CAVIN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAVIN4
Entrez Gene ID	347273
Full Name	caveolae associated protein 4
Synonyms	MURC,cavin-4
General protein information	Preferred Names caveolae associated protein 4 Names caveolae-associated protein 4 muscle related coiled-coil protein muscle-restricted coiled-coil protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q31.1
Summary	This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013].
Disorder MIM:	617714

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018116.2	NP_001018126.1	caveolae-associated protein 4

Pathways from BioSystems

Homologies

	MURC	XP_001111821.1
Bos taurus (cattle)	MURC	NP_001096734.2
Danio rerio (zebrafish)	murcb	NP_001008579.1
Gallus gallus (chicken)	MURC	XP_419073.2
Xenopus tropicalis (tropical clawed frog)	murc	XP_002935326.1
Canis lupus familiaris (dog)	MURC	XP_538754.1
Mus musculus (house mouse)	Murc	NP_080785.2
Rattus norvegicus (Norway rat)	Murc	NP_001101401.1
Danio rerio (zebrafish)	murca	NP_001073667.1
Homo sapiens (human)	MURC	NP_001018126.1
Pan troglodytes (chimpanzee)	MURC	XP_520155.1

Gene Ontology
Bibliography

Related articles in PubMed

The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.
Naito D, Ogata T, Hamaoka T, Nakanishi N, Miyagawa K, Maruyama N, Kasahara T, Taniguchi T, Nishi M, Matoba S, Ueyama T
American journal of physiology. Heart and circulatory physiology309(12)H2127-36(2015 Dec)

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line.
Faggi F, Codenotti S, Poliani PL, Cominelli M, Chiarelli N, Colombi M, Vezzoli M, Monti E, Bono F, Tulipano G, Fiorentini C, Zanola A, Lo HP, Parton RG, Keller C, Fanzani A
PloS one10(6)e0130287(2015)

A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly.
Chouraki V, De Bruijn RF, Chapuis J, Bis JC, Reitz C, Schraen S, Ibrahim-Verbaas CA, Grenier-Boley B, Delay C, Rogers R, Demiautte F, Mounier A, Fitzpatrick AL, , Berr C, Dartigues JF, Uitterlinden AG, Hofman A, Breteler M, Becker JT, Lathrop M, Schupf N, Alp?rovitch A, Mayeux R, van Duijn CM, Bu?e L, Amouyel P, Lopez OL, Ikram MA, Tzourio C, Lambert JC
Molecular psychiatry19(12)1326-35(2014 Dec)

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by ?1-adrenergic receptors.
Ogata T, Naito D, Nakanishi N, Hayashi YK, Taniguchi T, Miyagawa K, Hamaoka T, Maruyama N, Matoba S, Ikeda K, Yamada H, Oh H, Ueyama T
Proceedings of the National Academy of Sciences of the United States of America111(10)3811-6(2014 Mar)

FSHD myotubes with different phenotypes exhibit distinct proteomes.
Tassin A, Leroy B, Laoudj-Chenivesse D, Wauters A, Vanderplanck C, Le Bihan MC, Copp?e F, Wattiez R, Belayew A
PloS one7(12)e51865(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MURC/cavin-4, especially in combination with Cav-3, may play a consistent role in the differentiation process of rhabdomyosarcoma.
Title: MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line.

MURC mutations impart loss-of-function effects on MURC functions and probably are causal variants in human dilated cardiomyopathy
Title: Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy.

MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.
Title: MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.

The following CAVIN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAVIN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20583	NM_001018116.2 Latest version!	Homo sapiens caveolae associated protein 4 (CAVIN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAVIN4 ( NM_001018116.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018126.1 Homo sapiens caveolae associated protein 4 (CAVIN4), mRNA.

Price & Availability↑

CloneID	OHu20583
Clone ID Related Accession (Same CDS sequence)	NM_001018116.2
Accession Version	NM_001018116.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Homo sapiens(human)
Product	caveolae-associated protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300099.1, BC090888.1, EU487253.1, AL354917.8 and AA446953.1. This sequence is a reference standard in the RefSeqGene project. On Jun 26, 2013 this sequence version replaced NM_001018116.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK300099.1, BC090888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307584.6/ ENSP00000418668.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAACATA ATGGGTCTGC TTCAAATGCT GATAAAATCC ACCAGAATCG CCTGTCGAGT 
GTTACAGAAG ATGAAGACCA AGACGCTGCT CTTACCATTG TGACTGTGCT GGACAAAGTA 
GCCTCCATCG TGGACAGTGT GCAGGCAAGC CAGAAGAGAA TAGAAGAGAG ACACAGGGAA 
ATGGAAAATG CCATAAAATC CGTCCAGATT GACCTGTTGA AGCTTTCACA GTCGCATAGC 
AATACAGGGC ATATCATTAA CAAATTGTTT GAGAAAACCC GAAAAGTTAG TGCTCACATT 
AAAGATGTGA AAGCCCGGGT GGAGAAGCAA CAAATTCATG TTAAAAAAGT TGAAGTCAAG 
CAAGAGGAAA TAATGAAGAA AAACAAATTC CGCGTGGTAA TATTCCAGGA GAAGTTTCGG 
TGTCCGACAT CCCTGTCTGT TGTTAAAGAC AGAAACCTAA CTGAGAACCA AGAAGAGGAT 
GATGATGATA TCTTTGATCC CCCAGTAGAT CTGTCTTCGG ATGAAGAATA TTATGTTGAA 
GAAAGCAGAT CTGCCAGGCT TAGGAAGTCA GGCAAGGAGC ACATTGATAA TATCAAGAAG 
GCATTTTCCA AAGAAAACAT GCAGAAGACA CGGCAGAATC TTGACAAGAA AGTGAACAGA 
ATTAGAACTA GAATAGTGAC CCCGGAGAGG AGAGAGAGGC TAAGGCAGTC AGGAGAGAGG 
CTGAGACAGT CAGGGGAGAG GCTGAGACAG TCAGGGGAGA GGTTTAAGAA ATCTATTTCT 
AATGCAGCTC CCTCAAAGGA AGCTTTTAAG ATGCGCAGCC TCAGGAAAGG TAAGGACCGA 
ACAGTGGCTG AAGGTGAGGA ATGTGCCAGG GAGATGGGTG TGGACATCAT TGCCAGGAGC 
GAGTCTCTGG GCCCCATCAG TGAGCTCTAC TCTGATGAGC TCAGTGAACC AGAACACGAG 
GCAGCCAGGC CGGTGTATCC TCCCCATGAA GGAAGGGAAA TCCCCACCCC CGAGCCTTTA 
AAAGTTACTT TTAAATCTCA GGTGAAAGTA GAGGATGATG AATCTCTTTT GTTAGATTTA 
AAGCACTCAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018126.1
CDS	66..1160
Translation	MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS

Target ORF information:

RefSeq Version	NM_001018116.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolae associated protein 4 (CAVIN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018116.2

ORF Insert Sequence:

ATGGAACATA ATGGGTCTGC TTCAAATGCT GATAAAATCC ACCAGAATCG CCTGTCGAGT 
GTTACAGAAG ATGAAGACCA AGACGCTGCT CTTACCATTG TGACTGTGCT GGACAAAGTA 
GCCTCCATCG TGGACAGTGT GCAGGCAAGC CAGAAGAGAA TAGAAGAGAG ACACAGGGAA 
ATGGAAAATG CCATAAAATC CGTCCAGATT GACCTGTTGA AGCTTTCACA GTCGCATAGC 
AATACAGGGC ATATCATTAA CAAATTGTTT GAGAAAACCC GAAAAGTTAG TGCTCACATT 
AAAGATGTGA AAGCCCGGGT GGAGAAGCAA CAAATTCATG TTAAAAAAGT TGAAGTCAAG 
CAAGAGGAAA TAATGAAGAA AAACAAATTC CGCGTGGTAA TATTCCAGGA GAAGTTTCGG 
TGTCCGACAT CCCTGTCTGT TGTTAAAGAC AGAAACCTAA CTGAGAACCA AGAAGAGGAT 
GATGATGATA TCTTTGATCC CCCAGTAGAT CTGTCTTCGG ATGAAGAATA TTATGTTGAA 
GAAAGCAGAT CTGCCAGGCT TAGGAAGTCA GGCAAGGAGC ACATTGATAA TATCAAGAAG 
GCATTTTCCA AAGAAAACAT GCAGAAGACA CGGCAGAATC TTGACAAGAA AGTGAACAGA 
ATTAGAACTA GAATAGTGAC CCCGGAGAGG AGAGAGAGGC TAAGGCAGTC AGGAGAGAGG 
CTGAGACAGT CAGGGGAGAG GCTGAGACAG TCAGGGGAGA GGTTTAAGAA ATCTATTTCT 
AATGCAGCTC CCTCAAAGGA AGCTTTTAAG ATGCGCAGCC TCAGGAAAGG TAAGGACCGA 
ACAGTGGCTG AAGGTGAGGA ATGTGCCAGG GAGATGGGTG TGGACATCAT TGCCAGGAGC 
GAGTCTCTGG GCCCCATCAG TGAGCTCTAC TCTGATGAGC TCAGTGAACC AGAACACGAG 
GCAGCCAGGC CGGTGTATCC TCCCCATGAA GGAAGGGAAA TCCCCACCCC CGAGCCTTTA 
AAAGTTACTT TTAAATCTCA GGTGAAAGTA GAGGATGATG AATCTCTTTT GTTAGATTTA 
AAGCACTCAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.
American journal of physiology. Heart and circulatory physiology309(12)H2127-36(2015 Dec)
Naito D,Ogata T,Hamaoka T,Nakanishi N,Miyagawa K,Maruyama N,Kasahara T,Taniguchi T,Nishi M,Matoba S,Ueyama T

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line.
PloS one10(6)e0130287(2015)
Faggi F,Codenotti S,Poliani PL,Cominelli M,Chiarelli N,Colombi M,Vezzoli M,Monti E,Bono F,Tulipano G,Fiorentini C,Zanola A,Lo HP,Parton RG,Keller C,Fanzani A

A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly.
Molecular psychiatry19(12)1326-35(2014 Dec)
Chouraki V,De Bruijn RF,Chapuis J,Bis JC,Reitz C,Schraen S,Ibrahim-Verbaas CA,Grenier-Boley B,Delay C,Rogers R,Demiautte F,Mounier A,Fitzpatrick AL,,Berr C,Dartigues JF,Uitterlinden AG,Hofman A,Breteler M,Becker JT,Lathrop M,Schupf N,Alp?rovitch A,Mayeux R,van Duijn CM,Bu?e L,Amouyel P,Lopez OL,Ikram MA,Tzourio C,Lambert JC

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by ?1-adrenergic receptors.
Proceedings of the National Academy of Sciences of the United States of America111(10)3811-6(2014 Mar)
Ogata T,Naito D,Nakanishi N,Hayashi YK,Taniguchi T,Miyagawa K,Hamaoka T,Maruyama N,Matoba S,Ikeda K,Yamada H,Oh H,Ueyama T

FSHD myotubes with different phenotypes exhibit distinct proteomes.
PloS one7(12)e51865(2012)
Tassin A,Leroy B,Laoudj-Chenivesse D,Wauters A,Vanderplanck C,Le Bihan MC,Copp?e F,Wattiez R,Belayew A

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CAVIN4 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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