IL2RG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL2RG
Entrez Gene ID	3561
Full Name	interleukin 2 receptor subunit gamma
Synonyms	CD132,CIDX,IL-2RG,IMD4,P64,SCIDX,SCIDX1
General protein information	Preferred Names interleukin 2 receptor subunit gamma Names cytokine receptor common subunit gamma CD132 antigen IL-2 receptor subunit gamma IL-2R subunit gamma common cytokine receptor gamma chain gammaC interleukin 2 receptor, gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.1
Summary	The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010].
Disorder MIM:	308380
Disorder Html:	Severe combined immunodeficiency, X-linked, 300400 (3); Combined immunodeficiency, X-linked, moderate, 312863 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000206.2	NP_000197.1	cytokine receptor common subunit gamma precursor
NM_000206.3	NP_000197.1	cytokine receptor common subunit gamma precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Il2rg	NP_543165.1
Gallus gallus (chicken)	IL2RG	NP_989858.1
Danio rerio (zebrafish)	il2rgb	NP_001116522.1
Pan troglodytes (chimpanzee)	LOC101059843	XP_003954068.1
Canis lupus familiaris (dog)	IL2RG	NP_001003201.1
	IL2RG	NP_001030606.1
Homo sapiens (human)	IL2RG	NP_000197.1
Mus musculus (house mouse)	Il2rg	NP_038591.1
Danio rerio (zebrafish)	il2rga	NP_001121743.1
Xenopus tropicalis (tropical clawed frog)	LOC100492995	XP_002934932.1
Bos taurus (cattle)	IL2RG	NP_776784.1

Gene Ontology
Bibliography

Related articles in PubMed

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Alzubi J, Pallant C, Mussolino C, Howe SJ, Thrasher AJ, Cathomen T
Scientific reports7(1)12475(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

systematic scoping review highlights the many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
Title: Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.

A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype
Title: A novel deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype.

Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported.
Title: Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.

this study shows that downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines
Title: Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines.

analysis of the contribution of IL2Rgamma to the dynamic formation of IL2-IL2R complexes
Title: Quantitative Contribution of IL2R? to the Dynamic Formation of IL2-IL2R Complexes.

The following IL2RG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18193	NM_000206.3 Latest version!	Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18193	NM_000206.2	Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL2RG ( NM_000206.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000197.1 Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.

Price & Availability↑

CloneID	OHu18193
Clone ID Related Accession (Same CDS sequence)	NM_000206.2 , NM_000206.3
Accession Version	NM_000206.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	cytokine receptor common subunit gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345219.1 and BC014972.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2010 this sequence version replaced NM_000206.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.9136.1, SRR1163657.310776.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA 
GTGGGGCTGA ACACGACAAT TCTGACGCCC AATGGGAATG AAGACACCAC AGCTGATTTC 
TTCCTGACCA CTATGCCCAC TGACTCCCTC AGTGTTTCCA CTCTGCCCCT CCCAGAGGTT 
CAGTGTTTTG TGTTCAATGT CGAGTACATG AATTGCACTT GGAACAGCAG CTCTGAGCCC 
CAGCCTACCA ACCTCACTCT GCATTATTGG TACAAGAACT CGGATAATGA TAAAGTCCAG 
AAGTGCAGCC ACTATCTATT CTCTGAAGAA ATCACTTCTG GCTGTCAGTT GCAAAAAAAG 
GAGATCCACC TCTACCAAAC ATTTGTTGTT CAGCTCCAGG ACCCACGGGA ACCCAGGAGA 
CAGGCCACAC AGATGCTAAA ACTGCAGAAT CTGGTGATCC CCTGGGCTCC AGAGAACCTA 
ACACTTCACA AACTGAGTGA ATCCCAGCTA GAACTGAACT GGAACAACAG ATTCTTGAAC 
CACTGTTTGG AGCACTTGGT GCAGTACCGG ACTGACTGGG ACCACAGCTG GACTGAACAA 
TCAGTGGATT ATAGACATAA GTTCTCCTTG CCTAGTGTGG ATGGGCAGAA ACGCTACACG 
TTTCGTGTTC GGAGCCGCTT TAACCCACTC TGTGGAAGTG CTCAGCATTG GAGTGAATGG 
AGCCACCCAA TCCACTGGGG GAGCAATACT TCAAAAGAGA ATCCTTTCCT GTTTGCATTG 
GAAGCCGTGG TTATCTCTGT TGGCTCCATG GGATTGATTA TCAGCCTTCT CTGTGTGTAT 
TTCTGGCTGG AACGGACGAT GCCCCGAATT CCCACCCTGA AGAACCTAGA GGATCTTGTT 
ACTGAATACC ACGGGAACTT TTCGGCCTGG AGTGGTGTGT CTAAGGGACT GGCTGAGAGT 
CTGCAGCCAG ACTACAGTGA ACGACTCTGC CTCGTCAGTG AGATTCCCCC AAAAGGAGGG 
GCCCTTGGGG AGGGGCCTGG GGCCTCCCCA TGCAACCAGC ATAGCCCCTA CTGGGCCCCC 
CCATGTTACA CCCTAAAGCC TGAAACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000197.1
CDS	93..1202
Translation	MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET

Target ORF information:

RefSeq Version	NM_000206.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000206.2

ORF Insert Sequence:

ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA 
GTGGGGCTGA ACACGACAAT TCTGACGCCC AATGGGAATG AAGACACCAC AGCTGATTTC 
TTCCTGACCA CTATGCCCAC TGACTCCCTC AGTGTTTCCA CTCTGCCCCT CCCAGAGGTT 
CAGTGTTTTG TGTTCAATGT CGAGTACATG AATTGCACTT GGAACAGCAG CTCTGAGCCC 
CAGCCTACCA ACCTCACTCT GCATTATTGG TACAAGAACT CGGATAATGA TAAAGTCCAG 
AAGTGCAGCC ACTATCTATT CTCTGAAGAA ATCACTTCTG GCTGTCAGTT GCAAAAAAAG 
GAGATCCACC TCTACCAAAC ATTTGTTGTT CAGCTCCAGG ACCCACGGGA ACCCAGGAGA 
CAGGCCACAC AGATGCTAAA ACTGCAGAAT CTGGTGATCC CCTGGGCTCC AGAGAACCTA 
ACACTTCACA AACTGAGTGA ATCCCAGCTA GAACTGAACT GGAACAACAG ATTCTTGAAC 
CACTGTTTGG AGCACTTGGT GCAGTACCGG ACTGACTGGG ACCACAGCTG GACTGAACAA 
TCAGTGGATT ATAGACATAA GTTCTCCTTG CCTAGTGTGG ATGGGCAGAA ACGCTACACG 
TTTCGTGTTC GGAGCCGCTT TAACCCACTC TGTGGAAGTG CTCAGCATTG GAGTGAATGG 
AGCCACCCAA TCCACTGGGG GAGCAATACT TCAAAAGAGA ATCCTTTCCT GTTTGCATTG 
GAAGCCGTGG TTATCTCTGT TGGCTCCATG GGATTGATTA TCAGCCTTCT CTGTGTGTAT 
TTCTGGCTGG AACGGACGAT GCCCCGAATT CCCACCCTGA AGAACCTAGA GGATCTTGTT 
ACTGAATACC ACGGGAACTT TTCGGCCTGG AGTGGTGTGT CTAAGGGACT GGCTGAGAGT 
CTGCAGCCAG ACTACAGTGA ACGACTCTGC CTCGTCAGTG AGATTCCCCC AAAAGGAGGG 
GCCCTTGGGG AGGGGCCTGG GGCCTCCCCA TGCAACCAGC ATAGCCCCTA CTGGGCCCCC 
CCATGTTACA CCCTAAAGCC TGAAACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RG ( NM_000206.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000197.1 Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.

Price & Availability↑

CloneID	OHu18193
Clone ID Related Accession (Same CDS sequence)	NM_000206.2 , NM_000206.3
Accession Version	NM_000206.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	cytokine receptor common subunit gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345219.1 and BC014972.1. On Dec 4, 2019 this sequence version replaced NM_000206.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014972.1, D11086.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA 
GTGGGGCTGA ACACGACAAT TCTGACGCCC AATGGGAATG AAGACACCAC AGCTGATTTC 
TTCCTGACCA CTATGCCCAC TGACTCCCTC AGTGTTTCCA CTCTGCCCCT CCCAGAGGTT 
CAGTGTTTTG TGTTCAATGT CGAGTACATG AATTGCACTT GGAACAGCAG CTCTGAGCCC 
CAGCCTACCA ACCTCACTCT GCATTATTGG TACAAGAACT CGGATAATGA TAAAGTCCAG 
AAGTGCAGCC ACTATCTATT CTCTGAAGAA ATCACTTCTG GCTGTCAGTT GCAAAAAAAG 
GAGATCCACC TCTACCAAAC ATTTGTTGTT CAGCTCCAGG ACCCACGGGA ACCCAGGAGA 
CAGGCCACAC AGATGCTAAA ACTGCAGAAT CTGGTGATCC CCTGGGCTCC AGAGAACCTA 
ACACTTCACA AACTGAGTGA ATCCCAGCTA GAACTGAACT GGAACAACAG ATTCTTGAAC 
CACTGTTTGG AGCACTTGGT GCAGTACCGG ACTGACTGGG ACCACAGCTG GACTGAACAA 
TCAGTGGATT ATAGACATAA GTTCTCCTTG CCTAGTGTGG ATGGGCAGAA ACGCTACACG 
TTTCGTGTTC GGAGCCGCTT TAACCCACTC TGTGGAAGTG CTCAGCATTG GAGTGAATGG 
AGCCACCCAA TCCACTGGGG GAGCAATACT TCAAAAGAGA ATCCTTTCCT GTTTGCATTG 
GAAGCCGTGG TTATCTCTGT TGGCTCCATG GGATTGATTA TCAGCCTTCT CTGTGTGTAT 
TTCTGGCTGG AACGGACGAT GCCCCGAATT CCCACCCTGA AGAACCTAGA GGATCTTGTT 
ACTGAATACC ACGGGAACTT TTCGGCCTGG AGTGGTGTGT CTAAGGGACT GGCTGAGAGT 
CTGCAGCCAG ACTACAGTGA ACGACTCTGC CTCGTCAGTG AGATTCCCCC AAAAGGAGGG 
GCCCTTGGGG AGGGGCCTGG GGCCTCCCCA TGCAACCAGC ATAGCCCCTA CTGGGCCCCC 
CCATGTTACA CCCTAAAGCC TGAAACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000197.1
CDS	39..1148
Translation	MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET

Target ORF information:

RefSeq Version	NM_000206.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000206.3

ORF Insert Sequence:

ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA 
GTGGGGCTGA ACACGACAAT TCTGACGCCC AATGGGAATG AAGACACCAC AGCTGATTTC 
TTCCTGACCA CTATGCCCAC TGACTCCCTC AGTGTTTCCA CTCTGCCCCT CCCAGAGGTT 
CAGTGTTTTG TGTTCAATGT CGAGTACATG AATTGCACTT GGAACAGCAG CTCTGAGCCC 
CAGCCTACCA ACCTCACTCT GCATTATTGG TACAAGAACT CGGATAATGA TAAAGTCCAG 
AAGTGCAGCC ACTATCTATT CTCTGAAGAA ATCACTTCTG GCTGTCAGTT GCAAAAAAAG 
GAGATCCACC TCTACCAAAC ATTTGTTGTT CAGCTCCAGG ACCCACGGGA ACCCAGGAGA 
CAGGCCACAC AGATGCTAAA ACTGCAGAAT CTGGTGATCC CCTGGGCTCC AGAGAACCTA 
ACACTTCACA AACTGAGTGA ATCCCAGCTA GAACTGAACT GGAACAACAG ATTCTTGAAC 
CACTGTTTGG AGCACTTGGT GCAGTACCGG ACTGACTGGG ACCACAGCTG GACTGAACAA 
TCAGTGGATT ATAGACATAA GTTCTCCTTG CCTAGTGTGG ATGGGCAGAA ACGCTACACG 
TTTCGTGTTC GGAGCCGCTT TAACCCACTC TGTGGAAGTG CTCAGCATTG GAGTGAATGG 
AGCCACCCAA TCCACTGGGG GAGCAATACT TCAAAAGAGA ATCCTTTCCT GTTTGCATTG 
GAAGCCGTGG TTATCTCTGT TGGCTCCATG GGATTGATTA TCAGCCTTCT CTGTGTGTAT 
TTCTGGCTGG AACGGACGAT GCCCCGAATT CCCACCCTGA AGAACCTAGA GGATCTTGTT 
ACTGAATACC ACGGGAACTT TTCGGCCTGG AGTGGTGTGT CTAAGGGACT GGCTGAGAGT 
CTGCAGCCAG ACTACAGTGA ACGACTCTGC CTCGTCAGTG AGATTCCCCC AAAAGGAGGG 
GCCCTTGGGG AGGGGCCTGG GGCCTCCCCA TGCAACCAGC ATAGCCCCTA CTGGGCCCCC 
CCATGTTACA CCCTAAAGCC TGAAACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports7(1)12475(2017 Sep)
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

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IL2RG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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