAGC 
TTTAACTCAG ACCTGGTCAC CCTGCCCCTC ATCTCTAGCC TGCAGTCAAG TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001549.2
CDS	78..1814
Translation	MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

Target ORF information:

RefSeq Version	NM_001558.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001558.3

ORF Insert Sequence:

ATGCTGCCGT GCCTCGTAGT GCTGCTGGCG GCGCTCCTCA GCCTCCGTCT TGGCTCAGAC 
GCTCATGGGA CAGAGCTGCC CAGCCCTCCG TCTGTGTGGT TTGAAGCAGA ATTTTTCCAC 
CACATCCTCC ACTGGACACC CATCCCAAAT CAGTCTGAAA GTACCTGCTA TGAAGTGGCG 
CTCCTGAGGT ATGGAATAGA GTCCTGGAAC TCCATCTCCA ACTGTAGCCA GACCCTGTCC 
TATGACCTTA CCGCAGTGAC CTTGGACCTG TACCACAGCA ATGGCTACCG GGCCAGAGTG 
CGGGCTGTGG ACGGCAGCCG GCACTCCAAC TGGACCGTCA CCAACACCCG CTTCTCTGTG 
GATGAAGTGA CTCTGACAGT TGGCAGTGTG AACCTAGAGA TCCACAATGG CTTCATCCTC 
GGGAAGATTC AGCTACCCAG GCCCAAGATG GCCCCCGCAA ATGACACATA TGAAAGCATC 
TTCAGTCACT TCCGAGAGTA TGAGATTGCC ATTCGCAAGG TGCCGGGAAA CTTCACGTTC 
ACACACAAGA AAGTAAAACA TGAAAACTTC AGCCTCCTAA CCTCTGGAGA AGTGGGAGAG 
TTCTGTGTCC AGGTGAAACC ATCTGTCGCT TCCCGAAGTA ACAAGGGGAT GTGGTCTAAA 
GAGGAGTGCA TCTCCCTCAC CAGGCAGTAT TTCACCGTGA CCAACGTCAT CATCTTCTTT 
GCCTTTGTCC TGCTGCTCTC CGGAGCCCTC GCCTACTGCC TGGCCCTCCA GCTGTATGTG 
CGGCGCCGAA AGAAGCTACC CAGTGTCCTG CTCTTCAAGA AGCCCAGCCC CTTCATCTTC 
ATCAGCCAGC GTCCCTCCCC AGAGACCCAA GACACCATCC ACCCGCTTGA TGAGGAGGCC 
TTTTTGAAGG TGTCCCCAGA GCTGAAGAAC TTGGACCTGC ACGGCAGCAC AGACAGTGGC 
TTTGGCAGCA CCAAGCCATC CCTGCAGACT GAAGAGCCCC AGTTCCTCCT CCCTGACCCT 
CACCCCCAGG CTGACAGAAC GCTGGGAAAC AGGGAGCCCC CTGTGCTGGG GGACAGCTGC 
AGTAGTGGCA GCAGCAATAG CACAGACAGC GGGATCTGCC TGCAGGAGCC CAGCCTGAGC 
CCCAGCACAG GGCCCACCTG GGAGCAACAG GTGGGGAGCA ACAGCAGGGG CCAGGATGAC 
AGTGGCATTG ACTTAGTTCA AAACTCTGAG GGCCGGGCTG GGGACACACA GGGTGGCTCG 
GCCTTGGGCC ACCACAGTCC CCCGGAGCCT GAGGTGCCTG GGGAAGAAGA CCCAGCTGCT 
GTGGCATTCC AGGGTTACCT GAGGCAGACC AGATGTGCTG AAGAGAAGGC AACCAAGACA 
GGCTGCCTGG AGGAAGAATC GCCCTTGACA GATGGCCTTG GCCCCAAATT CGGGAGATGC 
CTGGTTGATG AGGCAGGCTT GCATCCACCA GCCCTGGCCA AGGGCTATTT GAAACAGGAT 
CCTCTAGAAA TGACTCTGGC TTCCTCAGGG GCCCCAACGG GACAGTGGAA CCAGCCCACT 
GAGGAATGGT CACTCCTGGC CTTGAGCAGC TGCAGTGACC TGGGAATATC TGACTGGAGC 
TTTGCCCATG ACCTTGCCCC TCTAGGCTGT GTGGCAGCCC CAGGTGGTCT CCTGGGCAGC 
TTTAACTCAG ACCTGGTCAC CCTGCCCCTC ATCTCTAGCC TGCAGTCAAG TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL10RA ( XM_024448493.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304261.1 Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu106668
Clone ID Related Accession (Same CDS sequence)	XM_024448493.1
Accession Version	XM_024448493.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	interleukin-10 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCCCG CAAATGACAC ATATGAAAGC ATCTTCAGTC ACTTCCGAGA GTATGAGATT 
GCCATTCGCA AGGTGCCGGG AAACTTCACG TTCACACACA AGAAAGTAAA ACATGAAAAC 
TTCAGCCTCC TAACCTCTGG AGAAGTGGGA GAGTTCTGTG TCCAGGTGAA ACCATCTGTC 
GCTTCCCGAA GTAACAAGGG GATGTGGTCT AAAGAGGAGT GCATCTCCCT CACCAGGCAG 
TATTTCACCG TGACCAACGT CATCATCTTC TTTGCCTTTG TCCTGCTGCT CTCCGGAGCC 
CTCGCCTACT GCCTGGCCCT CCAGCTGTAT GTGCGGCGCC GAAAGAAGCT ACCCAGTGTC 
CTGCTCTTCA AGAAGCCCAG CCCCTTCATC TTCATCAGCC AGCGTCCCTC CCCAGAGACC 
CAAGACACCA TCCACCCGCT TGATGAGGAG GCCTTTTTGA AGGTGTCCCC AGAGCTGAAG 
AACTTGGACC TGCACGGCAG CACAGACAGT GGCTTTGGCA GCACCAAGCC ATCCCTGCAG 
ACTGAAGAGC CCCAGTTCCT CCTCCCTGAC CCTCACCCCC AGGCTGACAG AACGCTGGGA 
AACAGGGAGC CCCCTGTGCT GGGGGACAGC TGCAGTAGTG GCAGCAGCAA TAGCACAGAC 
AGCGGGATCT GCCTGCAGGA GCCCAGCCTG AGCCCCAGCA CAGGGCCCAC CTGGGAGCAA 
CAGGTGGGGA GCAACAGCAG GGGCCAGGAT GACAGTGGCA TTGACTTAGT TCAAAACTCT 
GAGGGCCGGG CTGGGGACAC ACAGGGTGGC TCGGCCTTGG GCCACCACAG TCCCCCGGAG 
CCTGAGGTGC CTGGGGAAGA AGACCCAGCT GCTGTGGCAT TCCAGGGTTA CCTGAGGCAG 
ACCAGATGTG CTGAAGAGAA GGCAACCAAG ACAGGCTGCC TGGAGGAAGA ATCGCCCTTG 
ACAGATGGCC TTGGCCCCAA ATTCGGGAGA TGCCTGGTTG ATGAGGCAGG CTTGCATCCA 
CCAGCCCTGG CCAAGGGCTA TTTGAAACAG GATCCTCTAG AAATGACTCT GGCTTCCTCA 
GGGGCCCCAA CGGGACAGTG GAACCAGCCC ACTGAGGAAT GGTCACTCCT GGCCTTGAGC 
AGCTGCAGTG ACCTGGGAAT ATCTGACTGG AGCTTTGCCC ATGACCTTGC CCCTCTAGGC 
TGTGTGGCAG CCCCAGGTGG TCTCCTGGGC AGCTTTAACT CAGACCTGGT CACCCTGCCC 
CTCATCTCTA GCCTGCAGTC AAGTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304261.1
CDS	338..1627
Translation	MAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

Target ORF information:

RefSeq Version	XM_024448493.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448493.1

ORF Insert Sequence:

ATGGCCCCCG CAAATGACAC ATATGAAAGC ATCTTCAGTC ACTTCCGAGA GTATGAGATT 
GCCATTCGCA AGGTGCCGGG AAACTTCACG TTCACACACA AGAAAGTAAA ACATGAAAAC 
TTCAGCCTCC TAACCTCTGG AGAAGTGGGA GAGTTCTGTG TCCAGGTGAA ACCATCTGTC 
GCTTCCCGAA GTAACAAGGG GATGTGGTCT AAAGAGGAGT GCATCTCCCT CACCAGGCAG 
TATTTCACCG TGACCAACGT CATCATCTTC TTTGCCTTTG TCCTGCTGCT CTCCGGAGCC 
CTCGCCTACT GCCTGGCCCT CCAGCTGTAT GTGCGGCGCC GAAAGAAGCT ACCCAGTGTC 
CTGCTCTTCA AGAAGCCCAG CCCCTTCATC TTCATCAGCC AGCGTCCCTC CCCAGAGACC 
CAAGACACCA TCCACCCGCT TGATGAGGAG GCCTTTTTGA AGGTGTCCCC AGAGCTGAAG 
AACTTGGACC TGCACGGCAG CACAGACAGT GGCTTTGGCA GCACCAAGCC ATCCCTGCAG 
ACTGAAGAGC CCCAGTTCCT CCTCCCTGAC CCTCACCCCC AGGCTGACAG AACGCTGGGA 
AACAGGGAGC CCCCTGTGCT GGGGGACAGC TGCAGTAGTG GCAGCAGCAA TAGCACAGAC 
AGCGGGATCT GCCTGCAGGA GCCCAGCCTG AGCCCCAGCA CAGGGCCCAC CTGGGAGCAA 
CAGGTGGGGA GCAACAGCAG GGGCCAGGAT GACAGTGGCA TTGACTTAGT TCAAAACTCT 
GAGGGCCGGG CTGGGGACAC ACAGGGTGGC TCGGCCTTGG GCCACCACAG TCCCCCGGAG 
CCTGAGGTGC CTGGGGAAGA AGACCCAGCT GCTGTGGCAT TCCAGGGTTA CCTGAGGCAG 
ACCAGATGTG CTGAAGAGAA GGCAACCAAG ACAGGCTGCC TGGAGGAAGA ATCGCCCTTG 
ACAGATGGCC TTGGCCCCAA ATTCGGGAGA TGCCTGGTTG ATGAGGCAGG CTTGCATCCA 
CCAGCCCTGG CCAAGGGCTA TTTGAAACAG GATCCTCTAG AAATGACTCT GGCTTCCTCA 
GGGGCCCCAA CGGGACAGTG GAACCAGCCC ACTGAGGAAT GGTCACTCCT GGCCTTGAGC 
AGCTGCAGTG ACCTGGGAAT ATCTGACTGG AGCTTTGCCC ATGACCTTGC CCCTCTAGGC 
TGTGTGGCAG CCCCAGGTGG TCTCCTGGGC AGCTTTAACT CAGACCTGGT CACCCTGCCC 
CTCATCTCTA GCCTGCAGTC AAGTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL10RA ( NM_001558.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001549.2 Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22931
Clone ID Related Accession (Same CDS sequence)	NM_001558.4 , NM_001558.3
Accession Version	NM_001558.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1737bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	interleukin-10 receptor subunit alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291645.1, BC028082.1, AP002962.2 and CA307153.1. On Nov 22, 2019 this sequence version replaced NM_001558.3. Transcript Variant: This variant (1) is the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028082.1, U00672.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCGT GCCTCGTAGT GCTGCTGGCG GCGCTCCTCA GCCTCCGTCT TGGCTCAGAC 
GCTCATGGGA CAGAGCTGCC CAGCCCTCCG TCTGTGTGGT TTGAAGCAGA ATTTTTCCAC 
CACATCCTCC ACTGGACACC CATCCCAAAT CAGTCTGAAA GTACCTGCTA TGAAGTGGCG 
CTCCTGAGGT ATGGAATAGA GTCCTGGAAC TCCATCTCCA ACTGTAGCCA GACCCTGTCC 
TATGACCTTA CCGCAGTGAC CTTGGACCTG TACCACAGCA ATGGCTACCG GGCCAGAGTG 
CGGGCTGTGG ACGGCAGCCG GCACTCCAAC TGGACCGTCA CCAACACCCG CTTCTCTGTG 
GATGAAGTGA CTCTGACAGT TGGCAGTGTG AACCTAGAGA TCCACAATGG CTTCATCCTC 
GGGAAGATTC AGCTACCCAG GCCCAAGATG GCCCCCGCAA ATGACACATA TGAAAGCATC 
TTCAGTCACT TCCGAGAGTA TGAGATTGCC ATTCGCAAGG TGCCGGGAAA CTTCACGTTC 
ACACACAAGA AAGTAAAACA TGAAAACTTC AGCCTCCTAA CCTCTGGAGA AGTGGGAGAG 
TTCTGTGTCC AGGTGAAACC ATCTGTCGCT TCCCGAAGTA ACAAGGGGAT GTGGTCTAAA 
GAGGAGTGCA TCTCCCTCAC CAGGCAGTAT TTCACCGTGA CCAACGTCAT CATCTTCTTT 
GCCTTTGTCC TGCTGCTCTC CGGAGCCCTC GCCTACTGCC TGGCCCTCCA GCTGTATGTG 
CGGCGCCGAA AGAAGCTACC CAGTGTCCTG CTCTTCAAGA AGCCCAGCCC CTTCATCTTC 
ATCAGCCAGC GTCCCTCCCC AGAGACCCAA GACACCATCC ACCCGCTTGA TGAGGAGGCC 
TTTTTGAAGG TGTCCCCAGA GCTGAAGAAC TTGGACCTGC ACGGCAGCAC AGACAGTGGC 
TTTGGCAGCA CCAAGCCATC CCTGCAGACT GAAGAGCCCC AGTTCCTCCT CCCTGACCCT 
CACCCCCAGG CTGACAGAAC GCTGGGAAAC AGGGAGCCCC CTGTGCTGGG GGACAGCTGC 
AGTAGTGGCA GCAGCAATAG CACAGACAGC GGGATCTGCC TGCAGGAGCC CAGCCTGAGC 
CCCAGCACAG GGCCCACCTG GGAGCAACAG GTGGGGAGCA ACAGCAGGGG CCAGGATGAC 
AGTGGCATTG ACTTAGTTCA AAACTCTGAG GGCCGGGCTG GGGACACACA GGGTGGCTCG 
GCCTTGGGCC ACCACAGTCC CCCGGAGCCT GAGGTGCCTG GGGAAGAAGA CCCAGCTGCT 
GTGGCATTCC AGGGTTACCT GAGGCAGACC AGATGTGCTG AAGAGAAGGC AACCAAGACA 
GGCTGCCTGG AGGAAGAATC GCCCTTGACA GATGGCCTTG GCCCCAAATT CGGGAGATGC 
CTGGTTGATG AGGCAGGCTT GCATCCACCA GCCCTGGCCA AGGGCTATTT GAAACAGGAT 
CCTCTAGAAA TGACTCTGGC TTCCTCAGGG GCCCCAACGG GACAGTGGAA CCAGCCCACT 
GAGGAATGGT CACTCCTGGC CTTGAGCAGC TGCAGTGACC TGGGAATATC TGACTGGAGC 
TTTGCCCATG ACCTTGCCCC TCTAGGCTGT GTGGCAGCCC CAGGTGGTCT CCTGGGCAGC 
TTTAACTCAG ACCTGGTCAC CCTGCCCCTC ATCTCTAGCC TGCAGTCAAG TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001549.2
CDS	75..1811
Translation	MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

Target ORF information:

RefSeq Version	NM_001558.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001558.4

ORF Insert Sequence:

ATGCTGCCGT GCCTCGTAGT GCTGCTGGCG GCGCTCCTCA GCCTCCGTCT TGGCTCAGAC 
GCTCATGGGA CAGAGCTGCC CAGCCCTCCG TCTGTGTGGT TTGAAGCAGA ATTTTTCCAC 
CACATCCTCC ACTGGACACC CATCCCAAAT CAGTCTGAAA GTACCTGCTA TGAAGTGGCG 
CTCCTGAGGT ATGGAATAGA GTCCTGGAAC TCCATCTCCA ACTGTAGCCA GACCCTGTCC 
TATGACCTTA CCGCAGTGAC CTTGGACCTG TACCACAGCA ATGGCTACCG GGCCAGAGTG 
CGGGCTGTGG ACGGCAGCCG GCACTCCAAC TGGACCGTCA CCAACACCCG CTTCTCTGTG 
GATGAAGTGA CTCTGACAGT TGGCAGTGTG AACCTAGAGA TCCACAATGG CTTCATCCTC 
GGGAAGATTC AGCTACCCAG GCCCAAGATG GCCCCCGCAA ATGACACATA TGAAAGCATC 
TTCAGTCACT TCCGAGAGTA TGAGATTGCC ATTCGCAAGG TGCCGGGAAA CTTCACGTTC 
ACACACAAGA AAGTAAAACA TGAAAACTTC AGCCTCCTAA CCTCTGGAGA AGTGGGAGAG 
TTCTGTGTCC AGGTGAAACC ATCTGTCGCT TCCCGAAGTA ACAAGGGGAT GTGGTCTAAA 
GAGGAGTGCA TCTCCCTCAC CAGGCAGTAT TTCACCGTGA CCAACGTCAT CATCTTCTTT 
GCCTTTGTCC TGCTGCTCTC CGGAGCCCTC GCCTACTGCC TGGCCCTCCA GCTGTATGTG 
CGGCGCCGAA AGAAGCTACC CAGTGTCCTG CTCTTCAAGA AGCCCAGCCC CTTCATCTTC 
ATCAGCCAGC GTCCCTCCCC AGAGACCCAA GACACCATCC ACCCGCTTGA TGAGGAGGCC 
TTTTTGAAGG TGTCCCCAGA GCTGAAGAAC TTGGACCTGC ACGGCAGCAC AGACAGTGGC 
TTTGGCAGCA CCAAGCCATC CCTGCAGACT GAAGAGCCCC AGTTCCTCCT CCCTGACCCT 
CACCCCCAGG CTGACAGAAC GCTGGGAAAC AGGGAGCCCC CTGTGCTGGG GGACAGCTGC 
AGTAGTGGCA GCAGCAATAG CACAGACAGC GGGATCTGCC TGCAGGAGCC CAGCCTGAGC 
CCCAGCACAG GGCCCACCTG GGAGCAACAG GTGGGGAGCA ACAGCAGGGG CCAGGATGAC 
AGTGGCATTG ACTTAGTTCA AAACTCTGAG GGCCGGGCTG GGGACACACA GGGTGGCTCG 
GCCTTGGGCC ACCACAGTCC CCCGGAGCCT GAGGTGCCTG GGGAAGAAGA CCCAGCTGCT 
GTGGCATTCC AGGGTTACCT GAGGCAGACC AGATGTGCTG AAGAGAAGGC AACCAAGACA 
GGCTGCCTGG AGGAAGAATC GCCCTTGACA GATGGCCTTG GCCCCAAATT CGGGAGATGC 
CTGGTTGATG AGGCAGGCTT GCATCCACCA GCCCTGGCCA AGGGCTATTT GAAACAGGAT 
CCTCTAGAAA TGACTCTGGC TTCCTCAGGG GCCCCAACGG GACAGTGGAA CCAGCCCACT 
GAGGAATGGT CACTCCTGGC CTTGAGCAGC TGCAGTGACC TGGGAATATC TGACTGGAGC 
TTTGCCCATG ACCTTGCCCC TCTAGGCTGT GTGGCAGCCC CAGGTGGTCT CCTGGGCAGC 
TTTAACTCAG ACCTGGTCAC CCTGCCCCTC ATCTCTAGCC TGCAGTCAAG TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.
Inflammatory bowel diseases23(11)1950-1961(2017 Nov)
Shouval DS,Konnikova L,Griffith AE,Wall SM,Biswas A,Werner L,Nunberg M,Kammermeier J,Goettel JA,Anand R,Chen H,Weiss B,Li J,Loizides A,Yerushalmi B,Yanagi T,Beier R,Conklin LS,Ebens CL,Santos FGMS,Sherlock M,Goldsmith JD,Kotlarz D,Glover SC,Shah N,Bousvaros A,Uhlig HH,Muise AM,Klein C,Snapper SB

Impaired IL-10 Receptor Mediated Suppression in Monocyte from Patients with Crohn's Disease.
Journal of pediatric gastroenterology and nutrition(2017 Oct)
Nunberg MY,Werner L,Kopylov U,Haberman Y,Lahad A,Weiss B,Shouval DS

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IL10RA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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