APOH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOH
Entrez Gene ID	350
Full Name	apolipoprotein H
Synonyms	B2G1,B2GP1,BG
General protein information	Preferred Names apolipoprotein H Names beta-2-glycoprotein 1 APC inhibitor B2GPI activated protein C-binding protein anticardiolipin cofactor apo-H apolipoprotein H (beta-2-glycoprotein I) beta(2)GPI
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q24.2
Summary	Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008].
Disorder MIM:	138700

mRNA and Protein(s)

mRNA	Protein	Name
NM_000042.3	NP_000033.2	beta-2-glycoprotein 1 precursor
NM_000042.2	NP_000033.2	beta-2-glycoprotein 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	APOH	NP_001009118.1
Canis lupus familiaris (dog)	APOH	NP_001003265.1
Bos taurus (cattle)	APOH	NP_776417.1
Rattus norvegicus (Norway rat)	Apoh	NP_001009626.1
Homo sapiens (human)	APOH	NP_000033.2
Gallus gallus (chicken)	APOH	NP_001264923.1
Mus musculus (house mouse)	Apoh	NP_038503.4

Gene Ontology
Bibliography

Related articles in PubMed

Diminished expression of ?2-GPI is associated with a reduced ability to mitigate complement activation in anti-GPIIb/IIIa-mediated immune thrombocytopenia.
Zhu X, Zhang J, Wang Q, Fu H, Chang Y, Kong Y, Lv M, Xu L, Liu K, Huang X, Zhang X
Annals of hematology(2017 Dec)

Effects of reduced ?2 glycoprotein I on high glucose?induced cell death in HUVECs.
Zhang JY, Ma J, Yu P, Tang GJ, Li CJ, Yu DM, Zhang QM
Molecular medicine reports16(4)4208-4214(2017 Oct)

?eta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.
El-Assaad F, Qi M, Gordon AK, Qi J, Dong S, Passam F, Weaver JC, Giannakopoulos B, Krilis SA
Scientific reports7(1)8201(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pretransplant IgA-aB2GP1 was the main risk factor for graft thrombosis and early graft loss after renal transplantation.
Title: The Presence of Pretransplant Antiphospholipid Antibodies IgA Anti-?-2-Glycoprotein I as a Predictor of Graft Thrombosis After Renal Transplantation.

we have demonstrated a pathogenic role for aPL containing samples, mediated via aPL-2bGPI interactions, resulting in activation of the pro-apoptotic p38 MAPK pathway.
Title: Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK.

These results suggest that antibodies directed against domain 1 of beta-2-glycoprotein 1 may contribute to antiphospholipid syndrome risk assessment, due to their association with the diagnosis of systemic autoimmunity and with more aggressive triple antiphospholipid antibody profiles, such as triple positivity and lupus anticoagulant activity.
Title: Clinical implications of the detection of antibodies directed against domain 1 of ?2-glycoprotein 1 in thrombotic antiphospholipid syndrome.

Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein are Strongly Associated with the Occurrence of Acute Thrombotic Events.
Title: Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein are Strongly Associated with the Occurrence of Acute Thrombotic Events.

Genome-wide significant results in or near the APOH gene on chromosome 17 have been found for plasma apolipoprotein H levels in middle-aged and older adults.
Title: Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

The following APOH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24953	NM_000042.3 Latest version!	Homo sapiens apolipoprotein H (APOH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu24953	NM_000042.2	Homo sapiens apolipoprotein H (APOH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOH ( NM_000042.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000033.2 Homo sapiens apolipoprotein H (APOH), mRNA.

Price & Availability↑

CloneID	OHu24953
Clone ID Related Accession (Same CDS sequence)	NM_000042.3 , NM_000042.2
Accession Version	NM_000042.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	beta-2-glycoprotein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG566874.1 and BC026283.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000042.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M62839.1, SRR5189664.103267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000205948.11/ ENSP00000205948.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATTTCTC CAGTGCTCAT CTTGTTCTCG AGTTTTCTCT GCCATGTTGC TATTGCAGGA 
CGGACCTGTC CCAAGCCAGA TGATTTACCA TTTTCCACAG TGGTCCCGTT AAAAACATTC 
TATGAGCCAG GAGAAGAGAT TACGTATTCC TGCAAGCCGG GCTATGTGTC CCGAGGAGGG 
ATGAGAAAGT TTATCTGCCC TCTCACAGGA CTGTGGCCCA TCAACACTCT GAAATGTACA 
CCCAGAGTAT GTCCTTTTGC TGGAATCTTA GAAAATGGAG CCGTACGCTA TACGACTTTT 
GAATATCCCA ACACGATCAG TTTTTCTTGT AACACTGGGT TTTATCTGAA TGGCGCTGAT 
TCTGCCAAGT GCACTGAGGA AGGAAAATGG AGCCCGGAGC TTCCTGTCTG TGCTCCCATC 
ATCTGCCCTC CACCATCCAT ACCTACGTTT GCAACACTTC GTGTTTATAA GCCATCAGCT 
GGAAACAATT CCCTCTATCG GGACACAGCA GTTTTTGAAT GTTTGCCACA ACATGCGATG 
TTTGGAAATG ATACAATTAC CTGCACGACA CATGGAAATT GGACTAAATT ACCAGAATGC 
AGGGAAGTAA AATGCCCATT CCCATCAAGA CCAGACAATG GATTTGTGAA CTATCCTGCA 
AAACCAACAC TTTATTACAA GGATAAAGCC ACATTTGGCT GCCATGATGG ATATTCTCTG 
GATGGCCCGG AAGAAATAGA ATGTACCAAA CTGGGAAACT GGTCTGCCAT GCCAAGTTGT 
AAAGCATCTT GTAAAGTACC TGTGAAAAAA GCCACTGTGG TGTACCAAGG AGAGAGAGTA 
AAGATTCAGG AAAAATTTAA GAATGGAATG CTACATGGTG ATAAAGTTTC TTTCTTCTGC 
AAAAATAAGG AAAAGAAGTG TAGCTATACA GAGGATGCTC AGTGTATAGA TGGCACTATC 
GAAGTCCCCA AATGCTTCAA GGAACACAGT TCTCTGGCTT TTTGGAAAAC TGATGCATCC 
GATGTAAAGC CATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000033.2
CDS	37..1074
Translation	MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Target ORF information:

RefSeq Version	NM_000042.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein H (APOH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000042.3

ORF Insert Sequence:

ATGATTTCTC CAGTGCTCAT CTTGTTCTCG AGTTTTCTCT GCCATGTTGC TATTGCAGGA 
CGGACCTGTC CCAAGCCAGA TGATTTACCA TTTTCCACAG TGGTCCCGTT AAAAACATTC 
TATGAGCCAG GAGAAGAGAT TACGTATTCC TGCAAGCCGG GCTATGTGTC CCGAGGAGGG 
ATGAGAAAGT TTATCTGCCC TCTCACAGGA CTGTGGCCCA TCAACACTCT GAAATGTACA 
CCCAGAGTAT GTCCTTTTGC TGGAATCTTA GAAAATGGAG CCGTACGCTA TACGACTTTT 
GAATATCCCA ACACGATCAG TTTTTCTTGT AACACTGGGT TTTATCTGAA TGGCGCTGAT 
TCTGCCAAGT GCACTGAGGA AGGAAAATGG AGCCCGGAGC TTCCTGTCTG TGCTCCCATC 
ATCTGCCCTC CACCATCCAT ACCTACGTTT GCAACACTTC GTGTTTATAA GCCATCAGCT 
GGAAACAATT CCCTCTATCG GGACACAGCA GTTTTTGAAT GTTTGCCACA ACATGCGATG 
TTTGGAAATG ATACAATTAC CTGCACGACA CATGGAAATT GGACTAAATT ACCAGAATGC 
AGGGAAGTAA AATGCCCATT CCCATCAAGA CCAGACAATG GATTTGTGAA CTATCCTGCA 
AAACCAACAC TTTATTACAA GGATAAAGCC ACATTTGGCT GCCATGATGG ATATTCTCTG 
GATGGCCCGG AAGAAATAGA ATGTACCAAA CTGGGAAACT GGTCTGCCAT GCCAAGTTGT 
AAAGCATCTT GTAAAGTACC TGTGAAAAAA GCCACTGTGG TGTACCAAGG AGAGAGAGTA 
AAGATTCAGG AAAAATTTAA GAATGGAATG CTACATGGTG ATAAAGTTTC TTTCTTCTGC 
AAAAATAAGG AAAAGAAGTG TAGCTATACA GAGGATGCTC AGTGTATAGA TGGCACTATC 
GAAGTCCCCA AATGCTTCAA GGAACACAGT TCTCTGGCTT TTTGGAAAAC TGATGCATCC 
GATGTAAAGC CATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOH ( NM_000042.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000033.2 Homo sapiens apolipoprotein H (APOH), mRNA.

Price & Availability↑

CloneID	OHu24953
Clone ID Related Accession (Same CDS sequence)	NM_000042.3 , NM_000042.2
Accession Version	NM_000042.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	beta-2-glycoprotein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG566874.1, BC026283.1 and BM005736.1. This sequence is a reference standard in the RefSeqGene project. On Jul 24, 2007 this sequence version replaced NM_000042.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026283.1, M62839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTTCTC CAGTGCTCAT CTTGTTCTCG AGTTTTCTCT GCCATGTTGC TATTGCAGGA 
CGGACCTGTC CCAAGCCAGA TGATTTACCA TTTTCCACAG TGGTCCCGTT AAAAACATTC 
TATGAGCCAG GAGAAGAGAT TACGTATTCC TGCAAGCCGG GCTATGTGTC CCGAGGAGGG 
ATGAGAAAGT TTATCTGCCC TCTCACAGGA CTGTGGCCCA TCAACACTCT GAAATGTACA 
CCCAGAGTAT GTCCTTTTGC TGGAATCTTA GAAAATGGAG CCGTACGCTA TACGACTTTT 
GAATATCCCA ACACGATCAG TTTTTCTTGT AACACTGGGT TTTATCTGAA TGGCGCTGAT 
TCTGCCAAGT GCACTGAGGA AGGAAAATGG AGCCCGGAGC TTCCTGTCTG TGCTCCCATC 
ATCTGCCCTC CACCATCCAT ACCTACGTTT GCAACACTTC GTGTTTATAA GCCATCAGCT 
GGAAACAATT CCCTCTATCG GGACACAGCA GTTTTTGAAT GTTTGCCACA ACATGCGATG 
TTTGGAAATG ATACAATTAC CTGCACGACA CATGGAAATT GGACTAAATT ACCAGAATGC 
AGGGAAGTAA AATGCCCATT CCCATCAAGA CCAGACAATG GATTTGTGAA CTATCCTGCA 
AAACCAACAC TTTATTACAA GGATAAAGCC ACATTTGGCT GCCATGATGG ATATTCTCTG 
GATGGCCCGG AAGAAATAGA ATGTACCAAA CTGGGAAACT GGTCTGCCAT GCCAAGTTGT 
AAAGCATCTT GTAAAGTACC TGTGAAAAAA GCCACTGTGG TGTACCAAGG AGAGAGAGTA 
AAGATTCAGG AAAAATTTAA GAATGGAATG CTACATGGTG ATAAAGTTTC TTTCTTCTGC 
AAAAATAAGG AAAAGAAGTG TAGCTATACA GAGGATGCTC AGTGTATAGA TGGCACTATC 
GAAGTCCCCA AATGCTTCAA GGAACACAGT TCTCTGGCTT TTTGGAAAAC TGATGCATCC 
GATGTAAAGC CATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000033.2
CDS	60..1097
Translation	MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Target ORF information:

RefSeq Version	NM_000042.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein H (APOH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000042.2

ORF Insert Sequence:

ATGATTTCTC CAGTGCTCAT CTTGTTCTCG AGTTTTCTCT GCCATGTTGC TATTGCAGGA 
CGGACCTGTC CCAAGCCAGA TGATTTACCA TTTTCCACAG TGGTCCCGTT AAAAACATTC 
TATGAGCCAG GAGAAGAGAT TACGTATTCC TGCAAGCCGG GCTATGTGTC CCGAGGAGGG 
ATGAGAAAGT TTATCTGCCC TCTCACAGGA CTGTGGCCCA TCAACACTCT GAAATGTACA 
CCCAGAGTAT GTCCTTTTGC TGGAATCTTA GAAAATGGAG CCGTACGCTA TACGACTTTT 
GAATATCCCA ACACGATCAG TTTTTCTTGT AACACTGGGT TTTATCTGAA TGGCGCTGAT 
TCTGCCAAGT GCACTGAGGA AGGAAAATGG AGCCCGGAGC TTCCTGTCTG TGCTCCCATC 
ATCTGCCCTC CACCATCCAT ACCTACGTTT GCAACACTTC GTGTTTATAA GCCATCAGCT 
GGAAACAATT CCCTCTATCG GGACACAGCA GTTTTTGAAT GTTTGCCACA ACATGCGATG 
TTTGGAAATG ATACAATTAC CTGCACGACA CATGGAAATT GGACTAAATT ACCAGAATGC 
AGGGAAGTAA AATGCCCATT CCCATCAAGA CCAGACAATG GATTTGTGAA CTATCCTGCA 
AAACCAACAC TTTATTACAA GGATAAAGCC ACATTTGGCT GCCATGATGG ATATTCTCTG 
GATGGCCCGG AAGAAATAGA ATGTACCAAA CTGGGAAACT GGTCTGCCAT GCCAAGTTGT 
AAAGCATCTT GTAAAGTACC TGTGAAAAAA GCCACTGTGG TGTACCAAGG AGAGAGAGTA 
AAGATTCAGG AAAAATTTAA GAATGGAATG CTACATGGTG ATAAAGTTTC TTTCTTCTGC 
AAAAATAAGG AAAAGAAGTG TAGCTATACA GAGGATGCTC AGTGTATAGA TGGCACTATC 
GAAGTCCCCA AATGCTTCAA GGAACACAGT TCTCTGGCTT TTTGGAAAAC TGATGCATCC 
GATGTAAAGC CATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diminished expression of ?2-GPI is associated with a reduced ability to mitigate complement activation in anti-GPIIb/IIIa-mediated immune thrombocytopenia.
Annals of hematology(2017 Dec)
Zhu X,Zhang J,Wang Q,Fu H,Chang Y,Kong Y,Lv M,Xu L,Liu K,Huang X,Zhang X

Effects of reduced ?2 glycoprotein I on high glucose?induced cell death in HUVECs.
Molecular medicine reports16(4)4208-4214(2017 Oct)
Zhang JY,Ma J,Yu P,Tang GJ,Li CJ,Yu DM,Zhang QM

?eta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.
Scientific reports7(1)8201(2017 Aug)
El-Assaad F,Qi M,Gordon AK,Qi J,Dong S,Passam F,Weaver JC,Giannakopoulos B,Krilis SA

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APOH cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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