TBX10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBX10
Entrez Gene ID	347853
Full Name	T-box 10
Synonyms	TBX13,TBX7
General protein information	Preferred Names T-box 10 Names T-box transcription factor TBX10 T-box 7 T-box protein 10 T-box-containing transcriptional activator
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010].
Disorder MIM:	604648

mRNA and Protein(s)

mRNA	Protein	Name
XM_011544992.2	XP_011543294.1	T-box transcription factor TBX10 isoform X2
XM_011544993.1	XP_011543295.1	T-box transcription factor TBX10 isoform X1
NM_005995.4	NP_005986.2	T-box transcription factor TBX10

Pathways from BioSystems

Homologies

	LOC721689	XP_001117884.2
Canis lupus familiaris (dog)	TBX10	XP_005631453.1
Bos taurus (cattle)	TBX10	XP_002699446.2
Mus musculus (house mouse)	Tbx10	NP_001001320.1
Homo sapiens (human)	TBX10	NP_005986.2
Pan troglodytes (chimpanzee)	TBX10	XP_001152773.1
Rattus norvegicus (Norway rat)	Tbx10	XP_006230983.1
Gallus gallus (chicken)	TBX10	XP_426372.3

Gene Ontology
Bibliography

Related articles in PubMed

Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.
Mostowska A, Hozyasz KK, Wojcicki P, Biedziak B, Paradowska P, Jagodzinski PP
Birth defects research. Part A, Clinical and molecular teratology88(7)538-45(2010 Jul)

MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
Jagom?gi T, Nikopensius T, Krjutskov K, Tammekivi V, Viltrop T, Saag M, Metspalu A
European journal of oral sciences118(3)213-20(2010 Jun)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, F?lix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC
PLoS genetics1(6)e64(2005 Dec)

T-box genes in vertebrate development.
Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE
Annual review of genetics39219-39(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.

Observational study of gene-disease association. (HuGE Navigator)
Title: MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.

Observational study of gene-disease association. (HuGE Navigator)
Title: Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.

The following TBX10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBX10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00248	NM_005995.4 Latest version!	Homo sapiens T-box transcription factor 10 (TBX10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu79501	XM_011544993.1 Latest version!	Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu79500	XM_011544992.2 Latest version!	Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBX10 ( NM_005995.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005986.2 Homo sapiens T-box transcription factor 10 (TBX10), mRNA.

Price & Availability↑

CloneID	OHu00248
Clone ID Related Accession (Same CDS sequence)	NM_005995.4
Accession Version	NM_005995.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003385.2 and AY229977.1. On Nov 24, 2010 this sequence version replaced NM_005995.3. ##Evidence-Data-START## Transcript exon combination :: AY229977.1, BC113485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT TCCTATCTGC TGGCCTCGGC ATACTTGCAC CCTCAGAGAC CTACCCCCTA 
CCTACAACCA GCTCTGGCTG GGAGCCCCGG CTGGGGTCAC CATTCCCATC AGGCCCTTGC 
ACCAGCTCTA CTGGGGCCCA AGCTGTGGCC GAGCCCACTG GGCAGGGCCC CAAGAACCCA 
CGTGTGTCCA GAGTGACAGT TCAGCTGGAG ATGAAGCCTC TGTGGGAGGA ATTCAACCAG 
CTGGGCACTG AGATGATCGT CACCAAGGCA GGCAGGAGGA TGTTCCCCCC CTTCCAGGTG 
AAGATCCTGG GCATGGACTC CCTGGCCGAC TACGCCCTGC TCATGGACTT CATCCCCCTG 
GACGACAAGA GATACAGGTA TGCCTTCCAC AGCTCGGCCT GGCTGGTGGC GGGCAAGGCA 
GACCCAGCCA CACCTGGCCG CGTGCACTTC CACCCCGACT CGCCAGCCAA GGGTGCCCAG 
TGGATGCGCC AGATTGTGTC CTTTGACAAG CTCAAGCTGA CCAACAACCT GCTGGATGAC 
AATGGCCACA TCATTCTCAA CTCTATGCAC CGCTACCAGC CCCGTTTCCA CGTGGTCTTC 
GTGGACCCAC GCAAGGACAG TGAGCGCTAT GCCCAGGAGA ACTTCAAGTC CTTCATCTTC 
ACAGAGACCC AGTTCACAGC AGTGACAGCC TATCAGAACC ACAGGATCAC CCAGCTGAAA 
ATCGCCAGCA ACCCTTTTGC CAAAGGCTTT AGAGAGAGTG ACCTGGACTC CTGGCCTGTG 
GCCCCACGGC CCCTGCTCAG TGTCCCAGCC CGGAGTCACA GCAGCCTCAG TCCCTGTGTG 
CTGAAGGGTG CCACAGACAG GGAGAAAGAC CCCAACAAAG CTTCAGCTTC CACCTCCAAG 
ACCCCTGCTT GGCTCCATCA TCAGCTGCTG CCCCCACCTG AGGTCCTGCT GGCCCCGGCC 
ACCTACAGGC CTGTCACGTA TCAGAGCCTG TACTCTGGAG CCCCGAGCCA CCTAGGGATC 
CCAAGGACCC GACCAGCACC ATACCCCCTC CCCAACATCC GGGCTGATAG GGATCAAGGA 
GGCCTGCCTC TCCCAGCTGG GCTGGGGCTC CTGTCCCCCA CTGTGGTGTG CCTGGGGCCT 
GGCCAGGACT CCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005986.2
CDS	89..1246
Translation	MAAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPKNPRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSKTPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ

Target ORF information:

RefSeq Version	NM_005995.4
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 10 (TBX10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005995.4

ORF Insert Sequence:

ATGGCAGCCT TCCTATCTGC TGGCCTCGGC ATACTTGCAC CCTCAGAGAC CTACCCCCTA 
CCTACAACCA GCTCTGGCTG GGAGCCCCGG CTGGGGTCAC CATTCCCATC AGGCCCTTGC 
ACCAGCTCTA CTGGGGCCCA AGCTGTGGCC GAGCCCACTG GGCAGGGCCC CAAGAACCCA 
CGTGTGTCCA GAGTGACAGT TCAGCTGGAG ATGAAGCCTC TGTGGGAGGA ATTCAACCAG 
CTGGGCACTG AGATGATCGT CACCAAGGCA GGCAGGAGGA TGTTCCCCCC CTTCCAGGTG 
AAGATCCTGG GCATGGACTC CCTGGCCGAC TACGCCCTGC TCATGGACTT CATCCCCCTG 
GACGACAAGA GATACAGGTA TGCCTTCCAC AGCTCGGCCT GGCTGGTGGC GGGCAAGGCA 
GACCCAGCCA CACCTGGCCG CGTGCACTTC CACCCCGACT CGCCAGCCAA GGGTGCCCAG 
TGGATGCGCC AGATTGTGTC CTTTGACAAG CTCAAGCTGA CCAACAACCT GCTGGATGAC 
AATGGCCACA TCATTCTCAA CTCTATGCAC CGCTACCAGC CCCGTTTCCA CGTGGTCTTC 
GTGGACCCAC GCAAGGACAG TGAGCGCTAT GCCCAGGAGA ACTTCAAGTC CTTCATCTTC 
ACAGAGACCC AGTTCACAGC AGTGACAGCC TATCAGAACC ACAGGATCAC CCAGCTGAAA 
ATCGCCAGCA ACCCTTTTGC CAAAGGCTTT AGAGAGAGTG ACCTGGACTC CTGGCCTGTG 
GCCCCACGGC CCCTGCTCAG TGTCCCAGCC CGGAGTCACA GCAGCCTCAG TCCCTGTGTG 
CTGAAGGGTG CCACAGACAG GGAGAAAGAC CCCAACAAAG CTTCAGCTTC CACCTCCAAG 
ACCCCTGCTT GGCTCCATCA TCAGCTGCTG CCCCCACCTG AGGTCCTGCT GGCCCCGGCC 
ACCTACAGGC CTGTCACGTA TCAGAGCCTG TACTCTGGAG CCCCGAGCCA CCTAGGGATC 
CCAAGGACCC GACCAGCACC ATACCCCCTC CCCAACATCC GGGCTGATAG GGATCAAGGA 
GGCCTGCCTC TCCCAGCTGG GCTGGGGCTC CTGTCCCCCA CTGTGGTGTG CCTGGGGCCT 
GGCCAGGACT CCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBX10 ( XM_011544993.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543295.1 Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu79501
Clone ID Related Accession (Same CDS sequence)	XM_011544993.1
Accession Version	XM_011544993.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCCAGA TTGTGTCCTT TGACAAGCTC AAGCTGACCA ACAACCTGCT GGATGACAAT 
GGCCACATCA TTCTCAACTC TATGCACCGC TACCAGCCCC GTTTCCACGT GGTCTTCGTG 
GACCCACGCA AGGACAGTGA GCGCTATGCC CAGGAGAACT TCAAGTCCTT CATCTTCACA 
GAGACCCAGT TCACAGCAGT GACAGCCTAT CAGAACCACA GGATCACCCA GCTGAAAATC 
GCCAGCAACC CTTTTGCCAA AGGCTTTAGA GAGAGTGACC TGGACTCCTG GCCTGTGGCC 
CCACGGCCCC TGCTCAGTGT CCCAGCCCGG AGTCACAGCA GCCTCAGTCC CTGTGTGCTG 
AAGGGTGCCA CAGACAGGGA GAAAGACCCC AACAAAGCTT CAGCTTCCAC CTCCAAGACC 
CCTGCTTGGC TCCATCATCA GCTGCTGCCC CCACCTGAGG TCCTGCTGGC CCCGGCCACC 
TACAGGCCTG TCACGTATCA GAGCCTGTAC TCTGGAGCCC CGAGCCACCT AGGGATCCCA 
AGGACCCGAC CAGCACCATA CCCCCTCCCC AACATCCGGG CTGATAGGGA TCAAGGAGGC 
CTGCCTCTCC CAGCTGGGCT GGGGCTCCTG TCCCCCACTG TGGTGTGCCT GGGGCCTGGC 
CAGGACTCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543295.1
CDS	198..872
Translation	MRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSKTPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ

Target ORF information:

RefSeq Version	XM_011544993.1
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544993.1

ORF Insert Sequence:

ATGCGCCAGA TTGTGTCCTT TGACAAGCTC AAGCTGACCA ACAACCTGCT GGATGACAAT 
GGCCACATCA TTCTCAACTC TATGCACCGC TACCAGCCCC GTTTCCACGT GGTCTTCGTG 
GACCCACGCA AGGACAGTGA GCGCTATGCC CAGGAGAACT TCAAGTCCTT CATCTTCACA 
GAGACCCAGT TCACAGCAGT GACAGCCTAT CAGAACCACA GGATCACCCA GCTGAAAATC 
GCCAGCAACC CTTTTGCCAA AGGCTTTAGA GAGAGTGACC TGGACTCCTG GCCTGTGGCC 
CCACGGCCCC TGCTCAGTGT CCCAGCCCGG AGTCACAGCA GCCTCAGTCC CTGTGTGCTG 
AAGGGTGCCA CAGACAGGGA GAAAGACCCC AACAAAGCTT CAGCTTCCAC CTCCAAGACC 
CCTGCTTGGC TCCATCATCA GCTGCTGCCC CCACCTGAGG TCCTGCTGGC CCCGGCCACC 
TACAGGCCTG TCACGTATCA GAGCCTGTAC TCTGGAGCCC CGAGCCACCT AGGGATCCCA 
AGGACCCGAC CAGCACCATA CCCCCTCCCC AACATCCGGG CTGATAGGGA TCAAGGAGGC 
CTGCCTCTCC CAGCTGGGCT GGGGCTCCTG TCCCCCACTG TGGTGTGCCT GGGGCCTGGC 
CAGGACTCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBX10 ( XM_011544992.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543294.1 Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu79500
Clone ID Related Accession (Same CDS sequence)	XM_011544992.2
Accession Version	XM_011544992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-box transcription factor TBX10 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544992.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAGTG GGGGATCCTG TGAGAACACA GCCCTGGCAG TCAGGGAGGG CTTCCTGGAG 
GAAGAGGCAT ATAGGTGCAG CCTGAAGGAT AAGAGCTGGC TGGGTGATGC GTGGGGCCCA 
CACTTCCGTC CTCTCTCCAC AGCCTTCCTA TCTGCTGGCC TCGGCATACT TGCACCCTCA 
GAGACCTACC CCCTACCTAC AACCAGCTCT GGCTGGGAGC CCCGGCTGGG GTCACCATTC 
CCATCAGGCC CTTGCACCAG CTCTACTGGG GCCCAAGCTG TGGCCGAGCC CACTGGGCAG 
GGCCCCAAGA ACCCACGTGT GTCCAGAGTG ACAGTTCAGC TGGAGATGAA GCCTCTGTGG 
GAGGAATTCA ACCAGCTGGG CACTGAGATG ATCGTCACCA AGGCAGGCAG GAGGATGTTC 
CCCCCCTTCC AGGTGAAGAT CCTGGGCATG GACTCCCTGG CCGACTACGC CCTGCTCATG 
GACTTCATCC CCCTGGACGA CAAGAGATAC AGGTATGCCT TCCACAGCTC GGCCTGGCTG 
GTGGCGGGCA AGGCAGACCC AGCCACACCT GGCCGCGTGC ACTTCCACCC CGACTCGCCA 
GCCAAGGGTG CCCAGTGGAT GCGCCAGATT GTGTCCTTTG ACAAGCTCAA GCTGACCAAC 
AACCTGCTGG ATGACAATGG CCACATCATT CTCAACTCTA TGCACCGCTA CCAGCCCCGT 
TTCCACGTGG TCTTCGTGGA CCCACGCAAG GACAGTGAGC GCTATGCCCA GGAGAACTTC 
AAGTCCTTCA TCTTCACAGA GACCCAGTTC ACAGCAGTGA CAGCCTATCA GAACCACAGG 
ATCACCCAGC TGAAAATCGC CAGCAACCCT TTTGCCAAAG GCTTTAGAGA GAGTGACCTG 
GACTCCTGGC CTGTGGCCCC ACGGCCCCTG CTCAGTGTCC CAGCCCGGAG TCACAGCAGC 
CTCAGTCCCT GTGTGCTGAA GGGTGCCACA GACAGGGAGA AAGACCCCAA CAAAGCTTCA 
GCTTCCACCT CCAAGACCCC TGCTTGGCTC CATCATCAGC TGCTGCCCCC ACCTGAGGTC 
CTGCTGGCCC CGGCCACCTA CAGGCCTGTC ACGTATCAGA GCCTGTACTC TGGAGCCCCG 
AGCCACCTAG GGATCCCAAG GACCCGACCA GCACCATACC CCCTCCCCAA CATCCGGGCT 
GATAGGGATC AAGGAGGCCT GCCTCTCCCA GCTGGGCTGG GGCTCCTGTC CCCCACTGTG 
GTGTGCCTGG GGCCTGGCCA GGACTCCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543294.1
CDS	244..1536
Translation	MLSGGSCENTALAVREGFLEEEAYRCSLKDKSWLGDAWGPHFRPLSTAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPKNPRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSKTPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ

Target ORF information:

RefSeq Version	XM_011544992.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T-box transcription factor 10 (TBX10), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544992.2

ORF Insert Sequence:

ATGCTGAGTG GGGGATCCTG TGAGAACACA GCCCTGGCAG TCAGGGAGGG CTTCCTGGAG 
GAAGAGGCAT ATAGGTGCAG CCTGAAGGAT AAGAGCTGGC TGGGTGATGC GTGGGGCCCA 
CACTTCCGTC CTCTCTCCAC AGCCTTCCTA TCTGCTGGCC TCGGCATACT TGCACCCTCA 
GAGACCTACC CCCTACCTAC AACCAGCTCT GGCTGGGAGC CCCGGCTGGG GTCACCATTC 
CCATCAGGCC CTTGCACCAG CTCTACTGGG GCCCAAGCTG TGGCCGAGCC CACTGGGCAG 
GGCCCCAAGA ACCCACGTGT GTCCAGAGTG ACAGTTCAGC TGGAGATGAA GCCTCTGTGG 
GAGGAATTCA ACCAGCTGGG CACTGAGATG ATCGTCACCA AGGCAGGCAG GAGGATGTTC 
CCCCCCTTCC AGGTGAAGAT CCTGGGCATG GACTCCCTGG CCGACTACGC CCTGCTCATG 
GACTTCATCC CCCTGGACGA CAAGAGATAC AGGTATGCCT TCCACAGCTC GGCCTGGCTG 
GTGGCGGGCA AGGCAGACCC AGCCACACCT GGCCGCGTGC ACTTCCACCC CGACTCGCCA 
GCCAAGGGTG CCCAGTGGAT GCGCCAGATT GTGTCCTTTG ACAAGCTCAA GCTGACCAAC 
AACCTGCTGG ATGACAATGG CCACATCATT CTCAACTCTA TGCACCGCTA CCAGCCCCGT 
TTCCACGTGG TCTTCGTGGA CCCACGCAAG GACAGTGAGC GCTATGCCCA GGAGAACTTC 
AAGTCCTTCA TCTTCACAGA GACCCAGTTC ACAGCAGTGA CAGCCTATCA GAACCACAGG 
ATCACCCAGC TGAAAATCGC CAGCAACCCT TTTGCCAAAG GCTTTAGAGA GAGTGACCTG 
GACTCCTGGC CTGTGGCCCC ACGGCCCCTG CTCAGTGTCC CAGCCCGGAG TCACAGCAGC 
CTCAGTCCCT GTGTGCTGAA GGGTGCCACA GACAGGGAGA AAGACCCCAA CAAAGCTTCA 
GCTTCCACCT CCAAGACCCC TGCTTGGCTC CATCATCAGC TGCTGCCCCC ACCTGAGGTC 
CTGCTGGCCC CGGCCACCTA CAGGCCTGTC ACGTATCAGA GCCTGTACTC TGGAGCCCCG 
AGCCACCTAG GGATCCCAAG GACCCGACCA GCACCATACC CCCTCCCCAA CATCCGGGCT 
GATAGGGATC AAGGAGGCCT GCCTCTCCCA GCTGGGCTGG GGCTCCTGTC CCCCACTGTG 
GTGTGCCTGG GGCCTGGCCA GGACTCCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.
Birth defects research. Part A, Clinical and molecular teratology88(7)538-45(2010 Jul)
Mostowska A,Hozyasz KK,Wojcicki P,Biedziak B,Paradowska P,Jagodzinski PP

MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
European journal of oral sciences118(3)213-20(2010 Jun)
Jagom?gi T,Nikopensius T,Krjutskov K,Tammekivi V,Viltrop T,Saag M,Metspalu A

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
PLoS genetics1(6)e64(2005 Dec)
Vieira AR,Avila JR,Daack-Hirsch S,Dragan E,F?lix TM,Rahimov F,Harrington J,Schultz RR,Watanabe Y,Johnson M,Fang J,O'Brien SE,Orioli IM,Castilla EE,Fitzpatrick DR,Jiang R,Marazita ML,Murray JC

T-box genes in vertebrate development.
Annual review of genetics39219-39(2005)
Naiche LA,Harrelson Z,Kelly RG,Papaioannou VE

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TBX10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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