RBPMS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RBPMS2
Entrez Gene ID	348093
Full Name	RNA binding protein, mRNA processing factor 2
General protein information	Preferred Names RNA binding protein, mRNA processing factor 2 Names RNA-binding protein with multiple splicing 2 RNA binding protein with multiple splicing 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31
Summary	The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_194272.2	NP_919248.1	RNA-binding protein with multiple splicing 2
NM_194272.3	NP_919248.1	RNA-binding protein with multiple splicing 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RBPMS2	NP_919248.1
Gallus gallus (chicken)	RBPMS2	NP_990200.1
Danio rerio (zebrafish)	rbpms2a	NP_001002409.1
Xenopus tropicalis (tropical clawed frog)	rbpms2	XP_002938920.1
Rattus norvegicus (Norway rat)	Rbpms2	NP_001166897.1
Danio rerio (zebrafish)	rbpms2b	NP_956553.1
Pan troglodytes (chimpanzee)	RBPMS2	XP_001174270.1
Canis lupus familiaris (dog)	RBPMS2	XP_853385.2
Mus musculus (house mouse)	Rbpms2	NP_082306.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.
Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P
Nucleic acids research42(15)10173-84(2014 Sep)

High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.
Hapkova I, Skarda J, Rouleau C, Thys A, Notarnicola C, Janikova M, Bernex F, Rypka M, Vanderwinden JM, Faure S, Vesely J, de Santa Barbara P
Experimental and molecular pathology94(2)314-21(2013 Apr)

The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle.
Notarnicola C, Rouleau C, Le Guen L, Virsolvy A, Richard S, Faure S, De Santa Barbara P
Gastroenterology143(3)687-697.e9(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The study shows that RBPMS2 homodimerizes through a particular sequence motif located in its RNA recognition motif domain.
Title: Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.

RBPMS2 is up-regulated in Gastrointestinal stromal tumors compared to normal adult gastrointestinal tissues, indicating that RBPMS2 might represent a new diagnostic marker for GISTs and a potential target for cancer therapy.
Title: High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.

RBPMS3 transcripts are up-regulation in colons of patients with chronic psuedo obstruction syndrome.
Title: The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle.

The following RBPMS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RBPMS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02400	NM_194272.3 Latest version!	Homo sapiens RNA binding protein, mRNA processing factor 2 (RBPMS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
View Old Accession Versions >>
OHu02400	NM_194272.2	Homo sapiens RNA binding protein with multiple splicing 2 (RBPMS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RBPMS2 ( NM_194272.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919248.1 Homo sapiens RNA binding protein with multiple splicing 2 (RBPMS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02400
Clone ID Related Accession (Same CDS sequence)	NM_194272.2 , NM_194272.3
Accession Version	NM_194272.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	RNA-binding protein with multiple splicing 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK127873.1 and AI274305.1. On Aug 11, 2016 this sequence version replaced NM_194272.1. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: AK127873.1, AY369207.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAACC TGAAGCCGGA CGGCGAGCAC GGCGGCAGCA CCGGCACCGG CTCCGGCGCG 
GGCTCCGGCG GCGCCCTGGA GGAGGAGGTC CGGACACTGT TTGTCAGCGG CCTCCCTGTG 
GACATTAAAC CCAGAGAACT CTACTTGCTC TTCCGGCCGT TCAAGGGGTA TGAAGGGTCC 
CTGATCAAGC TCACTGCAAG ACAGCCTGTT GGTTTTGTGA TCTTTGACAG CCGTGCAGGA 
GCAGAAGCGG CCAAGAATGC GCTGAACGGT ATTCGCTTTG ATCCCGAAAA TCCACAGACT 
CTGAGGCTAG AGTTTGCCAA AGCCAACACC AAGATGGCCA AGAGCAAGCT AATGGCAACT 
CCAAATCCCA GCAACGTGCA CCCCGCCCTA GGAGCACACT TCATCGCACG GGACCCCTAT 
GACCTGATGG GGGCTGCTCT GATCCCTGCA TCCCCAGAGG CCTGGGCCCC CTACCCTTTG 
TACACCACAG AGCTGACCCC AGCCATCTCC CATGCTGCGT TCACCTACCC AACTGCCACT 
GCCGCTGCCG CCGCCCTCCA CGCTCAGGTG CGCTGGTACC CTTCCTCTGA CACCACCCAG 
CAAGGATGGA AGTACCGTCA GTTCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919248.1
CDS	269..898
Translation	MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC

Target ORF information:

RefSeq Version	NM_194272.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding protein with multiple splicing 2 (RBPMS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194272.2

ORF Insert Sequence:

ATGAGCAACC TGAAGCCGGA CGGCGAGCAC GGCGGCAGCA CCGGCACCGG CTCCGGCGCG 
GGCTCCGGCG GCGCCCTGGA GGAGGAGGTC CGGACACTGT TTGTCAGCGG CCTCCCTGTG 
GACATTAAAC CCAGAGAACT CTACTTGCTC TTCCGGCCGT TCAAGGGGTA TGAAGGGTCC 
CTGATCAAGC TCACTGCAAG ACAGCCTGTT GGTTTTGTGA TCTTTGACAG CCGTGCAGGA 
GCAGAAGCGG CCAAGAATGC GCTGAACGGT ATTCGCTTTG ATCCCGAAAA TCCACAGACT 
CTGAGGCTAG AGTTTGCCAA AGCCAACACC AAGATGGCCA AGAGCAAGCT AATGGCAACT 
CCAAATCCCA GCAACGTGCA CCCCGCCCTA GGAGCACACT TCATCGCACG GGACCCCTAT 
GACCTGATGG GGGCTGCTCT GATCCCTGCA TCCCCAGAGG CCTGGGCCCC CTACCCTTTG 
TACACCACAG AGCTGACCCC AGCCATCTCC CATGCTGCGT TCACCTACCC AACTGCCACT 
GCCGCTGCCG CCGCCCTCCA CGCTCAGGTG CGCTGGTACC CTTCCTCTGA CACCACCCAG 
CAAGGATGGA AGTACCGTCA GTTCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBPMS2 ( NM_194272.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_919248.1 Homo sapiens RNA binding protein, mRNA processing factor 2 (RBPMS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02400
Clone ID Related Accession (Same CDS sequence)	NM_194272.2 , NM_194272.3
Accession Version	NM_194272.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	RNA-binding protein with multiple splicing 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091582.17, AK127873.1 and AI274305.1. On Nov 23, 2018 this sequence version replaced NM_194272.2. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: AK127873.1, SRR3476690.399232.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300069.5/ ENSP00000300069.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAACC TGAAGCCGGA CGGCGAGCAC GGCGGCAGCA CCGGCACCGG CTCCGGCGCG 
GGCTCCGGCG GCGCCCTGGA GGAGGAGGTC CGGACACTGT TTGTCAGCGG CCTCCCTGTG 
GACATTAAAC CCAGAGAACT CTACTTGCTC TTCCGGCCGT TCAAGGGGTA TGAAGGGTCC 
CTGATCAAGC TCACTGCAAG ACAGCCTGTT GGTTTTGTGA TCTTTGACAG CCGTGCAGGA 
GCAGAAGCGG CCAAGAATGC GCTGAACGGT ATTCGCTTTG ATCCCGAAAA TCCACAGACT 
CTGAGGCTAG AGTTTGCCAA AGCCAACACC AAGATGGCCA AGAGCAAGCT AATGGCAACT 
CCAAATCCCA GCAACGTGCA CCCCGCCCTA GGAGCACACT TCATCGCACG GGACCCCTAT 
GACCTGATGG GGGCTGCTCT GATCCCTGCA TCCCCAGAGG CCTGGGCCCC CTACCCTTTG 
TACACCACAG AGCTGACCCC AGCCATCTCC CATGCTGCGT TCACCTACCC AACTGCCACT 
GCCGCTGCCG CCGCCCTCCA CGCTCAGGTG CGCTGGTACC CTTCCTCTGA CACCACCCAG 
CAAGGATGGA AGTACCGTCA GTTCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919248.1
CDS	271..900
Translation	MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC

Target ORF information:

RefSeq Version	NM_194272.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding protein, mRNA processing factor 2 (RBPMS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194272.3

ORF Insert Sequence:

ATGAGCAACC TGAAGCCGGA CGGCGAGCAC GGCGGCAGCA CCGGCACCGG CTCCGGCGCG 
GGCTCCGGCG GCGCCCTGGA GGAGGAGGTC CGGACACTGT TTGTCAGCGG CCTCCCTGTG 
GACATTAAAC CCAGAGAACT CTACTTGCTC TTCCGGCCGT TCAAGGGGTA TGAAGGGTCC 
CTGATCAAGC TCACTGCAAG ACAGCCTGTT GGTTTTGTGA TCTTTGACAG CCGTGCAGGA 
GCAGAAGCGG CCAAGAATGC GCTGAACGGT ATTCGCTTTG ATCCCGAAAA TCCACAGACT 
CTGAGGCTAG AGTTTGCCAA AGCCAACACC AAGATGGCCA AGAGCAAGCT AATGGCAACT 
CCAAATCCCA GCAACGTGCA CCCCGCCCTA GGAGCACACT TCATCGCACG GGACCCCTAT 
GACCTGATGG GGGCTGCTCT GATCCCTGCA TCCCCAGAGG CCTGGGCCCC CTACCCTTTG 
TACACCACAG AGCTGACCCC AGCCATCTCC CATGCTGCGT TCACCTACCC AACTGCCACT 
GCCGCTGCCG CCGCCCTCCA CGCTCAGGTG CGCTGGTACC CTTCCTCTGA CACCACCCAG 
CAAGGATGGA AGTACCGTCA GTTCTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.
Nucleic acids research42(15)10173-84(2014 Sep)
Sagnol S,Yang Y,Bessin Y,Allemand F,Hapkova I,Notarnicola C,Guichou JF,Faure S,Labesse G,de Santa Barbara P

High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.
Experimental and molecular pathology94(2)314-21(2013 Apr)
Hapkova I,Skarda J,Rouleau C,Thys A,Notarnicola C,Janikova M,Bernex F,Rypka M,Vanderwinden JM,Faure S,Vesely J,de Santa Barbara P

The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle.
Gastroenterology143(3)687-697.e9(2012 Sep)
Notarnicola C,Rouleau C,Le Guen L,Virsolvy A,Richard S,Faure S,De Santa Barbara P

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RBPMS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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