TICAM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TICAM2
Entrez Gene ID	353376
Full Name	toll like receptor adaptor molecule 2
Synonyms	MyD88-4,TICAM-2,TIRAP3,TIRP,TRAM
General protein information	Preferred Names toll like receptor adaptor molecule 2 Names TIR domain-containing adapter molecule 2 NF-kappa-B-activating protein 502 TRIF-related adaptor molecule cytoplasmic adaptor putative NF-kappa-B-activating protein 502 toll-like receptor adaptor protein 3 toll/interleukin-1 receptor (TIR) domain-containing adapter protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q22.3
Summary	TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004].
Disorder MIM:	608321

mRNA and Protein(s)

mRNA	Protein	Name
NM_021649.7	NP_067681.1	TIR domain-containing adapter molecule 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TICAM2	NP_001191266.1
Mus musculus (house mouse)	Ticam2	NP_775570.1
Homo sapiens (human)	TICAM2	NP_067681.1
Pan troglodytes (chimpanzee)	TICAM2	NP_001182133.1
Bos taurus (cattle)	TICAM2	NP_001039921.1
Rattus norvegicus (Norway rat)	Ticam2	NP_001102360.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T
Biochemical Society transactions45(4)929-935(2017 08)

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.
Carlsson E, Ding JL, Byrne B
Biochimica et biophysica acta1863(2)244-53(2016 Feb)

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T
Journal of immunology (Baltimore, Md. : 1950)195(9)4456-65(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that endosomal localization of TICAM2 is essential for TLR4-mediated type I interferon-inducing signaling from endosomes; TICAM2 acts as scaffold protein and activates TICAM1; N-terminal myristoylation allows TICAM2 to anchor to endosomal membrane. (TICAM2 = toll like receptor adaptor molecule-2; TICAM1 = toll like receptor adaptor molecule-1; TLR4 = toll-like receptor 4) [REVIEW]
Title: Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.

Data show that Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling.
Title: Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.

Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (P = 4.3 x 10(-5)) associated with TB.
Title: Polymorphisms in TICAM2 and IL1B are associated with TB.

TRAM acts as a sorting adaptor not only for TLR4, but also for TLR2, to facilitate signaling to IRF7 at the endosome, which explains how TLR2 is capable of causing type I IFN induction.
Title: TRAM is required for TLR2 endosomal signaling to type I IFN induction.

TRAM plays a role in TLR7 signaling through a novel signaling axis towards the activation of anti-viral immunity.
Title: The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production.

The following TICAM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TICAM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu12799	NM_021649.7 Latest version!	Homo sapiens toll like receptor adaptor molecule 2 (TICAM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TICAM2 ( NM_021649.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_067681.1 Homo sapiens toll like receptor adaptor molecule 2 (TICAM2), mRNA.

Price & Availability↑

CloneID	OHu12799
Clone ID Related Accession (Same CDS sequence)	NM_021649.7
Accession Version	NM_021649.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	TIR domain-containing adapter molecule 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA992598.1, AC010226.5, AB097022.1 and DA092564.1. On Mar 6, 2014 this sequence version replaced NM_021649.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA992598.1, SRR1660807.23442.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTATCG GGAAGTCTAA AATAAATTCC TGCCCTCTTT CTCTCTCTTG GGGTAAAAGG 
CACAGTGTGG ATACAAGTCC AGGATATCAT GAGTCAGATT CCAAGAAGTC TGAAGATCTA 
TCCTTGTGTA ATGTTGCTGA GCACAGCAAT ACAACAGAGG GGCCAACAGG AAAGCAGGAG 
GGAGCTCAGA GCGTGGAAGA GATGTTTGAA GAAGAAGCTG AAGAAGAGGT GTTCCTCAAA 
TTTGTGATAT TGCATGCAGA AGATGACACA GATGAAGCCC TCAGAGTCCA GAATCTGCTA 
CAAGATGACT TTGGTATCAA ACCCGGAATA ATCTTTGCTG AGATGCCATG TGGCAGACAG 
CATTTACAGA ATTTAGATGA TGCTGTAAAT GGGTCTGCAT GGACAATCTT ATTACTGACT 
GAAAACTTTT TAAGAGATAC TTGGTGTAAT TTCCAGTTCT ATACGTCCCT AATGAACTCC 
GTTAACAGGC AGCATAAATA CAACTCTGTT ATACCCATGC GGCCCCTGAA CAATCCCCTT 
CCCCGAGAAA GGACTCCCTT TGCCCTCCAA ACCATCAATG CCTTAGAGGA AGAAAGTCGT 
GGATTTCCTA CACAAGTAGA AAGAATTTTT CAGGAGTCTG TGTATAAGAC ACAACAAACT 
ATATGGAAAG AGACAAGAAA TATGGTACAA AGACAATTTA TTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067681.1
CDS	443..1150
Translation	MGIGKSKINSCPLSLSWGKRHSVDTSPGYHESDSKKSEDLSLCNVAEHSNTTEGPTGKQEGAQSVEEMFEEEAEEEVFLKFVILHAEDDTDEALRVQNLLQDDFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALQTINALEEESRGFPTQVERIFQESVYKTQQTIWKETRNMVQRQFIA

Target ORF information:

RefSeq Version	NM_021649.7
Organism	Homo sapiens(human)
Definition	Homo sapiens toll like receptor adaptor molecule 2 (TICAM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021649.7

ORF Insert Sequence:

ATGGGTATCG GGAAGTCTAA AATAAATTCC TGCCCTCTTT CTCTCTCTTG GGGTAAAAGG 
CACAGTGTGG ATACAAGTCC AGGATATCAT GAGTCAGATT CCAAGAAGTC TGAAGATCTA 
TCCTTGTGTA ATGTTGCTGA GCACAGCAAT ACAACAGAGG GGCCAACAGG AAAGCAGGAG 
GGAGCTCAGA GCGTGGAAGA GATGTTTGAA GAAGAAGCTG AAGAAGAGGT GTTCCTCAAA 
TTTGTGATAT TGCATGCAGA AGATGACACA GATGAAGCCC TCAGAGTCCA GAATCTGCTA 
CAAGATGACT TTGGTATCAA ACCCGGAATA ATCTTTGCTG AGATGCCATG TGGCAGACAG 
CATTTACAGA ATTTAGATGA TGCTGTAAAT GGGTCTGCAT GGACAATCTT ATTACTGACT 
GAAAACTTTT TAAGAGATAC TTGGTGTAAT TTCCAGTTCT ATACGTCCCT AATGAACTCC 
GTTAACAGGC AGCATAAATA CAACTCTGTT ATACCCATGC GGCCCCTGAA CAATCCCCTT 
CCCCGAGAAA GGACTCCCTT TGCCCTCCAA ACCATCAATG CCTTAGAGGA AGAAAGTCGT 
GGATTTCCTA CACAAGTAGA AAGAATTTTT CAGGAGTCTG TGTATAAGAC ACAACAAACT 
ATATGGAAAG AGACAAGAAA TATGGTACAA AGACAATTTA TTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Biochemical Society transactions45(4)929-935(2017 08)
Funami K,Matsumoto M,Oshiumi H,Inagaki F,Seya T

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.
Biochimica et biophysica acta1863(2)244-53(2016 Feb)
Carlsson E,Ding JL,Byrne B

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Journal of immunology (Baltimore, Md. : 1950)195(9)4456-65(2015 Nov)
Funami K,Matsumoto M,Enokizono Y,Ishii N,Tatematsu M,Oshiumi H,Inagaki F,Seya T

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TICAM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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