APOD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOD
Entrez Gene ID	347
Full Name	apolipoprotein D
General protein information	Preferred Names apolipoprotein D Names apolipoprotein D apo-D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Summary	This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008].
Disorder MIM:	107740

mRNA and Protein(s)

mRNA	Protein	Name
NM_001647.3	NP_001638.1	apolipoprotein D precursor
NM_001647.4	NP_001638.1	apolipoprotein D precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:123339	NP_001032784.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009281	XP_320076.4
Canis lupus familiaris (dog)	APOD	XP_535780.1
Bos taurus (cattle)	APOD	NP_001069769.1
Pan troglodytes (chimpanzee)	APOD	XP_516965.1
	LOC709223	XP_001098104.2
Mus musculus (house mouse)	Apod	NP_031496.2
Homo sapiens (human)	APOD	NP_001638.1
Rattus norvegicus (Norway rat)	Apod	NP_036909.1
Gallus gallus (chicken)	APOD	NP_001011692.1
Danio rerio (zebrafish)	apod	NP_001070050.1
Drosophila melanogaster (fruit fly)	NLaz	NP_001259867.1

Gene Ontology
Bibliography

Related articles in PubMed

Myelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal.
Garc?a-Mateo N, Pascua-Maestro R, P?rez-Castellanos A, Lillo C, Sanchez D, Ganfornina MD
Glia66(3)670-687(2018 Mar)

Apolipoprotein D expression does not predict breast cancer recurrence among tamoxifen-treated patients.
Klebaner D, Hamilton-Dutoit S, Ahern T, Crawford A, Jakobsen T, Cronin-Fenton DP, Damkier P, Janssen E, Kjaersgaard A, Ording AG, S?iland H, S?rensen HT, Lash TL, Hellberg Y
PloS one12(3)e0171453(2017)

[Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].
Allina DO, Andreeva YY, Zavalishina LE, Moskvina LV, Frank GA
Arkhiv patologii78(5)9-14(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ApoD expression is likely not a predictor of recurrence in tamoxifen-treated patients. IMPACT: This study eliminates the previously suggested marker ApoD as a predictor of recurrence among tamoxifen-treated women
Title: Apolipoprotein D expression does not predict breast cancer recurrence among tamoxifen-treated patients.

Our results provide a viable solution to the production of recombinant ApoD protein in lieu of previous obstacles in generating soluble and functional ApoD protein
Title: Production of a soluble and functional recombinant apolipoproteinD in the Pichia pastoris expression system.

The high rate of APOD expression in HGPIN and cancer, as well as the absence of its expression in the vast majority of morphologically normal glands allows the use of this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
Title: [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].

apoD protein levels are variable across different brain regions.
Title: Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions.

hepatic steatosis observed in apoD Tg mice is a consequence of increased PPARgamma transcriptional activity by AA leading to increased fatty acid uptake by the liver
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake.

The following APOD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03646	NM_001647.4 Latest version!	Homo sapiens apolipoprotein D (APOD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03646	NM_001647.3	Homo sapiens apolipoprotein D (APOD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOD ( NM_001647.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001638.1 Homo sapiens apolipoprotein D (APOD), mRNA.

Price & Availability↑

CloneID	OHu03646
Clone ID Related Accession (Same CDS sequence)	NM_001647.3 , NM_001647.4
Accession Version	NM_001647.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	apolipoprotein D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC069213.22, DA892855.1, BC007402.2 and BU727194.1. On Aug 12, 2008 this sequence version replaced NM_001647.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279838.1341.1, ERR279832.1614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGATGC TGCTGCTGCT GCTTTCCGCA CTGGCTGGCC TCTTCGGTGC GGCAGAGGGA 
CAAGCATTTC ATCTTGGGAA GTGCCCCAAT CCTCCGGTGC AGGAGAATTT TGACGTGAAT 
AAGTATCTCG GAAGATGGTA CGAAATTGAG AAGATCCCAA CAACCTTTGA GAATGGACGC 
TGCATCCAGG CCAACTACTC ACTAATGGAA AACGGAAAGA TCAAAGTGTT AAACCAGGAG 
TTGAGAGCTG ATGGAACTGT GAATCAAATC GAAGGTGAAG CCACCCCAGT TAACCTCACA 
GAGCCTGCCA AGCTGGAAGT TAAGTTTTCC TGGTTTATGC CATCGGCACC GTACTGGATC 
CTGGCCACCG ACTATGAGAA CTATGCCCTC GTGTATTCCT GTACCTGCAT CATCCAACTT 
TTTCACGTGG ATTTTGCTTG GATCTTGGCA AGAAACCCTA ATCTCCCTCC AGAAACAGTG 
GACTCTCTAA AAAATATCCT GACTTCTAAT AACATTGATG TCAAGAAAAT GACGGTCACA 
GACCAGGTGA ACTGCCCCAA GCTCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001638.1
CDS	363..932
Translation	MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS

Target ORF information:

RefSeq Version	NM_001647.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein D (APOD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001647.3

ORF Insert Sequence:

ATGGTGATGC TGCTGCTGCT GCTTTCCGCA CTGGCTGGCC TCTTCGGTGC GGCAGAGGGA 
CAAGCATTTC ATCTTGGGAA GTGCCCCAAT CCTCCGGTGC AGGAGAATTT TGACGTGAAT 
AAGTATCTCG GAAGATGGTA CGAAATTGAG AAGATCCCAA CAACCTTTGA GAATGGACGC 
TGCATCCAGG CCAACTACTC ACTAATGGAA AACGGAAAGA TCAAAGTGTT AAACCAGGAG 
TTGAGAGCTG ATGGAACTGT GAATCAAATC GAAGGTGAAG CCACCCCAGT TAACCTCACA 
GAGCCTGCCA AGCTGGAAGT TAAGTTTTCC TGGTTTATGC CATCGGCACC GTACTGGATC 
CTGGCCACCG ACTATGAGAA CTATGCCCTC GTGTATTCCT GTACCTGCAT CATCCAACTT 
TTTCACGTGG ATTTTGCTTG GATCTTGGCA AGAAACCCTA ATCTCCCTCC AGAAACAGTG 
GACTCTCTAA AAAATATCCT GACTTCTAAT AACATTGATG TCAAGAAAAT GACGGTCACA 
GACCAGGTGA ACTGCCCCAA GCTCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOD ( NM_001647.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001638.1 Homo sapiens apolipoprotein D (APOD), mRNA.

Price & Availability↑

CloneID	OHu03646
Clone ID Related Accession (Same CDS sequence)	NM_001647.3 , NM_001647.4
Accession Version	NM_001647.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	apolipoprotein D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA892855.1, BC007402.2 and BU727194.1. On Nov 22, 2018 this sequence version replaced NM_001647.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279845.5713.1, SRR5189652.131213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000343267.8/ ENSP00000345179.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGATGC TGCTGCTGCT GCTTTCCGCA CTGGCTGGCC TCTTCGGTGC GGCAGAGGGA 
CAAGCATTTC ATCTTGGGAA GTGCCCCAAT CCTCCGGTGC AGGAGAATTT TGACGTGAAT 
AAGTATCTCG GAAGATGGTA CGAAATTGAG AAGATCCCAA CAACCTTTGA GAATGGACGC 
TGCATCCAGG CCAACTACTC ACTAATGGAA AACGGAAAGA TCAAAGTGTT AAACCAGGAG 
TTGAGAGCTG ATGGAACTGT GAATCAAATC GAAGGTGAAG CCACCCCAGT TAACCTCACA 
GAGCCTGCCA AGCTGGAAGT TAAGTTTTCC TGGTTTATGC CATCGGCACC GTACTGGATC 
CTGGCCACCG ACTATGAGAA CTATGCCCTC GTGTATTCCT GTACCTGCAT CATCCAACTT 
TTTCACGTGG ATTTTGCTTG GATCTTGGCA AGAAACCCTA ATCTCCCTCC AGAAACAGTG 
GACTCTCTAA AAAATATCCT GACTTCTAAT AACATTGATG TCAAGAAAAT GACGGTCACA 
GACCAGGTGA ACTGCCCCAA GCTCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001638.1
CDS	98..667
Translation	MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS

Target ORF information:

RefSeq Version	NM_001647.4
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein D (APOD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001647.4

ORF Insert Sequence:

ATGGTGATGC TGCTGCTGCT GCTTTCCGCA CTGGCTGGCC TCTTCGGTGC GGCAGAGGGA 
CAAGCATTTC ATCTTGGGAA GTGCCCCAAT CCTCCGGTGC AGGAGAATTT TGACGTGAAT 
AAGTATCTCG GAAGATGGTA CGAAATTGAG AAGATCCCAA CAACCTTTGA GAATGGACGC 
TGCATCCAGG CCAACTACTC ACTAATGGAA AACGGAAAGA TCAAAGTGTT AAACCAGGAG 
TTGAGAGCTG ATGGAACTGT GAATCAAATC GAAGGTGAAG CCACCCCAGT TAACCTCACA 
GAGCCTGCCA AGCTGGAAGT TAAGTTTTCC TGGTTTATGC CATCGGCACC GTACTGGATC 
CTGGCCACCG ACTATGAGAA CTATGCCCTC GTGTATTCCT GTACCTGCAT CATCCAACTT 
TTTCACGTGG ATTTTGCTTG GATCTTGGCA AGAAACCCTA ATCTCCCTCC AGAAACAGTG 
GACTCTCTAA AAAATATCCT GACTTCTAAT AACATTGATG TCAAGAAAAT GACGGTCACA 
GACCAGGTGA ACTGCCCCAA GCTCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal.
Glia66(3)670-687(2018 Mar)
Garc?a-Mateo N,Pascua-Maestro R,P?rez-Castellanos A,Lillo C,Sanchez D,Ganfornina MD

Apolipoprotein D expression does not predict breast cancer recurrence among tamoxifen-treated patients.
PloS one12(3)e0171453(2017)
Klebaner D,Hamilton-Dutoit S,Ahern T,Crawford A,Jakobsen T,Cronin-Fenton DP,Damkier P,Janssen E,Kjaersgaard A,Ording AG,S?iland H,S?rensen HT,Lash TL,Hellberg Y

[Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].
Arkhiv patologii78(5)9-14(2016)
Allina DO,Andreeva YY,Zavalishina LE,Moskvina LV,Frank GA

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APOD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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