LRRTM3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRRTM3
Entrez Gene ID	347731
Full Name	leucine rich repeat transmembrane neuronal 3
General protein information	Preferred Names leucine rich repeat transmembrane neuronal 3 Names leucine-rich repeat transmembrane neuronal protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.3
Disorder MIM:	610869

mRNA and Protein(s)

mRNA	Protein	Name
NM_178011.4	NP_821079.3	leucine-rich repeat transmembrane neuronal protein 3 precursor
NM_178011.5	NP_821079.3	leucine-rich repeat transmembrane neuronal protein 3 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LRRTM3	XP_546127.2
Homo sapiens (human)	LRRTM3	NP_821079.3
Pan troglodytes (chimpanzee)	LRRTM3	XP_003312627.1
Mus musculus (house mouse)	Lrrtm3	NP_848793.1
Bos taurus (cattle)	LRRTM3	NP_001096753.1
Gallus gallus (chicken)	LRRTM3	NP_001186474.1
Rattus norvegicus (Norway rat)	Lrrtm3	NP_001099857.1
	LRRTM3	XP_002805754.1
Xenopus tropicalis (tropical clawed frog)	lrrtm3	XP_002936907.2

Gene Ontology
Bibliography

Related articles in PubMed

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
Um JW, Choi TY, Kang H, Cho YS, Choii G, Uvarov P, Park D, Jeong D, Jeon S, Lee D, Kim H, Lee SH, Bae YC, Choi SY, Airaksinen MS, Ko J
Cell reports14(4)808-822(2016 Feb)

Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.
Wang J, Yu JT, Jiang T, Tan MS, Wang HF, Tan L, Hu N, Sun L, Zhang W, Tan L
Experimental gerontology5218-22(2014 Apr)

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, Abdul-Hay SO, Springer W, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Lewis JM, Dickson D, Graff-Radford NR, Petersen RC, Eckman E, Younkin SG, Ertekin-Taner N
PloS one8(6)e64164(2013)

Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.
Reitz C, Conrad C, Roszkowski K, Rogers RS, Mayeux R
Archives of neurology69(7)894-900(2012 Jul)

LRRTM3 is dispensable for amyloid-? production in mice.
Laakso T, Muggalla P, Kysenius K, Laur?n J, Paatero A, Huttunen HJ, Airaksinen MS
Journal of Alzheimer's disease : JAD31(4)759-64(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRRTM3 polymorphisms may play a role in the pathogenesis of late-onset Alzheimer's disease (LOAD) in a Northern Han Chinese population.
Title: Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.

protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD
Title: LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

One single-nucleotide polymorphism in the promoter region and a block of 4 single-nucleotide polymorphisms in intron 2 were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set.
Title: Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.

LRRTM3 is not an essential regulator of amyloid-beta production in adult mice; there are no differences in genotype between levels of Abeta or Abeta protein precursor C-terminal fragments in vivo.
Title: LRRTM3 is dispensable for amyloid-? production in mice.

Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.
Title: Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.

The following LRRTM3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRTM3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23950	NM_178011.5 Latest version!	Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu23950	NM_178011.4	Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRRTM3 ( NM_178011.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_821079.3 Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23950
Clone ID Related Accession (Same CDS sequence)	NM_178011.4 , NM_178011.5
Accession Version	NM_178011.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	leucine-rich repeat transmembrane neuronal protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069536.4, BC111492.1 and AC022401.4. On Apr 1, 2014 this sequence version replaced NM_178011.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTTTCA ATGTAATTAG GCTACTGAGC GGATCAGCTG TAGCACTGGT TATAGCCCCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCC GAACGAGGAT GCCCTAAGGG CTGTAGGTGT 
GAAGGCAAAA TGGTATATTG TGAATCTCAG AAATTACAGG AGATACCCTC AAGTATATCT 
GCTGGTTGCT TAGGTTTGTC CCTTCGCTAT AACAGCCTTC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAACCAGCT CACCTGGCTA TACCTTGACC ATAACCATAT CAGCAATATT 
GACGAAAATG CTTTTAATGG AATACGCAGA CTCAAAGAGC TGATTCTTAG TTCCAATAGA 
ATCTCCTATT TTCTTAACAA TACCTTCAGA CCTGTGACAA ATTTACGGAA CTTGGATCTG 
TCCTATAATC AGCTGCATTC TCTGGGATCT GAACAGTTTC GGGGCTTGCG GAAGCTGCTG 
AGTTTACATT TACGGTCTAA CTCCCTGAGA ACCATCCCTG TGCGAATATT CCAAGACTGC 
CGCAACCTGG AACTTTTGGA CCTGGGATAT AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAACTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TTTTTCCAAG GTTGGTCAGC CTTCAGAACC TTTACTTGCA GTGGAATAAA 
ATCAGTGTCA TAGGACAGAC CATGTCCTGG ACCTGGAGCT CCTTACAAAG GCTTGATTTA 
TCAGGCAATG AGATCGAAGC TTTCAGTGGA CCCAGTGTTT TCCAGTGTGT CCCGAATCTG 
CAGCGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GTCAAGAGAT TTTGGATTCT 
TGGATATCCC TCAATGACAT CAGTCTTGCT GGGAATATAT GGGAATGCAG CAGAAATATT 
TGCTCCCTTG TAAACTGGCT GAAAAGTTTT AAAGGTCTAA GGGAGAATAC AATTATCTGT 
GCCAGTCCCA AAGAGCTGCA AGGAGTAAAT GTGATCGATG CAGTGAAGAA CTACAGCATC 
TGTGGCAAAA GTACTACAGA GAGGTTTGAT CTGGCCAGGG CTCTCCCAAA GCCGACGTTT 
AAGCCCAAGC TCCCCAGGCC GAAGCATGAG AGCAAACCCC CTTTGCCCCC GACGGTGGGA 
GCCACAGAGC CCGGCCCAGA GACCGATGCT GACGCCGAGC ACATCTCTTT CCATAAAATC 
ATCGCGGGCA GCGTGGCGCT TTTCCTGTCC GTGCTCGTCA TCCTGCTGGT TATCTACGTG 
TCATGGAAGC GGTACCCTGC GAGCATGAAG CAGCTGCAGC AGCGCTCCCT CATGCGAAGG 
CACAGGAAAA AGAAAAGACA GTCCCTAAAG CAAATGACTC CCAGCACCCA GGAATTTTAT 
GTAGATTATA AACCCACCAA CACGGAGACC AGCGAGATGC TGCTGAATGG GACGGGACCC 
TGCACCTATA ACAAATCGGG CTCCAGGGAG TGTGAGATAC CTTTATCAAT GAATGTGTCA 
ACCTTTCTGG CATACGACCA GCCCACAATA AGTTACTGTG GGGTGCATCA TGAACTTCTC 
TCCCATAAGT CCTTTGAAAC GAATGCACAG GAAGATACGA TGGAAACACA CCTAGAGACT 
GAGCTGGACC TGAGCACAAT CACAACAGCT GGCCGAATCA GTGACCATAA ACAGCAGCTA 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821079.3
CDS	551..2296
Translation	MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA

Target ORF information:

RefSeq Version	NM_178011.4
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178011.4

ORF Insert Sequence:

ATGGGTTTCA ATGTAATTAG GCTACTGAGC GGATCAGCTG TAGCACTGGT TATAGCCCCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCC GAACGAGGAT GCCCTAAGGG CTGTAGGTGT 
GAAGGCAAAA TGGTATATTG TGAATCTCAG AAATTACAGG AGATACCCTC AAGTATATCT 
GCTGGTTGCT TAGGTTTGTC CCTTCGCTAT AACAGCCTTC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAACCAGCT CACCTGGCTA TACCTTGACC ATAACCATAT CAGCAATATT 
GACGAAAATG CTTTTAATGG AATACGCAGA CTCAAAGAGC TGATTCTTAG TTCCAATAGA 
ATCTCCTATT TTCTTAACAA TACCTTCAGA CCTGTGACAA ATTTACGGAA CTTGGATCTG 
TCCTATAATC AGCTGCATTC TCTGGGATCT GAACAGTTTC GGGGCTTGCG GAAGCTGCTG 
AGTTTACATT TACGGTCTAA CTCCCTGAGA ACCATCCCTG TGCGAATATT CCAAGACTGC 
CGCAACCTGG AACTTTTGGA CCTGGGATAT AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAACTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TTTTTCCAAG GTTGGTCAGC CTTCAGAACC TTTACTTGCA GTGGAATAAA 
ATCAGTGTCA TAGGACAGAC CATGTCCTGG ACCTGGAGCT CCTTACAAAG GCTTGATTTA 
TCAGGCAATG AGATCGAAGC TTTCAGTGGA CCCAGTGTTT TCCAGTGTGT CCCGAATCTG 
CAGCGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GTCAAGAGAT TTTGGATTCT 
TGGATATCCC TCAATGACAT CAGTCTTGCT GGGAATATAT GGGAATGCAG CAGAAATATT 
TGCTCCCTTG TAAACTGGCT GAAAAGTTTT AAAGGTCTAA GGGAGAATAC AATTATCTGT 
GCCAGTCCCA AAGAGCTGCA AGGAGTAAAT GTGATCGATG CAGTGAAGAA CTACAGCATC 
TGTGGCAAAA GTACTACAGA GAGGTTTGAT CTGGCCAGGG CTCTCCCAAA GCCGACGTTT 
AAGCCCAAGC TCCCCAGGCC GAAGCATGAG AGCAAACCCC CTTTGCCCCC GACGGTGGGA 
GCCACAGAGC CCGGCCCAGA GACCGATGCT GACGCCGAGC ACATCTCTTT CCATAAAATC 
ATCGCGGGCA GCGTGGCGCT TTTCCTGTCC GTGCTCGTCA TCCTGCTGGT TATCTACGTG 
TCATGGAAGC GGTACCCTGC GAGCATGAAG CAGCTGCAGC AGCGCTCCCT CATGCGAAGG 
CACAGGAAAA AGAAAAGACA GTCCCTAAAG CAAATGACTC CCAGCACCCA GGAATTTTAT 
GTAGATTATA AACCCACCAA CACGGAGACC AGCGAGATGC TGCTGAATGG GACGGGACCC 
TGCACCTATA ACAAATCGGG CTCCAGGGAG TGTGAGATAC CTTTATCAAT GAATGTGTCA 
ACCTTTCTGG CATACGACCA GCCCACAATA AGTTACTGTG GGGTGCATCA TGAACTTCTC 
TCCCATAAGT CCTTTGAAAC GAATGCACAG GAAGATACGA TGGAAACACA CCTAGAGACT 
GAGCTGGACC TGAGCACAAT CACAACAGCT GGCCGAATCA GTGACCATAA ACAGCAGCTA 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRTM3 ( NM_178011.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_821079.3 Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23950
Clone ID Related Accession (Same CDS sequence)	NM_178011.4 , NM_178011.5
Accession Version	NM_178011.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	leucine-rich repeat transmembrane neuronal protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069536.4, BC111492.1 and AC022401.4. On Nov 22, 2018 this sequence version replaced NM_178011.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.24566.1, SRR1660805.223309.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361320.5/ ENSP00000355187.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTTTCA ATGTAATTAG GCTACTGAGC GGATCAGCTG TAGCACTGGT TATAGCCCCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCC GAACGAGGAT GCCCTAAGGG CTGTAGGTGT 
GAAGGCAAAA TGGTATATTG TGAATCTCAG AAATTACAGG AGATACCCTC AAGTATATCT 
GCTGGTTGCT TAGGTTTGTC CCTTCGCTAT AACAGCCTTC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAACCAGCT CACCTGGCTA TACCTTGACC ATAACCATAT CAGCAATATT 
GACGAAAATG CTTTTAATGG AATACGCAGA CTCAAAGAGC TGATTCTTAG TTCCAATAGA 
ATCTCCTATT TTCTTAACAA TACCTTCAGA CCTGTGACAA ATTTACGGAA CTTGGATCTG 
TCCTATAATC AGCTGCATTC TCTGGGATCT GAACAGTTTC GGGGCTTGCG GAAGCTGCTG 
AGTTTACATT TACGGTCTAA CTCCCTGAGA ACCATCCCTG TGCGAATATT CCAAGACTGC 
CGCAACCTGG AACTTTTGGA CCTGGGATAT AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAACTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TTTTTCCAAG GTTGGTCAGC CTTCAGAACC TTTACTTGCA GTGGAATAAA 
ATCAGTGTCA TAGGACAGAC CATGTCCTGG ACCTGGAGCT CCTTACAAAG GCTTGATTTA 
TCAGGCAATG AGATCGAAGC TTTCAGTGGA CCCAGTGTTT TCCAGTGTGT CCCGAATCTG 
CAGCGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GTCAAGAGAT TTTGGATTCT 
TGGATATCCC TCAATGACAT CAGTCTTGCT GGGAATATAT GGGAATGCAG CAGAAATATT 
TGCTCCCTTG TAAACTGGCT GAAAAGTTTT AAAGGTCTAA GGGAGAATAC AATTATCTGT 
GCCAGTCCCA AAGAGCTGCA AGGAGTAAAT GTGATCGATG CAGTGAAGAA CTACAGCATC 
TGTGGCAAAA GTACTACAGA GAGGTTTGAT CTGGCCAGGG CTCTCCCAAA GCCGACGTTT 
AAGCCCAAGC TCCCCAGGCC GAAGCATGAG AGCAAACCCC CTTTGCCCCC GACGGTGGGA 
GCCACAGAGC CCGGCCCAGA GACCGATGCT GACGCCGAGC ACATCTCTTT CCATAAAATC 
ATCGCGGGCA GCGTGGCGCT TTTCCTGTCC GTGCTCGTCA TCCTGCTGGT TATCTACGTG 
TCATGGAAGC GGTACCCTGC GAGCATGAAG CAGCTGCAGC AGCGCTCCCT CATGCGAAGG 
CACAGGAAAA AGAAAAGACA GTCCCTAAAG CAAATGACTC CCAGCACCCA GGAATTTTAT 
GTAGATTATA AACCCACCAA CACGGAGACC AGCGAGATGC TGCTGAATGG GACGGGACCC 
TGCACCTATA ACAAATCGGG CTCCAGGGAG TGTGAGATAC CTTTATCAAT GAATGTGTCA 
ACCTTTCTGG CATACGACCA GCCCACAATA AGTTACTGTG GGGTGCATCA TGAACTTCTC 
TCCCATAAGT CCTTTGAAAC GAATGCACAG GAAGATACGA TGGAAACACA CCTAGAGACT 
GAGCTGGACC TGAGCACAAT CACAACAGCT GGCCGAATCA GTGACCATAA ACAGCAGCTA 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821079.3
CDS	549..2294
Translation	MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA

Target ORF information:

RefSeq Version	NM_178011.5
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat transmembrane neuronal 3 (LRRTM3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178011.5

ORF Insert Sequence:

ATGGGTTTCA ATGTAATTAG GCTACTGAGC GGATCAGCTG TAGCACTGGT TATAGCCCCC 
ACTGTCTTAC TGACAATGCT TTCTTCTGCC GAACGAGGAT GCCCTAAGGG CTGTAGGTGT 
GAAGGCAAAA TGGTATATTG TGAATCTCAG AAATTACAGG AGATACCCTC AAGTATATCT 
GCTGGTTGCT TAGGTTTGTC CCTTCGCTAT AACAGCCTTC AAAAACTTAA GTATAATCAA 
TTTAAAGGGC TCAACCAGCT CACCTGGCTA TACCTTGACC ATAACCATAT CAGCAATATT 
GACGAAAATG CTTTTAATGG AATACGCAGA CTCAAAGAGC TGATTCTTAG TTCCAATAGA 
ATCTCCTATT TTCTTAACAA TACCTTCAGA CCTGTGACAA ATTTACGGAA CTTGGATCTG 
TCCTATAATC AGCTGCATTC TCTGGGATCT GAACAGTTTC GGGGCTTGCG GAAGCTGCTG 
AGTTTACATT TACGGTCTAA CTCCCTGAGA ACCATCCCTG TGCGAATATT CCAAGACTGC 
CGCAACCTGG AACTTTTGGA CCTGGGATAT AACCGGATCC GAAGTTTAGC CAGGAATGTC 
TTTGCTGGCA TGATCAGACT CAAAGAACTT CACCTGGAGC ACAATCAATT TTCCAAGCTC 
AACCTGGCCC TTTTTCCAAG GTTGGTCAGC CTTCAGAACC TTTACTTGCA GTGGAATAAA 
ATCAGTGTCA TAGGACAGAC CATGTCCTGG ACCTGGAGCT CCTTACAAAG GCTTGATTTA 
TCAGGCAATG AGATCGAAGC TTTCAGTGGA CCCAGTGTTT TCCAGTGTGT CCCGAATCTG 
CAGCGCCTCA ACCTGGATTC CAACAAGCTC ACATTTATTG GTCAAGAGAT TTTGGATTCT 
TGGATATCCC TCAATGACAT CAGTCTTGCT GGGAATATAT GGGAATGCAG CAGAAATATT 
TGCTCCCTTG TAAACTGGCT GAAAAGTTTT AAAGGTCTAA GGGAGAATAC AATTATCTGT 
GCCAGTCCCA AAGAGCTGCA AGGAGTAAAT GTGATCGATG CAGTGAAGAA CTACAGCATC 
TGTGGCAAAA GTACTACAGA GAGGTTTGAT CTGGCCAGGG CTCTCCCAAA GCCGACGTTT 
AAGCCCAAGC TCCCCAGGCC GAAGCATGAG AGCAAACCCC CTTTGCCCCC GACGGTGGGA 
GCCACAGAGC CCGGCCCAGA GACCGATGCT GACGCCGAGC ACATCTCTTT CCATAAAATC 
ATCGCGGGCA GCGTGGCGCT TTTCCTGTCC GTGCTCGTCA TCCTGCTGGT TATCTACGTG 
TCATGGAAGC GGTACCCTGC GAGCATGAAG CAGCTGCAGC AGCGCTCCCT CATGCGAAGG 
CACAGGAAAA AGAAAAGACA GTCCCTAAAG CAAATGACTC CCAGCACCCA GGAATTTTAT 
GTAGATTATA AACCCACCAA CACGGAGACC AGCGAGATGC TGCTGAATGG GACGGGACCC 
TGCACCTATA ACAAATCGGG CTCCAGGGAG TGTGAGATAC CTTTATCAAT GAATGTGTCA 
ACCTTTCTGG CATACGACCA GCCCACAATA AGTTACTGTG GGGTGCATCA TGAACTTCTC 
TCCCATAAGT CCTTTGAAAC GAATGCACAG GAAGATACGA TGGAAACACA CCTAGAGACT 
GAGCTGGACC TGAGCACAAT CACAACAGCT GGCCGAATCA GTGACCATAA ACAGCAGCTA 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
Cell reports14(4)808-822(2016 Feb)
Um JW,Choi TY,Kang H,Cho YS,Choii G,Uvarov P,Park D,Jeong D,Jeon S,Lee D,Kim H,Lee SH,Bae YC,Choi SY,Airaksinen MS,Ko J

Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.
Experimental gerontology5218-22(2014 Apr)
Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
PloS one8(6)e64164(2013)
Lincoln S,Allen M,Cox CL,Walker LP,Malphrus K,Qiu Y,Nguyen T,Rowley C,Kouri N,Crook J,Pankratz VS,Younkin S,Younkin L,Carrasquillo M,Zou F,Abdul-Hay SO,Springer W,Sando SB,Aasly JO,Barcikowska M,Wszolek ZK,Lewis JM,Dickson D,Graff-Radford NR,Petersen RC,Eckman E,Younkin SG,Ertekin-Taner N

Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.
Archives of neurology69(7)894-900(2012 Jul)
Reitz C,Conrad C,Roszkowski K,Rogers RS,Mayeux R

LRRTM3 is dispensable for amyloid-? production in mice.
Journal of Alzheimer's disease : JAD31(4)759-64(2012)
Laakso T,Muggalla P,Kysenius K,Laur?n J,Paatero A,Huttunen HJ,Airaksinen MS

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

LRRTM3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報