IGFBP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGFBP4
Entrez Gene ID	3487
Full Name	insulin like growth factor binding protein 4
Synonyms	BP-4,HT29-IGFBP,IBP4,IGFBP-4
General protein information	Preferred Names insulin like growth factor binding protein 4 Names insulin-like growth factor-binding protein 4 IBP-4 IGF-binding protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008].
Disorder MIM:	146733

mRNA and Protein(s)

mRNA	Protein	Name
NM_001552.2	NP_001543.2	insulin-like growth factor-binding protein 4 precursor
NM_001552.3	NP_001543.2	insulin-like growth factor-binding protein 4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGFBP4	NP_776982.1
Mus musculus (house mouse)	Igfbp4	NP_034647.1
Rattus norvegicus (Norway rat)	Igfbp4	NP_001004274.1
Xenopus tropicalis (tropical clawed frog)	igfbp4	XP_002942630.2
Canis lupus familiaris (dog)	IGFBP4	XP_850184.2
Gallus gallus (chicken)	IGFBP4	NP_989684.1
	IGFBP4	XP_001097914.1
Homo sapiens (human)	IGFBP4	NP_001543.2
Pan troglodytes (chimpanzee)	IGFBP4	XP_003953075.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.
Miyagawa I, Nakayamada S, Nakano K, Yamagata K, Sakata K, Yamaoka K, Tanaka Y
Journal of immunology (Baltimore, Md. : 1950)199(5)1616-1625(2017 Sep)

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.
Hjortebjerg R, Laugesen E, H?yem P, Oxvig C, Stausb?l-Gr?n B, Knudsen ST, Kim WY, Poulsen PL, Hansen TK, Bjerre M, Frystyk J
European journal of endocrinology176(5)521-531(2017 May)

Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
Li W, Sun D, Lv Z, Wei Y, Zheng L, Zeng T, Zhao J
Cell biology international41(4)384-391(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the results of this study raise the possibility that human mesenchymal stem cells actions involve a negative-regulatory mechanism that suppresses Treg proliferation by releasing IGFBP-4
Title: Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.

Patients with type 2 Diabetes Mellitus had lower serum concentrations of IGFBP-4 compared to controls.
Title: The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

IGFBP-4 maybe act as a potential negative regulator in the progression of lung cancer through downregulation of COX-2.
Title: Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.

Data show that insulin-like growth factor binding protein-4 (IGFBP-4) was significantly elevated in lupus nephritis, particularly those with renal pathology chronicity changes.
Title: Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.

Data show that co-transfection with cDNA encoding stanniocalcin-1 abrogates the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) toward IGF-binding protein 4 (IGFBP-4).
Title: Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.

The following IGFBP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGFBP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11242	NM_001552.3 Latest version!	Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11242	NM_001552.2	Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGFBP4 ( NM_001552.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001543.2 Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.

Price & Availability↑

CloneID	OHu11242
Clone ID Related Accession (Same CDS sequence)	NM_001552.2 , NM_001552.3
Accession Version	NM_001552.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN431519.1, AC018629.12, BC016041.1 and BU683435.1. On Apr 6, 2005 this sequence version replaced NM_001552.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.254149.1, ERR279854.329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCCC TCTGCCTCGT GGCCGCCCTG CTGCTGGCCG CCGGGCCCGG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCGCCCTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGCT GCGAGGAGCT GGTGCGAGAG CCGGGCTGCG GCTGTTGCGC CACTTGCGCC 
CTGGGCTTGG GGATGCCCTG CGGGGTGTAC ACCCCCCGTT GCGGCTCGGG CCTGCGCTGC 
TACCCGCCCC GAGGGGTGGA GAAGCCCCTG CACACACTGA TGCACGGGCA AGGCGTGTGC 
ATGGAGCTGG CGGAGATCGA GGCCATCCAG GAAAGCCTGC AGCCCTCTGA CAAGGACGAG 
GGTGACCACC CCAACAACAG CTTCAGCCCC TGTAGCGCCC ATGACCGCAG GTGCCTGCAG 
AAGCACTTCG CCAAAATTCG AGACCGGAGC ACCAGTGGGG GCAAGATGAA GGTCAATGGG 
GCGCCCCGGG AGGATGCCCG GCCTGTGCCC CAGGGCTCCT GCCAGAGCGA GCTGCACCGG 
GCGCTGGAGC GGCTGGCCGC TTCACAGAGC CGCACCCACG AGGACCTCTA CATCATCCCC 
ATCCCCAACT GCGACCGCAA CGGCAACTTC CACCCCAAGC AGTGTCACCC AGCTCTGGAT 
GGGCAGCGTG GCAAGTGCTG GTGTGTGGAC CGGAAGACGG GGGTGAAGCT TCCGGGGGGC 
CTGGAGCCAA AGGGGGAGCT GGACTGCCAC CAGCTGGCTG ACAGCTTTCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001543.2
CDS	313..1089
Translation	MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE

Target ORF information:

RefSeq Version	NM_001552.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001552.2

ORF Insert Sequence:

ATGCTGCCCC TCTGCCTCGT GGCCGCCCTG CTGCTGGCCG CCGGGCCCGG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCGCCCTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGCT GCGAGGAGCT GGTGCGAGAG CCGGGCTGCG GCTGTTGCGC CACTTGCGCC 
CTGGGCTTGG GGATGCCCTG CGGGGTGTAC ACCCCCCGTT GCGGCTCGGG CCTGCGCTGC 
TACCCGCCCC GAGGGGTGGA GAAGCCCCTG CACACACTGA TGCACGGGCA AGGCGTGTGC 
ATGGAGCTGG CGGAGATCGA GGCCATCCAG GAAAGCCTGC AGCCCTCTGA CAAGGACGAG 
GGTGACCACC CCAACAACAG CTTCAGCCCC TGTAGCGCCC ATGACCGCAG GTGCCTGCAG 
AAGCACTTCG CCAAAATTCG AGACCGGAGC ACCAGTGGGG GCAAGATGAA GGTCAATGGG 
GCGCCCCGGG AGGATGCCCG GCCTGTGCCC CAGGGCTCCT GCCAGAGCGA GCTGCACCGG 
GCGCTGGAGC GGCTGGCCGC TTCACAGAGC CGCACCCACG AGGACCTCTA CATCATCCCC 
ATCCCCAACT GCGACCGCAA CGGCAACTTC CACCCCAAGC AGTGTCACCC AGCTCTGGAT 
GGGCAGCGTG GCAAGTGCTG GTGTGTGGAC CGGAAGACGG GGGTGAAGCT TCCGGGGGGC 
CTGGAGCCAA AGGGGGAGCT GGACTGCCAC CAGCTGGCTG ACAGCTTTCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFBP4 ( NM_001552.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001543.2 Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.

Price & Availability↑

CloneID	OHu11242
Clone ID Related Accession (Same CDS sequence)	NM_001552.2 , NM_001552.3
Accession Version	NM_001552.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN431519.1, AC018629.12 and BC016041.1. On Nov 23, 2018 this sequence version replaced NM_001552.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016041.1, AK290810.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000269593.5/ ENSP00000269593.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCCCC TCTGCCTCGT GGCCGCCCTG CTGCTGGCCG CCGGGCCCGG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCGCCCTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGCT GCGAGGAGCT GGTGCGAGAG CCGGGCTGCG GCTGTTGCGC CACTTGCGCC 
CTGGGCTTGG GGATGCCCTG CGGGGTGTAC ACCCCCCGTT GCGGCTCGGG CCTGCGCTGC 
TACCCGCCCC GAGGGGTGGA GAAGCCCCTG CACACACTGA TGCACGGGCA AGGCGTGTGC 
ATGGAGCTGG CGGAGATCGA GGCCATCCAG GAAAGCCTGC AGCCCTCTGA CAAGGACGAG 
GGTGACCACC CCAACAACAG CTTCAGCCCC TGTAGCGCCC ATGACCGCAG GTGCCTGCAG 
AAGCACTTCG CCAAAATTCG AGACCGGAGC ACCAGTGGGG GCAAGATGAA GGTCAATGGG 
GCGCCCCGGG AGGATGCCCG GCCTGTGCCC CAGGGCTCCT GCCAGAGCGA GCTGCACCGG 
GCGCTGGAGC GGCTGGCCGC TTCACAGAGC CGCACCCACG AGGACCTCTA CATCATCCCC 
ATCCCCAACT GCGACCGCAA CGGCAACTTC CACCCCAAGC AGTGTCACCC AGCTCTGGAT 
GGGCAGCGTG GCAAGTGCTG GTGTGTGGAC CGGAAGACGG GGGTGAAGCT TCCGGGGGGC 
CTGGAGCCAA AGGGGGAGCT GGACTGCCAC CAGCTGGCTG ACAGCTTTCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001543.2
CDS	287..1063
Translation	MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE

Target ORF information:

RefSeq Version	NM_001552.3
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001552.3

ORF Insert Sequence:

ATGCTGCCCC TCTGCCTCGT GGCCGCCCTG CTGCTGGCCG CCGGGCCCGG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCGCCCTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGCT GCGAGGAGCT GGTGCGAGAG CCGGGCTGCG GCTGTTGCGC CACTTGCGCC 
CTGGGCTTGG GGATGCCCTG CGGGGTGTAC ACCCCCCGTT GCGGCTCGGG CCTGCGCTGC 
TACCCGCCCC GAGGGGTGGA GAAGCCCCTG CACACACTGA TGCACGGGCA AGGCGTGTGC 
ATGGAGCTGG CGGAGATCGA GGCCATCCAG GAAAGCCTGC AGCCCTCTGA CAAGGACGAG 
GGTGACCACC CCAACAACAG CTTCAGCCCC TGTAGCGCCC ATGACCGCAG GTGCCTGCAG 
AAGCACTTCG CCAAAATTCG AGACCGGAGC ACCAGTGGGG GCAAGATGAA GGTCAATGGG 
GCGCCCCGGG AGGATGCCCG GCCTGTGCCC CAGGGCTCCT GCCAGAGCGA GCTGCACCGG 
GCGCTGGAGC GGCTGGCCGC TTCACAGAGC CGCACCCACG AGGACCTCTA CATCATCCCC 
ATCCCCAACT GCGACCGCAA CGGCAACTTC CACCCCAAGC AGTGTCACCC AGCTCTGGAT 
GGGCAGCGTG GCAAGTGCTG GTGTGTGGAC CGGAAGACGG GGGTGAAGCT TCCGGGGGGC 
CTGGAGCCAA AGGGGGAGCT GGACTGCCAC CAGCTGGCTG ACAGCTTTCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.
Journal of immunology (Baltimore, Md. : 1950)199(5)1616-1625(2017 Sep)
Miyagawa I,Nakayamada S,Nakano K,Yamagata K,Sakata K,Yamaoka K,Tanaka Y

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.
European journal of endocrinology176(5)521-531(2017 May)
Hjortebjerg R,Laugesen E,H?yem P,Oxvig C,Stausb?l-Gr?n B,Knudsen ST,Kim WY,Poulsen PL,Hansen TK,Bjerre M,Frystyk J

Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
Cell biology international41(4)384-391(2017 Apr)
Li W,Sun D,Lv Z,Wei Y,Zheng L,Zeng T,Zhao J

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IGFBP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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